Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CANCER ; tumor ; Germany ; MODEL ; THERAPY ; INFORMATION ; LUNG-CANCER ; DISEASE ; EPIDEMIOLOGY ; HISTORY ; incidence ; MORTALITY ; POPULATION ; RISK ; TUMORS ; PATIENT ; FAMILY ; prognosis ; RISK-FACTORS ; SUSCEPTIBILITY ; BREAST ; DECREASE ; NUMBER ; AGE ; etiology ; risk factors ; RISK FACTOR ; RECURRENCE ; case-control studies ; CHILDREN ; PREDICTORS ; SARCOMA ; HEART-DISEASE ; AGENT ; ONCOLOGY ; PERSISTENT ; case-control study ; CHILDHOOD ; DISTRESS ; Ewing's sarcoma ; osteosarcoma
    Abstract: This case-control study investigates etiologically important factors for juvenile osteosarcomas and possible reasons for the relative scarcity of their incidence in the population. Information on a variety of risk factors, psychosocial factors, and factors possibly occurring in early childhood was obtained by interviewing 88 patients (ages 8-25 years) with osteosarcoma, Ewing's sarcomas and other bone tumors, and three age- and sex-matched control groups (hospital, neighbour and family controls), and their mothers. For both sexes, children's diseases in their history, which increased the risk were measles (RR = 1.56, not significant) and mumps (RR = 1.81, 95% Cl = 1.05-3.13), whereas clinically apparent chickenpox was associated with a significant decrease for bone tumors (RR = 0.46, 95% Cl = 0.26-0.8). Dermal and respiratory allergies (without hay fever) were also inversely associated with bone tumors. Breast feeding for longer than 2 months was associated with low risk for bone tumors for boys, whereas for girls, paternal age was a risk factor; remaining stable in a multivariate model (RR = 2.36, 95% CI = 0.90-6.21). A change in the presence of an emotionally significant person or changes of residence were risk factors both in univariate and multivariate analyses. The strongest and most persistent risk factor was difficulties in school, indicative of emotional disturbances (RR 2.58, 95% Q = 1.39-4.78). Considering such host factors as possibly . important modifiers of risk in addition to exogenous carcinogenic agents, these factors were consistent and statistically significant for both sexes and despite the small numbers recruited for this study, thus predicting susceptibility. The factors may become relevant for preventive psychotherapy applied to susceptible persons for improvement of prognosis after surgical therapy in preventing recurrences. (C) 2004 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 15225895
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 312 (1965), S. 216-231 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Das Chondromyxoidfibrom stellt einen seltenen, benignen, chondroplastischen Knochentumor dar. Seine Kenntnis scheint wegen der Gefahr der Überwertung des histologischen Bildes als Sarkom von praktischenr Bedeutung. Es erkranken vor allem Patienten zwischen dem 5. und 25. Lebensjahr. Bevorzugt ergriffen werden die Metaphysen von Tibia und Femur. Hier können oft typische röntgenologische Veränderungen nachweisbar sein, während diese bei anderer Lokalisation uncharakteristisch sind. Als Behandlung empfiehlt sich eine sehr exakte Excochleation, da sonst in einem hohen Prozentsatz mit Rezidiven zu rechnen ist. Es wird über drei Fälle berichtet, die in den Jahren 1940 bis 1960 am Pathologisch-anatomischen Institut der Universität Wien zur Beobachtung gelangten. Betroffen waren zwei Knaben und ein Mädchen im Alter von 8 bis 16 Jahren. Der Tumor war in der proximalen und distalen Tibiametaphyse und im Femurhals lokalisiert. Die Nachbeobachtungszeiten betragen 5 bis 24 Jahre nach der Operation. Einmal trat 11 Jahre nach der ersten Operation ein Rezidiv auf und 14Jahre nach der Excochleation desselben bestehen röntgenologisch wiederum Strukturveränderungen. Bezüglich der von manchen Autoren geübten Abgrenzung von “Myxomen” von den ChMF stehen Verfasser auf dem Standpunkt, daß erst weitere Erfahrungen gesammelt werden müssen und daß nur ein besonderes biologisches Verhalten dieser Myxome eine Unterteilung rechtfertigen kann.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1569-8041
    Keywords: chemotherapy ; cisplatin ; ifosfamide ; intraarterial therapy ; osteosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In an effort to intensify osteosarcoma therapy, systemic ifosfamide was added pre- and postoperatively to an already aggressive three-drug regimen. In a subgroup of patients, loco-regional treatment intensification was attempted by using the intraarterial route to give cisplatin. Patients and methods: Patients ≤40 years at diagnosis of a localised, de novo high-grade central extremity osteosarcoma were eligible for inclusion into study COSS-86 if registered within three weeks from biopsy. Doxorubicin, high-dose methotrexate, and cisplatin were given to all patients. Patients who fulfilled one or more of three defined high-risk criteria received early systemic treatment intensification by adding ifosfamide as the fourth agent. Preoperatively, these high-risk patients received cisplatin either intraarterially or intravenously. Results: 171 eligible patients were entered, of which 128 were stratified into the high-risk group. When all 171 were analysed by intention-to-treat, actuarial overall and event-free survival rates at ten years were 72% and 66%, respectively. No benefit of intraarterial cisplatin application was detected. Cumulative treatment toxicity was considerable. Conclusions: In a multicenter setting, intensive treatment of osteosarcoma according to protocol COSS-86 led to long-term disease-free survival for two thirds of patients. We saw no benefit of using the intraarterial route to administer cisplatin.