Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 0378-1119
    Keywords: Felis domesticus ; Polymerase chain reaction ; allergy ; alternate splicing ; differential tissue-specific expression
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0378-1119
    Keywords: Amino acid alignment ; allergy ; polymerase chain reaction ; recombinant DNA ; sequence comparison
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-041X
    Keywords: Key words Seven up ; Bar ; Photoreceptor cells ; Cone cells ; Pigment cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The lozenge locus is genetically complex, containing two functionally distinct units, cistrons A and B, that influence the structure of the compound eye. Extreme mutations of either cistron produce adult phenotypes that share similarities and that have striking differences. We have analyzed the expression of several developmentally important eye genes including boss, scabrous, rhomboid, seven-up, and Bar in lozenge mutant backgrounds representing both cistrons. This analysis follows the progressive recruitment of photoreceptor neurons during eye development and has confirmed that the initial development of photoreceptors is normal up to the five cell precluster stage (R8, R2/5 and R3/4). However, when lozenge is mutant, further eye development is perturbed. As cells R1, R6 and R7 are recruited, patterns of gene expression for seven-up and Bar become abnormal. We have also characterized the expression of two different enhancer trap alleles of lozenge. The lozenge product(s) appear to be first expressed in the eye disc in undifferentiated cells shortly after the five cell precluster forms. Then, as distinct cells are recruited to a fate, lozenge expression persists and is refined in those cells. Our data suggests that lozenge functions in cone cells and pigment cells as well as in specific glia. With respect to photoreceptor neurons, lozenge biases the developmental potential of cells R1, R6 and R7, by directly influencing the expression of genes important for establishing cell fate.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-0428
    Keywords: Diabetes ; retinopathy ; platelet adhesiveness ; ADP activated platelet aggregation ; ADP splitting enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'adhésivité des thrombocytes, l'activation par l'ADP de leur agrégation et l'activité des enzymes scindant l'ADP dans le sang et le plasma ont été étudiés chez 22 diabétiques porteurs de rétinopathie grave, chez 22 sujets diabétiques anciens avec une rétinopathie minime ou nulle et chez 28 sujets témoins. On a mesuré le taux d'agrégation des thrombocytes sous l'effet de 5, 3, 2 et 1 μM d'ADP, le maximum d'agrégation atteint et le taux de désagrégation de ces agrégats. Les thrombocytes des sujets atteints de rétinopathie fortement évolutive sont apparus plus sensibles à l'effet de faibles concentrations d'ADP; on a observé un accroissement significatif du degré d'agrégation et une diminution de la vitesse de désagrégation des agrégats thrombocytaires formés dans les conditions expérimentalesin vitro. Si cela se produisaitin vivo, il pourrait en résulter une occlusion des capillaires. Cette sensibilité accrue à l'ADP et cette incapacité à se désagréger n'étaient pas dues à une différence dans l'activité du système d'enzymes scindant l'ADP dans le sang. On n'observe pas de différences significatives dans ces paramètres si l'on compare le groupe important des diabétiques avec les sujets témoins. Contrairement à certains rapports, aucun des deux groupes de diabétiques ne présentait d'accroissement apparent de l'adhésivité des thrombocytes.
    Abstract: Zusammenfassung An 22 Diabetikern mit schwerer Retinopathie, an weiteren 22 Diabetikern mit langem Krankheitsverlauf, aber keiner oder minimaler Retinopathie und an 28 Kontrollpersonen wurde die Adhäsion der Thrombocyten, die Aggregation der durch ADP aktivierten Thrombocyten und die Aktivität von ADP spaltenden Encymen im Blut und Plasma gemessen. Der Grad der Thrombocytenaggregation, ihr Maximum und der Grad der Desaggregation wurden unter dem Einfluß von 5, 3, 2, und 1 μM ADP bestimmt. Die Thrombocyten bei aktiv fortschreitender Retinopathien waren gegenüber der Wirkung von geringen Konzentrationen von ADP empfindlicher. Es wurde auch eine signifikante Erhöhung des Ausmaßes der Aggregation und eine Verminderung des Desaggregationsgrades von Thrombocytenaggregaten, die sich unterin vitro Bedingungen gebildet hatten, festgestellt. Wenn diesin vivo vorkommen sollte, kann daraus ein Verschluß von Kapillaren entstehen. Die erhöhte Empfindlichkeit gegenüber ADP und die Unfähigkeit zur Desaggregation war nicht auf Unterschiede in der Aktivität von ADP spaltenden Enzymen des Blutsystems zurückzuführen. Bei dem Vergleich der großen Gruppe von Diabetikern mit der Kontrollgruppe wurden keine signifikanten Unterschiede der Parameter aufgedeckt. Im Gegensatz zu einigen Berichten in der Literatur konnte bei keiner der Diabetikergruppen eine Erhöhung der Adhäsion von Thrombocyten gefunden werden.
