Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: SURVIVAL ; CELL ; polymorphism ; ELEMENTS ; susceptibility loci ; GENOME-WIDE ASSOCIATION ; MODIFIERS ; EXPRESSION SIGNATURE ; CHIP-SEQ ; GENETIC INTERACTION NETWORKS
    Abstract: While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood approach. The association of HMMR rs299290 with breast cancer risk in BRCA1 mutation carriers was confirmed: per-allele hazard ratio (HR) = 1.10, 95% confidence interval (CI) 1.04 - 1.15, p = 1.9 x 10-4 (false discovery rate (FDR)-adjusted p = 0.043). Variation in CSTF1, located next to AURKA, was also found to be associated with breast cancer risk in BRCA2 mutation carriers: rs2426618 per-allele HR = 1.10, 95% CI 1.03 - 1.16, p = 0.005 (FDR-adjusted p = 0.045). Assessment of pairwise interactions provided suggestions (FDR-adjusted pinteraction values 〉 0.05) for deviations from the multiplicative model for rs299290 and CSTF1 rs6064391, and rs299290 and TUBG1 rs11649877 in both BRCA1 and BRCA2 mutation carriers. Following these suggestions, the expression of HMMR and AURKA or TUBG1 in sporadic breast tumors was found to potentially interact, influencing patients' survival. Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers.
    Type of Publication: Journal article published
    PubMed ID: 25830658
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    facet.materialart.
    German Medical Science; Düsseldorf, Köln
    In:  15. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie; 20060427-20060429; Weimar; DOC06dgt49 /20060426/
    Publication Date: 2006-04-27
    Keywords: Morbidität ; Manschettenresektion ; MEDES ; ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1573-7276
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied class I I antigen expression and tumor-infiltrating leukocytes (TIL) in tissue sections of 69 squamous cell carcinomas of the larynx and 24 lymph node metastases in the neck. HLA-DR expression was found only in eight well-differentiated, highly keratinizing squamous cell carcinomas comprising seven of the verrucous variety and one ventriculosaccular tumor. None of the metastases was positive for DR antigen. Neither primary tumors nor autologous metastases stained for DP or DQ antigens. DR-positive tumors shared a peculiar pattern of TIL composed mainly of T cells, most of which belonged to the cytotoxic/suppressor subset, and B cells. These neoplasms had in common a slow rate of growth, and are considered low-grade carcinomas in the literature. We conclude from our study that HLA-DR expression seems to characterize tumors with a prominent infiltrate and an excellent prognosis.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1573-7322
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1573-6857
    Keywords: Drosophila subobscura ; clines ; gene arrangements ; allozymes ; mitochondrial DNA ; gametic association ; cytonuclear association
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Mitochondrial DNA, sex linked allozymes, and chromosome A gene arrangement data, from eight European natural populations of Drosophila subobscura, were analyzed to determine the existence of latitudinal clines. Strong north-south correlations with latitude were found for gene arrangements and for the Hbdh and 6Pgdh allozymes. Gametic associations between the A2 gene arrangement, the Hbdh 96 and the 6Pgdh 96 alleles, point out some kind of epistatic interaction. At mtDNA level, the Hae III, A variant did not show a previously found north-south clinal variation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1572-9079
    Keywords: Azumaya coalgebras ; Brauer and Schur groups
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We introduce Shur and projective Schur subgroup of the Brauer group of a cocommutative coalgebra by means of twisted cogroup coalgebras and we study their properties. In particular we show that these subgroups are always torsion (in contrast with the whole Brauer group). Moreover, when C is coreflexive and irreducible both subgroups coincide with the coradical ones. We illustrate the theory with several examples.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2014-09-06
