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  • 1
    Abstract: Protection of endothelial integrity has been recognized as a frontline approach to alleviating sepsis progression, yet no effective agent for preserving endothelial integrity is available. Using an unusual anti-angiopoietin 2 (ANG2) antibody, ABTAA (ANG2-binding and TIE2-activating antibody), we show that activation of the endothelial receptor TIE2 protects the vasculature from septic damage and provides survival benefit in three sepsis mouse models. Upon binding to ANG2, ABTAA triggers clustering of ANG2, assembling an ABTAA/ANG2 complex that can subsequently bind and activate TIE2. Compared with a conventional ANG2-blocking antibody, ABTAA was highly effective in augmenting survival from sepsis by strengthening the endothelial glycocalyx, reducing cytokine storms, vascular leakage, and rarefaction, and mitigating organ damage. Together, our data advance the role of TIE2 activation in ameliorating sepsis progression and open a potential therapeutic avenue for sepsis to address the lack of sepsis-specific treatment.
    Type of Publication: Journal article published
    PubMed ID: 27099174
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS); 20160612-20160615; Frankfurt am Main; DOCDI.19.07 /20160608/
    Publication Date: 2016-06-17
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
  • 4
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nombre de travaux ont été effectués récemment afin d'expliquer l'évolution vers l'arthrose après méniscectomie. Les modifications mécaniques entraînant une concentration des contraintes sont considérées comme une des causes majeures. Mais il n'y a que peu d'études expérimentales concernant les différences de pression sur la surface de contact et le type de distribution des contraintes après méniscectomie partielle ou totale. En utilisant un film sensible à la pression (Pressensor) nous avons pu mesurer la surface de contact et son type de distribution dans les trois situations: ménisque intact, méniscectomie partielle et méniscectomie totale. Le matériel d'expérimentation consistait en cinq pièces d'amputation de cuisse. Pendant l'expérimentation le genou était placé en extension complète et fixé à la machine Instrom par une barre d'aluminium et une monture de résine. La charge était transmise par la machine à l'articulation fémoro-tibiale et au film Pressensor pré-inséré, dans les limites physiologiques. L'analyse de la surface de contact dans les trois situations a été permise par l'examen du film. En mesurant la surface de contact après méniscectomie nous avons montré que la fonction du ménisque est d'assurer la transmission des charges et l'absorption d'énergie dans le genou. La comparaison de la surface de contact interne de l'articulation avec la surface de contact externe montre que, lorsque le ménisque est intact, la première est toujours plus étendue que la seconde (le rapport est de 1.36). La différence diminue légérement en cas de méniscectomie partielle et beaucoup plus après méniscectomie totale. Le degré de concentration des contraintes augmente selon que le ménisque est intact, partiellement ou totalement réséqué. Il n'y a que de minimes modifications de la surface de contact du côté opposé de l'articulation après méniscectomie partielle, mais elles sont importantes après méniscectomie totale.
