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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  131. Kongress der Deutschen Gesellschaft für Chirurgie; 20140325-20140328; Berlin; DOC14dgch334 /20140321/
    Publication Date: 2014-03-25
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Keywords: OBESITY ; FAT ; PPAR-GAMMA ; ACTIVATED RECEPTOR-GAMMA ; DEFICIENCY ; INSULIN-RESISTANCE ; HORMONE-SENSITIVE LIPASE ; TRIGLYCERIDE LIPASE ; METABOLIC FLEXIBILITY ; IMPAIRS LIPOLYSIS
    Abstract: Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that the genetic inactivation of transcriptional cofactor transducin beta-like-related 1(TBLR1) blunts the lipolytic response of white adipocytes through the impairment of cAMP-dependent signal transduction. Indeed, mice lacking TBLR1 in adipocytes are defective in fasting-induced lipid mobilization and, when placed on a high-fat-diet, show aggravated adiposity, glucose intolerance, and insulin resistance. TBLR1 levels are found to increase under lipolytic conditions in WAT of both human patients and mice, correlating with serum free fatty acids (FFAs). As a critical regulator of WAT cAMP signaling and lipid mobilization, proper activity of TBLR1 in adipocytes might thus represent a critical molecular checkpoint for the prevention of metabolic dysfunction in subjects with obesity-related disorders.
    Type of Publication: Journal article published
    PubMed ID: 23499424
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  • 3
    Keywords: DIABETES-MELLITUS ; OXIDATIVE STRESS ; LIFE-STYLE ; ALPHA-TOCOPHEROL ; CARDIOVASCULAR-DISEASE ; INSULIN-RESISTANCE ; RANDOMIZED CONTROLLED-TRIAL ; WEIGHT-LOSS ; GLUCOSE-TOLERANCE ; LOW-FAT DIET
    Abstract: BACKGROUND/OBJECTIVES: This study addressed the question whether the composition of supposedly 'healthy' or 'unhealthy' dietary regimes has a calorie-independent short-term effect on biomarkers of metabolic stress and vascular risk in healthy individuals. SUBJECTS/METHODS: Healthy male volunteers (age 29.5 +/- 5.9 years, n = 39) were given a standardized baseline diet for two weeks before randomization into three groups of different dietary regimes: fast food, Mediterranean and German cooking style. Importantly, the amount of calories consumed per day was identical in all three groups. Blood samples were analyzed for biomarkers of cardiovascular risk and metabolic stress after two weeks of the baseline diet and after two weeks of the assigned dietary regime. RESULTS: No dietary intervention affected the metabolic or cardiovascular risk profile when compared in-between groups or compared to baseline. Subjects applied to the Mediterranean diet showed a statistically significant increase of uric acid compared to baseline and compared to the German diet group. Plasma concentrations of urea were significantly higher in both the fast food group and the Mediterranean group, when compared to baseline and compared to the German diet group. No significant differences were detected for the levels of vitamins, trace elements or metabolic stress markers (8-hydroxy-2-deoxyguanosine, malondialdehyde and methylglyoxal, a potent glycating agent). Established parameters of vascular risk (e.g. LDL-cholesterol, lipoprotein(a), homocysteine) were not significantly changed in-between groups or compared to baseline during the intervention period. CONCLUSIONS: The calorie-controlled dietary intervention caused neither protective nor harmful short-term effects regarding established biomarkers of vascular or metabolic risk. When avoiding the noxious effects of overfeeding, healthy individuals can possess the metabolic capacity to compensate for a potentially disadvantageous composition of a certain diet.
    Type of Publication: Journal article published
    PubMed ID: 25861423
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie; 70. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 92. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 47. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20061002-20061006; Berlin; DOCP.2.11-415 /20060928/
    Publication Date: 2007-03-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    ISSN: 1432-1041
    Keywords: Cardiac glycosides ; proscillaridin ; plasma levels ; 86Rb-erythrocyte assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels of proscillaridin, measured by a modified86Rb-erythrocyte method, have been studied in 6 healthy volunteers who received single oral doses of 2.5 mg. There were two maxima in the plasma curve, one after 0.5 h (median level 410 pg/ml) and another after 10 h (median value 390 pg/ml); and, a distinct minimum at 3 h (median value 98 pg/ml). After 24 h the median plasma concentration was 305 pg/ml, and after 48 h it was 115 pg/ml.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Der Chirurg 69 (1998), S. 102-104 
    ISSN: 1433-0385
    Keywords: Key words: Hypothenar hammer syndrome. ; Schlüsselwörter: Hypothenar-Hammer-Syndrom.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Arterienverletzungen als direkte Traumafolge führen meist zur Blutung oder Ischämie. Im Bereich der durch 2 Arterien versorgten Hand kann die akute Ischämie fehlen. Das Hypothenar-Hammer-Syndrom stellt einen Verschluß der distalen A. ulnaris als Folge eines Traumas dar. Abhängig von der Verletzungsart ist der klinische Beginn meist schleichend und erst eine gezielte duplexsonographische oder angiographische Untersuchung führen zur Diagnose. Bewährte Therapieempfehlungen gibt es nicht. Die Diagnostik des Verschluß der Arteria ulnaris als Unfallfolge ist für den Patienten wichtig und macht einen Therapieansatz erst möglich.
