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  • 1
    Unknown
    Cham : Springer International Publishing
    Keywords: Medicine ; Cancer Research ; Gene Expression ; Biomedicine ; Cancer Research ; Gene Expression ; Springer eBooks
    Description / Table of Contents: 1. Role of DNA methylation in the progression and clearance of cancer -- 2. Epigenetical role for RNA in cancer progression -- 3. Epigenetics and its role in prostate cancer -- 4. Epigenetics and ovarian cancer -- 5. Epigenetics and breast cancer -- 6. Epigenetics and thyroid cancer -- 7. Epigenetics and intestinal cancer -- 8. Epigenetics and lung cancer -- 9. Epigenetics and renal cancer -- 10. Epigenetics and cervical cancer -- 11. Epigenetical markers in cancer -- 12. Epigenetical role in pancreatic cancer
    Abstract: This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. ℗ Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease
    Pages: XI, 246 p. 12 illus., 11 illus. in color. : online resource.
    ISBN: 9783319249513
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  • 2
    Abstract: Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing the full spectrum of clinical, therapeutic, mutational, and biological heterogeneity of melanoma. PDX have been characterized using targeted sequencing and protein arrays and are clinically annotated. This exhaustive live tissue resource includes PDX from 57 samples resistant to targeted therapy, 61 samples from responders and non-responders to immune checkpoint blockade, and 31 samples from brain metastasis. Uveal, mucosal, and acral subtypes are represented as well. We show examples of pre-clinical trials that highlight how the PDX collection can be used to develop and optimize precision therapies, biomarkers of response, and the targeting of rare genetic subgroups.
    Type of Publication: Journal article published
    PubMed ID: 29141225
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  • 3
    Keywords: MODEL ; LOCI ; GENOME-WIDE ASSOCIATION ; COMMON VARIANTS ; CHRONIC HEART-FAILURE ; CARDIAC REPOLARIZATION ; SARCOPLASMIC-RETICULUM ; QRS DURATION ; PR INTERVAL ; TRPM7
    Abstract: The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain similar to 8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.
    Type of Publication: Journal article published
    PubMed ID: 24952745
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  • 4
    ISSN: 1432-2307
    Keywords: Bcl-2 protein ; Mesothelioma ; Pleura ; Immunohistochemistry ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunohistochemical study of bcl-2 protein immunoreactivity in human non-neoplastic mesothelium (44 cases) and in malignant mesothelioma (62 cases) using a murine monoclonal antibody (clone 124) showed cytoplasmic immunoreactivity for bcl-2 protein in five cases of malignant mesothelioma. Non-neoplastic mesothelium was not immunoreactive. Immunoreactivity for bcl-2 protein does not add useful prognostic information in malignant mesothelioma since survival times of bcl-2 positive and bcl-2 negative cases did not differ. Nevertheless, the detection of bcl-2 protein in malignant mesothelioma might be useful for the differentiation from reactive mesothelium.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2307
    Keywords: Bcl-2 protein ; Mesothelioma ; Pleura ; Immunohistochemistry ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunohistochemical study of bcl-2 protein immunoreactivity in human non-neoplastic mesothelium (44 cases) and in malignant mesothelioma (62 cases) using a murine monoclonal antibody (clone 124) showed cytoplasmic immunoreactivity for bcl-2 protein in five cases of malignant mesothelioma. Non-neoplastic mesothelium was not immunoreactive. Immunoreactivity for bcl-2 protein does not add useful prognostic information in malignant mesothelioma since survival times of bcl-2 positive and bcl-2 negative cases did not differ. Nevertheless, the detection of bcl-2 protein in malignant mesothelioma might be useful for the differentiation from reactive mesothelium.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  A mathematical model has been developed by performing a non-linear regression analysis to simulate the fermentation process of glucose to lactic acid by considering the product-inhibition situation and substrate requirement for cell maintenance. To account for such an effect a toxic power (n) and a cell-maintenance factor (m) have been incorporated into the model. In the present study the order of inhibition was calculated to be 0.88. Moreover, a small value for the cell maintenance factor (m) indicates that the effect of this parameter on the lactic acid fermentation is not appreciable and hence can be neglected.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Cytopathology 14 (2003), S. 0 
    ISSN: 1365-2303
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
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    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2012-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kumar, Subrat -- England -- Nature. 2012 Dec 6;492(7427):9. doi: 10.1038/492009a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biotechnology, KIIT University, Bhubaneshwar, India. subrat_kumar@yahoo.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23222570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Specimen Banks/supply & distribution ; Biotechnology/*methods/trends ; Conservation of Natural Resources/*methods/trends ; Endangered Species/*statistics & numerical data ; *Extinction, Biological ; Risk Assessment
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2012-08-24
    Description: Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby maintaining the coding region of genes in a hypoacetylated state. In the absence of Set2, H3K36 or Rpd3S acetylated histones accumulate on open reading frames (ORFs), leading to transcription initiation from cryptic promoters within ORFs. Although the co-transcriptional deacetylation pathway is well characterized, the factors responsible for acetylation are as yet unknown. Here we show that, in yeast, co-transcriptional acetylation is achieved in part by histone exchange over ORFs. In addition to its function of targeting and activating the Rpd3S complex, H3K36 methylation suppresses the interaction of H3 with histone chaperones, histone exchange over coding regions and the incorporation of new acetylated histones. Thus, Set2 functions both to suppress the incorporation of acetylated histones and to signal for the deacetylation of these histones in transcribed genes. By suppressing spurious cryptic transcripts from initiating within ORFs, this pathway is essential to maintain the accuracy of transcription by RNA polymerase II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Venkatesh, Swaminathan -- Smolle, Michaela -- Li, Hua -- Gogol, Madelaine M -- Saint, Malika -- Kumar, Shambhu -- Natarajan, Krishnamurthy -- Workman, Jerry L -- R01GM04867/GM/NIGMS NIH HHS/ -- England -- Nature. 2012 Sep 20;489(7416):452-5. doi: 10.1038/nature11326. Epub 2012 Aug 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22914091" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Cell Cycle Proteins/metabolism ; Genes, Fungal/*genetics ; Histones/chemistry/*metabolism ; Lysine/*metabolism ; Methylation ; Methyltransferases/deficiency/genetics/*metabolism ; Molecular Chaperones/metabolism ; Open Reading Frames/genetics ; Phenotype ; RNA Polymerase II/metabolism ; Saccharomyces cerevisiae/*genetics ; Saccharomyces cerevisiae Proteins/*genetics/metabolism ; Transcription, Genetic/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2011-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karanth, K Ullas -- Gopalaswamy, Arjun M -- Kumar, N Samba -- Delampady, Mohan -- Nichols, James D -- Seidensticker, John -- Noon, Barry R -- Pimm, Stuart L -- New York, N.Y. -- Science. 2011 May 13;332(6031):791. doi: 10.1126/science.332.6031.791-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21566176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Wild ; India ; Population Density ; Population Dynamics ; *Tigers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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