Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); 20170514-20170517; Magdeburg; DOCMi.26.05 /20170609/
    Publication Date: 2017-06-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie; 20180603-20180606; Münster; DOCV289 /20180618/
    Publication Date: 2018-06-19
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract To establish an electrochemical HPLC detection system which is suitable for the voltammetric characterisation of unknown contaminants and food components at working potentials lower than –1 V, a modified flow-through cell for the use of a hanging mercury drop electrode (HMDE) is described. The introduction of silanised glass capillaries and a new flow-channel design provide a high HMDE lifetime, which is recommended in HPLC detection. As test system the herbicides diquat, paraquat and difenzoquat and ethylviologen as internal standard were measured using differential pulse voltammetry (DPV) detection to improve selectivity. Spiked water samples were analysed with voltammetric and UV-detection and results agreed well.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Faktor-XII-Mangel ; APC-Resistenz ; Faktor-V-Mutation G1691:A ; Hyperhomocysteinämie ; Mutation C677:T im MTHFR-Gen ; von-Willebrand-Erkrankung Typ 1 ; Key words Factor XII deficiency ; APC resistance ; Factor V-mutation G 1691 A ; Hyperhomocysteinemia ; Mutation C 677 T in the MTHFR gene ; von Willebrand’s disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A young woman presenting with marked menstrual blood loss and prolonged bleeding after only minimal injuries was investigated. Because of an extremely prolonged PTT (more than 200 s) we measured the factor XII activity and found a severe deficiency. The bleeding symptoms however could be ascribed to the existence of von Willebrands disease type 1. In addition, the patient had an elevated resistance against activated protein C (APC-resistance) and a moderately elevated concentration of homocysteine in her blood plasma. At the genomic level we found heterozygosity for the factor V mutation G 1691 A and the mutation C 677 T in the methylenetetrahydrofolate reductase (MTHFR)-gene. The analysis of the factor XII gene revealed the existence of a point mutation in the promoter region (G→C transversion, nt–8). The same mutation could be found in the paternal factor XII gene. The low factor XII activity in the woman seems to be the result of a second mutation originating from the maternal factor XII gene (compound heterozygosity). However, this second mutation could not be found up to now. In the sister of the women, a 15 year old girl, there is also a marked menstrual blood loss. The coagulation analysis revealed reduced activities of the factor XII and also von Willebrands disease type 1. The reduced factor XII activity seems to be compatible with the heterozygous state of factor XII deficiency. In the girl there was also an increased APC resistance, corresponding with heterozygosity for the factor V mutation G 1691 A. Mother and father are heterozygous for the factor XII deficiency and the mutation C 677 T in the MTHFR gene. In the mother homozygosity for the mutation in the factor V gene (1691 AA) could be found. All family members investigated exhibited elevated D-dimer concentrations in the plasma. Discussion: It is the aim of this report to give attention to menorrhagias as predominant features of von Willebrand’s disease in females. Furthermore in women with von Willebrand’s disease in combination with inherited risk factors for thrombophilia problems could arise from the use of oral contraceptives and also during pregnancy. In our opinion, physicians, especially paediatricians, who take care of adolescents, should be familiar with such problems.