    Description: Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although it shows no sign of the whole-genome triplication identified in Solanaceae species such as tomato, the genome includes several species-specific gene family expansions, among them N-methyltransferases (NMTs) involved in caffeine production, defense-related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis. Comparative analyses of caffeine NMTs demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Denoeud, France -- Carretero-Paulet, Lorenzo -- Dereeper, Alexis -- Droc, Gaetan -- Guyot, Romain -- Pietrella, Marco -- Zheng, Chunfang -- Alberti, Adriana -- Anthony, Francois -- Aprea, Giuseppe -- Aury, Jean-Marc -- Bento, Pascal -- Bernard, Maria -- Bocs, Stephanie -- Campa, Claudine -- Cenci, Alberto -- Combes, Marie-Christine -- Crouzillat, Dominique -- Da Silva, Corinne -- Daddiego, Loretta -- De Bellis, Fabien -- Dussert, Stephane -- Garsmeur, Olivier -- Gayraud, Thomas -- Guignon, Valentin -- Jahn, Katharina -- Jamilloux, Veronique -- Joet, Thierry -- Labadie, Karine -- Lan, Tianying -- Leclercq, Julie -- Lepelley, Maud -- Leroy, Thierry -- Li, Lei-Ting -- Librado, Pablo -- Lopez, Loredana -- Munoz, Adriana -- Noel, Benjamin -- Pallavicini, Alberto -- Perrotta, Gaetano -- Poncet, Valerie -- Pot, David -- Priyono -- Rigoreau, Michel -- Rouard, Mathieu -- Rozas, Julio -- Tranchant-Dubreuil, Christine -- VanBuren, Robert -- Zhang, Qiong -- Andrade, Alan C -- Argout, Xavier -- Bertrand, Benoit -- de Kochko, Alexandre -- Graziosi, Giorgio -- Henry, Robert J -- Jayarama -- Ming, Ray -- Nagai, Chifumi -- Rounsley, Steve -- Sankoff, David -- Giuliano, Giovanni -- Albert, Victor A -- Wincker, Patrick -- Lashermes, Philippe -- New York, N.Y. -- Science. 2014 Sep 5;345(6201):1181-4. doi: 10.1126/science.1255274. Epub 2014 Sep 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Commissariat a l'Energie Atomique, Genoscope, Institut de Genomique, BP5706, 91057 Evry, France. CNRS, UMR 8030, CP5706, Evry, France. Universite d'Evry, UMR 8030, CP5706, Evry, France. ; Department of Biological Sciences, 109 Cooke Hall, University at Buffalo (State University of New York), Buffalo, NY 14260, USA. ; Institut de Recherche pour le Developpement (IRD), UMR Resistance des Plantes aux Bioagresseurs (RPB) [Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement (CIRAD), IRD, UM2)], BP 64501, 34394 Montpellier Cedex 5, France. ; CIRAD, UMR Amelioration Genetique et Adaptation des Plantes Mediterraneennes et Tropicales (AGAP), F-34398 Montpellier, France. ; IRD, UMR Diversite Adaptation et Developpement des Plantes (CIRAD, IRD, UM2), BP 64501, 34394 Montpellier Cedex 5, France. ; Italian National Agency for New Technologies, Energy and Sustainable Development (ENEA) Casaccia Research Center, Via Anguillarese 301, 00123 Roma, Italy. ; Department of Mathematics and Statistics, University of Ottawa, 585 King Edward Avenue, Ottawa, Ontario K1N 6N5, Canada. ; Commissariat a l'Energie Atomique, Genoscope, Institut de Genomique, BP5706, 91057 Evry, France. ; Institut de Recherche pour le Developpement (IRD), UMR Resistance des Plantes aux Bioagresseurs (RPB) [Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement (CIRAD), IRD, UM2)], BP 64501, 34394 Montpellier Cedex 5, France. Bioversity International, Parc Scientifique Agropolis II, 34397 Montpellier Cedex 5, France. ; Nestle Research and Development Centre, 101 Avenue Gustave Eiffel, Notre-Dame-d'Oe, BP 49716, 37097 Tours Cedex 2, France. ; ENEA Trisaia Research Center, 75026 Rotondella, Italy. ; Bioversity International, Parc Scientifique Agropolis II, 34397 Montpellier Cedex 5, France. ; Department of Mathematics and Statistics, University of Ottawa, 585 King Edward Avenue, Ottawa, Ontario K1N 6N5, Canada. Center for Biotechnology, Universitat Bielefeld, Universitatsstrasse 27, D-33615 Bielefeld, Germany. AG Genominformatik, Technische Fakultat, Universitat Bielefeld, 33594 Bielefeld, Germany. ; Institut National de la Recherche Agronomique (INRA), Unite de Recherches en Genomique-Info (UR INRA 1164), Centre de Recherche de Versailles, 78026 Versailles Cedex, France. ; Department of Biological Sciences, 109 Cooke Hall, University at Buffalo (State University of New York), Buffalo, NY 14260, USA. Department of Biology, Chongqing University of Science and Technology, 4000042 Chongqing, China. ; Department of Plant Biology, 148 Edward R. Madigan Laboratory, MC-051, 1201 West Gregory Drive, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. ; Departament de Genetica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Diagonal 