Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Unknown
    Glasgow : Blackie
    Call number: 08-HYP
    Keywords: Hyperthermia, Induced ; Neoplasms / therapy
    Pages: VII, 245 p.
    ISBN: 0-216-91792-1
    Signatur Availability
    08-HYP departmental collection or stack – please contact the library
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds265 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0307-4412
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 366 (1975), S. 203-222 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 50 Biopsien von menschlichen Normallebern aus verschiedenen Altersstufen und an 350 Punktaten von Fett-Lebern bei Diabetes, Alkoholismus und Fettcirrhose wurden Messungen der Kerndurchmesser mit dem Teilchengrößen-Analysator (TGZ 3 Zeiss) durchgeführt, die Kernflächen bestimmt und die Kernflächenklassen errechnet. 1. In der Normalleber ist jede Altersgruppe durch ein gut definiertes organspezifisches Kernmuster gekennzeichnet. Es besteht im 3. Dezennium vornehmlich aus Kernen der Regelklasse; die folgenden Jahrzehnte werden durch einen zunehmenden Ausbau zweier Großkernklassen charakterisiert, der im 6. Dezennium sein größtes Ausmaß erreicht. Im 7. Lebensjahrzehnt führt eine offenbar funktionelle Schrumpfung zu einer Reduktion der Kernfläche in allen Klassen. 2. Die Zunahme der Großkerne wird auf abortive Karyokinesen zurückgeführt, die während der physiologischen Zellmauserung infolge von Störungen des achromatischen Apparates mit zunehmendem Alter mehr und mehr an die Stelle normaler Mitosen treten. 3. Die alkoholische und besonders die diabetische Verfettung führt zur Bildung von ausgeprägten Großkernen. Sie ist wesentlich abhängig vom Umfang der Fetttropfen innerhalb der Einzelzellen. Das Ausmaß der Organverfettung spielt eine untergeordnete Rolle. 4. Die Ätiologie der Leberverfettung ist von sekundärem Belang für die Wandlung des Karyogramms. 5. Die Kernvergrößerung in verfetteten Lebern geht auf mehrere Teilfaktoren zurück. Sie beruht zum einen auf der altersbedingten Neigung zur Bildung von Großkernen überhaupt, zum anderen wird sie entscheidend gefördert durch zusätzliche Mitosealterationen infolge intracellulär raumbeengender Wirkung der Fetttropfen. 6. Beim chronischen Alkoholismus tritt die toxische Epithelläsion als entscheidender Faktor für die Umgestaltung des Karyogramms hinzu. Sie bewirkt infolge erhöhter Nekroserate und gesteigerter Teilungsstörungen zwar eine gewisse Zunahme von Großkernen über die Altersnorm hinaus. Besonders große Kerne kommen jedoch spärlich vor, was auf eine Unterdrückung von Zellersatz und -erneuerung als Folge der Alkohol-Intoxikation hindeutet. Das stimmt mit der Tendenz der Alkohol-Leber zum Organumbau überein. 7. Als Ursache für Großkernhäufungen im Karyogramm der Fettcirrhosen werden außer den Mitosealterationen pathologische Kernschwellungen als Folge des Leberumbaus wie der einwirkenden Noxen vermutet. 8. Eine beträchtliche Zunahme von Kleinkernen bei beiden Typen der Fettleber und bei der Fettcirrhose fällt kaum ins Auge, erst die quantitative Erfassung hebt ihren bedeutsamen Anteil in vollem Umfang hervor. 9. Die Vermehrung von Kleinkernen erreicht bei den verschiedenen untersuchten Typen pathologisch veränderter Lebern jeweils ein annähernd gleiches Ausmaß, sie wird als Adaptation an die vermehrte funktionelle Organbelastung, bzw. bei den Cirrhosen zusätzlich als mögliche Anpassungserscheinung an eine verschlechterte Stoffwechselsituation, verstanden.
