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  • 1
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    Cham : Springer International Publishing
    Keywords: Medicine ; Cancer Research ; Molecular Biology ; Oncology ; Biomedicine ; Cancer Research ; Molecular Medicine ; Oncology ; Springer eBooks
    Description / Table of Contents: The windows of susceptibility to breast cancer -- The so called pre-neoplastic lesions and carcinoma in situ -- The pathobiology of the breast cancer Invasive process.-The invasive Breast Cancer Types -- The Molecular Basis of Breast Cancer Subtypes -- Stem cells in breast cancer.-The mechanisms of Breast Cancer metastasis -- How to build up adequate Prognostic markers in the Molecular biology context of breast cancer -- Preclincial models for studying brest cancer.-Biological Basis of Breast Cancer Prevention
    Abstract: This monograph, written by well renowned breast cancer expect, Dr. Jose Russo, provides new insight on the pathobiology of breast cancer from the most current advances in the field, translational research, initiation and progression of the disease, the mechanism of invasion and metastasis and the concept of stem cells in treatment and drug resistance. The role of personalized medicine and genomic testing are also explored, which will provide a window to the future progress of cancer care
    Pages: VIII, 235 p. 126 illus., 109 illus. in color. : online resource.
    ISBN: 9783319408156
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  • 2
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
    ISBN: 9781461423973
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  • 3
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    Berlin : Springer
    Call number: QZ365WP870:387
    Keywords: Breast Neoplasms / prevention & control ; Breast Neoplasms / therapy
    Pages: xiv, 448 p. : ill.
    ISBN: 3540003916
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  • 4
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Preface -- The epidemiology of breast cancer and the basis for prevention -- In vivo model for breast cancer prevention -- Comparative effects of the preventive effect of pregnancy, steroidal hormones and hCG in the transcriptomic profile of the rat mammary gland -- The use of in vitro three-dimensional system for testing preventing agents -- Methodological approach fro studying the human breast -- The transcriptoma of breast cancer prevention -- Chromatin remodeling and pregnancy induced differentiation -- The role of spliceosome in the human breast -- Non coding RNAs and breast cancer prevention -- The role of stem cell in breast cancer prevention -- Index
    Abstract: 〈p〉This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed 〈i〉in vivo and in vitro〈/i〉 experimental systems that have demonstrated mechanistically how the differentiation takes place.℗ The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history.℗ This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.〈/p〉
    Pages: XIII, 453 p. 135 illus., 121 illus. in color. : digital.
    ISBN: 9781461448846
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  • 5
    Keywords: Medicine ; Oncology ; Gene Expression ; Proteomics ; Biomedicine ; Cancer Research ; Molecular Medicine ; Proteomics ; Biomedicine general ; Gene Expression ; Springer eBooks
    Description / Table of Contents: Laser Capture Microdissection as a Tool for Compartmentalization Studies -- Histological Evaluation of the Normal Breast -- Methodology for Studying the Compartments of the Human Breast -- Methodological approach to Tissue Micro Array for Studying the Normal and Cancerous Human Breast -- In Vitro Techniques for Studying the Normal Breast and the use of Cell Lines in Breast Cancer Research -- In situ Methods for Indentifying the Stem Cell of the Normal and Cancerous Breast -- Imaging Techniques for Evaluation in vitro Behavior of Normal and Cancerous Breast Tissue -- In vivo Studies of Breast Cancer Cells -- RNA Sequencing in the Human Breast -- Methodological Approaches for the Understanding the Epigenetic Landscape of the of the Human Breast and its Implications in Cancer and Prevention
    Abstract: This book provides a detailed description of the most common techniques used in breast cancer research, with a special emphasis on the study of the normal breast as the basis for understanding the pathological processes in this organ. The authors have poured their experience in the field of breast cancer research into this book, and described the process of handling and interpreting the complex organ that is the human breast using original data and unique material collected over the years. ℗ They have established the concept of normality of the human breast and the morphological parameters to be used for distinguishing the normal from the diseased breast. The quality of the breast tissue obtained from autopsy material vs. core biopsies are carefully detailed and discussed, showing the morphological differences among the specimens according to their collection site. The use of laser capture microdissection and tissue microarray is described in detail and discussed with special references to the problems faced when the normal breast is under study. A chapter dedicated to the use of breast cancer cell lines is crafted around the importance of each cell line and its particularities for in vitro studies. In addition, the authors explore the new concept that cancer originates from two main cell types, basal and luminal cells . Particular attention is given to the study of the phenotypes commonly used for determining cell transformation, either spontaneously or by induced chemical agents. A companion chapter using in vivo models provides the adequate tools for those interested in studying the early events of cancer initiation, progression and metastasis. Special emphasis is given to the analysis of cells either by Flow cytometry and immuno-fluorescence techniques and the great potential of the use of in situ hybridization to study RNA transcripts. The book also features an original analysis of the putative markers of stem cells in breast cancer using immuno-cytochemical techniques, their interpretation and correlation with the prognosis of the disease. The last two chapters of the book are engaged in the utilization of RNA and DNA sequencing techniques and their values in understanding the physiological differences in the human breast, as well as the utilization of epigenetic methodologies in the understanding of the normal human breast. The authors have established the methodological basis for studying the human breast in its normal and pathological conditions providing a unique set of tools and valuable references for researchers pursuing a deeper understanding of the human breast
    Pages: XVI, 287 p. 192 illus., 167 illus. in color. : online resource.
