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  • 1
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Introduction -- Current Approaches To APSD Measurement of OIPs Based on Inertial Impaction -- Physical Causes of APSD Changes in Aerosols From OIPs and their Impact on Cascade Impactor Measurements -- Good Cascade Impactor Practices -- The AIM and EDA Concepts: Why they are Needed -- Product Lifecycle Approach to Cascade Impaction Measurements -- Theoretical Basis for the EDA Concept -- Performance Characterization of EDA and its Potential to Improve Decision Making in Product Batch Release -- Verification of the EDA Concept through an Assessment of Theoretical Failure Modes, Failure Mode Analysis and Case Studies with Real Data -- Validating AIM-Based Instrumentation and Associated Measurement Techniques -- The Regulatory and Compendial Acceptance Pathways for AIM and EDA -- Applying the AIM Concept in Support of Developing Improved In Vitro-In Vivo Relationships for OIPs -- Future Directions for the AIM and EDA Concepts -- Conclusions
    Abstract: Aerodynamic particle size characteristics of orally inhaled products (OIPs) are critical to their performance.℗ Testing based on cascade impaction has been the primary tool used to characterize this critical quality attribute and is a regulatory expectation for Quality Control purposes.℗ In recent years, there have been substantial efforts directed at improving aerodynamic particle size determinations.℗ Good Cascade Impactor Practices, AIM and EDA for℗ Orally Inhaled Products brings together for the first time a review of best practices for performing cascade impactor testing with a thorough discussion of the℗ recently introduced concepts of abbreviated impactor measurements (AIM) and efficient data analysis (EDA). ℗ ℗ Topics covered include:℗ ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Review of pharmacopeial methods (US and European) for assessment of aerodynamic particle size distribution (APSD) of℗ OIPs. ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Physical processes that underlie aerosol formation from OIPs and the mechanisms that affect the APSD.℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Good cascade impactor practice (GCIP) related to either full resolution or abbreviated impactor measurements.℗ ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Introduction of the AIM and EDA concepts.℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Selection of the type of testing through the development lifecycle of an OIP.℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Theoretical basis for EDA.℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Performance evaluation of EDA as a quality control element.℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Case studies related to the application of℗ EDA.℗ ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Experimental studies validating the AIM concept conducted by European Pharmaceutical Aerosol Group (EPAG) and the Cascade Impaction Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS).℗ ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Regulatory and compendial pathways to adoption of AIM and EDA. ℗ʺ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Exploration and extension of AIM as a potential approach to measures that could be more predictive of particle deposition in the human respiratory tract.℗ ℗ This comprehensive volume was written by a group of prominent international experts in aerosol testing led by members of the Cascade Impaction Working Group of IPAC-RS.℗ IPAC-RS is an international association of pharmaceutical companies committed to advancing consensus-based, scientifically driven standards and regulations for orally inhaled and nasal drug products
    Pages: : digital.
    ISBN: 9781461462965
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  • 2
    Oxford : Oxford University Press
    Call number: B020:7
    Keywords: Chemistry, Physical and theoretical
    Pages: xxi, 1149 p. : ill.
    Edition: 7th ed.
    ISBN: 0198792859
    Signatur Availability
    B020:7 departmental collection or stack – please contact the library
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  • 3
    Keywords: Medicine ; Family medicine ; Internal Medicine ; Cardiology ; Nursing ; Medicine & Public Health ; Internal Medicine ; Cardiology ; General Practice / Family Medicine ; Nursing ; Springer eBooks
    Pages: : digital
    ISBN: 9781603279635
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  • 4
    New York, NY : Landes Bioscience and Springer Science+Business Media, LLC
    Keywords: Medicine ; Biomedicine ; Biomedicine general ; Springer eBooks
    Pages: : digital
    ISBN: 9781441963154
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  • 5
    Keywords: Medicine ; Nephrology ; Urology ; Medicine & Public Health ; Urology/Andrology ; Nephrology ; Springer eBooks
    Pages: : digital
    ISBN: 9781848003620
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  • 6
    Keywords: Medicine ; Neurosciences ; Ophthalmology ; Neurobiology ; Biomedicine ; Neurosciences ; Ophthalmology ; Neurobiology ; Springer eBooks
    Description / Table of Contents: 1. Introduction -- 2. Fundamental Retinal Circuitry for Circadian Rhythms -- 3. Circadian photoreception: from phototransduction to behaviour -- 4. Role of Melatonin and Dopamine in the Regulation of Retinal Circadian Rhythms -- 5. Circadian Organization of the Vertebrate Retina -- 6. Rhythmicity of the Retinal Pigment Epithelium -- 7. Retinal Circadian Rhythms in Mammals Revealed Using Electroretinography -- 8. Circadian Clock and Light Induced Retinal Damage -- 9. Circadian Rhythms and Vision in Zebrafish -- 10. Circadian Modulation of the Limulus Eye for Day and Night Vision -- 11. Molluscan Ocular Pacemakers: Lessons Learned. ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗
    Abstract: The retina plays a critical role in the organization of the circadian system by synchronizing the braiń€™s central clock with the external day through transduction of the daily light/dark cycle.℗ However, the substantial variation in luminance imposed on the retina between day and night also poses a challenge to its role as a sensory tissue ́€“ how is it possible to faithfully encode the enormous dynamic range of luminance that can exceed 10 orders of magnitude? The Retina and Circadian Rhythms summarizes the knowledge accumulated over the last 30 years about the organization of the retinal circadian clock in many different species, concentrating on the roles that this circadian system plays in retinal function. About the Series: The Springer Series in Vision Research is a comprehensive update and overview of cutting edge vision research, exploring, in depth, current breakthroughs at a conceptual level. It details the whole visual system, from molecular processes to anatomy, physiology and behavior and covers both invertebrate and vertebrate organisms from terrestrial and aquatic habitats. Each book in the Series is aimed at all individuals with interests in vision including advanced graduate students, post-doctoral researchers, established vision scientists and clinical investigators.The series editors are N. Justin Marshall, Queensland Brain Institute, The University of Queensland, Australia and Shaun P. Collin, Neuroecology Group within the School of Animal Biology and the Oceans Institute at the University of Western Australia
    Pages: VIII, 238 p. 50 illus., 33 illus. in color. : online resource.
    ISBN: 9781461496137
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  • 7
    Call number: QP501Z:41/46
    Keywords: Proteins / Congresses ; Biomolecules / Congresses ; Biological transport / Congresses ; Membranes (Biology) / Congresses
    Notes: "Held at St.George's Hospital Medical School, London, December 1980."
    Pages: x, 277 p. : ill.
    ISBN: 0904498131
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    QP501Z:41/46 available
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  • 8
    Hoboken, N.J. : Wiley-Liss
    Call number: QH427:1(2)
    Keywords: Genetics ; Genomics ; Proteome
    Notes: Rev. ed. of: Genetics manual. c1998.
    Pages: xi, 1379 p. : ill.
    Edition: 2nd ed.
    ISBN: 0471268216
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    QH427:1(2) available
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  • 9
    Call number: QZ202:28
    Keywords: Viral carcinogenesis / Congresses ; CEA (Oncology) / Congresses ; Genomes / Congresses ; Leukemia / Genetic aspects
    Notes: Organized by the Netherlands Cancer Institute and the Netherlands Organization for the Fight Against Cancer.
    Pages: xiv, 380 p. : ill.
    ISBN: 0444103678
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    QZ202:28 available
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  • 10
    Call number: QZ202GF7:4
    Keywords: Neoplasms ; Statistics ; France
    Pages: 257 p. : ill.
    Signatur Availability
    QZ202GF7:4 available
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