    Notes: Summary Many investigators have attempted to find the cause of the osteoarthritic changes after meniscectomy. Alteration of the mechanical factors resulting in stress concentration, is now thought to be one of the most important causes but few experimental studies have reported the differences in contact area and pressure distribution after partial or total meniscectomy. By using pressure sensitive film, we have calculated the contact area and the pattern of weight distribution in three different situations; intact meniscus, partial and total meniscectomy. The experimental materials were obtained from 5 above knee amputation specimens. The knee joint was fixed in full extension to an Instron machine using an aluminium box and mounting resin. Load was transmitted to the tibiofemoral joint containing the special film, within a physiological range. Analysis of the contact area for each situation (intact meniscus, partial and total meniscectomy) was made by reviewing the film, By measuring the contact area after meniscectomy, we showed that the meniscus performs a load transmitting function in the knee joint. The medial contact area of the tibiofemoral joint with an intact meniscus is always larger than the lateral compartment (1.36:1), but in partial and total meniscectomy the difference between them gradually decreased. There was a minor decrease in contact area after partial meniscectomy and a much greater decrease after total meniscectomy. The degree of stress concentration in the contact area was increased when part or all the meniscus was excised. There was little change of contact area in the opposite, intact side of the joint after partial meniscectomy, but marked change after total meniscectomy.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0942-0940
    Keywords: Keywords: Gliomatosis cerebri; magnetic resonance image; radiation therapy; prognosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  To clarify clinical features and to elucidate prognostic factors and prognosis, the authors retrospectively analyzed 16 cases of gliomatosis cerebri treated at Seoul National University Hospital between January 1988 and December 1995. Age at diagnosis ranged from 19 to 62 (median 34) years and male to female ratio was 10:6. Most presented with headache or seizure, and the mean duration of symptoms was 12.8 months. A poorly defined diffuse high signal intensity lesion, extending in T2-weighted images for two lobes or more, was the characteristic magnetic resonance (MR) image finding. On postcontrast T1-weighted MR imaging, focal enhancement of the lesion was detected in five cases. All patients underwent histological confirmation by craniotomy (9 cases) or stereotactic biopsy (7 cases). Histologically, all patients had compatible findings of gliomatosis cerebri which are the widespread infiltration of neoplastic glial cells with minimal destruction of pre-existing structures.  After histological diagnosis, external radiation therapy was begun except in one case, who declined this treatment. Fourteen patients completed the whole procedure and received the planned dose (mean 5780 cGy). Median survival time after diagnosis was 38.4 months. In univariate analysis, the Ki-67 labelling index (〉1) showed significant correlation with the length of survival (p=0.006).  It is suggested that 1) gliomatosis cerebri can be diagnosed by a combination of MR imaging findings and histological examination; 2) histological diagnosis and external radiation therapy might be a good treatment modality; 3) the Ki-67 labelling index correlates significantly with survival time.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract To produce xylobiose from xylan, high-level expression of an endoxylanase gene from Bacillus sp. was carried out in Bacillus subtilis DB104. A 1.62-kb SmaI DNA fragment, coding for an endoxylanase of Bacillus sp., was ligated into the Escherichia coli/B. subtilis shuttle vector pJH27Δ88, producing pJHKJ4, which was subsequently transformed into B. subtilis DB104. A maximum endoxylanase activity of 105 U/ml was obtained from the supernatant of B. subtilis DB104 harboring pJHKJ4. The endoxylanase was purified to homogeneity by ion-exchange chromatography and the production profile of xylooligosaccharides from xylan by the endoxylanase was examined by HPLC with a carbohydrate analysis column. Xylobiose was the major product from xylan at 40 °C and its proportion in the xylan hydrolyzates increased with the reaction time; at 12 h, over 60% of the reaction products was xylobiose. These results suggest that xylobiose, which has a stimulatory effect on the selective growth of the intestinal bacterium Bifidobacterium, can be mass-produced effectively by the endoxylanase of Bacillus sp. cloned in B. subtilis.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe clinicopathological features of an unusual case of CD30+/CD56+ T-cell lymphoma in a 58-year-old Korean man who presented with disseminated nodules, papules and hyperpigmented patches. Coexpression of CD30 and CD56 in T-cell lymphoma is very rare. Our patient did not respond to an intensive chemotherapy regimen, in contrast to the previously reported cases of primary cutaneous CD30+ anaplastic large cell lymphoma. Coexpression of CD56 might therefore identify a subset of CD30+ lymphomas with more aggressive features.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 34 (1991), S. 604-606 
    ISSN: 1432-0428
    Keywords: Islets of Langerhans ; duodenal wall ; immunocytochemistry ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present study we report the existence of typical islets of Langerhans in the duodenal wall of the rat. The nature of the cells and of their corresponding secretory granules were assessed by morpho-cytochemical techniques. The insulin cells formed the core of the islets while the glucagon, the somatostatin and the pancreatic polypeptide cells were located at the periphery. These islets were located in the connective tissue between the duodenal crypts and the muscle layer, neighbouring the last portion of the bile duct. The morphological features of these endocrine cells indicate the presence of high secretory activities which may play an important role in the maintenance of glucose homeostasis, particularly during absorption of nutrients.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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