643, Barcelona 08028, Spain. ; Department of Mathematics, University of Maryland, Mathematics Building 084, University of Maryland, College Park, MD 20742, USA. School of Electrical Engineering and Computer Science, University of Ottawa, 800 King Edward Avenue, Ottawa, Ontario K1N 6N5, Canada. ; Department of Life Sciences, University of Trieste, Via Licio Giorgieri 5, 34127 Trieste, Italy. ; Indonesian Coffee and Cocoa Institute, Jember, East Java, Indonesia. ; Laboratorio de Genetica Molecular, Nucleo de Biotecnologia (NTBio), Embrapa Recursos Geneticos e Biotecnologia, Final Av. W/5 Norte, Parque Estacao Biologia, Brasilia-DF 70770-917, Brazil. ; CIRAD, UMR RPB (CIRAD, IRD, UM2), BP 64501, 34394 Montpellier Cedex 5, France. ; Department of Life Sciences, University of Trieste, Via Licio Giorgieri 5, 34127 Trieste, Italy. DNA Analytica Srl, Via Licio Giorgieri 5, 34127 Trieste, Italy. ; Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St. Lucia 4072, Australia. ; Central Coffee Research Institute, Coffee Board, Coffee Research Station (Post) - 577 117 Chikmagalur District, Karnataka State, India. ; Hawaii Agriculture Research Center, Post Office Box 100, Kunia, HI 96759-0100, USA. ; BIO5 Institute, University of Arizona, 1657 Helen Street, Tucson, AZ 85721, USA. ; Department of Biological Sciences, 109 Cooke Hall, University at Buffalo (State University of New York), Buffalo, NY 14260, USA. vaalbert@buffalo.edu pwincker@genoscope.cns.fr philippe.lashermes@ird.fr. ; Commissariat a l'Energie Atomique, Genoscope, Institut de Genomique, BP5706, 91057 Evry, France. CNRS, UMR 8030, CP5706, Evry, France. Universite d'Evry, UMR 8030, CP5706, Evry, France. vaalbert@buffalo.edu pwincker@genoscope.cns.fr philippe.lashermes@ird.fr. ; Institut de Recherche pour le Developpement (IRD), UMR Resistance des Plantes aux Bioagresseurs (RPB) [Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement (CIRAD), IRD, UM2)], BP 64501, 34394 Montpellier Cedex 5, France. vaalbert@buffalo.edu pwincker@genoscope.cns.fr philippe.lashermes@ird.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25190796" target="_blank"〉PubMed〈/a〉
    Keywords: Caffeine/biosynthesis/*genetics ; Coffea/classification/*genetics ; *Evolution, Molecular ; *Genome, Plant ; Methyltransferases/genetics/*physiology ; Phylogeny ; Plant Proteins/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2012-02-10
    Description: A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683990/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683990/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackay, Trudy F C -- Richards, Stephen -- Stone, Eric A -- Barbadilla, Antonio -- Ayroles, Julien F -- Zhu, Dianhui -- Casillas, Sonia -- Han, Yi -- Magwire, Michael M -- Cridland, Julie M -- Richardson, Mark F -- Anholt, Robert R H -- Barron, Maite -- Bess, Crystal -- Blankenburg, Kerstin Petra -- Carbone, Mary Anna -- Castellano, David -- Chaboub, Lesley -- Duncan, Laura -- Harris, Zeke -- Javaid, Mehwish -- Jayaseelan, Joy Christina -- Jhangiani, Shalini N -- Jordan, Katherine W -- Lara, Fremiet -- Lawrence, Faye -- Lee, Sandra L -- Librado, Pablo -- Linheiro, Raquel S -- Lyman, Richard F -- Mackey, Aaron J -- Munidasa, Mala -- Muzny, Donna Marie -- Nazareth, Lynne -- Newsham, Irene -- Perales, Lora -- Pu, Ling-Ling -- Qu, Carson -- Ramia, Miquel -- Reid, Jeffrey G -- Rollmann, Stephanie M -- Rozas, Julio -- Saada, Nehad -- Turlapati, Lavanya -- Worley, Kim C -- Wu, Yuan-Qing -- Yamamoto, Akihiko -- Zhu, Yiming -- Bergman, Casey M -- Thornton, Kevin R -- Mittelman, David -- Gibbs, Richard A -- GM 45146/GM/NIGMS NIH HHS/ -- R01 GM 059469/GM/NIGMS NIH HHS/ -- R01 GM 085183/GM/NIGMS NIH HHS/ -- R01 GM045146/GM/NIGMS NIH HHS/ -- U54 HG003273/HG/NHGRI NIH HHS/ -- England -- Nature. 2012 Feb 8;482(7384):173-8. doi: 10.1038/nature10811.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA. trudy_mackay@ncsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22318601" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Centromere/genetics ; Chromosomes, Insect/genetics ; Drosophila melanogaster/*genetics ; *Genome-Wide Association Study ; *Genomics ; Genotype ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Selection, Genetic/genetics ; Starvation/genetics ; Telomere/genetics ; X Chromosome/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...