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  • 1
    Publication Date: 2014-11-14
    Description: Female mosquitoes are major vectors of human disease and the most dangerous are those that preferentially bite humans. A 'domestic' form of the mosquito Aedes aegypti has evolved to specialize in biting humans and is the main worldwide vector of dengue, yellow fever, and chikungunya viruses. The domestic form coexists with an ancestral, 'forest' form that prefers to bite non-human animals and is found along the coast of Kenya. We collected the two forms, established laboratory colonies, and document striking divergence in preference for human versus non-human animal odour. We further show that the evolution of preference for human odour in domestic mosquitoes is tightly linked to increases in the expression and ligand-sensitivity of the odorant receptor AaegOr4, which we found recognizes a compound present at high levels in human odour. Our results provide a rare example of a gene contributing to behavioural evolution and provide insight into how disease-vectoring mosquitoes came to specialize on humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286346/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286346/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McBride, Carolyn S -- Baier, Felix -- Omondi, Aman B -- Spitzer, Sarabeth A -- Lutomiah, Joel -- Sang, Rosemary -- Ignell, Rickard -- Vosshall, Leslie B -- 5UL1TR000043/TR/NCATS NIH HHS/ -- HHSN272200900039C/AI/NIAID NIH HHS/ -- HHSN272200900039C/PHS HHS/ -- K99 DC012069/DC/NIDCD NIH HHS/ -- R00 DC012069/DC/NIDCD NIH HHS/ -- UL1 TR000043/TR/NCATS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2014 Nov 13;515(7526):222-7. doi: 10.1038/nature13964.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York 10065, USA [2] Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA. ; Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York 10065, USA. ; Unit of Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Box 102, Sundsvagen 14, 230 53 Alnarp, Sweden. ; Center for Virus Research, Kenya Medical Research Institute, PO Box 54840 - 00200, Off Mbagathi Way, Nairobi, Kenya.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25391959" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/*physiology ; Alleles ; Animals ; Arthropod Antennae/metabolism ; *Biological Evolution ; Female ; Forests ; Gene Expression Profiling ; Host Specificity ; Humans ; Ketones/analysis/metabolism ; Ligands ; Male ; Molecular Sequence Data ; Receptors, Odorant/*metabolism ; Species Specificity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Theriogenology 31 (1989), S. 264 
    ISSN: 0093-691X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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