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  • 1
    Keywords: Life sciences ; Cytology ; Developmental Biology ; Plant anatomy ; Microscopy ; Life sciences ; Plant Anatomy/Development ; Cell Biology ; Developmental Biology ; Biological Microscopy ; Springer eBooks
    Description / Table of Contents: FM Preface -- 1 Nuclei and Chromosomes -- 2 Mitochondria -- 3 Chloroplasts -- 4 The Endoplasmic Reticulum, Golgi Apparatuses, and Endocytic Organelles -- 5 Vacuoles and Storage Organelles -- 6 Cytoskeletons -- 7 Cell Walls -- 8 Generative Cells -- 9 Meristems
    Abstract: This atlas presents beautiful photographs and 3D-reconstruction images of cellular structures in plants, algae, fungi, and related organisms taken by a variety of microscopes and visualization techniques. Much of the knowledge described here has been gathered only in the past quarter of a century and represents the frontier of research. The book is divided into nine chapters: Nuclei and Chromosomes; Mitochondria; Chloroplasts; Endoplasmic Reticulum, Golgi Apparatuses, and Endocytic Organelles; Vacuoles and Storage Organelles; Cytoskeletons; Cell Walls; Generative Cells; and Meristems. Each chapter includes several illustrative photographs accompanied by a short text explaining the background and meaning of the image and the method by which it was obtained, with references. Readers can enjoy the visual tour within cells and will obtain new insights into plant cell structure. This atlas is recommended for plant scientists, students, their teachers, and anyone else who is curious about the extraordinary variety of living things
    Pages: XXV, 202 p. 92 illus., 66 illus. in color. : online resource.
    ISBN: 9784431549413
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  • 2
    Keywords: CDNA ; CLONES ; BIOLOGY ; alternative splicing ; CDNAS ; ASSEMBLIES ; assembly ; ANNOTATION ; COMPLETE GENOM
    Abstract: The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for nonprotein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology
    Type of Publication: Journal article published
    PubMed ID: 15103394
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  • 3
    ISSN: 1432-5241
    Keywords: Key words: Nipple—Inverted nipple—Nipple plasty— Lactiferous function—Dermal flap
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Severe cases of inverted nipple usually cannot be corrected by a simple procedure, especially if the nipple cannot be pulled out above the areolar level by manipulation. We describe a new method for these cases and we classify the inverted nipple into 3 grades following the choice of their required operative procedure. Our classification for inverted nipple is as follows. Grade I: The inversion is corrected simply by manipulation; the nipple protrusion is long-lasting. Grade II: The inversion can be corrected by manipulation, but recurrence of the inversion is frequent. Grade III: The inversion cannot be corrected without a surgical procedure. Cases of Grades I and II can be corrected by conventional simple surgical procedures. But some cases of Grade II and almost all of Grade III cannot be corrected by conventional methods, in spite of the high frequency of relapse. Cutting of the lactiferous duct, such as the Pitanguy and Broadbent methods, can correct the very severely inverted nipple. But if we want to maintain the lactiferous function after correction, we had better not cut the lactiferous ducts. Our new procedure for correcting very severe cases can keep the lactiferous function after correction without any relapse. In order to avoid the recurrence of nipple retraction and to maintain the lactiferous function, the new surgical procedure that we performed makes an incision deeply and vertically on the nipple to free the lactiferous ducts from the contracted tissues surrounding them. After extension or resection of the restricting tissues, the nipple is raised easily. This procedure will preserve the feeding function and prevent the recurrence of nipple inversion. For very severe cases, using a dermal flap inserted into the base of the nipple may be necessary due to its role of interposing tissue to prevent reverting to inversion.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Pendant 15 ans et 7 mois de janvier 1965 à juillet 1980, 306 malades ont subi une gastrectomie subtotale ou totale. Au cours des 7 dernières années, diverses opérations ont été pratiquées en fonction des différentes lésions: les malades présentant des lésions bénignes ou des tumeurs au stade I ou II ont été soumis à une gastrectomie subtotale avec interposition d'une anse jéjunale entre l'oesophage et le moignon gastrique; ceux qui présentaient des tumeurs au stade III ont subi une gastrectomie totale avec interposition d'une anse jéjunale entre l'oesophage et le duodénum; enfin, ceux qui étaient porteurs de tumeurs au stade IV ont subi une gastrectomie totale avec rétablissement de la continuité par anastomose oesophago-jéjunale sur anse en Y. Le taux des complications a été variable en fonction du type de l'opération: le plus bas après interposition d'une anse jéjunale entre l'oesophage et le moignon gastrique, relativement plus important lorsque la gastrectomie totale a été suivie de l'interposition de l'anse jéjunale entre l'oesophage et le duodénum, le plus élevé enfin après oesophago-jéjunostomie sur anse en Y.
