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  • 1
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthese und IR-Untersuchungen von Methylgallium(III) und Gallium(III) Komplexen mit dreizähnigen LigandenMehrere neue 1:1 Komplexverbindungen, neutral bzw. anionisch, von Methylgallium(III) und Gallium(III) mit dreizähnigen Liganden (H2L; mit ONO und SNO) sowie ein Glycylglycin-Derivat werden dargestellt und ihre IR-Spektren in festem Zustand untersucht. Eine mögliche Anordnung der Liganden um das zentrale Atom in trigonal-bipyramidaler Form wird vorgeschlagen und diskutiert; so z. B. in den komplexen Anionen [Cl2GaL]- sowie in CH3GaL- und ClGaL-Verbindungen; in den letzteren in dimeren Anordnungen mit dreifach koordinierten Sauerstoffbrücken.
    Notes: Several new 1:1 complexes, neutral or anionic, formed by Methylgallium(III) and Gallium(III) with tridentate ligands (H2L; ONO and SNO donor atoms), as well as a glycylglycine derivative, have been synthesized, and characterized in the solid state by infrared spectroscopy. Data have been interpreted in terms of trigonal bipyramidal type configurations of the environment of the metal centre, in the complex anions [Cl2GaL]- as well as in compounds CH3GaL and ClGaL: in the latter two, dimerization would occur through bridging, three-coordinating oxygen atoms.
    Additional Material: 2 Ill.
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  • 2
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Infrarot- und MÖSSBAUER-spektroskopische Untersuchungen an Komplexen von Hal2SnIV mit dreizähnigen LigandenNeue Komplexverbindungen von Typ hal2Sntrid werden dargestellt (hal = Cl, Br, und trid2- = ebene, dreizähnige Liganden mit ONO- und SNO-Atomen, als zweiwertige Anionen). In festem Zustand wurden die Strukturen durch IR- und MÖSSBAUER-Spektren untersucht. Mögliche Anordnungen der Liganden um das Zinn(IV)-Atom werden vorgeschlagen und diskutiert.Wahrscheinlich sind alle diese Verbindungen monomer mit einer trigonal-bipyramidalen Struktur; aber es können polymere oder dimere Anordnungen mit O- oder Cl-Brücken, besonders bei Br2Sntrid, nicht völlig ausgeschlossen werden.
    Notes: Novel complexes hal2Sntrid, where hal = Cl, Br, and trid2- are dianions of „planar“ tridentate ligands with ONO and SNO donor basic atoms, were synthesized and structurally investigated in the solid state mainly by far infrared and MÖSSBAUER spectroscopy. Possible configurations were advanced and discussed, and it was concluded that the most probable is a monomeric trigonal bipyramidal structure for all compounds, although polymers, or dimers with O or Cl bridges, were not a priori excluded, in a special way for Br2Sntrid.
    Additional Material: 2 Ill.
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  • 3
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Komplexe des Zinn (IV) mit dreizähigen Liganden. Mössbauer- und IR-Spektren sowie Untersuchungen von LösungenDie Struktur von SnIV-Komplexen mit dreizähnigen “planaren” Liganden, Sn(trid)2 und HNEt3Cl2Sntrid, wurde in fester Phase und in Lösung untersucht mit Hilfe von IR- und MÖSSBAUER-Spektroskopie (für den festen Zustand) sowie osmometrisch, mit Leitfähigkeitsmessungen, UV-VIS- und NMR-Spektroskopie. Danach wird das Vorliegen von monomerem Sn(trid)2 und ionischem [HKEt3]+[Cl3Sntrid]- angenommen. Bei beiden Arten von Verbindungen liegt vermutlich oktaedrische Konfiguration vor.
    Notes: The configuration in the solid state and in solution phase of complexes of SuIV wit,li tridentate “planar” ligands, Sn(trid)2 and HNEt3Cl3 Sntrid, have been investigated by infrared and MÖSSBAUER spectroscopy, as well as by osmometry, conductivity, and electronic and PMR spectroscopy. The presence of monomeric Sn(trid)2 and ionic [HNEt+3] [Cl3Sn trid-] species has been inferred. Octahedral type configurations are advanced for both classes of compounds.
