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  • 1
    ISSN: 1432-1041
    Keywords: Antihypertensives ; vasodilator ; PR-G-138-Cl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary PR-G-138-Cl, a new antihypertensive agent with vasodilating properties, was studied in ten patients with moderate to severe hypertension. The patients were admitted to a metabolic ward and followed on a 2 gm salt diet. Placebo was given daily until blood pressure and weight were stabilized. A dose titration was then started with increasing single daily doses of 3, 5, 8, and 10 mg of PR-G-138-Cl orally. The dose at which the mean arterial pressure was reduced by 15 mm Hg was continued for a total of seven days. PR-G-138-Cl lowered sitting mean arterial pressures significantly in all subjects (133.8±15.1 → 116.0±12.4 mm Hg, p〈0.001). The antihypertensive effect was first noted 30 minutes following drug administration and persisted for as long as six hours with a peak effect at one hour. All patients had a significant increase in sitting pulse rate (80.4±9.11 → 90.0 ±6.91/min, p〈0.002). Blood pressure reduction and increase in pulse rate were dose related. The most common side effects noted were headaches in eight out of ten patients and postural dizziness in seven out of ten patients. There were no signs of fluid retention (weight gain or edema). Electrocardiogram and other laboratory parameters remained essentially unchanged.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; long-term diabetes ; Quarter Century Victory Medal for Diabetes ; vascular complications in diabetes ; microangiopathy of diabetes ; diabetic retinopathy ; diabetic nephropathy ; parental longevity ; obesity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Quarante-huit patients ayant une durée moyenne de diabète de 36 ans ont été examinés dans le but d'établir les facteurs cliniques et sociaux responsables de cette longue survie inhabituelle. La survie exceptionnelle de ces patients a été démontrée par une comparaison avec 48 patients se trouvant dans les mêmes conditions, parmi lesquels 9 sont morts dans les 10 ans apres l'apparition du diabéte et 19 dans les 25 ans aprés. — Parmi les 48 patients examinés, 24 avaient reçu précédemment la médaille de la ≪Quarter-Century Victory≫ pour avoir passé 25 années de diabéte démontré, sans complications vasculaires. Les 24 autres diabétiques de longue durée étaient comparables aux patients ayant reçu la médaille, en ce qui concerne le sexe, l'âge et la durée du diabète. — Une caractéristique frappante des 48 patients et particulièrement dans le groupe ayant reçu la médaille, était la faible proportion de maladie des gros vaisseaux. La micro-angiopathie était plus fréquente. Ainsi la rétinopathie non proliférative était présente chez 5 patients ayant reçu la médaille et chez 11 des diabétiques de longue durée. La rétinopathie proliférative a été trouvée chez 10 diabétiques de longue durée, mais chez aucun des patients ayant reçu la médaille. Des manifestations cliniques de néphropathie ont été trouvées chez 8 patients et la neuropathie chez 28 des 48 patients. — Parmi les patients ayant reçu la médaille, on a trouvé une prédominance relativement élevée de longévité parentale et une faible fréquence d'obèses et de gros fumeurs de cigarettes. — D'autres facteurs contribuant apparemment au prognostic favorable chéz les 48 patients examinés, étaient la pratique réguliére de sports ou d'autres activités physiques (93%) ainsi que le maintien d'un bon équilibre diabétique (79%). Trente-cinq pour cent des patients avaient de proches parents dans la profession médicale.
