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  • 1
    Keywords: Life sciences ; Biomedical Engineering ; Regenerative Medicine ; Tissue Engineering ; Biomaterials ; Life sciences ; Regenerative Medicine/Tissue Engineering ; Biomedical Engineering/Biotechnology ; Biomaterials ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: Part I: Current Challenges in Osteochondral Repair and Regeneration: Trauma vs Disease -- Advances for treatment of knee OC defects -- Emerging Concepts in Treating Cartilage, Osteochondral Defects and Osteoarthritis of the Knee and Ankle -- Osteoarthritis: Trauma Vs Disease -- Surgical Treatment Paradigms of Ankle Lateral Instability, Osteochondral Defects and Impingement -- Part II: Viscosupplementation -- Clinical management in early OA -- Hyaluronic Acid -- Semi-IPNs and IPNs Based Hydrogels -- Promising biomolecules -- Part III: Technological Advances in Osteochondral Tissue Engineering -- Nanoparticles-based systems for Osteochondral Tissue Engineering -- Stem cells for osteochondral regeneration -- PRP Therapy -- Enhancing biological and biomechanical fixation of osteochondral scaffold: a grand challenge -- Part IV: Osteochondral Tissue Engineering approaches -- Combination of polymeric supports and drug delivery systems for ostechondral regeneration -- Osteochondral Angiogenesis and Promoted Vascularization: New Therapeutic Target -- Models Of Disease -- Part V: In vitro models for Osteochondral Regeneration -- Tissue Engineering Strategies for Osteochondral Repair -- In vitro mimetic models for the bone-cartilage interface regeneration -- Bioreactors and microfluidics for osteochondral interface maturation -- Part VI: In vivo models for Osteochondral Regeneratio -- nSmall Animal Models -- Large animal models for Osteochondral Regeneration -- Index
    Abstract: This book covers the most recent developments in the field of osteochondral tissue engineering (OCTE) and covers in detail the concepts and current challenges for bone and cartilage repair and regeneration. Specific topics include viscosupplementation, biologicals, tissue engineering approaches, in vitro and in vivo models, and technological advances with stem cells, bioreactors, and microfluidics. Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances presents challenges and strategies in the field of osteochondral regeneration and serves as a core reference for biomedical engineering students and a wide range of established researchers and professionals working in orthopedics
    Pages: IX, 511 p. 86 illus., 79 illus. in color. : online resource.
    ISBN: 9783319767352
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  • 2
    Keywords: Life sciences ; Biomedical Engineering ; Regenerative Medicine ; Tissue Engineering ; Biomaterials ; Life sciences ; Regenerative Medicine/Tissue Engineering ; Biomedical Engineering/Biotechnology ; Biomaterials ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: Part I: Biomaterials advances in Osteochondral Tissue -- Natural Origin Materials for Osteochondral Tissue Engineering -- Synthetic Materials for Osteochondral Tissue Engineering -- Bioceramics for Osteochondral Tissue Engineering and Regeneration -- Part II: Nanotechnology approaches for Osteochondral Tissue Engineering -- Nanomaterials/nanocomposites for Osteochondral Tissue -- Nano- and Micro-Fibers for Osteochondral Tissue Engineering -- Micro/Nano Scaffolds for Osteochondral Tissue Engineering -- Part III: Osteochondral Tissue Scaffolding -- Mimetic Hierarchical Approaches for Osteochondral Tissue Engineering -- Porous scaffolds for regeneration of cartilage, bone and osteochondral tissue -- Layered Scaffolds for Osteochondral Tissue Engineering -- Part IV: Advanced Processing Methodology -- Preparation of polymeric and composite scaffolds by 3D Bioprinting -- The Use of Electrospinning Technique on OsteoChondral Tissue Engineering -- Supercritical Fluid Technology as a Tool to Prepare Gradient Multifunctional Architectures towards Regeneration of Osteochondral Injuries -- Part V: Hydrogels Systems for Osteochondral Tissue Applications -- Gellan Gum-based Hydrogels for Osteochondral Repair -- Silk Fibroin-Based Hydrogels and Scaffolds for Osteochondral Repair and Regeneration -- In Situ Crosslinkable Polymer Systems and Composites for Osteochondral Regeneration -- Part VI: Translation of Osteochondral Tissue Products -- Stem Cells in Osteochondral Tissue Engineering -- Osteochondral Tissue Engineering: Translational Research and Turning Research into Products -- Clinical trials and Management of Osteochondral Lesions -- Commercial Products for Osteochondral Tissue Repair and Regeneration -- Index
    Abstract: This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field
    Pages: IX, 438 p. 101 illus., 79 illus. in color. : online resource.
    ISBN: 9783319767116
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  • 3
    Call number: QZ241:162
    Keywords: Neoplasms / diagnosis ; Tumor Markers, Biological / congresses
    Pages: ix, 355 p. : ill.
