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  • 1
    Keywords: DIFFERENTIATION ; PROGRESSION ; AMPLIFICATION ; neuroblastoma ; BRAIN-TUMORS ; medulloblastoma ; PROMINENT NUCLEOLI
    Type of Publication: Journal article published
    PubMed ID: 22057788
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  • 2
    Keywords: metastases ; GADOPENTETATE DIMEGLUMINE ; gadobenate dimeglumine ; MULTICENTER ; ENHANCEMENT ; 1.5 T ; 3 TESLA ; FIELD-STRENGTH ; HUMAN BLOOD-PLASMA ; GADOTERIDOL
    Abstract: Objectives To compare the contrast agent effect of a full dose and half the dose of gadobenate dimeglumine in brain tumours at 7 Tesla (7T) MR versus 3 Tesla (3T). Methods Ten patients with primary brain tumours or metastases were examined. Signal intensities were assessed in the lesion and normal brain. Tumour-to-brain contrast and lesion enhancement were calculated. Additionally, two independent readers subjectively graded the image quality and artefacts. Results The enhanced mean tumour-to-brain contrast and lesion enhancement were significantly higher at 7T than at 3T for both half the dose (91.8 +/- 45.8 vs. 43.9 +/- 25.3 [p=0.010], 128.1 +/- 53.7 vs. 75.5 +/- 32.4 [p=0.004]) and the full dose (129.2 +/- 50.9 vs. 66.6 +/- 33.1 [p=0.002], 165.4 +/- 54.2 vs. 102.6 +/- 45.4 [p=0.004]). Differences between dosages at each field strength were also significant. Lesion enhancement was higher with half the dose at 7T than with the full dose at 3T (p=. 037), while the tumour-to-brain contrast was not significantly different. Subjectively, contrast enhancement, visibility, and lesion delineation were better at 7T and with the full dose. All parameters were rated as good, at the least. Conclusion Half the routine contrast agent dose at 7T provided higher lesion enhancement than the full dose at 3T which indicates the possibility of dose reduction at 7T.
    Type of Publication: Journal article published
    PubMed ID: 25194707
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  • 3
    Keywords: GLIOMAS ; temozolomide ; GLIOBLASTOMA
    Abstract: The Brain Tumor Epidemiology Consortium (BTEC) is an open scientific forum, which fosters the development of multi-center, international and inter-disciplinary collaborations. BTEC aims to develop a better understanding of the etiology, outcomes, and prevention of brain tumors (http://epi.grants.cancer.gov/btec/). The 15th annual Brain Tumor Epidemiology Consortium Meeting, hosted by the Austrian Societies of Neuropathology and Neuro-oncology, was held on September 9 - 11, 2014 in Vienna, Austria. The meeting focused on the central role of brain tumor epidemiology within multidisciplinary neuro-oncology. Knowledge of disease incidence, outcomes, as well as risk factors is fundamental to all fields involved in research and treatment of patients with brain tumors; thus, epidemiology constitutes an important link between disciplines, indeed the very hub. This was reflected by the scientific program, which included various sessions linking brain tumor epidemiology with clinical neuro-oncology, tissue-based research, and cancer registration. Renowned experts from Europe and the United States contributed their personal perspectives stimulating further group discussions. Several concrete action plans evolved for the group to move forward until next year's meeting, which will be held at the Mayo Clinic at Rochester, MN, USA.
