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  • 1
    ISSN: 1432-0533
    Keywords: Amyloid β-protein ; Progressive dementia ; Cerebellar plaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the immunolocalization of extensive amyloid β-protein in senile plaques, cerebrovascular amyloid deposits, neurofibrillary tangles and preamyloid in a 32-year-old man with progressive dementia not to trisomy 21 or trauma. These amyloid deposits were non-reactive to antibodies directed against scrapie amyloid. Our data indicate that the presence of amyloid β-protein is not limited to normal aging, Alzheimer's disease and related disorders but is also found in younger individuals with progressive dementia.
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  • 2
    ISSN: 1432-0533
    Keywords: Gliomas ; Heterotransplantation ; Tissue Culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Observations concerning transplantation of 5 cases of malignant dysplastic gliomas to the anterior chamber of the guinea-pig eye have been presented. This type of gliomas, composed mainly of cytoplasm-abundant cells, show weak transplantability, slow rate of growth, and particular tendency to degeneration and necrosis. At the same time, in subsequent passages, an intensive proliferation of small-cell component occurs, comparing with cytoplasm-abundant cells.
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  • 3
    ISSN: 0942-0940
    Keywords: Skull meningioma ; cranioplasty ; knitted polypropyloen-polyester prothesis “Codubix”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report a case of transitional cell meningioma of the convexity which destroyed a large portion of the calvarium and invaded subcutaneous tissue. The tumour was totally removed and a large cranial defect/430 cm2 in size/ was filled with a polypropyleno-polyester knitted prothesis “Codubix” with an excellent result. The problems of chronioplastic closure of such an unusually large skull defect and the advantages of the use of the material “Codubix” are discussed.
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  • 4
    ISSN: 1432-0533
    Keywords: Gliomas ; Rosenthal Fibers ; Fibrillary Degeneration ; Birefringency ; Tissue Cultures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Bildung von Rosenthalschen Fasern in den in vitro gezüchteten Gliomen geht fast immer eine Überproduktion der Fibrillen in ungewöhnlich langen, gewundenen Zellfortsätzen voraus, die ein dichtes Netzwerk in der Wachstumszone der Kulturen bilden. Kleingranuläre Desintegration dieser Fortsätze — bzw. der ganzen Zelleiber — und sekundäre Kondensation des granulären Materials sind die nächsten Phasen in der Bildung der Rosenthalschen Fasern, die aber selbst in ihrer endgültigen Form keine Doppelbrechung zeigen. Die doppelbrechenden gliofibrillären Veränderungen entstehen auf dem Wege einer primären intracellulären Kondensation der Fibrillen, die in diesem Stadium keiner Desintegration unterliegen. Die kondensierten Fibrillen sind von Anfang an doppelbrechend, sowohl in den frühen Entwicklungsstadien von Längsfasern, als auch in den späteren Stadien von Schleifen, Verflechtungen und Knäueln. Beide Arten von fibrillären Veränderungen werden in denselben Kulturen angetroffen, wenn auch die Rosenthalschen Fasern vorwiegend in cerebellaren Astrocytomen auftreten und die doppelbrechenden gliofibrillären Veränderungen für die subependymalen Gliome mit Zeichen einer astroblastomatösen oder oligodendrogliomatösen Differenzierung eher typisch sind. Beide Veränderungen sind als Merkmale einer fehlerhaften Hyperaktivität der proliferierenden und aberrant sich differenzierenden Zellen der subependymalen Anlage zu betrachten und nicht als Folgen einer einfachen Degeneration, welche wahrscheinlich durch homogene intracelluläre Konglomerate — die dritte Art der beschriebenen Veränderungen — repräsentiert ist. Die formale und kausale Genese der fibrillären Veränderungen wird diskutiert.
    Notes: Summary The formation of Rosenthal fibers in gliomas grown in vitro is usually preceded by overproduction of fibrilles within fine, unusually elongated and muddled cellular processes, which form dense meshwork in the growth zone of cultures. Small-granular desintegration of these processes—or of entire cell bodies—and secondary condensation of are the next steps in the production of Rosenthal fibres, which as a rule do not show birefringency. The birefringent gliofibrillary changes develop by primary intracellular condensation of fibrilles which is not preceded by desintegration. The condensed fibrilles show birefringency both in early, longitudinal formations and in subsequently formed loops, tangles and balls. Both types of changes may be observed in the same cultures, although Rosenthal fibers develop mostly in cerebellar astrocytomas, whereas birefringent gliofibrillary changes are particularly frequent in immature, subependymal gliomas with signs of astroblastic or oligodendroglial differentiation. Both kinds of features are considered to be the results of failed metabolic hyperactivity of aberrantly differentiating cells of subependymal Anlage, in course of their pathological proliferation (dysplasia) and not as products of an ordinary degeneration, which seem to be the homegenous intracellular conglomerates, the third type of the described changes. The nature of cells which show fibrillary changes and the pathomechanism of these changes are discussed.
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  • 5
    ISSN: 1432-1459
    Keywords: Subcortical arteriosclerotic encephalopathy ; Cerebral amyloid angiopathy ; Normotensive subject
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subcortical arteriosclerotic encephalopathy was diagnosed in a 56-year-old female normotensive patient with gradually progressing dementia, pseudobulbar palsy and motor deficits. CT scan showed white matter low attenuation in the frontal and parietal lobes. Neuropathological examination revealed degeneration of the white matter. Amyloid was found in walls of small cortical vessels. The walls of small vessels in the white matter showed severe thickening, fibrosis and hyalinization but not amyloid. Cerebral amyloid angiopathy may be responsible for subcortical arteriosclerotic encephalopathy.
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