Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CANCER ; tumor ; Germany ; human ; INFORMATION ; NEW-YORK ; POPULATION ; RISK ; TUMORS ; ASSOCIATION ; BREAST ; BREAST-CANCER ; hormone ; AGE ; POPULATIONS ; UNITED-STATES ; urinary estrogen metabolites ; FOOD FREQUENCY QUESTIONNAIRE ; POSTMENOPAUSAL WOMEN ; AGE 50 ; GENISTEIN CONTENT ; PHYTO-ESTROGENS ; RECEPTOR-POSITIVE TUMORS ; RELATIVE VALIDITY ; SERUM ENTEROLACTONE CONCENTRATION ; WESTERN DISEASES
    Abstract: A diet high in isoflavonoids (soy) is associated with lower breast cancer risk in Asian populations. Due to the low soy intake, dietary lignans may be the more important phytoestrogen class in Western populations. We used a population-based case-control study of breast cancer by age 50 in southern Germany to evaluate the association between dietary intake of different phytoestrogens and premenopausal breast cancer risk. Dietary information was collected from 278 premenopausal cases and 666 age-matched controls, using a validated FFQ. Using multivariate logistic regression, the highest vs. lowest intake quartiles of daidzein and genistein yielded significantly reduced ORs (95% CI) for breast cancer risk of 0.62 (0.40-0.95) and 0.47 (0.29-0.74), respectively. The protective effects of daidzein and genistein were found only for hormone receptor-positive tumors. High intake of other isoflavonoids, e.g., formorionetin and biochanin A, as well as the sum of isoflavonoids were not associated with a decrease in risk. Breast cancer risk significantly decreased with a high intake of the plant lignan matairesinol (OR = 0.58, 95% CI 0.37-0.94) but not secoisolariciresinol or the sum of plant lignans. However, both estimated mammalian lignans, enterodiol and enterolactone, were inversely associated with breast cancer risk, with ORs (95% CI) of 0.61 (0.39-0.98) and 0.57 (0.35-0.92), respectively. No effect was found for total phytoestrogen intake. Our results suggest an important role of dietary intake of daidzein and genistein, despite low levels, as well as of matairesinol and mammalian lignans to reduce premenopausal breast cancer risk in this study population. (C) 2004 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 15069695
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CELLS ; GROWTH-FACTOR ; BLOOD ; CELL ; Germany ; human ; VIVO ; EXPOSURE ; PROTEIN ; PROTEINS ; COMPLEX ; COMPLEXES ; DONOR ; BIOMARKERS ; BODY-WEIGHT ; INTERVENTION ; BIOLOGY ; MOLECULAR-BIOLOGY ; BREAST-CANCER ; ACID ; GLYCOPROTEIN ; PLASMA ; NUMBER ; STRESS ; MEN ; ATHEROSCLEROSIS ; DIETARY ; BODY ; OXIDATIVE STRESS ; PERIPHERAL-BLOOD ; CONSUMPTION ; LIGNANS ; PROTEOMICS ; METABOLITE ; proteome analysis ; BODIES ; molecular biology ; molecular ; RE ; EX-VIVO ; WEIGHT ; CARDIOVASCULAR-DISEASE ; body weight ; RENAL-DISEASE ; LEVEL ; biomarker ; analysis ; methods ; PLASMA-LEVELS ; ENTEROLACTONE ; COMPOUND ; RISK-FACTOR ; in vivo ; peripheral blood mononuclear cells ; PLASMA ENTEROLACTONE ; TIME-RESOLVED FLUOROIMMUNOASSAY ; SERUM ENTEROLACTONE ; STEADY-STATE ; GLYCOPROTEIN-IIB/IIIA ; HYPERCHOLESTEROLEMIC ATHEROSCLEROSIS ; INTESTINAL MICROFLORA
    Abstract: Flaxseed is one of the richest sources of lignans that are converted to enterolactone by the intestinal microflora. Enterolactone has been suggested to be the prime active compound mediating atherosclerosis-protective effects that were shown for flaxseed. The effects of a 1-wk intervention with 0.4 g of flaxseed/kg body weight per day on enterolactone plasma levels in seven healthy men revealed that all participants (PAs) responded with enhanced enterolactone plasma levels. Proteome analysis of peripheral blood mononuclear cells (PBMC) from donors before, during, and after the intervention showed that flaxseed consumption affected significantly the steady-state levels of 16 proteins of which four were altered in a similar manner when blood mononuclear cells were exposed ex vivo to enterolactone. Enhanced levels of peroxiredoxin and reduced levels of the long-chain fatty acid beta-oxidation multienzyme complex may be taken as indicators of a reduced oxidative stress whereas reduced levels of glycoprotein IIIa/II could indicate improved protection from thrombotic and inflammatory processes. In conclusion, the blood mononuclear cell proteome responds to dietary flaxseed intake with changes in a number of atherosclerosis-relevant proteins that may be taken as biomarkers of exposure and some of these changes observed can be attributed to the action of the lignan metabolite enterolactone
    Type of Publication: Journal article published
    PubMed ID: 17708591