    Notes: Summary The karyograms of normal human livers (50 biopsies from patients of varied age) and of fatty livers (350 biopsies from patients with diabetes, alcoholism, and fatty cirrhosis) were investigated. The nuclear diameters were measured with an analyzer of particle size-the “TGZ-3 Zeiss”-,the cut surface of the nuclei was determined and the nuclei categorized accordingly. 1. The normal liver in each age group is characterized by a well-defined nuclear pattern that is specific for this organ. In the 3rd decade nuclei of the main class predominate. In later decades 2 classes of large nuclei gradually appear and reach their maximum after the 50th year. In the 7th decade a reduction of the cut nuclear surface takes place in all the categories, presumably determined by a reduction of function. 2. The increase in the number of large nuclei is explained by abortive karyokineses which in the course of the normal turnover of cells (“Zellmauserung”), increasingly replace normal mitoses. This is attributed to disturbances of the achromatic apparatus that occur with increasing age. 3. Alcoholic, and even more so diabetic, fatty change leads to the formation of particularly large nuclei. This appears to depend on the volume of the individual fat droplet within the individual cell rather than on the degree of fatty change of the whole liver. 4. The etiology of fatty change of the liver is of minor importance for the change of the nuclear pattern. 5. Several factors influence the nuclear enlargement of the fatty liver. One of these is the general tendency of the aging liver to form large nuclei. Another important factor is the additional impairment of mitoses by the space occupying effect of the fat droplets. 6. In the chronic alcoholic, an additional decisive factor influencing the change of the karyogram is the toxic effect on the hepatocytes. Although, because of an increased incidence of necroses and of disturbed mitoses, the number of large nuclei somewhat increases beyond that considered as normal for the age; yet particularly large nuclei are scarce, which suggests a suppression of the turnover-replacement and renewal-of cells as a result of the intoxication by alcohol. This interpretation agrees with the tendency of the alcoholic liver to undergo a process of remodelling that terminates in cirrhosis. 7. In addition to the impairment of mitoses, a pathologic swelling of the nucleus is assumed to contribute to the increase in the number of large nuclei seen in the karyogram. This swelling is interpreted to be a result of the restructuring of the liver and/or of noxious stimuli. 8. The increase in the number of small nuclei in the alcoholic or diabetic fatty liver, as well as in fatty cirrhosis, although marked, is not easily noted on mere scanning of the slide. Only a numerical evaluation fully reveals its extent and significance. 9. The increase in the number of small nuclei in the types of fatty livers studied here appears to be approximately equal. It is interpreted as an adaptation of the cell to the increased functional load of the organ. In cirrhosis a possible adaptation to an impaired metabolic state has to be considered in addition.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Trente-huit patients ayant des métastases hépatiques multiples non reséquables d'origine colorectale ont été traités soit par chimiothérapie par voie artérielle (CVA) associée à la cryothérapie (n=27) soit par cryothérapie seule (n=11). Les survies ont été analysées selon la méthode d'analyse du Modèle de Cox. En tenant compte de l'effet de la pathologie de la tumeur primitive et du niveau préopératoire de l'ACE, les patients n'ayant pas eu de de décéder que ceux qui en ont eu (RR 3.3, 95% IC 12 à 9.3). L'estimation de la survie médiane des patients traités par la cytoréduction seule a été de 245 jours, alors que celle des patients traités par les deux avec une CVA d'au moins trois mois, a été de 570 jours. On recommande que tous les patients ayant des métastases multiples du foie à partir des cancers colorectaux aient une CVA par la suite.
    Abstract: Resumen En el presente estudio, 38 pacientes con metástasis hepáticas múltiples y no resecables de carcinoma colo-rectal fueron tratados con quimioterapia administrada en la arteria hepática (HAC) y crioterapia (n=27) o crioterapia sola (n=11). Los datos del seguimiento fueron resumidos según el método de regresión de Cox. Teniendo en cuenta el efecto de la patología del tumor primario y el nivel preoperatorio de antígeno carcino-embrionario, se halló que aquellos pacientes que no recibieron HAC luego de la citorreducción tuvieron una probabilidad de muerte 3 veces mayor que los que recibieron HAC (RR 3.3, 95% CI 1.2 a 9.3). La sobrevida media estimada de los pacientes tratados con crioterapia sola fue de 245 días, en tanto que aquellos que recibieron HAC por tres meses y terapia de citorreducción fue de 570 días. Se recomienda que todos los pacientes que reciben crioterapia para metástasis hepáticas múltiples de carcinoma colo-rectal reciban luego quimioterapia por vía de la arteria hepática.
    Notes: Abstract Thirty-eight patients with unresectable multiple liver metastases from colorectal carcinoma were treated with either hepatic artery chemotherapy (HAC) and cryotherapy (n=27) or cryotherapy alone (n=11). Follow-up survival data were summarized using Cox regression. Allowing for the effect of the pathology of the primary tumor and the preoperative carcinoembryonic antigen (CEA) level, those patients who did not receive HAC after cytoreduction were three times as likely to die as those given HAC (RR 3.3, 95%; CI 1.2–9.3). The estimated median survival of patients treated with cryotherapy alone was 245 days, whereas for those given more than 3 months of HAC plus cytoreduction therapy it was 570 days. It is recommended that all patients who receive cryotherapy for multiple liver metastases from colorectal rectal carcinoma be given subsequent hepatic artery chemotherapy.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Karyometry and frequency analyses indicate that at the peak of the tubulocellular restitution following temporary renal ischemia in the rat, there is (when compared with the normal kidney) a marked displacement towards larger nuclei and a simultaneous increase of populations of nuclei of intermediate size in all regions of the parenchyma. The nuclear enlargement is geometrical, whereas in normal kidneys it is arithmetrical. The reasons for this may be due to various processes: 1) to a functional nuclear swelling indicating a general recovery and repair, or intensified cellular resorptive functions (whereby there is a proportional karyoplasm:nucleolus ratio). 2) to a post-ischemic nuclear hydrops resulting from a continuous deficiency of energy (enlargement exceeding the duplication rhythm, non-proportional displacement of the karyoplasm-nucleolus ratio). 3) to a doubling of volume or a multiplication of the substance (limited entirely by chromosomes). In contrast to the average, the increase of nuclei of intermediate size represent in part certain phases of the DNA synthesis, in part an aneuploidy, and in part a nuclear dehydration. The persistence of large nuclei in our studies is evidence of a previous active regenerative process.
