Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Language
  • 1
    Keywords: Medicine ; Neurosciences ; Medical virology ; Public Health ; Neurology ; Biomedicine ; Neurosciences ; Virology ; Public Health ; Neurology ; Springer eBooks
    Description / Table of Contents: Overview on neglected and tropical diseases -- Travel, migration and neglected tropical diseases -- Stigma in neurological diseases at the Tropics -- Nematode infections: Neurological involvement and neurobiology -- Amoebiasis: Neurological involvement and neurobiology -- Neuroschistosomiasis -- Neurocysticercosis -- Neurocysticercosis: Neurology and neurobiology -- Onchocerciasis: Neurological involvement -- Human African trypanosomiasis: Neurobiology -- Chagas' disease: Neurology and neurobiology -- Neurodegeneration in leprosy: Insights from model systems and patients -- Rabies: Neurology -- Rabies: Neurobiology -- Japanese encephalitis and other arbovirus infections: Neurology and neurobiology -- Khat addiction: Neurology -- Khat addiction: Neurobiology -- Konzo: neurology of a permanent and non-progressive motor neuron -- Food preservation, snake venoms and stroke in the Tropics -- Infectious causes of epilepsy? -- Cognitive impairment and behavioural disturbances following malaria or HIV infection in childhood
    Abstract: A number of diseases and conditions that occur primarily in remote rural or poor urban areas of low-income countries have traditionally been neglected by the neuroscience research community. These diseases and conditions affect the nervous system directly (sometimes with lethal consequences) and/or are associated with severe neurological sequels such as epilepsy, cognitive deficits, and sleep disruption. Several diseases also have the effect of promoting poverty by leaving sufferers unable to lead economically productive lives due to cognitive and behavioral disturbances or severe stigmatization. The pathogenesis of neural dysfunction in the diseases addressed in this book and their sequels remains unclear. Neuroscience of Neglected Diseases and Conditions makes available much needed information about how these diseases affect the human nervous system as well as to promote interest in further research. Further research into neglected diseases and conditions will uncover information that sheds light on more general topics of interest to the neuroscience research community
    Pages: VIII, 401 p. 122 illus., 51 illus. in color. : online resource.
    ISBN: 9781461481003
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    facet.materialart.
    Philadelphia : W.B. Saunders
    Associated volumes
    Call number: QZ200Z:237/9,3
    Keywords: Sarcoma
    Pages: xi p., p. 513-705
    Signatur Availability
    QZ200Z:237/9,3 available
    BibTip Others were also interested in ...
  • 3
    Call number: QH506:60/327
    Keywords: Epidermal Growth Factor / analysis ; Epidermal Growth Factor / physiology ; Receptor, Epidermal Growth Factor / analysis ; Receptor, Epidermal Growth Factor / physiology
    Description / Table of Contents: A historical perspective of EGF receptor and related systems / Francis Edwin ... [et al.] -- Purification and assay of kinase-active EGF receptor from mammalian cells by immunoaffinity chromatography / Gregory J. Wiepz ... [et al.] -- Soluble epidermal growth factor receptor acrydinium-linked immunosorbent assay / Jacqueline M. Lafky, Andre T. Baron, and Nita J. Maihle -- Analysis of epidermal growth factor receptor and interactions with the [alpha] subunit of the stimulatory GTP binding protein of adenylyl cyclase, Gs / Deepti Chaturvedi ... [et al.] -- Regulator of epidermal growth factor signaling : sprouty / Esther Sook Miin Wong and Graeme R. Guy -- Dissecting the epidermal growth factor signal transactivation pathway / Oliver M. Fischer, Stefan Hart, and Axel Ullrich -- A sensitive method to monitor ectodomain shedding of ligands of the epidermal growth factor receptor / Umut Sahin ... [et al.] -- In vitro and in vivo assays of monoubiquitnation of receptor tyrosine kinases / Manachem Katz, Yaron Mosesson, and Yosef Yarden -- Assays to monitor degradation of the EGF receptor / Mirko H.H. Schmidt and Ivan Dikic -- Assessment of degradation and ubiquitination of CXCR4, a GPCR regulated by EGFR family members / Adriano Marchese -- Epithelial cell migration in response to epidermal growth factor / Reema Zeineldin and Laurie G. Hudson -- Motility signaled from EGF receptors and related systems / Alan Wells ... [et al.] -- Methods for determining the proliferation of cells in response to EGFR ligands / Gregory J. Wiepz ... [et al.] -- Clinical advancement of EGFR inhibitors in cancer therapy / Prakash Chinnaiyan and Paul M. Harari
    Pages: xi, 208 p. : ill.
    ISBN: 1588294218
    Signatur Availability
    QH506:60/327 available
    BibTip Others were also interested in ...