    ISBN: 044481065X
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    QZ241:162 available
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  • 4
    ISSN: 1432-072X
    Keywords: Key wordsParacoccidioides brasiliensis ; Fungal ; dimorphism ; Ornithine decarboxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Ornithine decarboxylase in Paracoccidioides brasiliensis, a dimorphic human pathogenic fungus, was more active at 37° C in the yeast phase and at 30° C in the mycelial phase. In contrast to other fungal systems, yeast growth and mycelium-to-yeast transition in P. brasiliensis were accompanied by a high activity of ornithine decarboxylase at the onset of the budding process, the activity of which was inhibited by 1,4-diamino-2-butanone. The activity of ornithine decarboxylase remained at a basal level during vegetative growth of both the mycelial phase and the late stage of yeast phase, and also through the yeast-to-mycelium transition.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-072X
    Keywords: Paracoccidioides brasiliensis ; Fungal dimorphism ; Polyamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Putrescine and spermidine were the only polyamines found inParacoccidioides brasiliensis, a dimorphic fungus pathogenic for humans. Free polyamines (putrescine〉spermidine) increased during the first 24 h of yeast growth, with a second peak at 42 h, and also during the first 12 h of mycelium-to-yeast transition (spermidine〉putrescine). Conjugated and bound polyamines were also quantified. 1,4-Diamino-2-butanone decreased free putrescine and spermidine accumulation by inhibiting the activity of ornithine decarboxylase. The increase in free polyamines corresponds to bud emergence in yeast growth and to the mycelium-to-yeast transition ofP. brasiliensis.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0568
    Keywords: Key words Inner ear development ; Cochleovestibular ganglion ; Microtubule associated proteins ; Neurotrophin-3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Microtubule-associated proteins (MAPs) are essential cytoskeletal components during development for neurogenesis and neuronal plasticity. Inner ear innervation is accomplished by cochleovestibular ganglion (CVG) neurons in a highly specific, well-defined pattern, which is regulated by neurotrophic factors belonging to the neurotrophin family. The inner ear offers a suitable model for studying the expression of MAPs and assessing their role in neurotrophin-induced effects that are required for neuron-target innervation. The present study was undertaken to analyze the expression and localization of MAP5 isoforms during development of CVG neurons in vivo and in vitro; as well as the regulation of MAP5 by neurotrophin-3 (NT3) in cell culture. MAP5 expression in the inner ear of chick embryos and postnatal specimens was monitored using immunoblots and immunohistochemistry on frozen sections. MAP5 was highly expressed during the early stages of CVG development, at embryonic day (E)4, being located in both neuronal perikarya and neurites. Expression was maintained during the neurite outgrowth phase (E6–E12), when strong MAP5 immunostaining was observed at the same cellular locations. MAP5 expression decreased suddenly at E14, after the establishment of specific connections between the CVG neurons and their targets, the sensory epithelium of the inner ear. In cultured CVG neurons addition of NT3 led to increased MAP5 expression and produced neurite outgrowth. Both effects are differentially regulated in parallel by low (0.5 ng/ml) and high (5 ng/ml) NT3 concentrations. Present results suggest that MAP5 may be involved in neurotrophin-induced microtubule bundling during neurite outgrowth of auditory neurons.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Medium-chain fatty acids (C6 to C12), produced by yeast metabolism during alcoholic fermentation, are known to be inhibitory to lactic acid bacteria. The purpose of this work was to clarify the effect of both ethanol and decanoic and dodecanoic acids on the growth and malolactic activity of a Leuconostoc oenos strain isolated from Portuguese red wine. Ethanol in concentrations up to 12% had no significant effect on malolactic activity but strongly inhibited cell growth. The fatty acids decanoic acid, in concentrations up to 12.5 mg l-1, and, dodecanoic acid up to 2.5 mg l-1 seemed to act as growth factors stimulating also malolactic activity; at higher concentrations they exerted an inhibitory effect. We found clear pH dependence between pH 3.0 and pH 6.0, between decanoic acid concentration and its effect on malolactic activity, indicating that the undissociated molecule is the active form. At pH 3.0 the results can be explained by considering that fatty acids enter the cell as protonated molecules and dissociate in the cytoplasm due to the higher internal pH, leading to increased intracellular hydrogenous concentration. This may be the basis of two different effects that contribute to the observed inhibition: decrease in the intracellular pH and dissipation of the transmembrane proton gradient, thus inhibiting intracellular enzymes and ΔpH-dependent transport systems.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Strips of rabbit anococcygeus muscle were submaximally contracted by the addition of phenylephrine to the bath fluid.2. Acetylcholine, dimethylphenylpiperazinium and electrical field stimulation caused relaxation. Relaxation induced by acetylcholine and field stimulation was blocked by tetrodotoxin but only the acetylcholine-induced response was inhibited by lignocaine, tetraethylammonium and hexamethonium. The responses to both acetylcholine and field stimulation were resistant to atropine, practolol, and sotalol.3. Relatively high concentrations of ATP caused relaxation.4. Histological investigation did not show any cells resembling autonomic ganglion cells.5. It is suggested that both acetylcholine and field stimulation release an inhibitory transmitter from nerve endings and that the release by acetylcholine is mediated through nicotinic receptor stimulation.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-072X
    Keywords: Key wordsParacoccidioides brasiliensis ; Fungal ; dimorphism ; Polyamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Putrescine and spermidine were the only polyamines found in Paracoccidioides brasiliensis, a dimorphic fungus pathogenic for humans. Free polyamines (putrescine 〉 spermidine) increased during the first 24 h of yeast growth, with a second peak at 42 h, and also during the first 12 h of mycelium-to-yeast transition (spermidine 〉 putrescine). Conjugated and bound polyamines were also quantified. 1,4-Diamino-2-butanone decreased free putrescine and spermidine accumulation by inhibiting the activity of ornithine decarboxylase. The increase in free polyamines corresponds to bud emergence in yeast growth and to the mycelium-to-yeast transition of P. brasiliensis.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Results of chemical analysis and ultrastructural study of the cell wall of a thermosensitive dimorphic mutant ofParacoccidioides brasiliensis support the involvement of α-1,3-glucan in the process of dimorphism, but do not support a possible role of this glucan as being responsible for the yeast-like morphology of this pathogenic fungus.
    Type of Medium: Electronic Resource
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