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  • 1
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer interklinischen Studie werden 126 Fälle von kindlichen Osteosarkomen analysiert. Es findet sich eine zunehmende Häufigkeit bis zum 15. Lebensjahr bei geringem Überwiegen des männlichen Geschlechtes. Das kindliche Osteosarkom bevorzugt den distalen Femur, die proximale Tibia und den proximalen Humerus. Die Behandlung wurde — bedingt durch die verschiedenen Kooperationszentren — uneinheitlich durchgeführt. Überlebende finden sich in allen Altersgruppen. Multiple Metastasen — meist in den Lungen, aber auch im Skelet — treten gehäuft innerhalb des 1. Jahres und fast immer innerhalb der ersten 2 1/2 Jahre nach Diagnosestellung auf. Zur Prognosebeurteilung genügt daher die 21/2-Jahres-Grenze. Die anscheinend besseren Ergebnisse nach frühzeitiger Amputation lassen diese Methode beim kindlichen Osteosarkom empfehlenswert erscheinen. Mit der alleinigen Strahlentherapie konnten keine Heilungen erzielt werden. Zusätzlich zur frühzeitigen Radikalbehandlung läßt die intensive prophylaktische Chemotherapie bessere Resultate erwarten.
    Notes: Summary 126 osteosarcoma under the age of 15 years are followed up in an interclinical study. There is a steady increase of tumor incidence towards the 15th year with a slight male preponderance. The main sites of the tumor are the distal femur followed by the proximal tibia and humerus. Evidence of multiple metastases is most often present in the lungs, less often in the skeleton. Nearly always metastases became evident within 2 1/2 years after diagnosis (98%). Therefore the 2 1/2-year disease—free survival rate seems to be sufficient for prognostic evaluation. The over all 2 1/2-year survival rate was 17,5%. Though the different methods of treatment are not statistically valid, the best results can be expected after early amputation. By radiotherapy alone no cure has been achieved. Survivals were seen at any age and at any site of long bones (distal femur, proximal tibia, humerus, femur, distal radius). Prognosis of osteosarcoma in the childhood is similar to that of the adult group.
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 184.1959, 4688, B.A.76-, (2 S.) 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The most likely explanation of these differences in age, sex and site would seem to lie in the relatively advanced skeletal growth of girls, and in the general cephalad-caudad sequence of growth progression. It is well known of course that the majority of osteogenic sarcomata of adolescents arise ...
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 1 (1976), S. 15-19 
    ISSN: 1432-2161
    Keywords: Paget's disease ; Myelomatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report concerns a 69-year-old woman with Paget's disease, manifested by osteoporosis circumscripta, and myelomatosis, both confirmed at autopsy. Brief reference is made to another six patients known to have had both Paget's disease and myelomatosis. The combination appears in patients around the age of seventy years. Either condition may be monostotic. Only rarely are the same bones involved by both diseases. The myelomatosis may simulate metastatic carcinoma. The observed and expected frequencies of Paget's disease in patients with myelomatosis are in close agreement. The converse proportion of individuals affected by myelomatosis amongst a population with a high endemic incidence of Paget's disease cannot be calculated from the records of the Bristol Bone Tumour Registry. Association of the two diseases is suggested to be fortuitous.
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