    Notes: Summary. Traumatic injuries of arteries lead to acute bleeding or ischemia. In the hand, which is perfused by two arteries, this symptom could be missed. The hypothenar hammer syndrome is a traumatic occlusion of the distal arteria ulnaris. Dependent on the mechanism of the trauma the clinical symptoms may appear late. A specific angiographic or duplex sonographic diagnostic investigation is necessary to show the arterial occlusion. There is no proven therapeutic procedure. Exact diagnosis of the occlusion as an effect of the trauma is important for the patient and is the basis of any therapeutic intervention.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1912
    Keywords: Cardiac Glycosides ; Proscillaridin ; Antibodies ; Radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbits were immunized for 10 weeks with a complex between the bufadienolide glycoside proscillaridin (p.) and human serum albumin. Antibodies were obtained with a binding capacity of 47 ng of p. per μl of undiluted serum. The antibodies migrated with the Ig A immunoglobulin fraction. Precipitation of the antigen-antibody complex was demonstrated by agargel electrophoresis, immunoelectrophoresis and immunodiffusion. When added to a 86Rb-erythrocyte system the antiserum prevented the inhibition of Rb-uptake due to p. with a linear doseresponse relationship. Displacement studies with different chemically related steroids were performed using a 3H-p.-antibody system in order to test the specificity of the antibody. Changes in the conformation and the substituents in position 3 and 4 did not influence antibody binding to a major degree. Quabain, digoxin and digitoxin, however, had a much lower affinity to the antibody. The radioimmunological system described is able to detect amounts of p. above 15 ng.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-1285
    Keywords: Key words Radial artery puncture — coronary angiography ; Schlüsselwörter Arteria radialis — Koronarangiographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Radial artery canulation is described as a way of diagnostic coronary angiography or coronary angioplasty. Because of the small diameter of the radial artery and the varying arterial perfusion of the hand we suggest some points to reduce the interventional risk. The perfusion of the hand should not depend on the radial artery demonstrated by Doppler or duplex-sonographic investigation. After canulation a local angiography of the punctured radial artery is useful to prove the correct position of the canule and to demonstrate the perfusion of the hand. If there is an ischemia of the hand after instrumentation a decanulation is not the first choice in every case. The performation in the radial artery limits an intraarterial lysis which may be the adequate therapy.
    Notes: Zusammenfassung Die Punktion der Arteria radialis ist als ein alternativer Zugang für die Koronarangiographie oder Koronarangioplastie beschrieben. Aufgrund des kleinen Gefäßdurchmessers und der stark variierenden arteriellen Versorgung der Hand sind einige Probleme zu berücksichtigen, um so da Risiko möglicher Spätschäden zu reduzieren. Eine Punktion sollte nicht erfolgen, wenn die arterielle Versorgung überwiegend von der Arteria radialis abhängt. Die Versorgung der Hand ist durch doppler- oder duplexsonographische Untersuchung zu klären. Nach erfolgreicher Punktion ist zunächst eine angiographische Dokumentation der Punktionsstelle sinnvoll, um Fehllagen zu erkennen und die ausreichende Perfusion der Hand nachzuweisen. Falls eine akute Ischämie auftritt, ist die zügige Entfernung der eingelegten Schleuse nicht immer indiziert, da das Punktionsloch z.B. eine intraarterielle Lyse als adäquate Therapie verhindern würde.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-2451
    Keywords: Venous insufficiency ; Venous malformation ; Venöse Insuffizienz ; Frühmanifestation ; Venöse Angiodysplasie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Unterscheidung kongenitaler und erworbener Beckenvenenblockade bzw. Aplasie oder Hypoplasie wurden 4 Fälle mit frühmanifester Veneninsuffizienz morphologisch und funktionell untersucht: 1. Für kongenitale Genese sprechen die Kombination mit anderen Fehlbildungen, Kompensation durch eine atypisch verlaufende singuläre Drainagevene, geringgradige funktionelle Veränderungen. 2. Für erworbenen Beckenvenenverschluß sprechen der Nachweis multipler Kollateralvenen mit geschlängeltem Verlauf, irregulären Wandkonturen und erheblichen funktionellen Veränderungen.
    Notes: Summary The morphologic and functional pattern of four cases with onset of venous insufficiency during childhood and occlusion or absence of an iliac segment were analyzed: (1) Congenital etiology was assumed if there was evidence of concomittant malformation such as hemangiomas or abnormal venous return through a Single anastomotic channel (persistant embryologic drainage); (2) thrombotic etiology was assumed if phlebography showed multiple wriggled collateral channels and if functional test (venous pressure, plethysmo graphy) showed marked changes.
    Type of Medium: Electronic Resource
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