    Additional Material: 1 Ill.
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  • 4
    ISSN: 0268-2605
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The title of this paper, published in Applied Organometallic Chemistry 11, 499-511 (1977), was incorrect. The correct version is as above.
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  • 5
    ISSN: 0268-2605
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Analysis of literature data on the antitumor activity of organotin compounds reveals that R2SnX2 and their complexes containing Sn—O, Sn—N or Sn—S bonds often exhibit biological activity, especially if such bonds are formed by means of intramolecular coordination. Furthermore, a wide range of biological activities, from fungicidal, bactericidal and antiseptic to psychotropic and antitumor, is found to be characteristic for some organic hydroxamic acids (N-acylhydroxylamines). From this point of view the diorgantion bis-hydroxamates in this paper are of particular interest as potential biologically active antitumor drugs. Di-n-butyltin bis(N-methyl-N-p-bromobenzoylhydroxylamine) is being screened for antitumor activity.
    Additional Material: 2 Ill.
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  • 6
    ISSN: 0268-2605
    Keywords: Organotin(IV)chloropenG derivatives ; Aphanius fasciatus ; genotoxicity ; chromosome aberration ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In order to obtain a continuous source of mitotic metaphases, gill tissue of Aphaius fasciatus (Pisces, Cyprinodontiformes) has been successfully employed. Results gathered after exposure of fish to R2SnClpenG, R3SnClpenGNa, to the parents R2SnCl2, R3SnCl and to penGNa (penGNa = penicillinGNa; R = methyl, butyl and phenyl) suggest that both the parent organotin (IV) chloride and organotin (IV) chloropenG derivatives are toxic while penGNa exerts no significant toxic activity. Essentially, all of the chromosome abnormalities are classifiable as irregularly staining of chromosomes, breakages, side-arm bridges or pseudochiasmata.
    Additional Material: 5 Ill.
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  • 7
    ISSN: 0268-2605
    Keywords: organotin ; porphyrin ; structures ; Mössbauer ; infrared ; NMR ; biologial activity ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The synthesis, the structural features and the in vivo biological activity of diorganotin(IV) and triorganotin(IV) derivatives of [meso-tetra(4-carboxyphenyl)porphine] (H4TPPC) are reported. Derivatives with general formula (R2Sn)2TPPC and (R3Sn)4TPPC (R=Me, Bu, and Ph) were obtained, and the main information extracted from the infrared and Mössbauer spectral data, in the solid state, was in favor of the occurrence of five-coordinated tin(IV) atoms, in a polymeric trigonal-bipyramidal configuration, attained through two differently coordinated, ester-type and chelating respectively, carboxylate anions in [R2Sn]2TPPC, while in [Alk3Sn]4TPPC five-coordination of the tin(IV) atom is reached through bridging carboxylate groups.1H and 13C NMR spectra, in DMSO-d6 or CDCl3 suggested that the soluble derivatives, at room temperature or at 342 K, were present in solution as simple monomers.The interactions of (trimethyltin)4[meso-tetra(4-carboxyphenyl)porphinate] (TMTPPC) and (tributyltin)4[meso-tetra(4-carboxyphenyl)porphinate] (TBTPPC) with Bluescript KS(+) plasmid and cultured 3T3 fibroblasts were studied.Both compounds have a clear inhibitory effect on the growth of cultured mouse embryonal fibroblasts (NIH-3T3), TBTPPC being much more active. No evidence was found, however, for DNA cleavage by the compounds at molar ratios as high as 1:10 (TMTPPC, TBTPPC/DNA base pairs).According to our observations, the cytotoxicity of TBTPPC and TMTPPC does not seem to be based on direct interaction with DNA. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 5 Ill.