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 302 (1963), S. 755-778 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über sieben Fälle von “benignem Osteoblastom” (Jaffe-Lichtenstein) berichtet, die in den Jahren 1940–1961 am Pathologisch-anatomischen Institut der Universität Wien zur Beobachtung gelangten. Es waren sechs Knaben und ein Mädchen im Alter von 6-29 Jahren erkrankt. Der Tumor war zweimal in der Wirbelsäule, zweimal im Schädel und je einmal in Tibia, Talus und Zehenendphalange lokalisiert. Sechs der Patienten sind 7 1/2–22 Jahre nach der — teilweise nicht totalen — Exstirpation des Tumors gesund. Ein Patient (Fall 4) kam 15 Monate nach der Operation an den Folgen der durch Teilresektion des Tumors nicht gebesserten Querschnittsläsion ad exitum. Klinik, Therapie und Pathologie werden an Hand des eigenen Materials und der einschlägigen Literatur besprochen. Differential-diagnostisch müssen das Osteosarkom, der Riesenzelltumor, die Knochencyste und die monostische Form der Fibrösen Dysplasie in Erwägung gezogen werden. Auf die besondere feingewebliche Ähnlichkeit mit dem Osteoid-Osteom wird hingewiesen. Die Prognose des Osteoblastom ist günstig, eine maligne Entartung wurde bisher noch nicht beobachtet.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1335
    Keywords: Chondrosarcoma ; Clear-cell chondrosarcoma ; Sarcoma ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Report of a case of clear-cell chondrosarcoma at the upper end of the left femur of a 32-year-old woman. She had two pathologic fractures during a period of 4 years. After the first fracture an excochleation and after the second fracture a resection were done. Two years after resection she had no local recurrence and was free from metastasis.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-2307
    Keywords: Osteosarcoma ; Chemotherapy ; Quantitative Caryometry ; Morphometry ; Tumour regression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A current strategy for osteosarcoma treatment is neo-adjuvant chemotherapy prior to the resection of the tumour. It appears that some tumours respond very well to the cytostatic therapy, while others show little or no effect. It is desirable to be able predict the response of the tumour before starting chemotherapy. 16 biopsy specimens from patients with osteosarcoma who had been treated according to the protocol of the study COSS-80 and COSS-82 were examined. 100 tumour cells from each biopsy have been measured by an electronic interactive image analysis system (IBAS II; Kontron/ ZEISS). After completion of chemotherapy en bloc resection of the tumour was performed. The entire surgical specimen was completely examined at two levels by means of undecalcified sections, and assigned a grade for the effect of chemotherapy analogous to the grading of Salzer-Kuntschik et al. (1983). The quantitative analysis of tumour cell nuclei revealed two different patterns of nuclear sizes, which were correlated significantly with the chemotherapy response (P〈0.002). Tumour cell nuclei of well responders were significantly larger and showed a greater variance in size (mean value 66 + 41 µm2), than those of poor responders (mean value 38 + 18 µm2). We conclude from our results that quantitative analysis and classification of nuclear size of osteosarcoma cells may be useful for predicting chemotherapy response in patients with osteosarcoma.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-2161
    Keywords: Osteosarcoma ; Chemotherapy ; Plain film radiography ; Angiography ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prognosis of osteosarcoma has improved significantly with recent advances in chemotherapy. Evaluation of the effect of chemotherapy is important for optimal timing of surgery, for selecting an alternative drug regimen in instances of poor response to chemotherapy and for testing combinations of new drugs. The purpose of this paper is to define the value of plain radiographs and angiography in assessing tumor response to chemotherapy. Studies were obtained before and after chemotherapy. The radiographic results were correlated with histologic evaluation of the resected specimen. Patients with less than 10% residual viable tumor in the resected bone were designated “responders” and patients with more than 10% of remaining viable tumor were “nonresponders”. Angiographic appearances correctly separated 15 patients with good response to chemotherapy from seven patients who were not responsive. Conversely, comparison of plain radiographs obtained before and after chemotherapy did not allow a reliable differentiation between patients with good, poor, or no response to chemotherapy. The current role of angiography in the management of patients with osteosarcoma is discussed. It is concluded that — in contrast to plain film radiography — angiography is an accurate method for assessing the response of osteosarcoma to chemotherapy.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In this abstract, the authors are presenting three own cases under the title “ganglions affecting also the bones”, taking into account the medical literature on this matter. The anatomical caracteristics shows two groups of ganglions: 1. the ganglions which develop (themselves) in the soft tissue and are able to destroy the adjoining bones. 2. the ganglions which seem to be in the bone itself and for which it is not possible to prove with certitude that it exists a relation between them and the adjacent joint and the soft tissue. Particularly group I shows a typical radiograph. As link between group I and II, the authors relate a case where one ganglion destroyed a bone from the outside and then expanded in the internal bone. Such a case does not seem to be mentioned until now in the pertinent literature. The authors mention the morphological likeness between ganglions and the formation of cystes in bones in case of arthroses. For reason of practical therapy a separation of the two diseases would be desirable.