    ISBN: 9781493907182
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  • 6
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    Cham : Springer International Publishing
    Keywords: Medicine ; Cancer Research ; Molecular Biology ; Biomedicine ; Cancer Research ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: 1 The paradigms in breast cancer prevention -- 2 The role genistein in breast cancer prevention -- 3 The role of omega 3 in breast cancer prevention -- 4 Is there a role for Raloxifene and Tamoxifene for the prevention of breast cancer? -- 5 Aromatase inhibitors for breast cancer prevention -- 6 Inhibition of the estrogen metabolism pathways as a preventive strategy in hormone dependent cancer -- 7 The molecular mechanisms of the dual effect of pregnancy in risk and prevention of breast cancer -- 8 Beyond aspirin in breast cancer prevention -- 9 Role of anti-inflammatory drugs in the prevention of pregnancy associated breast cancer -- 10 Vaccination against breast cancer and it role in prevention
    Abstract: This volume, with contributions from the most recognized experts in preventive strategies in breast cancer, presents the accepted as well as the novel ideas that have been introduced for the prevention of breast cancer. There is no single preventive agent that can stop the incidence of breast cancer—the malignant disease most frequently diagnosed in women of all races and nationalities. Furthermore, its incidence around the globe is increasing in industrialized countries. The worldwide incidence of breast cancer has increased 30-40% since the 1970s, reaching an excess of 1,390,000 new cases and a mortality of more than 460,000 cases in 2015. Therefore, what is needed is the development of rational strategies for the prevention of this fatal disease
    Pages: XVII, 284 p. 55 illus., 34 illus. in color. : online resource.
    ISBN: 9783319271354
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  • 7
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    New York, NY : Springer Science+Business Media, LLC
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441998965
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 134 (1971), S. 235-242 
    ISSN: 1432-0568
    Keywords: Leydig cells ; Differentiation ; Ultrastructure ; Hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper describes the morphological events which take place in the hamster Leydig cell during its process of prenatal and postnatal differentiation. The most strinking feature of the prenatal differentiation is the high development of the vesicular form of the smooth endoplasmic reticulum (S.E.R.). At around the end of the first month of postnatal life the vesicular form of the S.E.R. is replaced by a truly reticular S.E.R. formed by numerous interconnected cisternae. From fetal to adult life the amount of ribosomes decreases whereas the number of mitochondria and Golgi cisternae increases. It is concluded that the differentiation mechanism of the hamster Leydig cell differs from that observed in the Leydig cell of other species, even of those closely related to the hamster, such as the mouse.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0568
    Keywords: Leydig cells ; Differentiation ; Explants ; Ultrastructure ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Testes of newborn mice not older than one day were transplanted into the anterior chamber of one eye of an adult male white Holtzman rat. The events observed in the Leydig cells of the grafted testes can be divided into two periods. Period one is marked by differentiation; period two, by dedifferentiation. In period one, the lipid and glycogen inclusions disappear, possibly owing to the gonadotropins of the host. In period two, which starts after day 15 post-grafting, the lipids and glycogen reappear; the Leydig cells now contain residual bodies, whereas the S.E.R. disappears. Immunological mechanisms can be implicated; it is suggested that the Leydig cells dedifferentiate because the host's gonadotropins may be incapable of evoking and/or activating the genetic memory of the grafted Leydig cells.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-7217
    Keywords: animal models ; carcinogens ; DMBA-induced rat mammary tumors ; terminal end buds ; tumor evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among the multiple experimental animal models employed for analyzing the various aspects of mammary carcinogenesis, the induction of mammary tumors in rats by chemical carcinogens is one of the models most utilized. Experimentally-induced mammary tumors in rodents have proven to constitute useful tools for the study of the pathogenesis of cancer and of the molecular mechanisms involved in the initiation and progression of the neoplastic process. In vivo experimental animal models provide information not available in human populations; they are adequate for hazard identification, dose-response modeling, exposure assessment, and risk characterization, the four required steps for quantifying the estimated risk of cancer development associated with toxic chemical exposure. Using the DMBA rat mammary model, we have been able to demonstrate that the carcinogen acts on the intermediate cell of the terminal end bud (TEB), and that this structure is the one that evolves to intraductal proliferation, carcinoma in situ, and invasive carcinoma. There are several factors that regulate the susceptibility of the TEB; some of them are: a) topographic location of the mammary gland, b) age of the animal, and c) reproductive history. The understanding of the mechanisms that modulate tumorigenesis will further our knowledge and understanding in the prevention of the disease, as a result of the development of strategies for stopping the progression of the initiated cells.
    Type of Medium: Electronic Resource
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