    Notes: Zusammenfassung Eine junge Frau mit verstärkten Regelblutungen und länger anhaltenden Blutungen aus nur geringgradigen Verletzungen wurde untersucht, wobei eine sehr stark verlängerte PTT ( 〉200 s) auffiel. Die Messung der Faktor-XII-Aktivität ergab mit weniger als 2% einen hochgradigen Mangel. Die angegebenen Blutungssymptome sind jedoch auf eine gleichzeitig bestehende von-Willebrand-Erkrankung Typ 1 zurückzuführen. Zusätzlich waren die APC-Resistenz pathologisch und die Homocysteinkonzentration im Plasma der Patientin erhöht. Auf genomischer Ebene konnten die Mutationen G1691:A im Faktor-V-Gen und C677:T im Methylentetrahydrofolatreduktase(MTHFR)-Gen heterozygot nachgewiesen werden. Die Analyse des Faktor-XII-Gens ergab eine Punktmutation in der Promotorregion (G:C-Transversion, nt–8), die auch im Faktor-XII-Gen des Vaters nachzuweisen ist. Die niedrige Faktor-XII-Aktivität bei der jungen Frau deutet auf die Anwesenheit einer 2. Mutation hin (Compound-Heterozygotie), die sie von ihrer Mutter geerbt haben muß. Diese 2. Mutation ist bis jetzt nicht gefunden worden. Die 15jährige Schwester der Patientin berichtet ebenfalls über verstärkte Regelblutungen. Die Gerinnungsanalyse ergab eine verminderte Faktor-XII-Aktivität und eine von-Willebrand-Erkrankung Typ 1. Die verminderte Faktor-XII-Aktivität ist mit dem heterozygoten Status für diesen Defekt vereinbar. Die erhöht gefundene Resistenz gegenüber APC konnte durch den Nachweis der Mutation G 1691 A im Faktor-V-Gen in heterozygoter Form bestätigt werden. Mutter und Vater der Schwestern sind für den Faktor-XII-Mangel und die Mutation im MTHFR-Gen heterozygot. Bei der Mutter besteht Homozygotie für die Mutation im Faktor-V-Gen (1691 AA). Alle untersuchten Familienmitglieder zeigten erhöhte D-Dimer-Konzentrationen im Plasma. Diskussion: Mit diesem Fallbericht soll auf die Bedeutung der Menorrhagie als häufiges Symptom einer von-Willebrand-Erkrankung hingewiesen werden. Da zusätzlich Risikofaktoren für eine Thrombophilie bestehen, wird auf die Probleme, die den Patientinnen aus der Anwendung oraler Kontrazeptiva entstehen können, ebenso hingewiesen wie auf mögliche Komplikationen im Verlauf einer Schwangerschaft.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-0517
    Keywords: Key words Analytical quality control ; Reference materials ; Moss ; Organic surface soil ; Intercalibration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  In order to ensure quality assurance in large-scale environmental contamination studies involving many different analytical laboratories, the use of calibrated reference materials is essential. Prior to a survey of atmospheric metal deposition in 1995 comprising 20 countries and covering large parts of Europe, the lack of suitable reference materials of moss and organic-rich soil was apparent. In order to improve the quality of analytical data to be produced in this international survey, candidate analytical laboratories were invited to participate in an intercomparison exercise. Three moss and three soil humus reference samples specifically prepared for this purpose were distributed anonymously among the laboratories, which were asked to report data for ten priority elements (V, Cr, Fe, Ni, Cu, Zn, As, Cd, Hg, Pb) and as many additional elements as they determined normally. In this paper the analytical data from the intercomparison are evaluated, and recommended values for the ten priority elements and 17 additional elements (B, Na, Mg, Al, S, K, Ca, Mn, Co, Se, Rb, Sr, Sb, Cs, Ba, La, Th) in each of the six reference samples are established. These samples should be useful for similar future studies including areas where the contamination levels are very low.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The removal of implant coatings may be necessary if rough implant surfaces are exposed subgingivally due to progressive peri-implant bone loss or if they are also supragingivally exposed because of progressive gingival recession, thus facilitating plaque formation and impairing tooth cleaning done at home. The aim of this experimental study was to develop diamond-coated files and rubberized polishers for machine-driven instrumentation of implant cylinders, and present an instrumentation concept for the complete removal of rough titanium plasma spray (TPS) and hydroxylapatite (HA) layers and polishing exposed titanium surfaces. The surface structure and its possible contamination by the instrumentation process was investigated using laser profilometry, scanning electron