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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  27. Deutscher Krebskongress; 20060322-20060326; Berlin; DOCPO525 /20060320/
    Publication Date: 2006-04-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  27. Deutscher Krebskongress; 20060322-20060326; Berlin; DOCPO519 /20060320/
    Publication Date: 2006-04-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi); 20110926-20110929; Mainz; DOC11gmds426 /20110920/
    Publication Date: 2011-09-20
    Keywords: Tumordokumentation ; GTDS ; TUREK2 ; ddc: 610
    Language: German
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  • 4
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Kopf-Hals-Tumoren ; PEG ; Komplikationen ; Langzeiternährung ; Key words Head and neck cancer ; PEG ; Complications ; Long-term nutrition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Percutaneous endoscopically controlled gastrostomy (PEG) enables patients suffering from a tumor of the upper aerodigestive tract to receive direct gastric feedings. The procedure also avoids the social stigma of a nasal feeding tube. The results of 630 PEG procedures used in 555 patients suffering from various head and neck cancers are reported. The mean age of the patients was 58.0 years with a range from 11 to 92 years. The PEG procedure was carried out under local anesthesia in 60% of the cases and with general anesthesia in 40%. In 512 patients the initial PEG procedure was successful while 43 of the patients required a second PEG procedure after loss of the PEG. In 19 patients the PEG procedure was not successful because of tumor obstruction or it was not possible to perform endoscopy. Twenty-four patients were successfully treated in a second or third session. Altogether 97% (n = 563) of all 555 patients and 92% (n = 579) of all PEG procedures were successful. The mean duration of PEG use was 243 days (range: 0–2271 days). In 66 patients (10.5%) complications occurred but severe complications developed in only 8 patients (1.3%). Operative interventions were necessary in two cases. No deaths resulted from the PEG. These findings show that the PEG technique is safe to do with only few complications when performed by a skilled team.
    Notes: Zusammenfassung Die perkutane endoskopisch kontrollierte Gastrostomie (PEG) emöglicht Patienten mit Tumoren des oberen Aerodigestivtraktes eine direkte intragastrale Ernährung unter Ausschaltung der sowohl durch den Tumor selbst als auch die Tumortherapie stark alterierten Schluckstraße und erspart ihnen die soziale Stigmatisierung durch eine Nasensonde. Die Ergebnisse von 630 PEG-Prozeduren bei 555 Patienten mit Kopf-Hals-Tumoren werden vorgestellt. Die Patienten waren zum Zeitpunkt der PEG-Anlage im Durchschnitt 58,0 (11–92) Jahre alt. Der Eingriff erfolgte in 60% in Lokalanästhesie, in 40% in Intubationsnarkose. 512 Patienten wurden primär erfolgreich mit einer PEG versorgt. Von diesen 512 Patienten unterzogen sich 43 Patienten im Beobachtungszeitraum erneut einer erfolgreichen PEG-Prozedur nach Sondenverlust. Bei 19 Patienten war die Anlage einer PEG wegen endoskopisch – auch nach Bougierungsbehandlung – nicht passierbarer Tumorobstruktion oder fehlender Darstellbarkeit der Diaphanoskopie nicht möglich. Weitere 24 Patienten wurden nach zunächst erfolglosen Versuchen mit einer PEG versorgt. Somit war bei 97% (n = 536) der 555 Patienten bzw. bei 92% (n = 579) der 630 PEG-Prozeduren die PEG-Anlage erfolgreich. Bei einer mittleren Sondentragedauer von 243 (Spanne 0–2271) Tagen beobachteten wir bei insgesamt 10,5% (n = 66) der PEG-Anlagen Komplikationen, davon in nur 1,3% (n = 8) schwere Komplikationen; lediglich bei zwei Patienten war eine operative Intervention notwendig. Durch die Methode bedingte Todesfälle ereigneten sich nicht. Die Technik der PEG erweist sich damit in den Händen des erfahrenen Endoskopikers als sicher, komplikationsarm und den Patienten wenig belastend.