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  • 8
    ISSN: 0268-2605
    Keywords: Organotin ; organosilicon ; organolead ; steroids ; structures ; anti-tumor agents ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Some organo-Main-Group-IV-element compounds of steroids of the type R3M(COL), R2Sn(COL)2 and (R3M)2(HDCA) (where R = Me or Ph; M = Si, Sn and Pb; HCOL = cholest-5-en-3β-ol; H3DCA = 3α, 12α-dihydroxy-5β-cholan-24-oic acid), have been synthesized. The structures of these compounds have been investigated by vibrational, mass, NMR (1H, 13C, 29Si, 119Sn and 207Pb) and 119Sn Mössbauer spectroscopy. For Me3Sn(COL) both in solution and in the solid state an associated structure with distorted trigonal bipyramidal geometry around tin and three-coordinated oxygen atoms is postulated. Discrete tetrahedral geometries are assigned to Ph3M(COL) complexes and to R2Sn(COL)2 complexes in solution. The latter compounds probably have an associated distorted trigonal bipyramidal structure in the solid state. The complexes (Ph3M)2(HDCA) also have tetrahedral geometries around the central atoms M in solution, but for (Ph3Sn)2(HDCA) a polymeric structure with both tin atoms pentacoordinated in the solid state is proposed.
    Additional Material: 1 Ill.
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  • 9
    ISSN: 0268-2605
    Keywords: Organotin ; antibiotics ; Penicillin G ; structure ; Mössbauer ; point charge ; infrared ; toxicity ; Ciona intestinalis ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Several new diorganotin(IV)chloro and triorganotin(IV)chloro penicillin G derivatives have been prepared. The isolated compounds showed 1:1 stoichiometry, with formulae R2SnClpenG and R3SnClpenGNa, respectively (penG- = penicillin G- = 4- thia - 1 - azabicyclo[3.2.0]heptane-2-carboxylate, 3,3-dimethyl-7-oxo-6-(2-phenylacet-amido) anion; R = Me, Bu, Ph). The coordination environment around the the tin(IV) atom, in all of the complexes, was trigonal bipyramidal. Penicillin G behaved as a monoanionic, bismonodentate ligand in R2SnClpenG through the β-lactamic carbonyl and unidentate ester-type carboxylate anion, and as unidentate through the β-lactamic carbonyl in R3SnClpenGNa, as inferred on the basis of IR spectra.The rationalization of the Mössbauer parameter nuclear quadrupole splitting, ΔE (mm s-1), according to the point-charge model formalism, supported such an hypothesis.The partial atomic charges on tin atoms, QSn, calculated for all the diorganotin(IV)chloropenG and triorganotin(IV)chloropenGNa compounds by the CHELEQ program, correlated well with the experimental 119Sn Mössbauer parameter isomer shift, δ (mm s-1). The δ/QSn data for diorganotin(IV)chloropenG and for triorganotin(IV)-chloropenGNa dervatives have been correlated with the δ/QSn values of triorganotin(IV) halide, cyanide, thiocyanate and cyanate compounds, whose trigonal bipyramidal polymeric structure has been well established.Finally, the biological activity of diorganotin(IV)chloropenG and triorganotin(IV)chloropenGNa derivatives has been tested using Ciona intestinalis fertilized eggs at different stages of development.
    Additional Material: 15 Ill.
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  • 10
    ISSN: 0268-2605
    Keywords: Bis[dimethyltin(IV)chloro]protoporphyrin IX ; chromosomes ; alterations ; Crustacea ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In order to obtain chromosome preparations from early-developing embryos of Anilocra physodes, a squash technique has been successfully employed.Results gathered after exposure of this material to bis[dimethyltin(IV)chloro]protoporphyrin IX {[(CH3)2SnCl]2 - Protoporphyrin IX} solutions at different exposure times suggest that this chemical complex is capable of producing abnormal metaphase and anaphase figures in proportion to its concentration and not to exposure length.Essentially, all of the chromosome abnormalities are classifiable as chromosome fragments mainly observed at the metaphase stage; chromosome bridges; and large decondensed chromosome regions.
    Additional Material: 11 Ill.
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