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  • 1
    Publication Date: 2018-01-09
    Description: Expansion and death of effector CD8 T cells are regulated to limit immunopathology and cells that escape contraction go on to generate immunological memory. CD44, a receptor for the extracellular matrix component hyaluronan, is a marker of activated and memory T cells. Here, we show with a murine model that the increase in CD44 expression and hyaluronan binding induced upon CD8 T cell activation was proportional to the strength of TCR engagement, thereby identifying the most strongly activated T cells. When CD44 −/− and CD44 +/+ OT-I CD8 T cells were adoptively transferred into mice challenged with Listeria -OVA, there was a slight increase in the percentage of CD44 +/+ cells at the effector site. However, CD44 +/+ cells were out-competed by CD44 −/− cells after the contraction phase in the lymphoid tissues, and the CD44 −/− cells preferentially formed more memory cells. The hyaluronan-binding CD44 +/+ CD8 effector T cells showed increased pAkt expression, higher glucose uptake, and were more susceptible to cell death during the contraction phase compared to non-binding CD44 +/+ and CD44 −/− OT-I CD8 T cells, suggesting that CD44 and its engagement with hyaluronan skews CD8 T cells towards a terminal effector differentiation state that reduces their ability to form memory cells. This article is protected by copyright. All rights reserved
    Print ISSN: 0014-2980
    Electronic ISSN: 1521-4141
    Topics: Medicine
    Published by Wiley-Blackwell
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