    Notes: Abstract During the 15 years and 7 months from January, 1965 to July, 1980, a total of 306 patients were subjected to proximal or total gastrectomy. In the latest period of 7 years, various operative procedures were employed depending on the pathological conditions of individual patients, as follows: patients with benign lesions or stage I and II tumors were subjected mainly to proximal gastrectomy plus pedicled jejunal interposition between the esophagus and gastric stump; those with stage III tumors were subjected to total gastrectomy plus pedicled jejunal interposition between the esophagus and duodenum; and those with stage IV tumors were subjected to total gastrectomy plus Roux-en-Y esophagojejunostomy. The incidence of postoperative complications was lowest after pedicled jejunal interposition between the esophagus and gastric stump, followed by pedicled jejunal interposition between the esophagus and duodenum. Roux-en-Y esophagojejunostomy had the highest incidence of complications.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY:  Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Light and electron microscopic studies and energy dispersive X-ray analysis disclosed that the essential cause of gingival discoloration following the placement of a metallic crown, was marked deposition of melanin pigment. Deposition of melanin pigment was observed in epithelial cells, on basement membranes, and in fibroblasts, macrophages and among intercellular ground substance of the proprial layer. Brown or dark brown colored granules were observed in the deep portion of the proprial layer. Some metallic elements as silver and sulfur were detected. It was presumed that these materials were dental metals accidentally implanted in gingival tissues during the therapeutic procedure. The deposition of melanin pigment closely corresponded with mucosal tissue where these materials were present in the deep portion of the proprial layer. These findings suggested that these materials influenced the physiological metabolism of melanin and induced its pathological deposition in the proprial tissue.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair. Two forms of fibronectin have been identified: plasma fibronectin (pFn), which is expressed by hepatocytes and secreted in soluble form into plasma; and cellular fibronectin (cFn), an ...
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-7373
    Keywords: glioblastoma multiforme ; external beam-radiotherapy ; CDDP ; intraoperative radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This trial tested the assumed efficacy and safety of externalbeam-radiotherapy combined with daily administration of low dose cisplatin(CDDP) (ERCLC therapy) for patients with glioblastoma multiforme (GBM).Thirty adult patients with supratentorial GBM received daily postoperativetreatment with low dose intravenous CDDP (4–6 mg/m2) administered30 minutes before external irradiation. In 10 patients, intraoperativeradiotherapy (IORT) following surgery was given prior to ERCLC therapy.Tumor response on MRI, interval to tumor progression, survival, andtoxicities were analyzed. None of the patients showed a tumor response toERCLC therapy. Overall, the median time to tumor progression was 6 monthswith a 1-year tumor progression-free rate of 26.7% and a 2-year rateof 0%. The median survival time was 15 months with a 1-year survivalrate of 69.9% and a 2-year rate of 31.5%. The survival rate ofpatients with IORT was better than that of those without IORT, however,there was no significant difference. Anorexia associated with nauseaoccurred in 70% and general fatigue in 10.0%. Leukopenia andthrombocytopenia occurred in 26.7% and 33.3%, respectively.However, none of the patients had to be withdrawn from therapy due to thesetoxicities. Other toxicities were not observed. This clinical study showedthat daily administration of low dose CDDP did not enhance tumor response toirradiation for GBM on MRI. Regarding toxicity, however, ERCLC therapy waswell tolerated. Although this trial did not provide sufficient data todetermine whether ERCLC therapy was effective for GBM due to the smallnumber of patients, additional clinical trials of this therapy may bewarranted because that the survival rate in this study was equal to thebetter results recently reported for newly diagnosed GBM.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-7373
    Keywords: DCC ; glioma ; RT-PCR ; recurrent tumor ; survival rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Deleted in colorectal carcinoma (DCC) gene has been as a candidate of tumor suppressor genes, has been identified recently and is thought to relate to the metastatic potential in some cancers. We examined the gene in 60 human gliomas (26 glioblastomas multiforme (GBMs), 16 anaplastic astrocytomas (AAs), 6 low grade astrocytomas (LGAs) of WHO Grade II, and 11 recurrent gliomas) and A172 human GBM cell line by reverse transcription polymerase chain reaction (RT-PCR). Twenty (77%) GBMs, 11 (69%) AAs, and 1 (17%) LGA revealed the reduced or absent DCC expression. Reduced DCC expression was also shown in 10 (91%) recurrent gliomas. Furthermore, in 5 cases with both primary and recurrent GBM, the DCC expressions of all recurrent tumors were lower than those of primary tumors. No significant correlation between DCC expression and Mib-1 labeling index was confirmed. The survival rate of patients without reduced DCC expression was significantly superior to that of patients with reduced DCC expression in overall malignant astrocytic tumors. In GBM and AA separately, DCC expression also tended to correlate with patient's prognosis. These results suggest that reduced DCC expression is an important marker in tumor malignancy and recurrence in astrocytic tumors and that may be a useful prognostic factor in patients with malignant astrocytic tumors.
    Type of Medium: Electronic Resource
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