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  • 5
    ISSN: 1432-0584
    Keywords: Hodgkin's lymphoma ; Clinical trial ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a national multicentre trial in the FRG patients with Hodgkin's lymphoma in stages CS/PS III B/IV were entered into the HD 3 protocol and received induction chemotherapy with 3× (COPP+ABVD). Patients in complete remission (CR) received consolidation therapy by either radiotherapy (20 Gy IF) or chemotherapy (COPP+ABVD). Patients not in CR received salvage therapy (40 Gy in case of persisting nodal disease, else 4× CEVD chemotherapy). Between July 1983 and May 1987 230 untreated patients aged 15 to 60 qualified for this HD 3 protocol. This analysis is based on the first 137 patients evaluable for response. Of these, 86 (63%) achieved CR after induction chemotherapy. Including salvage therapy a total of 104 patients (76%) achieved CR. Univariate and multivariate prognostic risk factor analyses were performed using freedom from treatment failure (FFTF) as endpoint. Sex, age, splenectomy, bone marrow, liver and bone involvement had no prognostic impact nor had stage according to the Ann Arbor classification. In contrast, a pretreatment erythrocyte sedimentation rate (ESR) above 80 mm/h and a serum alkaline phosphatase (AP) above 230 IU/ml appeared as significant risk factors (p〈0.01, relative risk 2.3). The two parameters were not independent. Comparing a group A (ESR ≤ 80 and AP ≤ 230) versus a pooled group B (ESR〉80 and/or AP〉230) increased the difference (p〈0.001, relative risk of 2.8) which was also significant for survival (p〈0.04).
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Physics and chemistry of minerals 24 (1997), S. 264-273 
    ISSN: 1432-2021
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Abstract  We have investigated grain boundary diffusion rates in enstatite by heating single crystals of quartz packed in powdered San Carlos olivine (Mg0.90Fe0.10)2SiO4 at controlled oxygen fugacities in the range 10−5.7 to 10−8.7 atm and temperatures from 1350° to 1450 °C for times from 5 to 100 h at 1 atm total pressure. Following the experiments, the thickness of the coherent polycrystalline reaction rim of pyroxene that had formed between the quartz and olivine was measured using backscatter scanning imaging in the electron microprobe. Quantitative microprobe analysis indicated that the composition of this reaction phase is (Mg0.92Fe0.08)2Si2O6. The rate of growth of the pyroxene increases with increasing temperature, is independent of the oxygen fugacity, and is consistent with a parabolic rate law, indicating that the growth rate is controlled by ionic diffusion through the pyroxene rim. Microstructural observations and platinum marker experiments suggest that the reaction phase is formed at the olivine-pyroxene interface, and is therefore controlled by the diffusion of silicon and oxygen. The parabolic rate constants determined from the experiments were analyzed in terms of the oxide activity gradient across the rim to yield mean effective diffusivities for the rate-limiting ionic species, assuming bulk transport through the pyroxene layer. These effective diffusivities are faster than the lattice diffusivities for the slowest species (silicon) calculated from creep experiments, but slower than measured lattice diffusivities for oxygen in enstatite. Thus, silicon grain boundary diffusion is most likely to be the rate-limiting process in the growth of the pyroxene rims. Also, as oxygen transport through the pyroxene rims must be faster than silicon transport, diffusion of oxygen along the grain boundaries must be faster than through the lattice. The grain boundary diffusivity for silicon in orthopyroxenite is then given by D¯gbSiδ=(3.3±3.0)×10−9f0.0O2e−400±65/RT m3s−1, where the activation energy for diffusion is in kJ/mol, and δ is the grain boundary width in m. Calculated growth rates for enstatite under these conditions are significantly slower than predicted by an extrapolation from similar experiments performed at 1000 °C under high pressure (hydrous) conditions by Yund and Tullis (1992), perhaps due to water-enhancement of diffusion in their experiments.
    Type of Medium: Electronic Resource
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