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  • 1
    Keywords: GROWTH ; GENE ; PROTEINS ; FAMILY ; DELETION ; IKAROS
    Abstract: Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL). To verify and further examine the relationship between these variants and ALL risk, we genotyped 1384 cases of precursor B-cell childhood ALL and 1877 controls from Germany and the United Kingdom. The combined data provided statistically significant support for an association between genotype at each of these loci and ALL risk; odds ratios (OR), 1.69 (P = 7.51 x10(-22)), 1.80 (P = 5.90 x 10(-28)), and 1.27 (P = 4.90 x 10(-6)), respectively. Furthermore, the risk of ALL increases with an increasing numbers of variant alleles for the 3 loci (OR(per-allele) = 1.53, 95% confidence interval, 1.44-1.62; P(trend) = 3.49 x 10(-42)), consistent with a polygenic model of disease susceptibility. These data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases.
    Type of Publication: Journal article published
    PubMed ID: 20042726
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  • 2
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Parasitology research 50 (1976), S. 81-86 
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Experiments carried out to study the influence of progesterone and cortisone on the initiation of ovarian maturation, fecundity rate and fertility of the two species of rat fleas Xenopsylla cheopis (Rothschild) and X. astia (Rothschild) indicated that these hormones do not exert any influence on their reproductive potentials. This along with earlier observations show that the factors which regulate ovarian maturation and fecundity in these rat fleas are different from those of the rabbit flea Spilopsyllus cuniculi (Dale).
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1439-6327
    Keywords: Antarctica ; Thyroid function ; Cortisol ; Thyrotropin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adaptation of the thyroid gland to the Antarctic environment was studied in nine healthy euthyroid tropical men of the Sixth Indian Antarctic Expedition during 1 year of their residence at polar latitudes. Circulatory concentrations of thyroid hormones, total T4 (TT4), total T3 (TT3), free T4 (FT4), free T3 (FT3), reverse T3 (rT3), thyroxine binding globulin. (TBG), T3 uptake and thyroid stimulating hormone (TSH) were estimated in New Delhi and during the first week of each month of the stay in Antarctica. At the end of the Austral summer in March, the TT3 concentrations were found to be significantly lower (P 〈 0.01) compared to values recorded in New Delhi and showed a significant increase (P 〈 0.05) during the Austral winter in August. The mean TT3 concentrations from May to December were found to be significantly higher than the March or April values. Plasma TT4 and rT3 concentrations tended to decline in March but remained unaltered during the entire period in Antarctica. The FT4, FT3, TBG and T3 uptake did not show any appreciable change. Though, the TT3 : TT4 ratio tended to decline in March and April suggesting decreased peripheral conversion of T4 to T3 as the possible mechanism for a decline in TT3 in March, physical exertion and prolonged exposure to extreme cold appeared to be the major contributory factors. The TSH concentration in March, April, November and December were found to be significantly higher than the New Delhi values. The morning as well as evening cortisol concentrations during the Austral winter were higher than the March values suggesting that cortisol rhythmicity was well maintained in Antarctica, albeit at a higher level. These observations indicated that the subtle changes in thyroid hormones during a prolonged stay at polar latitudes are related not only to the extreme cold but also to other factors such as physical activity, polar days and polar nights.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    ISSN: 0268-2575
    Keywords: ammoximation ; cyclohexanone oxime ; caprolactam ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The ammoximation of cyclohexanone to cyclohexanone oxime with H2O2 and NH3, in liquid phase, over γ-Al2O3 supported titanium silicates, is reported. The effects of temperature, reactant concentrations and support to catalyst ratio on the efficiency of the process are examined. A maximum yield of 94·48% with selectivity 98·49% for oxime could be achieved over 50 wt% γ-Al2O3 supported titanium silicates, at a cyclohexanone: NH3: H2O2 molar ratio of 1:1·5:1, and at a temperature of 313 K. Studies suggest that in the case of a supported catalyst, the catalyst: ketone ratio is about eight times less than that needed for an unsupported catalyst. A batchwise addition of cyclohexanone and ammonia and a dropwise addition of H2O2 produced the best results. A tentative mechanism for the production of oxime and by-products is suggested. © 1997 SCI.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 189-197 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Infrared spectra of ethyl chloroacetate and ethyl bromoacetate in the region 4000-600 cm-1 have been recorded, together with laser Raman spectra of the molecules in the region 4000-100 cm-1. These spectra, in conjunction with CNDO 2 computations, were employed to study the conformational behaviour of the molecules. A normal coordinate analysis was carried out for the cis-trans isomers of these molecules and supported the frequency assignments fairly well.