    Type of Publication: Journal article published
    PubMed ID: 25518914
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  • 4
    Keywords: RECEPTOR ; CANCER ; EXPRESSION ; GROWTH ; proliferation ; tumor ; CELL ; Germany ; MICROSCOPY ; THERAPY ; CLASSIFICATION ; FOLLOW-UP ; SUPPORT ; HISTORY ; DISTINCT ; GENE ; HYBRIDIZATION ; PROTEIN ; DIFFERENTIATION ; TUMORS ; SURGERY ; TIME ; PATIENT ; COMPARATIVE GENOMIC HYBRIDIZATION ; COPY NUMBER ; MALIGNANCIES ; MEMBRANE ; NUMBER ; AGE ; RECURRENCE ; vimentin ; pathology ; IMBALANCES ; MOLECULAR-CLONING ; LACKING ; FEATURES ; MALIGNANCY ; ELECTRON-MICROSCOPY ; HIGH-RESOLUTION ; GLIOMA ; analysis ; TUMOR-CELL ; USA ; LOSSES ; PHOSPHATASE ; epilepsy ; genomic ; RARE ; NECROSIS ; IMMUNOREACTIVITY ; CHROMOSOME-6 ; angiocentric ; NEUROFIBRILLARY TANGLES ; TANYCYTIC EPENDYMOMA
    Abstract: Angiocentric glioma has recently been described as a novel epilepsy associated tumor with distinct clinico-pathologic features. We report the clinical and pathologic findings in 8 additional cases of this rare tumor type and extend its characterization by genomic profiling. Almost all patients had a history of long-standing drug-resistant epilepsy. Cortico-subcortical tumors were located in the temporal and parietal lobes. Seizures began at 3 to 14 years of age and surgery was performed at 6 to 70 years. Histologically, the tumors were characterized by diffuse growth and prominent perivascular tumor cell arrangements with features of astrocytic/ependymal differentiation, but lacking neoplastic neuronal features. Necrosis and vascular proliferation were not observed and mitoses were sparse or absent. M1B-1 proliferation indices ranged from 〈 1% to 5%. Immunohistochemically, all cases stained positively for glial fibrillary acidic protein, vimentin, protein S100B, variably for podoplanin, and showed epithelial membrane antigen-positive cytoplasmic dots. Electron microscopy showed ependymal characteristics in 2 of 3 cases investigated. An analysis of genomic imbalances by chromosomal comparative genomic hybridization revealed loss of chromosomal bands 6q24 to q25 as the only alteration in I of 8 cases. In I of 3 cases, a high-resolution screen by array-comparative genomic hybridization identified a copy number gain of 2 adjacent clones from chromosomal band 11p11.2 containing the protein-tyrosine phosphatase receptor type J (PTPRJ) gene. All patients are seizure free and without evidence of tumor recurrence at follow-up times ranging from 1/2 to 6.9 years. Our findings support 2 previous reports proposing that angiocentric glioma is a novel glial tumor entity of low-grade malignancy
    Type of Publication: Journal article published
    PubMed ID: 18059228
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  124. Kongress der Deutschen Gesellschaft für Chirurgie; 20070501-20070504; München; DOC07dgch7725 /20071001/
    Publication Date: 2007-10-02
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    ISSN: 1432-0584
    Keywords: Key words Globus pallidus necrosis ; Allogeneic marrow transplantation ; Myelodysplastic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 21-year-old Caucasian man received an allogeneic marrow transplant (BMT) from his HLA-identical brother because of myelodysplastic syndrome. He remained red blood cell (RBC) transfusion dependent with persistent antibodies against the donor's RBC. Six months following BMT the patient suddenly developed a severe akinetic syndrome with gait disturbance and frequent falls and bilateral symmetrical lesions in basal ganglia. Concomitantly, micrococcus species septicemia from an infected Hickman catheter developed. Despite antimicrobial therapy and withdrawal of cyclosporin A, neurologic abnormalities persisted and were unresponsive to various therapies. Ischemic damage due to a vascular event during severe infection could be the most probable reason for the lesions seen in our patient, although infectious or toxic complications cannot be ruled out.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2102
    Keywords: Schlüsselwörter ; Zerebralinfarkt ; Krampfanfall ; Neugeborenes ; Dopplersonographie ; Vasospasmus ; Key words ; Cerebral artery infarction ; Seizure ; Newborn ; Doppler sonography ; Vasospasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A cerebral artery infarction is an important differential diagnosis in the newborn with neurological abnormalities. Based on clinical data, its incidence is estimated to be 1 in 4000 newborns. Since the course is often subclininal, the true incidence is probably higher. Diagnosis: Cerebral ultrasound and Doppler sonography as readily available screening tools play a central role in the initial diagnosis of neonatal cerebral infarction. Definitive diagnosis is made by computed tomography or magnetic resonance imaging. Beside symptomatic anticonvulsive therapy, treatment aims at the prevention of secondary ischemic injury. Discussion: Three term infants with different clinical courses of neonatal stroke are presented to sensitize the clinician and the radiologist for this probably underdiagnosed entity. The role of imaging modalities in the diagnosis and follow-up of neonatal cerebral infarction is discussed.