  • 4
    Keywords: Medicine ; Pharmaceutical technology ; Ophthalmology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Ophthalmology ; Springer eBooks
    Description / Table of Contents: Part I- Introduction and basic concept of drug delivery for retina and posterior segment disease -- Anatomy and physiology of retina and posterior segment of the eye -- Pharmacotherapy of diabetic macular edema and retinopathy -- Drug delivery to posterior segment of eye: Conventional delivery strategies, their barriers and restrictions -- Penetration routes to retina and posterior segment -- Diabetic Retinopathy: Pathogenesis, Treatment, and Complications -- PART II-Nanotechnology based formulations for retina and posterior segment disease -- Liposomes for retina and posterior segment disease -- Nano/microparticles for retina and posterior segment disease -- Non-viral delivery systems for gene therapy for retina and posterior segment disease -- Oxidative stress in ocular disorders: Exploring the link to pesticide exposure and potential for using nanotechnology for antioxidant delivery -- Advances in the microbial infection in cornea and role of nanotechnology to cure ocular surface -- Nanomedicine based delivery to the posterior segment of eye: Brighter tomorrow -- Part III-Transscleral iontophoresis for retina and posterior segment disease -- Transscleral drug delivery to retina and posterior segment disease -- Colloidal carrier systems transscleral drug delivery -- Transscleral Iontophoretic Drug Delivery for Treating Retinal Diseases -- Part IV-Implant formulation for posterior eye segment -- Biodegradable polymeric implants for retina and posterior segment disease -- Nanomedicine based gene delivery for the retina and posterior segment diseases -- Part V-Prodrug strategies for retina and posterior segment disease -- Transporter targeted Pro-drug approach for retina and posterior segment disease -- Lipid Prodrug based delivery for retina and posterior segment disease -- Injectable Pro-drugs approach for retina and posterior segment disease -- Stereoisomeric dipeptide Pro-drug approach for retina and posterior segment disease -- Part VI-Other advances for retina and posterior segment diseases -- Receptor targeted Pro-drug approach for retina and posterior segment disease -- Intravitreal injection drug delivery for retina and posterior segment disease: Challenges and Future ahead -- Thermoresponsive gels drug delivery for retina and posterior segment disease -- Peptide synthesis and delivery for retina and posterior segment disease -- Corneal haze, refractive surgery and its implications on choroidal neovascularisation
    Abstract: This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles
    Pages: XIX, 494 p. 68 illus., 47 illus. in color. : online resource.
    ISBN: 9783319958071
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: Medicine ; Cancer Research ; Pharmacology ; Oncology ; Biomedicine ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Serum uric acid and biomarkers of lumbar spine bone mineral density -- Use of alkaline phosphatase (ALP) activity and disease severity to determine secular changes in bone disease as applied to Paget's disease of the bone -- Bone Turnover and Spinal Cord Injury -- Bone-related proteins as markers in vascular remodelling -- Serum Sclerostin as Biomarker in Osteogenesis Imperfecta -- Parathyroid Hormone (PTH) assays and applications to bone disease: Overview on methodology -- Registered microcomputed tomography data as a four dimensional imaging biomarker of bone formation and resorption -- Use of bone biomarkers after weight loss: Example of bariatric surgery -- Adiponectin as biomarker of osteoporosis -- Effect of statins on bone turnover markers -- Chitinases as biomarkers in bone studies -- Hormone relaxin as biomarker for bone health and disease -- Panoramic radiomorphometric indices of mandible: Biomarker for osteoporosis -- Hip Fracture Risk is Strongly Related to Circulating Levels of the Advanced Glycation End-product Carboxy-Methyl Lysine (CML) -- Effects of glucose on bone markers: Overview of current knowledge with focus on diabetes, glucose, and bone markers -- Traditional medicine and use of bone biomarkers -- Osteosarcoma Biomarkers discovery using "omics" approaches -- Creatine kinase as biomarker in osteogenesis imperfecta -- Ameloblastin as biomarker of bone -- Biomarker genes in autosomal dominant osteopetrosis type II (ADO II) -- Bone markers in Rett syndrome -- Bone Specific Alkaline Phosphatase and Exercise -- Bone turnover markers and glucocorticoid treatments -- Overview of biochemical markers of bone metabolism -- Biomarkers of natural radionuclides in bone and teeth -- Bone markers throughout sexual development: epidemiological significance and population-based findings -- Parathyroid hormone (PTH) and the relationship between PTH and bone health: structure, physiology, actions, and ethnicity -- Quantitative ultrasound as a biomarker tool in newborn infants for bone -- Bone biomarkers in gestational hypertension -- Bone biomarkers in intrauterine growth restriction -- Raman spectroscopy as a biomarker-investigative tool in bone metabolism -- Pentosidine as a biomarker for poor bone quality and elevated fracture risk -- Spine bone texture and the trabecular bone score (TBS) -- Bone biomarkers in HIV -- Bone Biomarkers Related to Osteoarthritis -- Dietary Soy Phytoestrogens and Biomarkers of Osteoporosis -- Utilisation and reference values of osteocalcin and procollagen type 1 n-propeptide -- Analysis of integrin alpha2beta1 (a2b1) expression as a biomarker of skeletal metastasis -- Circulating Sclerostin in Bone Sclerosing Disorders -- Pentraxin 3 as a bone biomarker -- Sirtuins as markers of bone disease: a focus on osteoarthritis and osteoporosis -- Tartarate resistant acid phosphatase as a biomarker of bone remodeling
    Abstract: There are many conditions that affect the skeletal system. On a worldwide basis, osteoarthritis alone affects 10%-15 percent of those over 60 years of age and in some countries more than 30-50% of postmenopausal women will have osteopenia or osteoporosis. With the increasing ageing population, maintaining skeletal health is particularly important. Fractures in the aged, for example, can lead to premature deaths. It is therefore imperative that appropriate use is made of conventional, new and emerging biomarker platforms. Biomarkers in Bone Disease embraces a holistic approach by combining information on different conditions that affect the skeletal system and the use of biomarkers. Biomarkers are described in terms of conventional, new and emerging analytes, techniques, platforms and applications. It covers the latest knowledge, trends and innovations. New platforms are described which combine advances in biomedical sciences, physics, computing and chemistry
    Pages: 186 illus., 108 illus. in color. eReference. : online resource.