    Notes: Summary Platelet adhesiveness, ADP-activated platelet aggregation and the activity of the ADP-splitting enzymes in blood and plasma have been studied in 22 diabetics with severe retinopathy, 22 long-duration diabetics with minimal or no retinopathy and 28 control subjects. The rate of platelet aggregation under the influence of 5, 3, 2 and 1 μM ADP, the maximum aggregation attained and the rate of disaggregation of these aggregates were measured. The platelets from actively deteriorating retinopaths were found to be more sensitive to the effect of low concentrations of ADP; a significant increase in the extent of aggregation and a decrease in the rate of disaggregation of platelet aggregates formed under the experimental conditions,in vitro were observed. If this should occurin vivo, then capillary occlusion might ensue. This increased sensitivity to ADP and inability to disaggregate, was not due to any differences in the activity of the ADP-splitting enzyme systems in blood. Significant differences in the parameters were not observed when the large diabetic groups were compared with the control subjects. Contrary to some reports, an increase in platelet adhesiveness was not apparent in either diabetic group.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1365-2524
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This paper reports the results of the first stage of an evaluation study of a health visitor caseload weighting system. In Bristol, health visitor caseloads are compiled annually to complete caseload weighting summaries based on 28 health and social factors known to reflect long-term health outcome. The main study aims to determine the validity and reliability of the caseload weighting system by assessing health visitor variation in interpretation of the health and social factors, the accuracy of caseload factor recording and methods of analysis used in interpreting their significance. This paper describes the exploratory phase of the study involving the distribution of a questionnaire to 252 health visitors in five Trust areas where no caseload weighting system operates. The purpose of the questionnaire and follow-up interviews with 28 health visitors was to develop a multiple-choice questionnaire to assess how health and social factors were being interpreted by health visitors using them in their everyday work. The study indicated that the 28 health and social factors were perceived to significantly influence the need for health visiting services. Some differences in perception of a small number of factors were identified according to the level of deprivation on the caseload. Health visitors' prioritization of child protection, and child protection related health and social factors, raised the possibility that caseload weighting might be used as a ‘child protection check list’ rather than as an overall measure of health visitor need. Interviews showed that a range of thresholds governs the health visitors' application of a particular factor to a family. Health visitor workload is also affected by other factors relating to practice location, which would need to be taken into account if these health and social factors were to be used for estimating workload. Health visitors not currently using the factors view them positively for the assessment of health needs in an area, and for planning work on an individual or management level, but the interviews identified a need for training in their use and suggested more work is needed to tighten and standardize definitions for use in the field.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 0014-5793
    Keywords: Allergen ; Amino acid sequence ; Lolium perenne ; Nucleotide sequence ; cDNA cloning
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1420-9071
    Keywords: Key words. Hypermutability; lozenge; ruby; blistered; Drosophila simulans.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. A hypermutable strain of Drosophila simulans that originated from a single spontaneous mutant male was characterized. Seven different mutations were isolated from roughly 100 generations of offspring. The genetic analysis of the viable mutants showed two mutations on the X chromosome, one in the lozenge locus and the other in the ruby gene. The autosomic mutations characterized were a dpp-held out-like, a blistered-like and a homoeotic dominant mutant with an antenna-to-leg transformation and ectopic eyes that we called Zoinho-napata.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Annals of vascular surgery 5 (1991), S. 320-324 
    ISSN: 1615-5947
    Keywords: Grafts ; gelatin-sealed aortic grafts ; aortic implantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A gelatin-sealed knitted Dacron graft has been developed which has zero porosity at Implantation and does not require preclotting. Its patency rate up to 57 months and effectiveness at saving blood loss have been studied. Gelatin-sealed aortic grafts were implanted into 100 consecutive patients-77 men, 23 women. Surgery was performed for aneurysm in 36 patients (including four with rupture), intermittent claudication in 44, rest pain in 17, and gangrene in three, over an 18 month period. The patients were followed up prospectively for 57 months. Perioperative mortality was 1%. Cumulative primary graft patency was 99%. There was no measurable blood loss at implantation. Forty-seven patients required blood transfusion: mean volume transfused was 430 ml. There were no problems related to the sealant.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 2143-2145 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Medium density (3×109 cm−3) and high density (3×1012 cm−3) plasmas, generated by low and medium power rf techniques, have been used for the implantation of 10–20 keV nitrogen ions into mild steel targets which were immersed in the plasma and biased to −20 kV. Use of the high density plasma resulted in significant damage to the surface by arcing. At medium densities the nitrogen was implanted to a depth and dose consistent with expectations, there was no arcing damage, and tests showed improved wear and hardness compatible with the level of implantation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...