    Notes: Zusammenfassung Ein Infarkt im Stromgebiet der Zerebralarterien stellt eine wichtige Differentialdiagnose bei neurologischen Auffälligkeiten in der Neonatalperiode dar. Die Inzidenz wird anhand von klinischer Daten auf 1:4000 Lebendgeborene geschätzt. Da der Verlauf oft subklinisch ist, liegt die wahre Inzidenz wahrscheinlich höher. Diagnose: Bei der Diagnosestellung kommen dem Schädelultraschall und der Dopplersonographie als leicht verfügbaren Screening-Methoden eine zentrale Rolle zu. Die definitive Diagnose wird, je nach Verfügbarkeit, mittels Computertomographie oder Kernspintomographie gestellt. Die Behandlung ist neben der symptomatischen (antikonvulsiven) Therapie auf die Vermeidung von ischämischen Sekundärschäden gerichtet. Diskussion: Wir wollen mit der vorliegenden Arbeit anhand von 3 Kindern mit verschiedenen klinischen Verläufen eines sog. Neonatal stroke den Stellenwert der bildgebenden Verfahren bei der Diagnostik und Verlaufskontrolle aufzeigen und die Sensibilität für dieses vermutlich unterdiagnostizierte Krankheitsbild erhöhen.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; diffusion-weighted ; Gonadal steroids ; White-matter maturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have demonstrated the ability of high-resolution diffusion-weighted MRI to show maturation of white-matter structures in the developing rat brain. The purpose of this study was to investigate the influence of gonadal steroid hormones on the rate of this development. Starting from their second postnatal day, 16 rat-pups of either sex were repeatedly treated with subcutaneous implants containing 17-beta estradiol or delta-androstene 3,17 dione, respectively. Serial T1-, T2- and diffusion-weighted MRI was performed weekly for 8 weeks using a 4.7 T unit. Maturation of anterior optic pathways and hemisphere commissures was assessed. Diffusion-weighted images were processed to produce “anisotropy index maps”, previously shown to be sensitive to white-matter maturation. Compared with untreated rat-pups, estrogen-treated animals showed accelerated, and testosterone-treated animals delayed maturation on anisotropy index maps and histological sections. In all animals, maturational changes appeared earlie on anisotropy index maps than on other MRI sequences or on myelin-sensitive stained sections. Diffusion-weighted imaging, and the construction of spatial maps sensitive to diffusion anisotropy, seem to be the most sensitive approach for the detection of maturational white-matter changes, and thus may hold potential for early diagnosis of temporary delay or permanent disturbances of white-matter development.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1920
    Keywords: Key words Virchow-Robin spaces ; Magnetic resonance imaging ; Childhood migraine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Virchow-Robin spaces (VRS) are pia-lined extensions of the subarachnoid space which surround penetrating arteries as they enter the brain on its surface. Using high-resolution MRI, which shows small penetrating arteries, we studied a possible association of accentuated VRS in children with tension-type headache (TTH) or migraine. We studied 58 children aged 3–14 years (mean 10.8 years) with a clinical diagnosis of migraine (31) or TTH (27), who underwent cerebral MRI, and 30 headache-free patients of the same age (mean 10.2 years) and 30 adult migraineurs with postpubertal onset of symptoms, who served as controls. The images were reviewed for structural abnormalities in the regions of the small penetrating arteries. Accentuated VRS were found in 61 % of the children with migrainous headaches and in 22 % of children of those with TTH. Prominent VRS were seen in 27 % of the control children and in only 13 % of the adults. Small infarcts and gliosis were rare in children with or without headache, but were seen in 30 % of the adult migraineurs. Our findings show that accentuated VRS are significantly more common in children with migraine than in those with TTH or headache-free controls. Detection of accentuated VRS may therefore enhance differential diagnosis of primary headaches in children, contributing to an improvement in management.
    Type of Medium: Electronic Resource
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