    Abstract: Résumé Dans ce memoire, les auteurs présentent trois cas traites par eux, sous le titre „ganglions avec affection conjointe de l'os“, en se rapportant a la littérature concernant de sujet. On distingue deux groupes de ganglions, classés d'après les caractères anatomiques: I. les ganglions qui se developpent dans les chairs et qui sont capables de détruiere les os situés à proximite. II. les ganglions qui paraissent être situes dans l'os même et pour lesquels is est difficile de prouver un contact avec les articulations ou chaires voisines. Le groupe I plus particulièrement présente une radiographie très caractéristique. Comme intermédiaire entre le groupe I et le groupe II les auteurs présentent un cas où le ganglion détruisit un os de l'extérieur et avant de s'étendre dans l'os même. A notre connaissance, nul cas similaire n'a encore été rélaté dans la littérature rélative ce genre d'affections. Les auteurs signalent la ressemblance morphologique de ces ganglions avec les kystes qui se developpent dans l'os dans les arthroses. Pour des considérations de pratique therapeutique, une séparation des deux maladies serait souhaitable.
    Notes: Zusammenfassung An Hand von drei eigenen Fällen und unter Berücksichtigung von Literaturangaben wird das Krankheitsbild des „Ganglion mit Knochenbeteiligung“ besprochen. Nach dem anatomischen Verhalten werden zwei Gangliengruppen unterschieden: Erstens solche, bei denen Ganglien in den Weichteilen entstehen und durch Druckusur den benachbarten Knochen zerstören können. Zweitens solche, die anscheinend primär rein intraossär gelegen sind, bei denen zumindest ein Zusammenhang mit dem benachbarten Gelenk oder anschließenden Weichteilen nicht sicher nachweisbar ist. Besonders Gruppe I zeigt ein typisches Röntgenbild. Beide Gruppen bevorzugen das mittlere und höhere Lebensalter. Als Bindeglied zwischen Gruppe I und II wird über einen Fall berichtet, bei dem ein Ganglion von außen den Knochen zerstörte und sich dann aber selbständig intraossär weiter ausbreitete. Ein derartiger Fall dürfte in der uns zugänglichen Literatur bisher nicht beschrieben worden sein. Auf die morphologische Ähnlichkeit zwischen diesen Ganglien und Cystenbildungen im Knochen bei Arthrosen wird hingewiesen und die Beziehung dieser beiden Läsionen zueinander diskutiert, wobei eine enge Verwandtschaft angenommen wird. Beide Veränderungen sind als Degenerationscysten anzusehen. Praktisch-therapeutische Gründe lassen eine Trennung der beiden Krankheitsbilder wünschenswert erscheinen.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Report in literatur and 3 own cases serve in discussing the clinical picture, X-ray picture, morphological behavior, differential diagnosis of the benign chondroblastoma (Codmantumor). The knowledge of the tumor, which only seldom occurs, appears to be very important owing to the danger of its wrong interpretation especially of the morphological picture and the therapeutic consequence resulting thereform. With an exact conservativ surgical treatment the prognosis of the condition is a very good one. It is especially pointed to the problem of the atypical chondroblastoma.
    Abstract: Résumé On présente la clinique, l'aspect radiologique et morphologique ainsi que le diagnostic differentiel du chondroblastome benin (tumeur de Codman). Révue de litterature à laquelle trois nouveaux cas sont ajoutés. La conaissance de cette rare tumeur osseuse paraît importante en vue de fausse interpretation, surtout de l'aspect morphologique et des consequences therapeutiques qui en ressortent. L'exacte therapie chirurgicale conservatrice (excochleation, eventuellement resection) permet un bon prognostique de la maladie. Le probleme de chondroblastomes atypiques est demontré.
    Notes: Zusammenfassung An Hand von Literaturberichten und drei eigenen Fällen werden Klinik, Röntgenbild, morphologisches Verhalten und Differentialdiagnose desbenignen Chondroblastoms („Codmantumor“) besprochen. Die Kenntnis der selten vorkommenden Knochengeschwulst erscheint wegen der Gefahr einer Fehlinterpretation vor allem des morphologischen Bildes und der sich daraus ergebenden therapeutischen Konsequenzen wichtig. Bei exakter konservativ chirurgischer Therapie (Excochleation und evtl. Resektion) ist die Prognose der Erkrankung eine sehr gute. Auf die Problematik atypischer Chondroblastome wird hingewiesen.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...