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  • 1
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    Cham : Springer International Publishing
    Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
    Abstract: This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.℗
    Pages: VIII, 111 p. 36 illus., 24 illus. in color. : online resource.
    ISBN: 9783319684482
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  • 2
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    Cham : Springer International Publishing
    Keywords: Medicine ; Cancer Research ; Oncology ; Pathology ; Pharmacotherapy ; Biomedicine ; Cancer Research ; Oncology ; Pathology ; Pharmacotherapy ; Springer eBooks
    Description / Table of Contents: Prelims -- Tumor microenvironment -- Tumor blood vessels and tumor endothelial cells -- Tumor angiogenesis -- Inflammatory cells in tumor microenvironment -- Therapeutic strategies, the concept of “normalization” and the role of VEGF inhibition -- Index
    Abstract: This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment
    Pages: XI, 86 p. 28 illus., 12 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319278209
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  • 3
    Keywords: Life sciences ; Angiography ; Cytology ; Life sciences ; Cell Biology ; Angiology ; Springer eBooks
    Description / Table of Contents: The Development of the Vascular System: An Historical Overview -- The Corneal Pocket Assay -- The Mouse Hindbrain: An In Vivo Model to Analyze Developmental Angiogenesis -- Three Dimensional In Vitro Assay of Endothelial Cell Invasion and Capillary Tube Morphogenesis -- Vascular Casting for the Study of Vascular Morphogenesis -- Cell-Based Computational Modeling of Vascular Morphogenesis Using Tissue Simulation Toolkit -- miRNAs Expression Profile in Zebrafish Developing Vessels -- Imaging of Cardiovascular Development in Mammalian Embryos Using Optical Coherence Tomography -- Live Confocal Microscopy of the Developing Mouse Embryonic Yolk Sac Vasculature -- Zebrafish Embryo Intersegmental Vessels: A Tool for Investigating Sprouting Angiogenesis -- Avian Area Vasculosa and CAM as Rapid In Vivo Pro- and Anti-Angiogenic Models -- Investigating In Vitro Angiogenesis by Computer-Assisted Image Analysis and Computational Simulation -- A Chimeric Embryoid Body Model to Study Vascular Morphogenesis -- Avians as a Model System of Vascular Development -- Microfluidic Model of Angiogenic Sprouting -- The Rat Aortic Ring Model of Angiogenesis -- The Co-Culture Organotypic Assay of Angiogenesis
    Abstract: Vascular Morphogenesis: Methods and Protocols provides a range of techniques for studying vascular morphogenesis in vivo and in vitro, reflecting advances in the field. Endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation, and postnatal tissue remodeling. Understanding the concept of vascular bed specificity represents a major challenge for future investigations. Indeed, one of the most interesting theoretical perspectives and practical applications of endothelial cell signaling is the possibility for these cells to maintain their inductive potential during adult life. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Vascular Morphogenesis: Methods and Protocols will serve as a instructive and useful reference for cell biologists, anatomists, pathologists, and physiologists, as well as all those interested in this area of biological study
    Pages: XI, 272 p. 61 illus., 40 illus. in color. : online resource.
    ISBN: 9781493914623
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  • 4
    Keywords: Medicine ; Immunology ; Neurosciences ; Pharmacology ; Virology ; Biomedicine ; Immunology ; Neurosciences ; Pharmacology/Toxicology ; Virology ; Springer eBooks
    Description / Table of Contents: Preface -- Introductory remarks -- Giant Cell Arteritis -- Takayasu Arteritis -- Polyarteritis Nodosa -- Mechanisms of ANCA-Associated Vasculitides -- Granulomatosis with Polyangiitis (Wegeneŕ€™s) and Similar €œÁAV with Probable Etiologý€ -- Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss) -- Anti-Glomerular Basement Membrane Disease -- IgA Vasculitis -- HCV-Related Cryoglobulinemic Vasculitis -- Vasculitis and Pulmonary Hypertension: New Therapeutic Approaches -- Vasculitis in SLE, RA and Other Connective Tissue Diseases: Diagnosis and Treatment -- Central Nervous System Vasculitis -- Uveitis -- IgG4 Syndrome -- Beh©ʹet Syndrome -- Urticarioid Vasculitis -- Guidelines for the Diagnosis and Treatment of Vasculitides -- Index
    Abstract: The systemic vasculitides,includinglarge, medium, small, and variable vessel vasculitis,have been the focus of intensive basic and clinical investigations over the last twodecades. Among theimportant advances stemming from these efforts are new definitions, classifications, and diagnostic criteria for the different classes of vasculitis; the addition of anti-neutrophil cytoplasmic autoantibodies as a new criterion for classifying vasculitis; the recognition of the viral etiology of conditions such as cryoglobulinemic vasculitis and polyarteritis nodosa; an appreciation of thebroad spectrum of clinical manifestations and potentially devastating complicationsassociated with vasculitis; the many features and remarkable clinical heterogeneity of IgG4-related, immune-mediated diseases; and the proposal of intriguing pathogenetic hypotheses for certain chronic, relapsing vasculitides. This improved understanding of the systemic vasculitides has been accompanied by a trend away from the use of eponyms for these conditions; thus, established terms such as Wegeneŕ€™s granulomatosis and Churg-Strauss syndrome have been replacedby the more descriptive definitions ́€œgranulomatosis with polyangiitiś€ and €œéosinophilic granulomatosis with polyangiitis,́€ respectively. Additional clinical laboratory tests,rapidly developing imaging techniques that can assess inflammation, especially in large-vessel vasculitis, and artificial neural network approaches will no doubt bring a wealth of informationthat ultimately leads to the identification of novel disease biomarkers. Expected applications include the identification of individuals at increased risk ofrelapsewho would benefit from patient-tailored therapy. Although the conventional combination of glucocorticoids and immunosuppressive drugs is effective in the treatment of a large proportion of vasculitic disorders, safer medications, with fewer side effects, are being developed, includingseveral biological agents now being closely evaluated in multi-center studies. This volume brings togethercomprehensive and up-to-date reviews written by experiencedscientists and clinicians from many countries. Its aim is toprovide readers with state-of-the-art knowledge of the major vasculitides and cutting-edge insights into their multi-faceted features. It is our hope that this book serves as a valuable and stimulating resourcefor basic and clinical researchers, specialists in related disciplines, as well as practicing physicians and advanced medical students interested in this fascinating branch of pathology. Franco Dammacco, Domenico Ribatti, Angelo Vacca
    Pages: XI, 438 p. 78 illus., 55 illus. in color. : online resource.
