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  • 1
    Keywords: Medicine ; Oncology ; Bioorganic chemistry ; Pharmacy ; Cytology ; Engineering mathematics ; Nanotechnology ; Biomedicine ; Cancer Research ; Cell Biology ; Nanotechnology ; Appl.Mathematics/Computational Methods of Engineering ; Bioorganic chemistry ; Pharmacy ; Springer eBooks
    Description / Table of Contents: Editorial and Introduction to Volume 2 -- Part I Novel nanocarrier design and processing -- Proprietary nanofiber technologies and scale-up -- Magnetically responsive (nano)biocomposites.-Zwitterionic nanocarriers for gene delivery -- Stimuli-responsive polymeric nanocarriers as promising drug and gene delivery systems -- ℗ Photo-responsive polymeric nanocarriers for on-demand drug delivery -- Part II Nanocarrier characterization and function -- Considerations on uptake and intracellular trafficking of nanocarriers -- Mucus as physiological barrier to intracellular delivery -- Investigation of nanoparticles in biological objects by electron microscopy techniques -- Gold nanoparticles for high resolution imaging in modern immunocytochemistry -- Design of functional polymers for intracellular drug nucleic acids delivery -- Membrane-domain-selective drug targeting based on lipid modification -- Multifuntional protein-based nanoparticles for theragnosis -- Cytocompatible phospholipid polymer for noninvasive nanodevice -- Intracellular protein delivery using self-assembled amphiphilic polysaccharide nanogels -- Part III Simulation for delivery and function -- Molecular dynamics simulations of polyplexes and lipoplexes -- Computational studies of highly pegylated sterically stabilized micelles self-assembly and drug solubilization -- Toward intracellular delivery and drug discovery,Stochastic logic networks as efficient computational models for gene regulatory networks -- Part IV Nanocarriers for drug discovery and treatment -- Nanodiamonds as intracellular probes for imaging in biology and medicine -- Intracellular delivery of RNA using RNA-binding proteins or peptides -- Hyaluronic acid based nanofibers for wound dressing and drug delivery carriers -- Potential of siRNA therapy in chronic myeloid leukemia
    Abstract: This volume is a continuation of Volume 1 following the previously published Editorial. More emphasis is given to novel nanocarrier designs, their characterization and function, and applications for drug discovery and treatment. A number of chapters will deal with nanofibers as a new major application within the biomedical field with a very high success rate particularly in wound healing and diabetic foot and spine injuries. A major new subdivision will deal with mathematical methods for the assembly of nanocarriers ℗ both for simulation and function
    Pages: XIX, 479 p. 168 illus., 110 illus. in color. : online resource.
    ISBN: 9789401788960
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  • 2
    Unknown
    Dordrecht : Springer Science+Business Media B.V.
    Keywords: Life sciences ; Cytology ; Life sciences ; Cell Biology ; Springer eBooks
    Pages: : digital
    ISBN: 9789400712485
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  • 3
    Call number: 08-PHYS
    Keywords: Tumor / Entstehung
    Pages: 225 S., ILL.
    Edition: 3., VOELLIG NEU BEARB. AUFL.
    ISBN: 3-432-84473-5
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    08-PHYS departmental collection or stack – please contact the library
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  • 4
    Keywords: Medicine ; Pharmaceutical technology ; Biotechnology ; Microbiology ; Biomedicine ; Biomedicine general ; Biotechnology ; Applied Microbiology ; Pharmaceutical Sciences/Technology ; Springer eBooks
    ISBN: 9789400728493
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  • 5
    Keywords: Medicine ; Computer Simulation ; Microbial genetics ; Biomedical Engineering ; Biomedicine ; Biomedicine general ; Microbial Genetics and Genomics ; Simulation and Modeling ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: Functional genomics, proteomics, metabolomics and bioinformatics for systems biology -- Comparing biological networks: a survey on graph classifying techniques -- Emergent properties of gene regulatory networks – models and data -- Regulatory crosstalk analysis of biochemical networks in the nucleus accumbens -- Properties of biological networks -- Network analysis for systems biology -- Computational approaches for reconstruction of time-varying biological networks from Omics data -- Probabilistic graphical modeling in systems biology: a framework for integrative approaches -- Innovations of the rule-based modeling approach -- Reproducibility of model-based results in systems biology -- Parameter identifiability and redundancy, with applications to a general class of stochastic carcinogenesis models -- Semantic systems biology: formal knowledge representation in systems biology for model construction, retrieval, validation and discovery -- Computational infrastructures for data and knowledge management in systems biology -- Computational tools and resources for integrative modeling in systems biology -- Agent-based modeling approaches to multi-scale systems biology: An example agent-based model of acute pulmonary inflammation -- Reconstructing cellular signaling and regulatory networks - an integrative approach for systems-level drug discovery -- A survey of current integrative network algorithms for systems biology -- Direct Computer Mapping based modeling of a multiscale process, involving p53/miR-34a signaling
    Abstract: Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory
    Pages: XXXI, 553 p. 105 illus., 53 illus. in color. : online resource.