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: CANCER ; Germany ; POPULATION ; RISK ; BIOMARKERS ; ASSOCIATION ; BREAST ; breast cancer ; BREAST-CANCER ; prevention ; PLASMA ; WOMEN ; cancer risk ; Jun ; DIETARY ; case-control studies ; LIGNANS ; DIETARY-INTAKE ; case-control study ; population-based case-control study ; RE ; AGE 50 ; PHYTO-ESTROGENS ; case control studies ; INTERVAL ; PREMENOPAUSAL WOMEN ; ENTEROLACTONE ; phytoestrogens ; odds ratio ; population-based ; CANCER-RISK ; PLASMA ENTEROLACTONE ; TIME-RESOLVED FLUOROIMMUNOASSAY ; isoflavonoids ; DIETARY PHYTOESTROGEN INTAKE ; premenopausal breast cancer ; DAIDZEIN ; genistein ; SERUM ENTEROLACTONE ; SPOT URINE ; URINARY PHYTOESTROGENS
    Abstract: Background The scientific debate on the role of dietary phytoestrogens for prevention of breast cancer is still ongoing. We previously reported an inverse association between dietary phytoestrogen intake and premenopausal breast cancer risk and now examine the relationship with plasma phytoestrogen concentrations. Methods We measured enterolactone (mammalian lignan) and genistein (isoflavone) concentrations in plasma samples of 220 premenopausal cases and 237 age-matched controls from a population-based case-control study in Germany. Results Median plasma enterolactone concentrations in cases and controls were 6.3 and 9.7 nmol/l, respectively, and median genistein concentrations were 4.5 and 3.7 nmol/l, respectively. Premenopausal breast cancer risk decreased with increasing plasma enterolactone concentrations. Adjusted odds ratios (95% confidence intervals) were 0.42 (0.20-0.90) and 0.38 (0.17-0.85) (P for trend 0.007) for women in the third and fourth quartile of plasma enterolactone compared to those in the lowest quartile. There was no significant association between plasma genistein concentration and premenopausal breast cancer risk. Conclusion Using biomarkers of phytoestrogen intake, we confirmed the strong inverse association between enterolactone and premenopausal breast cancer risk as found with dietary intake estimates. This result gives support to the potential role of mammalian lignans for breast cancer prevention among premenopausal women in Western populations. European Journal of Cancer Prevention 15:225-232 (c) 2006 Lippincott Williams & Wilkins
    Type of Publication: Journal article published
    PubMed ID: 16679865
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: CANCER ; Germany ; human ; POPULATION ; RISK ; PATIENT ; ASSOCIATION ; polymorphism ; ALPHA ; BREAST ; breast cancer ; BREAST-CANCER ; HUMANS ; WOMEN ; cancer risk ; CANCER-PATIENTS ; DIETARY ; CONSUMPTION ; PRECURSORS ; LIGNANS ; urinary estrogen metabolites ; POSTMENOPAUSAL WOMEN ; REGRESSION ; RE ; PHYTO-ESTROGENS ; SERUM ENTEROLACTONE CONCENTRATION ; LEVEL ; ENTEROLACTONE ; CANCER-RISK ; PLASMA ENTEROLACTONE ; TIME-RESOLVED FLUOROIMMUNOASSAY ; isoflavonoids ; cYP17 ; DIETARY PHYTOESTROGEN INTAKE ; GENE CYP17 ; HORMONE CONCENTRATIONS ; MSPA1 POLYMORPHISM ; premenopausal breast cancer
    Abstract: Cytochrome P450c17 alpha (CYP17) has been associated with alterations in steroid hormone levels and premenopausal breast cancer risk and could modify the association between phytoestrogen intake and breast cancer risk. We examined plasma concentrations of enterolactone and genistein, estimated dietary phytoestrogen intake, CYP175'-UTR MspA1 genetic polymorphism, and breast cancer risk in 267 premenopausal breast cancer patients and 573 age-matched population controls from Germany. Multivariate logistic regression was used to estimate breast cancer risk associated with quartiles of phytoestrogen intake by genotype and to investigate gene-nutrient interactions. Premenopausal breast cancer risk was not significantly associated with the CYP17 A2 genotype. We observed a significant modifying effect of CYP17 genotype on plasma enterolactone-associated breast cancer risk (P for interaction 〈 0.01). Plasma enterolactone was significantly inversely related to breast cancer risk only in A2A2 carriers, showing odds ratios and 95% Cl of 0.02 (0.00-0.41) and 0.01 (0.00-0.21) for the third and fourth quartiles vs. the lowest quartile, respectively. This inverse association was also found for the calculated enterolignan production as well as matairesinol intake. Compared with A1A1 carriers with the lowest enterolactone supply, the risk reduction associated with a high enterolactone supply resulted in a comparably decreased breastcancer risk for all genotypes. For genistein, no clear indication for a differential effect by CYP17 genotype was obtained. Our results suggest that CYP17 genotype modifies the protective effect of lignans on premenopausal breast cancer risk. Women homozygous for A2 allele benefit most from high plasma enterolactone concentrations and a high consumption of dietary precursors
    Type of Publication: Journal article published
    PubMed ID: 16702327
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...