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  • 1
    ISSN: 1573-904X
    Keywords: o-(N-phthalimide)acetophenone ; hypolipidemic agents ; cholesterol ; high-density lipoprotein (HDL) cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract o-(N-Phthalimido)acetophenone has proven to be an effective hypolipidemic agent in rats at 20 mg/kg/ day orally. The agent suppressed the activity of the rate-limiting enzyme of the liver involved in de novo synthesis of triglycerides. The synthetic rate-limiting enzyme for cholesterol esters was also inhibited by the drug in vivo. o-(N-Phthalimido)acetophenone lowered cholesterol in the liver and the aorta wall and generally caused an increase in phospholipids in body tissues. Serum lipoproteins were modulated by the drug with a decrease in cholesterol and triglycerides in the chylomicron, very low-density lipoproteins (VLDL), and low-density lipoproteins (LDL) and an increase in high-density lipoprotein (HDL) cholesterol. The phospholipid content was increased in the chylomicron, VLDL, and LDL fractions. In hyperlipidemic rats, o-(N-phthalimido)acetophenone lowered elevated blood lipid levels at 20 mg/kg/day orally after 3 weeks of administration. The hypolipidemic rat after drug treatment had a lower LDL cholesterol and a higher HDL cholesterol content, which is therapeutically desirable to protect against cardiovascular disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Culture, medicine and psychiatry 13 (1989), S. 457-463 
    ISSN: 0165-005X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Ethnic Sciences , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Psychiatric quarterly 53 (1981), S. 201-202 
    ISSN: 1573-6709
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-904X
    Keywords: hypolipidemic agents ; diphenimide ; high-density lipoprotein (HDL)-cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract N(4-Methylphenyl)diphenimide proved to be an effective hypolipidemic agent in rats at 10 and 20 mg/kg/day. Both serum cholesterol and triglyceride levels were reduced significantly. Decreases in tissue lipids as well as VLDL cholesterol levels were observed. HDL-cholesterol was elevated even at 10 mg/kg/day. The agent was equally effective in hyperlipidemic diet-induced rats, lowering serum lipids and VLDL- and LDL-cholesterol while elevating HDL-cholesterol levels. The drug interfered with the incorporation of 3H-cholesterol and 3H-palmitic acid into chylomicrons, VLDL, and LDL. The two precursors were incorporated at a higher rate into HDL.3H-Leucine was incorporated into chylomicrons, VLDL, and LDL at a higher rate, but not into HDL. Reduced uptake of the precursor for lipid synthesis was noted in tissues after treatment with the drug.
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  • 5
    ISSN: 1573-904X
    Keywords: hypolipidemic agents ; cholesterol ; triglycerides ; cyclic imides ; 3-imino-l-oxoisoindolines ; lipoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A series of substituted 3-imino-l-oxoisoindolines derivatives demonstrated significant hypolipidemic activity, lowering both serum cholesterol and triglycerides levels after 16 days of dosing at 20 mg/kg/ day ip in CF1 mice. 2-Butyl-3-butylimino-l-oxoisoindoline lowered serum cholesterol levels 52% and serum triglyceride 42%. 2-Pentyl-3-imino-l-oxoisoindoline lowered serum cholesterol levels 42% and serum triglyceride 61%. These derivatives resulted in better activity than the parent compound, 3-imino-1-oxoisoindoline. These studies showed that compounds with N-alkyl substitution of nitrogen atoms in the ring and outside the ring possessed potent hypolipidemic activity at the low dose of 20 mg/kg/day ip in normolipidemic CF1 mice. Studies with 2-butyl-3-butylimino-l-oxoisoinodine in rats showed that serum cholesterol was reduced 60% and serum triglyceride 43% after 14 days of dosing at 20 mg/kg/day, orally. Treatment with this agent lowered lipid levels in the liver and aorta tissue, with increases in lipid levels in the small intestine tissue. Higher levels of cholesterol and phospholipids were excreted in the feces of treated animals compared to the control. Cholesterol levels of the very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL) fractions were reduced, whereas the HDL cholesterol levels were elevated significantly. This ratio of low-density lipoprotein (LDL) cholesterol:HDL cholesterol levels suggests that the agent may be effective in treating hyperlipidemic states in humans.
