Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Results from two pilot studies using White Carneau pigeons on high cholesterol diets have demonstrated substantial reduction in arterial plaque accumulations when the birds were periodically injected with dilute aqueous solutions of a drag reducing polymer (Separan AP-30) so as to maintain circulating blood concentrations of approximately 60 ppm. Initiation of arterial plaque formation may be fluid-mechanically motivated such that regions subjected to fluid turbulence, rapidly developing boundary layers, and alternate separation and reattachment, arc; the most prone lo attack. Viscoelastic fluid response, as seen in drag reducing media, is known to alter such phenomena. Comparative documentation of plaque deposition in experimental as well as control birds shows significant differences in both the aortas and coronary arteries, at optical magnifications from 20 to 15000X.
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