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  • 1
    Abstract: Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (ER, PR, and HER2), alcohol intake, and MTHFR polymorphisms (677C〉T and 1298A〉C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1 = 1.26; 95% CI 1.00-1.58; Ptrend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1 = 1.29; 95% CI 1.02-1.62; Ptrend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation. This article is protected by copyright. All rights reserved.
    Type of Publication: Journal article published
    PubMed ID: 27905104
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  • 2
    Abstract: OBJECTIVE: To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. DESIGN: Multicentre case-cohort study. SETTING: A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries. PARTICIPANTS: 32 549 participants without baseline CVD, comprised of incident CVD cases and a subcohort for comparison. MAIN OUTCOME MEASURES: Non-fatal and fatal CHD and stroke (including ischaemic and haemorrhagic stroke). RESULTS: There were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated with non-fatal CHD, with a hazard ratio of 0.94 (95% confidence interval 0.92 to 0.96) per 12 g/day higher intake. There was a J shaped association between baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and 0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake, respectively, compared with 0.1-4.9 g/day. In contrast, hazard ratios for non-fatal and fatal stroke risk were 1.04 (1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day increase in baseline alcohol intake, respectively, including broadly similar findings for ischaemic and haemorrhagic stroke. Associations with cardiovascular outcomes were broadly similar with average lifetime alcohol consumption as for baseline alcohol intake, and across the eight countries studied. There was no strong evidence for interactions of alcohol consumption with smoking status on the risk of CVD events. CONCLUSIONS: Alcohol intake was inversely associated with non-fatal CHD risk but positively associated with the risk of different stroke subtypes. This highlights the opposing associations of alcohol intake with different CVD types and strengthens the evidence for policies to reduce alcohol consumption.
    Type of Publication: Journal article published
    PubMed ID: 29844013
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  133. Kongress der Deutschen Gesellschaft für Chirurgie; 20160426-20160429; Berlin; DOC16dgch233 /20160421/
    Publication Date: 2016-04-22
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Zoologica Scripta 13 (1984), S. 195-200 
    ISSN: 0300-3256
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 112 (1965), S. 282-287 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1084
    Keywords: MRI, meningeal diverticula ; MRI, meningocele ; MRI, perineurial cyst ; MRI, spine ; Spine, meningeal cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Meningeal cysts (MC) are rare extensions of the meninges and are diverticula of the spinal meningeal sac, nerve root sheath or arachnoid that contain cerebrospinal fluid (CSF). They communicate with the subarachnoid space (SAS). The aim of this study was to demonstrate the MRI findings and to emphasise the contribution of MRI to the diagnosis of this rare pathology. MRI findings were evaluated according to a new classification that divides MCs into extradural cysts without (type 1) or with (type 2) spinal nerve root fibres and intradural cysts (type 3). Because of its high contrast resolution MRI can distinguish the three types of MC. The use of the different levels of signal intensity of the cyst and CSF in T2-weighted images to distinguish communicating from non-communicating MCs is illustrated. This diagnostic sign exploitats the signal loss due to flow phenomena of CSF pulsations on ungated sequences to reveal the communication of the MC with the SAS. We recommend MRI as the most sensitive and specific modality for the study of MCs.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1084
    Keywords: Spine, discitis ; Spine, Gd-DTPA ; Spine, MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-six patients with a clinical diagnosis of spondylodiscitis were examined with non-contrast and contrast-enhanced MRI in order to define the contribution of gadolinium-DTPA (Gd-DTPA) and different pulse sequences, including a fat suppression sequence (SPIR). Spin echo (SE) T1-weighted images before and after Gd-DTPA injection and SE T2-weighted images were obtained in all patients. Twelve patients were also examined using the SPIR sequence following Gd-DTPA injection. Signal intensity and morphological features of the disc and vertebral lesions were then evaluated. The SE T1-weighted sequence with Gd-DTPA was very effective in showing the pathological changes at the level of the disc as an area of low signal intensity surrounded by a peripheral rim of enhancement in 24 of 26 cases (92%). This feature was not visible on non-enhanced images. As regards contiguous vertebral lesions this sequence was less informative, since in 8 of 26 cases (31%) the vertebral lesions became isointense