    ISBN: 9789400768031
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  • 6
    Keywords: Medicine ; Nanotechnology ; Biomedicine ; Biomedicine general ; Nanotechnology ; Springer eBooks
    Description / Table of Contents: 1 Overview of present problems facing commercialization of nanomedicines, Aleš Prokop and Volkmar Weissig -- 2 Precision medicine and site-specific drug delivery, Karel Petrák -- 3 Extracellular matrix degrading enzymes for nanocarrier-based anticancer therapy, Pablo Scodeller -- 4 Nanocarrier-based anticancer therapies with the focus on strategies for targeting the tumor microenvironment, Francisca Leonard and Biana Godin -- 5 New approach to minimize the MPS/RES uptake resulting a reduce toxic side effects of nanodrugs, Li Liu and Chien Ho -- 6 Authentic vascular and stromal structure in animal disease model for nanomedicine, Hiroshi Nishihara and Mitsunobu R Kano -- 7 Ligand-targeted nanocarriers with respect to their translation into the clinic, in particular in comparison with non-targeted nano-medicines, Roy Van der Meel, Laurens J.C. Vehmeijer, Robbert Jan Kok, Gert Storm, Ethlinn V.B. van Gaaland Gert Storm -- 8 Anti-angiogenic therapy by targeting the tumor vasculature with liposomes, Yu Sakurai and Hideyoshi Harashima -- 9 Accessing mitochondrial targets using nanocargos, Ru Wen, Afoma C. Umeano and Shanta Dhar -- 10 Redox-responsive nano-delivery systems for cancer therapy, Amit Singh, Thanh-Huyen Tran and Mansoor M. Amiji -- 11 Nano-emulsions for drug delivery and biomedical imaging, Nicolas Anton, François Hallouard, Mohammed F. Attia and Thierry F. Vandamme -- 12 The tumor microenvironment in nanoparticle delivery and the role of Imaging to navigate roadblocks and pathways, Dmitri Artemov and Zaver M Bhujwalla -- 13 Microscopic mass spectrometry for the precise design of drug delivery systems, Yasuhiro Matsumura and Masahiro Yasunaga -- 14 Pharmacokinetics and pharmacodynamics of nano-drug delivery systems, David Stepensky -- 15 Intracellular drug delivery in PBPK modelling though active and passive transport processes, Lars Kuepfer, Christoph Niederalt, Thomas Wendl, Jan-Frederil Schlender, Michael Block, Thomas Eissing, Donato Teutonic -- 16 Exploiting nanocarriers for combination cancer therapy, Yi Wen Kong, Erik C. Dreaden, Paula T. Hammond and Michael B. Yaffe -- 17 Commercialization of nanotechnology for medical applications, David W. Hobson -- Index
    Abstract: A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile
    Pages: XIII, 453 p. 81 illus., 65 illus. in color. : online resource.
    ISBN: 9783319435251
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 7 (1997), S. S58 
    ISSN: 1432-1084
    Keywords: Key words: Storage phosphor plates ; Digital radiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Storage phosphor radiography is a digital technique that uses photo-stimulable phosphor screens to substitute for conventional screen-film combinations. While the technique is more than 15 years old, it is only recently that technological and economic aspects of these systems have become favourable enough to envisage a more widespread clinical application.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 7 (1997), S. S73 
    ISSN: 1432-1084
    Keywords: Key words: Digital radiography ; Image processing ; Quality optimisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. The image quality of a radiograph is determined by the local contrast, spatial resolution, latitude and the image noise. The goal of digital processing is to improve the visualisation of pathology by optimising these physical parameters. Processing parameters need to be chosen correctly in order to overcome the inverse relationship between contrast and latitude while producing images that retain a conventional appearance. Unsharp mask filtering (UMF) is a simple technique for improving image quality. This technique, however, suffers from serious drawbacks, such as the suppression of pathologic lesions or artifacts that may simulate pathology. Manufacturers have developed different approaches in order to overcome problems and artifacts derived from this technique.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 36 (1996), S. 457-469 
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Spiral-CT ; Lungendiagnostik ; Key words Spiral CT ; Helical CT ; Technique ; Pulmonary diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Spiral CT allows for examination of the whole chest within a single breathhold. As compared to standard CT, spiral CT has an increased sensitivity for the detection of pulmonary nodules, of small mediastinal and bronchopulmonary lymph nodes, and of pleural plaques improves characterization of lesion morphology. New diagnostic applications include the detection of very subtle diffuse lung disease and the diagnosis of pulmonary embolism and vascular malformations. For the diagnosis of tracheobronchial pathology, spiral CT is an ideal supplement to bronchoscopy.
    Notes: Zusammenfassung Die Spiral-CT ermöglicht es, den Thorax innerhalb einer Atemphase kontinuierlich zu erfassen. Im Vergleich zur Standard-CT zeigt die Spiral-CT eine erhöhte Sensitivität zum Nachweis intrapulmonaler Rundherde, kleiner mediastinaler und bronchopulmonaler Lymphome, pleuraler Plaques sowie eine verbesserte morphologische Charakterisierung von Läsionen. Neue diagnostische Aufgaben umfassen den Nachweis subtiler diffuser Lungenerkrankungen, den Nachweis von Pulmonalembolien sowie vaskulärer Malformationen. Für die Diagnostik tracheobronchialer Pathologie stellt die Spiral-CT eine ideale Ergänzung zur Bronchoskopie dar.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 44 (1955), S. 343-355 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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