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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  46. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 20. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20151001-20151003; Berlin; DOC132 /20150928/
    Publication Date: 2015-09-29
    Keywords: Dermabrasion ; Akne ; Haut Pits ; Narben ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Keywords: ANGIOGENESIS ; CELLS ; GROWTH ; SURVIVAL ; CELL ; MODEL ; THERAPY ; SUPPORT ; HEPATOCELLULAR-CARCINOMA ; GENE ; PROTEIN ; MICE ; MECHANISM ; REDUCTION ; mechanisms ; MATURATION ; MIGRATION ; VESSELS ; HYPOXIA ; molecular ; RE ; THERAPIES ; TUMORIGENESIS ; BLOOD-VESSELS ; antiangiogenic therapy ; MOLECULAR-MECHANISMS ; LOSSES ; ENGLAND ; EDEMA ; PROMOTES ; PERICYTES ; RGS5
    Abstract: The vasculature of solid tumours is morphologically aberrant and characterized by dilated and fragile vessels, intensive vessel sprouting and loss of hierarchical architecture(1). Constant vessel remodelling leads to spontaneous haemorrhages(2) and increased interstitial fluid pressure in the tumour environment(3,4). Tumour-related angiogenesis supports tumour growth and is also a major obstacle for successful immune therapy as it prevents migration of immune effector cells into established tumour parenchyma(2,5,6). The molecular mechanisms for these angiogenic alterations are largely unknown. Here we identify regulator of G-protein signalling 5 (Rgs5) as a master gene responsible for the abnormal tumour vascular morphology in mice. Loss of Rgs5 results in pericyte maturation, vascular normalization and consequent marked reductions in tumour hypoxia and vessel leakiness. These vascular and intratumoral changes enhance influx of immune effector cells into tumour parenchyma and markedly prolong survival of tumour-bearing mice. This is the first demonstration, to our knowledge, of reduced tumour angiogenesis and improved immune therapeutic outcome on loss of a vascular gene function and establishes a previously unrecognized role of G-protein signalling in tumour angiogenesis
    Type of Publication: Journal article published
    PubMed ID: 18418378
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  • 3
    Keywords: B-vitamin . Bcl-2 . Cell death . Epilepsy . Kainate . Programmed cell death
    Abstract: The regulation of programmed cell death in the nervous system of vertebrates is a complex mechanism aimed to remove superfluous or damaged cells. Epileptic seizures can lead to an activation of pathways resulting in neuronal cell death. B-vitamins might have a neuroprotective potential reducing cell death following appropriate stimulation. Here, the role of the B-vitamins B(1) (thiamine), B(6) (pyridoxine), and B(12) (cobalamine) was investigated in a mouse model of experimental epilepsy induced by kainate. B-vitamin pre-treated animals showed a significantly reduced epileptic score during the first 15 min after kainate injection. The molecular response to kainate showed a bi-phased time course with early induction of Bcl-2 expression within 12 h and a second induction after 7 days of kainate exposure. B-vitamin pre-treatment resulted in significant higher Bcl-2 expression in control animals (no kainate) and at 12 h within the early phase. Bcl-2 expression was not affected by B-vitamins within the second phase. BAX expression was not significantly influenced during the whole experiment. Three days after kainate stimulation, the number of TdT-mediated dUTP-biotin nick end labeling-positive cells in the hippocampal region was lower in B-vitamin-treated animals. Therefore, B-vitamin pre-treatment may attenuate the response to epileptic stimulation.
    Type of Publication: Journal article published
    PubMed ID: 19777382
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  • 4
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Infection of Vicia faba with Bothytis fabae causes significant decreases in growth vigour, total nitrogen content, number of nodules and nutrient accumulation. Na-uptake and phenolics concentration increased compared to that of noninfected plants. In contrast, dual inoculation of Rhizobium and VA mycorrhizae increased all above parameters suggesting a distinct improvement of the plants. The results also revealed that an inverse correlation may exist between phenolic, calcium, magnesium and zinc concentrations in mycorrhizal plant tissues grown in presence of rhizobial bacteria and the disease severity. From these findings we conclude a possible role of both VA mycorrhizal fungi and rhizobial bacteria in the decrease of susceptibility of plants.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-0832
    Keywords: Mycotoxins ; Toxic Aspergilli ; Pistachio nuts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Pistachio nut samples taken during various stages of development from orchards in Iran, showed that contamination with fungi occurred mainly during the later stages of nut development. Members of the genera Aspergillus and Penicillium occurred most frequently. Of the Aspergilli, the species A. niger, A. flavus and A. fischeri var. spinosus occurred most frequently, followed by A. terreus, A. tamarii and A. nidulans. Twenty-two isolates comprising 13 species were tested for toxicity to ducklings. Isolates of known toxic fungi included A. flavus, A. niger, A. parasiticus, A. ochraceus, A. versicolor, A. nidulans and A. terreus. The toxicity of A. fischeri var. spinosus is reported. Chemical analysis showed that all isolates of A. flavus and A. parasiticus produced aflatoxin B1, the isolates of A. versicolor and A. nidulans produced sterigmatocystin while the toxic isolate of A. ochraceus did not produce ochratoxins. Toxic fungi have been shown to occur in a variety of nuts (4), (5), (11), (12), (13), (15), (18), (20), (21). Aflatoxin contamination of pistachio nuts has been reported and has in the past led to the rejection of consignments of Iranian pistachio nuts (1). In Iran, pistachio nuts are produced mainly in the south eastern provinces (Kerman & Zahedan) and to a limited extent in the Northern part (Kazvin & Damghan). In 1975 it was estimated (7) that there were some 24 million pistachio trees in Iran, of which 60% were situated in Rafsanjan, Kerman (Table 1). Economic considerations as well as the potential health hazard posed by aflatoxin-contaminated nuts, prompted the University of Isfahan to initiate a study of various aspects of the mycotoxin problem in pistachio nuts.