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  • 6
    ISSN: 0165-005X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Ethnic Sciences , Medicine
    Notes: Abstract Morita psychotherapy, a form of therapy developed in Japan some sixty years ago, has survived extensive changes in Japanese society, and is now enjoying popularity in the United States. This gives us an opportunity to look closely at the concept of ‘cultural fit’ between an important therapeutic technique and its social milieu, and to speculate about recent changes in American culture that may account for the growing popularity of Moritism. In contrast to Western style `talking therapies' like psychoanalysis, Morita psychotherapy is relatively group-centered, ritualistic, and behavioristic. One would expect to find these features in a Japanese therapy, but their acceptance in America suggests that previously popular Western techniques may not be optimum for handling certain problems of the post-industrial American. McLuhan, Peacock, Douglas, and others have suggested some emerging traits of Western character that might shed some light on this question.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We tested the hypothesis that histamine mediates the changes in cation permeability and potential difference characteristic of gastric mucosal barrier disruption. Canine Heidenhain pouches were exposed to 20 mM sodium taurocholate both with and without combined histamine H1- and H2-receptor blockade with diphenhydramine 2 mg/kg and metiamide 10 μmol (2.5 mg)/kg/hr. Histamine-receptor blockade did not attenuate the flux, clearance rate, or permeability of hydrogen ion due to bile salt exposure and had no effect on the fluxes of sodium, chloride, and volume. Although the potential difference was higher with combined histamine-receptor blockade, the fall in potential difference due to bile salt was not attenuated. Using a pH-stat system to measure acid loss with the incremental addition of sodium taurocholate to final concentrations of 0, 5, 10, and 20 mM, we failed to observe any difference between control and histamine-receptor blockade in hydrogen flux or permeability. Increases in gastric blood flow due to intraarterial injection of histamine were attenuated with diphenhydramine, 2 mg/kg. Further attenuation of this vasodilation was observed with the addition of a histamine H2 antagonist but not with increasing the dose of the H1 antagonist to 10 mg/kg. Thus we were unable to document that doses sufficient to antagonize histamine H1 and H2 receptors prevent the increase in sodium-hydrogen flux and decrease in potential difference observed with exposure of the canine stomach to bile salt.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-2681
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The hyperelasticity condition imposed on a material in which the stress is given as a function of the deformation gradient requires the existence of a strain-energy density function. If the material is incompressible, the indeterminacy of the pressure field is normally an additional postulate on material behavior. However, it is shown that in the case of a material in which the strain is determined as a function of an appropriately chosen stress measure, hyperelasticity demands the existence of a complementary strain-energy density function and the incompressibility condition isequivalent to the indeterminacy of the pressure field. The dependence of the complementary strain-energy density on the pressure, necessary and sufficient for incompressibility, is presented.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-2789
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The study, treatment, and efforts at prevention of suicide take place within a cultural milieu. To date, however, emphasis has been placed almost entirely on the self-destructive individual, his relevant health, and the mental health specialists. An ongoing study of death and bereavement in a cross-ethnic context in the Los Angeles area provided the means of exploring the attitudes of the general population regarding various aspects of suicide. The focus here is on the variables of age, sex, and education as they affect the views and experiences of 400 respondents on the subject of suicide.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1572-8897
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mathematics
    Notes: Abstract We present a new class of techniques for the solution of the chemical and phase equilibria problem for reacting species in a closed system. The minimisation of the Gibbs free energy for all the species in the system is conducted using the technique of simulated annealing (SA). The SA objective function incorporates non‐ideal equations of state. This new approach is demonstrably able to solve multi‐species and multi‐phase LTCE problems in ideal‐gas solutions, ideal solutions and mixtures of ideal and non‐ideal solutions.
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