    ISBN: 9789400776937
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Call number: QZ200Z:237/23,1
    Keywords: Gastrointestinal Stromal Tumors
    Notes: Formerly CIP.
    Pages: xiv, 158 p. : ill.
    ISBN: 9781437704860
    Signatur Availability
    QZ200Z:237/23,1 available
    BibTip Others were also interested in ...
  • 7
    Keywords: Oncology ; Oncology   ; Toxicology ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer Nature Living Reference
    Description / Table of Contents: Cardiolog -- Addictions -- Immunology -- Birth Defects -- Genetics
    Abstract: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists
    Pages: Approx. 800 p. 50 illus. : online resource.
    ISBN: 9789400777415
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Keywords: Life sciences ; Medicine ; Chemistry ; Biochemistry ; RNA-ligand interactions ; Crystallography ; Life sciences ; Protein-Ligand Interactions ; Medicinal Chemistry ; Molecular Medicine ; Theoretical and Computational Chemistry ; Crystallography ; Springer eBooks
    Description / Table of Contents: Preface -- List of Contributors -- Engineering G Protein-Coupled Receptors for Drug Design -- Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors -- Epigenetic Drug Discovery -- Crystallography and Biopharmaceuticals -- Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors -- Considerations for Structure-Based Drug Design Targeting HIV-1 Reverse Transcriptase.-Protein-Ligand Interactions as the Basis for Drug Action -- The Protein Data Bank: Overview and Tools for Drug Discovery -- Small Molecule Crystal Structures in Drug Discovery -- Protein Aggregation and its Prediction -- Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets -- Protein-Protein Interactions: Structures and Druggability -- Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design -- Molecular Obesity, Potency and Other Addictions in Drug Discovery -- Adventures in Small Molecule Fragment Screening by X-ray Crystallography for Drug Discovery -- Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition -- Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function
    Abstract: The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design
    Pages: XI, 240 p. 107 illus., 89 illus. in color. : online resource.
    ISBN: 9789401797191
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Biomarker for Amyotrophic Lateral Sclerosis (Motor Neurone Disease) -- Biomarkers and their applications to toxicology and toxicogenomics -- Biomarkers for Depression -- Biomarkers in Chronic Obstructive Pulmonary Disease (COPD): Current Concerns and Future Prospects -- Biomarkers in Urine and Use of Creatinine -- Biomarkers of Graft-Versus-Host Disease -- Biomarkers of Menopause -- Biomarkers of Parkinson's Disease -- Biomarkers of Vector Bites -- Biomarkers of the menopause.-℗ Chronic Heart Failure and Serum Collagen -- FABP3 as biomarkers -- Fetal Membrane Biomarkers.-℗ Flow Cytometry as Platform for Biomarker Evaluation -- Formalin-fixed paraffin-embedded tissue (FFPET) sections for biomarker discovery -- Glycomics as biomarkers -- Inflammasome Proteins as Biomarkers of Injury and Disease -- Isoprostanes as biomarkers of disease and early biological effect.-Mass spectrometry for biomarker discovery -- Micro RNA as Biomarker for Brain Injury -- MIP-1alpha as biomarker -- Natriuretic Peptides for Diagnosis, Prognosis and Management of Heart Failure -- OMICS-based approaches to biomarker discovery and challenges of subsequent validation -- Pediatric biomarkers after cardac surgery -- Pentraxin 3 as Biomarker -- Pfetin: Novel prognostic biomarker -- Plasma galectin-3 as biomarker -- S100B as a Biomarker -- Salivary amylase as a stress biomarker -- Seasonal allergic rhinitis and systems biology-oriented biomarker discovery -- Serum Heat Shock Proteins as Novel Biomarker for Heart Failure -- Urinary Biomarkers of Environmental Health: Jet Fuel -- YKL-40 as Biomarker: Focus on Cardiovascular Disease
    Abstract: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics and so on. The chapters are written by national or international experts and specialists
    Pages: XXIX, 1324 p. 204 illus., 130 illus. in color. eReference. : online resource.
    ISBN: 9789400776968
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer eBooks
    Abstract: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists
    Pages: XXVIII, 992 p. 180 illus., 134 illus. in color. eReference. : online resource.
    ISBN: 9789400776814
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...