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The mechanism of the reaction12C(P,α)9B is studied using zero range distorted wave Born approximation. The knock out mechanism is assumed to represent this reaction both in the forward and backward angles.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-0832
    Keywords: Fusarium beomiforme ; F. dlamini ; F. moniliforme ; F. napiforme ; F. nygamai ; moniliformin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Four recently described species, Fusarium nygamai, F. dlamini, F. beomiforme and F. napiforme and two uncertain taxa, F. nygamai from millet in Africa and Fusarium species from rice with Bakanae disease, were tested for toxicity and moniliformin production. Cultures grown on autoclaved corn were fed to groups of four one-day-old ducklings for 14 days. Isolates that caused the death of 3 or 4 out of 4 ducklings were considered to be toxic and analyzed for moniliformin. All 15 isolates of F. dlamini tested were nontoxic. The other taxa contained some isolates that were toxic to ducklings and produced moniliformin in corn cultures. This is the first report of moniliformin production by F. beomiforme (200–890 μg/g), and F. napiforme (16–388 μg/g), and by F. nygamai not obtained from millet in Africa (15–874 μg/g). The highest production of moniliformin was obtained from the 19 isolates of F. nygamai from millet in Africa (4300–18200μg/g) and the 15 isolates from rice with Bakanae disease (2300–19300 μg/g). The taxonomic position of these two uncertain taxa should be re-evaluated.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 40-42 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Planar shocks generated by short pulse lasers are useful in studies of shock compression phenomena and may have applications in materials science, biology, and medicine. We have found the fluence profiles of 120–400 fs duration Gaussian spatial mode incident laser pulses are reproducibly flattened via surface optical breakdown and Kerr focusing in thin dielectric substrates at fluences just above the ablation threshold. These flat laser profiles have been used to produce planar shocks that are flat to 0.7 nm root-mean-square over a 75–100 μm diameter. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Some properties of the membranes obtained by the preirradiation grafting of acrylic acid onto poly(tetrafluoroethylene) (PTFE) film have been studied. The dimensional change by grafting and swelling, water uptake, electric conductivity, and mechanical properties of the grafted PTFE films were measured and were found to increase as the grafting proceeds. These properties were found to be dependent mainly on the degree of grafting regardless of grafting conditions except higher monomer concentration (80 wt %). The electric conductivity and mechanical properties of the membranes at 80 wt % monomer concentration is lower than those at a lower monomer concentration. The results suggest that the membranes obtained at 80-wt % acrylic acid solution have a somewhat heterogeneous distribution of electrolyte groups as compared with those prepared at a monomer concentration less than 60 wt %. X-ray microscopy of the grafted films revealed that the grafting begins at the part close to the film surface and proceeds into the center with progressive diffusion of monomer to give finally the homogeneous distribution of electrolyte groups. The membranes show good electrochemical and mechanical properties which make them acceptable for the practical uses as cation exchange membrane.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Infrared absorption spectroscopy has been used to investigate the combined effect of γ-radiation and heat on poly(vinyl chloride) (PVC). The recorded spectra showed that exposure of PVC samples to gamma doses from 0.5 to 15 Mrad results in remarkable changes in the absorbances of their absorption bands. Also, the exposure to doses from 3 to 15 Mrad results in an appearance of a C=O band at 1720 cm-1 and O—H band at 3450 cm-1. The nature of the formation of these bands was discussed in terms of peroxide-mediated oxidative degradation mechanism. Moreover, it was found that heat treatment of PVC samples over the temperature range 25-180°C causes no noticeable changes in their spectra apart from slight changes in the absorbances of the bands. On other hand, it was found that heat treatment of the irradiated samples causes considerable increase in the intensity of the C=O band. In addition to the well-defined and sharp band appearing at 1720 cm-1, the spectra of the samples irradiated with 10 and 15 Mrad exhibited two bands at 1070 and 1120 cm-1. The obtained data led also to the conclusion that the C—Cl bands cannot be used as a measure of crystallinity of PVC.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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