Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
Language
  • 1
    Unknown
    Berkshire, England : Queensgate Instruments
    Keywords: Nanotechnology. ; Physical instruments, Design and construction. ; Physical measurements, Standards.
    Pages: vi, 119 p.
    Edition: Reprinted [ed.]
    ISBN: 1-417-52671-8
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: Medicine ; Cancer Research ; Immunology ; Pharmacology ; Oncology ; Biomedicine ; Immunology ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Introduction -- Enhancing the efficacy of checkpoint blockade through combination therapies -- Novel Immunomodulatory Targets in the Immunoglobulin-Superfamily -- Parallel Costimulation of Effector and Regulatory T Cells by OX40, GITR, TNFRSF25, CD27 and CD137 -- NK Cell Responses in Immunotherapy -- Reversing T cell dysfunction for tumor immunotherapy -- Immunomodulation within a single tumor site to induce systemic anti-tumor immunity -- Novel Targets and Their Assessment for Cancer Treatment -- The New Frontier of Antibody Drug Conjugates -- Cellular Therapies -- Targeting the Physicochemical, Cellular, and Immunosuppressive Properties of the Tumor Microenvironment by Depletion of Hyaluronan to Treat Cancer
    Abstract: Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers
    Pages: XI, 276 p. 25 illus. in color. : online resource.
    ISBN: 9783319298276
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    facet.materialart.
    Unknown
    PHILADELPHIA U. A.: SAUNDERS
    Associated volumes
    Call number: QZ200Z:237/8,6
    Keywords: BLUT / TRANSFUSION ; Hämatologie
    Pages: XII, S. 1045-1278.
    Signatur Availability
    QZ200Z:237/8,6 available
    BibTip Others were also interested in ...
  • 4
    Call number: C050:46
    Keywords: SAS (Computer file) ; Regression analysis / Data processing
    Pages: vi, 288 p. : ill.
    Edition: 5th printing.
    ISBN: 978-0-471-22175-3
    Signatur Availability
    C050:46 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 5
    Call number: H0800:19
    Keywords: Molecular cloning ; Polymerase Chain Reaction ; Reverse Transcriptase ; Gene Expression ; Gene Amplification
    Pages: xiv, 350 p. : ill.
    ISBN: 1881299147
    Signatur Availability
    H0800:19 departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 6
    Keywords: Life sciences ; Animal genetics ; Life sciences ; Animal Genetics and Genomics ; Springer eBooks
    Pages: : digital
    ISBN: 9789048190232
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    facet.materialart.
    Unknown
    PHILADELPHIA U. A.: SAUNDERS
    Associated volumes
    Call number: QZ200Z:237/9,1
    Keywords: BLUT / TRANSFUSION ; Hämatologie
    Pages: VIII, 237 S.
    Signatur Availability
    QZ200Z:237/9,1 available
    BibTip Others were also interested in ...
  • 8
    Keywords: Medicine ; Emerging infectious diseases ; Bacteriology ; Medicine & Public Health ; Infectious Diseases ; Bacteriology ; Springer eBooks
    Abstract: Due to the highly collaborative nature of investigators working in the field, we have rapidly advanced our understanding of Staphylococcus epidermidis and other staphylococci in the last two decades.℗ The chapters in Staphylococcus Epidermidis: Methods and Protocols are designed to give the new investigator a series of tools so they can ask novel and exciting questions related to the biology of this opportunistic pathogen, as many exciting and unexplored questions such as defining the interaction of S. epidermidis and other normal flora remain to be discovered. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. ℗ Authoritative and easily accessible, Staphylococcus Epidermidis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies
    Pages: X, 208 p. 30 illus., 18 illus. in color. : online resource.
    ISBN: 9781627037365
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Keywords: Medicine ; Gene Therapy ; Immunology ; Toxicology ; Rheumatology ; Biomedicine ; Gene Therapy ; Pharmacology/Toxicology ; Immunology ; Rheumatology ; Molecular Medicine ; Springer eBooks
    Pages: : digital
    ISBN: 9783034601658
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Igk-J locus of the mouse encodes the immunoglobulin κ light chain joining (J) segments. Four Igk-J alleles have been described on the basis of restriction enzyme length polymorphisms. The nucleotide sequences of the Igk-J a allele (type strain, C.C58), Igk-J c allele (type strain, SJL/J), and Igk-J d allele (type strain, SK/CamRk) have been determined and are compared with the previously reported Igk-J b allele sequence (type strain, BALB/c). The mouse sequences are also compared with published sequences for rat and human J k sequences. Far more differences were found between the Igk-J a allele and the other mouse alleles than between any two of the latter. These result in two amino acid substitutions which distinguish the J2 and J3 1 segments of the Igk-J a allele from the other three alleles. Use of the Phylogenetic Analysis Using Parsimony program to generate a phylogenetic tree strongly indicates that after divergence from the rat ancestor, there appears to have been an early split between the Igk-J a allele and the evolutionary precursor of the other mouse alleles. There also appears to have been far less divergence from the ancestral condition in the Igk-J a allele than in the other alleles. Also, the presence of only one convergent mutation among the four mouse alleles provides strong evidence against any crossing over within the Igk-J locus during the history of these alleles. Finally, the differences in rates of evolution of the Igk-J alleles are in marked contrast to the relatively uniform rates of divergence of four alleles of a mouse V k gene, Igk-VSer.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...