microscopy, and x-ray fluorescence analysis. The effect of impurities on the growth of human fibroblasts was tested in cell culture. The results show that TPS and HA implant coatings can be removed with the modified implant files. After polishing the exposed titanium surfaces, roughness depths of Rz=4.6 μm (TPS) and Rz=5.7 μm (HA) and, for implant cylinders, 3.4 μm were found. During the instrumentation of implant surfaces, contamination with the material of the instrument must be expected. It was shown that, in principle, growth of human gingival fibroblasts on the instrumented surfaces is possible. The cells were intimately associated with one another and, compared to culture controls, demonstrated good adhesion with strict orientation to the microstructure of the scoring left by instrumentation. The biological consequences and mechanisms of cell adhesion on instrumented surfaces require further investigation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: In an in vitro study, the surface wear on cervical restorations and adjacent enamel and root cementum caused by different tooth-cleaning methods in simulated long-term therapy was investigated.Methods: Cervical restorations of amalgam (Oralloy®), modified composite resin (Dyract®), glass-ionomer cement (ChemFill Superior®), and composite (Tetric®) were instrumented by POL (polishing), CUR+POL (curette and polishing), US+POL (ultrasonic device with polishing) and the polishing agents Cleanic® and Proxyt® in a computer-controlled test bench. Treatment time corresponding to a real-time period of 5 or 10 years. Substance loss from instrumented surfaces was measured with a digital gauge. A three-way anova was used in the statistical evaluation.Results: The results showed that POL led to slight substance loss, which was greater using Cleanic® (27 μm) than Proxyt® (5 μm). CUR+POL produced a significantly greater substance loss than did US+POL, with 186 μm versus 35 μm on glass-ionomer cement, respectively, and 123 μm versus 18 μm, respectively, on root cementum, followed by composite (111 μm versus 27 μm, respectively), polyacid modified composite resin/compomer (89 μm versus 36 μm), amalgam (75 μm versus 19 μm), and enamel (32 μm versus 23 μm).Conclusions: As opposed to the use of US+POL or POL, substance loss on cervical restorations and especially root cementum must be expected to result from tooth-cleaning during long-term maintenance treatment using CUR+POL.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background, aims: In a manikin study we recently assessed how effectively student operators were able to learn scaling with curettes (GRA) and power-driven instruments (PP). Calculating the debrided root area effectiveness was low in both groups without systematic training or without a motivational program. After 10 weeks (20 h) of training, operators reached a high effectiveness of 84.7% (GRA) and 81.6% (PP). The purpose of the present study was to evaluate the clinical outcome of nonsurgical treatment as performed by these student operators.Methods: In a clinical trial, 19 students trained in the use of Gracey curettes for 10 weeks (=20 h) (GRA10) and Periopolisher® system for 1 week (=2 h) (PP1), and 20 students trained in the use of Gracey curettes for 1 week (GRA1) and the Periopolisher for 10 weeks (PP10) treated one patient each in a split-mouth design. At baseline and 6 months, we recorded probing depth (PD), probing attachment level (PAL) and bleeding on probing (BOP) by computer-assisted probing. Statistical analysis was carried out for moderate (category B) and deep sites (category C). Groups were compared using Student's t-tests (p〈0.05).Results: Category B sites showed a PD reduction of 1.2/1.0 mm (GRA10/GRA1) and 1.1 mm (PP10/PP1). PAL gain was 0.5/0.3 mm (GRA10/GRA1) and 0.4/0.2 mm (PP10/PP1). In category C sites, PD reduction was 2.1/2.3 mm (GRA10/GRA1) and 2.0 mm (PP10/PP1) with a PAL gain of 0.6/0.9 mm (GRA10/GRA1) and 0.4 mm (PP10/PP1). BOP was significantly lower in all groups.Conclusion: The results show that student operators who had received a systematical training on manikins and had attained different effectiveness results were able to treat periodontally diseased patients successfully using both Gracey and Periopolisher instruments.