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  • 1
    Keywords: CANCER ; LUNG ; LUNG-CANCER ; DISEASE ; EPIDEMIOLOGY ; RISK ; GENE ; GENES ; GENETIC POLYMORPHISMS ; ASSOCIATION ; polymorphism ; HEALTH ; smoking ; SQUAMOUS-CELL CARCINOMA ; case-control studies ; lung neoplasms ; glutathione-S-transferase ; case-control study ; WORLDWIDE ; review ; METAANALYSIS ; GENOTYPE ; CHINESE POPULATION ; PUBLICATION BIAS ; DNA ADDUCT LEVELS ; NULL-GENOTYPE ; Asian continental ancestry group ; glutathione S-transferase pi ; GSTP1 ; HONG-KONG ; P1 POLYMORPHISMS ; PI-GENE
    Abstract: Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A -〉 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio = 1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites
    Type of Publication: Journal article published
    PubMed ID: 19240225
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  • 2
    Keywords: CANCER ; LUNG ; lung cancer ; LUNG-CANCER ; EPIDEMIOLOGY ; RISK ; GENE ; GENES ; METABOLISM ; ASSOCIATION ; FREQUENCY ; polymorphism ; POLYMORPHISMS ; SUSCEPTIBILITY ; FREQUENCIES ; DELETION ; MALIGNANCIES ; GLUTATHIONE ; meta-analysis ; smoking ; INVOLVEMENT ; TOBACCO ; CHROMOSOMAL LOCALIZATION ; FACTOR-I ; lung neoplasms ; glutathione-S-transferase ; GLUTATHIONE S-TRANSFERASE ; MALIGNANCY ; TOBACCO-SMOKE ; GSTT1 ; METAANALYSIS ; ENVIRONMENTAL TOBACCO-SMOKE ; INTERVAL ; GENETIC-POLYMORPHISM ; pooled analysis ; CANDIDATE ; odds ratio ; tobacco smoke ; RISK-FACTOR ; E ; CHEMICALS ; genetic predisposition to disease ; ENVIRONMENTAL-FACTORS ; ADENOCARCINOMA SUSCEPTIBILITY ; disease susceptibility ; EPOXIDE HYDROLASE ; ETHYLENE-OXIDE ; GSTP1 POLYMORPHISMS ; INDIVIDUAL SENSITIVITY ; TISSUE DISTRIBUTION
    Abstract: Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer
    Type of Publication: Journal article published
    PubMed ID: 17000715
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