and therefore not detectable. In 12 cases there was extension into the surrounding structures (spinal canal and/or paravertebral tissues). An enhanced SE T1-weighted sequence provided good anatomical definition of the extension of the infection in the spinal canal in all cases with this type of involvement (7 of 12). Regarding the 7 cases with paravertebral extension, no extension was visible in 1 case due to the reduced contrast with the surrounding fat following Gd-DTPA injection. The enhanced SPIR sequence was very effective, particularly in detecting the lesions in the vertebral bodies, avoiding the limitation of the enhanced SE T1-weighted sequence. The SPIR sequence was also effective in showing the extension within the spinal canal and the paravertebral fat. On the basis of our results the combination of a SE T1-weighted sequence without contrast and SPIR sequence with Gd-DTPA seems to be the best approach in cases of spondylodiscitis.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2218
    Keywords: Computed tomography (CT-scan) ; Magnetic resonance imaging (MRI) ; Mediastinal tumor ; Thoracoscopic resection ; Cystic schwannoma ; One-lung ventilation (OLV)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mediastinal cystic schwannoma is of very rare occurrence. Our patient came with chest pain of 6 months duration. Abnormal shadow on chest x-ray was found. A sharp dissection space was evident by computed tomography (CT-scan) and magnetic resonance imaging (MRI) between the tumor, the left pulmonary artery, and the descending aorta. The patient underwent surgical removal using thoracoscopic surgery. Postoperative discomfort was markedly reduced and hospitalization short. We can conclude that interventional thoracoscopy is a safe, well-tolerated procedure, with excellent therapeutic potentials.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0428
    Keywords: Monocomponent lente insulin ; monospecies lente insulin ; insulin immunogenicity ; insulin antibodies ; high insulin requirement ; insulin allergy ; insulin lipoatrophy ; diabetic microangiopathy ; clinical control of diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunogenicity of pork Monocomponent (MC) Lente insulin (Monotard®) was studied for more than one year in a clinical trial series of 43 insulin-dependent diabetics in comparison with Monospecies (MS) Lente pork insulin (5 X crystallized, not monocomponent). The antigenicity was estimated by determination of total extractable serum insulin by radioimmunoassay and of I-125 insulin-binding of the serum IgG measured by radioimmunoelectrophoresis. MC Lente insulin was nonimmunogenic in newly diagnosed diabetics: at the end of the observation, the antibody titre was generally under the level of detection. Long-term diabetics transferred to MC Lente insulin from conventional insulin preparations showed a marked reduction in the high initial levels of insulin antibodies, sometimes with a multiphasic pattern; low initial levels remained unchanged at the end of the trial. MS Lente insulin was found to be, even if weakly, immunogenic in newly diagnosed diabetics. In long-term insulin-treated diabetics transferred to MS Lente insulin a tendency to reduction in the high antibody starting level was often observed. Diabetic manifestations such as high insulin requirement, insulin allergy, insulin lipoatrophy and diabetic microangiopathy showed — in some instances — a clinical course independent of immunological modifications. Clinical control of diabetes achieved both with MC and MS Lente insulins was rated as good. There was no ketosis or severe hypoglycaemia, and the daily insulin requirement was reduced in several cases.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : A standard third-line treatment is lacking, and European guidelines recommend performing culture in these patients. However, the use of this procedure as ‘routine practice’ is definitively not feasible.Aim : To evaluate the eradication rate of a 10-day levofloxacin-based triple therapy in patients who have failed two eradication courses for Helicobacter pylori.Methods : A total of 151 patients with persistent Helicobacter pylori infection after two treatments were studied. Patients were considered positive if two of three endoscopic tests were positive. Susceptibility testing was also performed. Patients received a standard dose of proton-pump inhibitors twice daily, levofloxacin 250 mg twice daily and amoxicillin 1 g twice daily, for 10 days. Endoscopic follow-up was carried out 4–6 weeks after the end of eradication therapy.Results : About 76% (95% CI: 68.8–82.3), and 85% (95% CI: 77.5–89.7) of patients were eradicated according to intention-to-treat and per-protocol analysis, respectively. Eradication rates of the strains showed as 92% (95% CI: 83.2–96.7) of those resistant to both metronidazole and clarithromycin but susceptible to levofloxacin.Conclusions : In patients who failed previous regimens, the 10-day levofloxacin-based triple therapy is safe and effective, allowing eradication in almost 80% of the patients.
    Type of Medium: Electronic Resource
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