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A two-dimensional detector array has been fabricated from a single 10-mm-diam by 100-μm-thick chemical vapor deposition diamond disk by applying a 1×1 mm2 metallization grid of 4×4 pixels with centered bias connections. This diamond has been exposed to high power pulsed laser radiation. It has been shown that this kind of diamond array operates as a radiation hard, ultrafast laser beam profiler and can obtain spatial profiles with 500 ps temporal resolution. Ten spatial profiles were obtained within a single 5 ns duration laser pulse, revealing in detail the temporal and spatial development of the laser beam intensity. No attenuation is necessary for this profiler when making single-shot measurements at intensities up to ∼100 MW/cm2. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 1551-1553 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Presently, investigation of the sodium-neon photopump x-ray laser scheme on Z pinches is hindered by the lack of a well-defined sodium source. Metal vapor sources have been pursued; however, they have tended to be less characterized than the traditional wire arrays and gas puffs. In this note, the development of a sodium wire extruder which produces an array of 6 or 12, greater than 50 μm diameter, wires is described and successful implosions of the said array on the DNA/Double-EAGLE generator are reported.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 792-807 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: One of the recently established results concerns the fractal-like properties of surfaces such as the turbulent/nonturbulent interface. Although several confirmations have been reported in recent literature, enough discussion does not exist on how various flow features as well as measurement techniques affect the fractal dimension obtained; nor, in one place, is there a full discussion of the physical interpretation of such measurements. This paper serves these two purposes by examining in detail the specific case of the interface of scalar-marked regions (scalar interface) in turbulent shear flows. Dimension measurements have been made in two separate scaling regimes, one of which spans roughly between the integral and Kolmogorov scales (the K range), and the other between the Kolmogorov and Batchelor scales (the B range). In the K range, the fractal dimension is 2.36±0.05 to high degree of reliability. This is also the dimension of the vorticity interface. The dimension in the B range approaches (logarithmically) the value 3 in the limit of infinite Schmidt number, and is 2.7±0.03 when the diffusing scalar in water is sodium fluorescein (Schmidt number of the order 1000). Among the effects considered are those of (a) the flow Reynolds number, (b) developing regions such as the vicinity of a jet nozzle or a wake generator, (c) the free-stream and other noise effects, (d) the validity of the method of intersections usually invoked to relate the dimension of a fractal object to that of its intersections, (e) the effect of intersections by "slabs'' of finite thickness and "lines'' of finite width, and (f) the computational algorithm used for fractal dimension measurement, etc. The authors' previous arguments concerning the physical meaning of the fractal dimension of surfaces in turbulent flows are recapitulated and amplified. In so doing, turbulent mixing is examined, and by invoking Reynolds and Schmidt numbers similarities, the fractal dimensions of scalar interfaces are deduced when the Schmidt number is small, unity, and large.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 4906-4910 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Enhancement of the collision-induced absorption (CIA) spectra of the first overtone infrared band of H2 in the H2–Kr and H2–Xe binary mixtures were recorded at 295 K for base densities of H2 in the range 30–57 amagat and for partial densities in the range 50–250 amagat for each of Kr and Xe. The observed spectra consist of single transitions O2(J), Q2(J), and S2(J) corresponding to the selection rule ΔJ=−2, 0, and 2, respectively. Binary, ternary, and quarternary absorption coefficients of the band arising from collisions of the type H2–X, H2–X–X, H2–H2–X,H2–X–X–X, H2–H2–X–X, and H2–H2–H2–X, where X represents Kr or Xe, have been determined from the integrated absorption coefficients of the band. The spectra are interpreted in terms of the quadrupolar induction mechanism and no evidence of the contribution from the isotropic overlap induction mechanism is found unlike in the CIA spectra of the fundamental band of H2 [see S. P. Reddy, in Phenomena Induced by Intermolecular Interactions, edited by G. Birnbaum (Plenum, New York, 1985), p. 129]. Analysis of the absorption profiles of the observed spectra was carried out using the Birnbaum–Cohen line-shape function [G. Birnbaum and E. R. Cohen, Can. J. Phys. 54, 593 (1976)] for individual components of the band and characteristic line shape parameters were determined from the analysis. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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