    Notes: Zusammenfassung Karyometrie und HÄufigkeitsanalyse ergeben auf dem Höhepunkt der tubulocellulÄren Restitution (nach temporÄrer NierenischÄmie bei der Ratte), verglichen mit der normalen Niere, eine starke Anteilsverschiebung zugunsten von Gro\kernen sowie eine gleichzeitige Vermehrung von Teilkollektiven in allen Parenchymbezirken. Die Kernvergrö\erung folgt der geometrischen Reihe (im Gegensatz zur arithmetischen Reihe der normalen Niere). Sie kann auf verschiedenen VorgÄngen beruhen: 1. auf einer funktionellen Kernschwellung im Dienste der allgemeinen Restitution und Reparation oder im Rahmen verstÄrkter resorptiver Zelleistungen (dabei proportionierte Relation Karyoplasma: Nucleolus), 2. auf einem postischÄmischen Kernhydrops infolge weiter bestehenden Energiemangels (Vergrö\erung au\erhalb des Verdoppelungsrhythmus, unproportionierte Verschiebung der Relation Karyoplasma:Nucleolus), 3. auf einer volumengerechten Verdoppelung oder Vervielfachung der Substanz (rein chromosomal bedingt). Die gegenüber der Norm vermehrten „Zwischenkollektive“ reprÄsentieren zum Teil bestimmte Phasen der DNS-Synthese, zum Teil eine Aneuploidie und zum Teil eine Kerndehydratation. Persistenz von Gro\kernen ist in unseren Versuchen ein Restsymptom lebhafter regeneratorischer Prozesse.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-0584
    Keywords: Hemopoiesis ; Extramedullar ; Spleen ; Dextran sulfate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spleen of normal dogs (beagles) shows only slight hemopoietic activity, characterized by the presence of megakaryocytes in mitosis and small groups of erythroblasts scattered throughout the red pulp of the organ. Repeated intravenous injection of dextran sulfate, at a dose of 15 mg per kg body weight, produced markedly enhanced erythropoietic and megakaryocytopoietic activity in the splenic red pulp, without concomitant increase in splenic granulopoiesis. The probable existence of a micro-environment adequate for erythro- and megakaryocytopoietic differentiation of stem cells is discussed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. In this review we describe some of our recent studies on the developing marsupial visual pathway. The description focuses on retinal ganglion cells, considering the formation of their dendritic trees, the outgrowth of axons and the formation of connections within the brain.2. Both dendritic trees and outgrowing axons undergo a period of exuberance, followed by one of refinement. The dendritic tree transiently develops a more complex branching pattern than is found in adults. Short side branches, referred to as spines, are a feature of immature dendrites and, to a lesser extent, of axons. These structures are mostly lost as development proceeds. However, they are retained on the dendritic trees of small-field ganglion cells and, for a proportion of axons, on that part within the nerve fibre layer of the retina. Although most axons navigate fairly direct routes towards their targets, a minority follow inappropriate courses, such as doubling back towards the eye or entering the opposite optic nerve at the chiasm. As such errant axons are not seen in the adult, we assume that their parent cell bodies die during development.3. Throughout development, optic axons are arranged in an approximate retinotopic order along the length of the visual pathway; as a result, axons approach the visual centres aligned to form, at least, a crude retinotopic map. Axons from dorsal and ventral retina exchange locations along the optic nerve and in this way correct for the inversion of the image brought about by the lens.4. We also describe the topography of cells in the retinal ganglion cell layer and the organization of the optic nerve in an unusual marsupial, the honey possum (Tarsips rostratus). Unexpected features in the adult were the low proportion of displaced amacrine to ganglion cells and an unmyelinated macular outflow in the retro-bulbar portion of the optic nerve.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 13 (1876), S. 366-367 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WITH reference to Prof. Stokes's courteous bit rather theoretical explanation in NATURE, vol. x:ii. page 247 (which I have been prevented from acknowledging before), I would ask him or yourself for a practical explanation of the following simple experiment;- 1. If platinum wire b2 ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 13 (1876), S. 224-224 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WILL Prof. Stokes give us the reason of his now holding that his first—to all appearance, extremely rational—conclusion, that, in consequence of “the powerful affinities of sodium, it could not exist in a free state in the flame of a spirit-lamp,” is ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...