    ISBN: 9783319401362
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  • 5
    Keywords: Medicine ; Life sciences ; Biomedicine ; Biomedicine general ; Medicine/Public Health, general ; Life Sciences, general ; Springer eBooks
    Description / Table of Contents: Preface.-℗ Introduction.-℗ Human hematopoietic development.-The Bursa of Fabricius.-℗ The Thymus.-℗ Clinical correlates -- References -- Index. ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗
    Abstract: This book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals. Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction. A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters. Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology
    Pages: VIII, 60 p. 29 illus., 7 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319246635
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  • 6
    Keywords: Medicine ; Oncology ; Pathology ; Cytology ; Biomedicine ; Cancer Research ; Oncology ; Pathology ; Cell Biology ; Springer eBooks
    Pages: : digital
    ISBN: 9789048138456
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  • 7
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    Dordrecht : Springer Netherlands
    Keywords: Medicine ; Oncology ; Cytology ; Biomedicine ; Cancer Research ; Oncology ; Cell Biology ; Springer eBooks
    Pages: : digital.
    ISBN: 9789400749368
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  • 8
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    Dordrecht : Springer Science+Business Media B.V.
    Keywords: Medicine ; Oncology ; Pathology ; Cytology ; Biomedicine ; Cancer Research ; Oncology ; Pathology ; Cell Biology ; Springer eBooks
    Pages: : digital
    ISBN: 9789400714694
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  • 9
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    Dordrecht : Springer Science+Business Media B.V.
    Keywords: Medicine ; Oncology ; Medicine / Philosophy ; Science / Philosophy ; Biomedicine ; Cancer Research ; Oncology ; History of Medicine ; Philosophy of Medicine ; Philosophy of Science ; Springer eBooks
    Pages: : digital
    ISBN: 9789048137411
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  • 10
    Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
    Description / Table of Contents: The Discovery of Tumor Angiogenesis Factors: An Historical Overview -- Morphological Aspects of Tumor Angiogenesis -- Exosomes in Tumor Angiogenesis -- Co-Culture Assays for Endothelial Cells: Mural Cells Interactions -- Characterization of Cancer Stem Cells -- The Aortic Ring Assay and its Use for the Study of Tumor Angiogenesis -- Surface Plasmon Resonance Analysis of Heparin-Binding Angiogenic Growth Factors -- An Ex Vivo Tissue Culture Model for Anti-Angiogenic Drug Testing -- The Chorioallantoic Membrane of the Chick Embryo to Assess Tumor Formation and Metastasis -- Transgenic Zebrafish -- High Resolution Intravital Microscopy of Tumor Angiogenesis -- Subcutaneous Murine Xenograft Models: A Critical Tool for Studying Human Tumor Growth and Angiogenesis In Vivo -- Orthotopic Models of Ovarian Cancer -- The Rip1Tag2 Transgenic Mouse Model -- Tumor Blood Vessel Visualization -- Uncovering Metabolic Effects of Anti-Angiogenic Therapy in Tumors by Induced Metabolic Bioluminescence Imaging -- Quantitation of Tumor Angiogenesis In Vitro: An All-In-One Angiogenesis Assay
    Abstract: This volume aims to provide a range of methods and protocols for studying tumor angiogenesis in vitro and in vivo to reflect advances in the field. The chapters in this book cover topics such as: morphological aspects of tumor angiogenesis, aortic ring assay and its use for the study of tumor angiogenesis, ex vivo tissue culture model for anti-angiogenic drug testing, transgenic zebrafish, orthotopic models of ovarian cancer, and uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Tumor Angiogenesis Assays: Methods and Protocols is a valuable resource for anyone interested in tumor angiogenesis assay research
    Pages: XI, 194 p. 57 illus., 40 illus. in color. : online resource.
    ISBN: 9781493939992
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