    Abstract: Zusammenfassung 48 Patienten mit einer mittleren Diabetesdauer von 36 Jahren wurden in der Absicht untersucht, die klinischen und sozialen Faktoren zu eruieren, die diese ungewöhnlich lange Überlebenszeit bewirkten. Wie ungewöhnlich der Krankheitsverlauf bei diesen Patienten war, ergab eine Gegenüberstellung mit 48 vergleichbaren Patienten, von denen 9 innerhalb 10 Jahren und 19 innerhalb 25 Jahren nach Ausbruch des Diabetes verstorben waren. — Von den 48 untersuchten Patienten hatten 24 schon früher die Quarter Century Victory Medal dafür erhalten, daß bei ihnen nach 25 Jahren dokumentierten Diabetes keine Gefäßkomplikationen festzustellen waren. Die verbleibenden 24 Langzeitdiabetiker waren mit den „Medaillen”-Patienten nach Geschlecht, Alter und Diabetesdauer vergleichbar. Auffä llig bei allen 48 Patienten und vor allem bei der „Medaillen”-Gruppe war der niedrige Prozentsatz von Erkrankungen der großen Gefäße. Eine Mikroangiopathie bestand häufiger. So lag eine nichtproliferative Retinopathie bei 5 der „Medaillen-patienten” und 11 der Langzeitdiabetiker vor. Eine proliferative Retinopathie fand sich bei 10 Langzeitdiabetikern, jedoch bei keinem der „Medaillen”-Patienten. Klinische Hinweise auf eine Nephropathie ergaben sich bei 8 und auf eine Neuropathie bei 28 der 48 Patienten. — Bei den „Medaillen”-Patienten fanden sich relativ viele Angaben über Langlebigkeit der Eltern und nur selten eine Fettsucht oder hoher Zigarettenkonsum. Weiter schienen zu der günstigen Prognose bei den 48 untersuchten Patienten regelmäßige Sportausübung und körperliche Bewegung (93%) und eine befriedigende bis gute Stoffwechselkontrolle beizutragen (79%). 35% der Patienten hatten nahe Verwandte in medizinischen Berufen.
    Notes: Summary Forty-eight patients with a mean duration of diabetes of 36 years were examined in an attempt to establish the clinical and social factors responsible for this unusually long survival. The exceptional course of these patients was demonstrated by a comparison with 48 matched patients 9 of whom had died within 10 years and 19 within 25 years of the onset of diabetes. — Of the 48 patients examined, 24 had received earlier the Quarter-Century Victory Medal for having passed 25 years of documented diabetes without vascular complications. The remaining 24 Long Term Diabetics were matched to the “Medal” patients as to sex, age and duration of diabetes. — A striking feature of all 48 patients and especially the “Medal” group was the low prevalence of large vessel disease. Microangiopathy was more frequent. Thus nonproliferative retinopathy was present in 5 of the “Medal” patients and in 11 of the Long Term Diabetics. Proliferative retinopathy was found in 10 Long-Term Diabetics, but in none of the Medal patients. Clinical evidence of nephropathy was found in 8 and neuropathy in 28 of the 48 patients. — A relatively high prevalence of parental longevity and a low frequency of obesity and of heavy cigarette smoking, were found in the “Medal” patients. Other factors apparently contributing to the favourable prognosis in the 48 patients examined included regular sports and other physical activity (93%) and maintenance of fair to good diabetic control (79%). Thirty-five percent of the patients had close relatives in the medical profession.
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  • 3
    ISSN: 1432-2161
    Keywords: Key words Massive bone allograft ; Magnetic resonance imaging ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. The objective of this study was to better understand the MRI appearance of massive bone allografts. Design. The MRI findings of three massive bone allografts imaged in vivo were correlated with the histologic findings following removal of the allografts. A fourth allograft, never implanted, was imaged and evaluated histologically. Patients. Allografts were placed for the treatment of primary or recurrent osteosarcoma. Results and conclusions. The in-vivo allografts have a heterogeneous appearance on MRI which we attribute to the revascularization process. Fibrovascular connective tissue grows into the graft in a patchy, focal fashion, down the medullary canal from the graft-host junction and adjacent to the periosteum. The marrow spaces are initially devoid of normal cellular elements and occupied by fat and gelatinous material. This normal postoperative appearance of massive bone allografts must not be interpreted as recurrent neoplasm or infection in the allograft. Recognition of these complications rests on features outside the marrow.
    Type of Medium: Electronic Resource
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