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: This retrospective study determined the treatment outcomes of 142 compliant periodontal patients observed for at least 10 years at the University of Kiel. All patients had been treated for moderate to advanced periodontitis and regularly received supportive periodontal therapy (SPT).Methods: Patient- and tooth-related variables [tooth loss and pocket probing depth (PPD)] were analysed.Results: Of a total of 3353 teeth, 167 were extracted during active treatment and 99 during SPT, mainly for periodontal reasons. Forty-five per cent of the patients did not lose any teeth during 11.7 years of observation. Thirty-seven per cent underwent extractions during active treatment or SPT, 18% both during active periodontal therapy and SPT. Mean tooth loss per patient was 0.07 teeth/year during SPT. Mobility, furcation involvement, smoking, and prescription antibiotics had a negative impact on prognosis. Intraindividual differences in PPD were significant between single- and multirooted teeth with initial PPD ≥ 4 mm at baseline, following active treatment and at the end of SPT, and between firm and mobile teeth at baseline. Interindividual differences in mean PPD were only significant between smokers and non-smokers at the end of the observation period.Conclusions: Long-term maintenance of our patients was effective. Periodontal disease represented the major cause of tooth loss in a minority of the population.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Altenpflegeausbildung – Reformen mit offenen Fragen – Ansätze zur Neuordnung der Altenpflegeausbildung – empirische Untersuchung zu Erwartungen an die Ausbildung und den Beruf des Altenpflegers ; Key words Training as geriatric nurse – reforms with unanswered questions – approaches to the reorganisation of the training of geriatric nurses – empirical survey on the expectations of the training and profession of geriatric nurse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Historically, the profession of geriatric nurse has arisen from the care of the sick and has developed very differently from region to region. A question as to the status of development of the profession of geriatric nurse cannot be answered by reference to the current status of legislation on professional law matters. If experts in that field focus too long on such matters, there is a danger that decisive developments in the profession of geriatric nurse take place outside their field of vision. This longitudinal survey involving trainees in their first year of training has revealed a series of interesting links and developments which had not been reckoned with. In the core training areas, for example, expected modes of behaviour with specific regard to age, education and gender were outlined which should result, in terms of the consequences for training, in measures to improve quality. Furthermore, there is a need for criteria to assure the quality of the training of geriatric nurses so as to guarantee a minimum quality standard. For example, there is currently a lack of any binding framework curriculum and provisions assuring the quality of the manpower and facilities available at training locations. Also questionable is the level of qualification of those who supervise the practical training of trainees at such locations and the whole area of further training of teaching staff.
    Notes: Zusammenfassung Der Altenpflegeberuf ist historisch aus der Krankenpflege entstanden und hat sich regional sehr unterschiedlich entwickelt. Die Frage nach dem Stand der Entwicklung des Altenpflegeberufes läßt sich nicht mit einem Hinweis auf den aktuellen Stand der Gesetzgebung zu berufsrechtlichen Regelungen beantworten. Fokussiert sich die Fachöffentlichkeit länger auf diese Fragen, besteht die Gefahr, daß entscheidende Entwicklungen des Altenpflegeberufes außerhalb ihres Blickfeldes stattfinden. Die vorliegende Längsschnittuntersuchung mit Auszubildenden im ersten Ausbildungsjahr hat eine Reihe von interessanten Zusammenhängen und Entwicklungen aufgezeigt, mit denen so nicht gerechnet wurde.1 In Kernbereichen der Ausbildung wurden z.B. alters-, bildungs- und geschlechtsspezifische Erwartungshaltungen herausgearbeitet, die qualitätsverbessernde Maßnahmen als Folgen für die Ausbildung nach sich ziehen sollten. Darüber hinaus sind zur Qualitätssicherung der Altenpflegeausbildung Kriterien erforderlich, die eine Mindestqualität sicherstellen. So fehlen derzeit ein verbindliches Rahmencurriculum sowie qualitätssichernde Bestimmungen über personelle und sachliche Mindestausstattungen der Ausbildungsstätten. Offen bleiben die Qualifizierung von Praxisanleitungen und der gesamte Bereich der Weiterbildung der Lehrkräfte.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...