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  • 1
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Brain Proteomics: Decoding Neuroproteomes using Mass-Spectrometry -- Applications of Amine-Reactive Tandem Mass Tags (TMT) in Human Neuroproteomics -- Application of Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) to Monitor Olfactory Proteomes during Alzheimer´s Disease Progression -- Protein Microarrays in Neurodegenerative Diseases -- Comprehensive Shotgun Proteomic Analyses of Oligodendrocytes using Ion Mobility and Data Independent Acquisition -- Non-Targeted Brain Lipidomics Profiling Performed by UPLC-ESI-qTOF-MS/MS -- Methods for Human Olfactory Bulb-Tissue Studies using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS) -- Neuroproteomics using Short GeLC-SWATH: From the Evaluation of Proteome Changes to the Clarification of Protein Function -- Analysis of Brain Phosphoproteome using Titanium Dioxide Enrichment and High Resolution LC-MS/MS -- N-Glycomics and N-Glycoproteomics of Human Cerebrospinal Fluid -- In Vivo Strategies to Isolate and Characterize the Neuronal Ubiquitinated Proteome -- Characterization of the Phosphoproteome and Sialoproteome in Brain Tissues by Mass Spectrometry -- Proteomic Analysis of SUMOylation in the Post-Ischemic Brain -- S-Nitrosylation in Alzheimer´s Disease using Oxidized Cysteine-Selective cPILOT -- Proteomic Analysis of Extracellular Vesicles in Neurological Diseases -- Quantitative In-Depth Profiling of the Postsynaptic Density Proteome to Understand the Molecular Mechanisms Governing Synaptic Physiology and Pathology -- Nuclear Proteomics for Exploring MK-801 Treated Oligodendrocytes to Better Understand Schizophrenia -- Localized Proteomics of Individual Neurons Isolated from Formalin-Fixed, Paraffin Embedded Tissue Sections using Laser Capture Microdissection -- Creation of Reusable Bioinformatics Workflows for Reproducible Analysis of LC-MS Proteomics Data -- Integration of Transcriptomic and Proteomic Data for Disease Insights
    Abstract: This volume focuses on protein analysis covering a wide spectrum of the utility of mass spectrometry within neurobiological disciplines. The chapters in this book discuss label (iTRAQ, TMT, protein arrays) and label-free workflows (SWATH, MALDI Imaging, and label-free quantitation). Other chapters look at experimental strategies targeted to the identification and quantitation of specific lipids and post-translational modifications, as well as proteomic workflows that focus on characterization of subcellular proteomes. The last few chapters in the book describe various bioinformatics pipelines used to analyze the molecular data derived from high-throughput transcriptomic and proteomic experiments on brain tissue. The Neuromethods series offers chapters with key advice and procedure specifics to empower the readers to successfully achieve their own scientific and experimental goals. Thorough and comprehensive, Current Proteomic Approaches Applied to Brain Function is a valuable resource for graduate students and postdoctoral fellows interested in neuroproteomics, as well as researchers looking for further insight into the growing field of mass spectrometry in neuroscience
    Pages: XVI, 360 p. 91 illus., 61 illus. in color. : online resource.
    ISBN: 9781493971190
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  • 2
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume discusses techniques to synthesize and functionalize nanoparticles, monitor their delivery and uptake, and identify and evaluate their lethal and non-lethal effects on the metabolic activity of the nervous system. The chapters in this book are divided into 4 sections: photo-stimulation, thermal stimulation, mechanical perturbation, and toxicity and physiological effects. The first 3 sections ℗ focus on nanoparticle interactions with external sources that disturb the neuronal system, while the 4th explores the effects of having nanoparticles in a neuronal system in the absence of external stimuli. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Use of Nanoparticles in Neuroscience is a valuable resource for graduate students and specialized researchers that want to learn techniques needed to quantify experiments that use nanoparticles in the nervous system
    Pages: XVI, 296 p. 98 illus., 66 illus. in color. : online resource.
    ISBN: 9781493975846
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  • 3
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Brain Proteomics: Decoding Neuroproteomes using Mass-Spectrometry -- Applications of Amine-Reactive Tandem Mass Tags (TMT) in Human Neuroproteomics -- Application of Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) to Monitor Olfactory Proteomes during Alzheimer´s Disease Progression -- Protein Microarrays in Neurodegenerative Diseases -- Comprehensive Shotgun Proteomic Analyses of Oligodendrocytes using Ion Mobility and Data Independent Acquisition -- Non-Targeted Brain Lipidomics Profiling Performed by UPLC-ESI-qTOF-MS/MS -- Methods for Human Olfactory Bulb-Tissue Studies using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS) -- Neuroproteomics using Short GeLC-SWATH: From the Evaluation of Proteome Changes to the Clarification of Protein Function -- Analysis of Brain Phosphoproteome using Titanium Dioxide Enrichment and High Resolution LC-MS/MS -- N-Glycomics and N-Glycoproteomics of Human Cerebrospinal Fluid -- In Vivo Strategies to Isolate and Characterize the Neuronal Ubiquitinated Proteome -- Characterization of the Phosphoproteome and Sialoproteome in Brain Tissues by Mass Spectrometry -- Proteomic Analysis of SUMOylation in the Post-Ischemic Brain -- S-Nitrosylation in Alzheimer´s Disease using Oxidized Cysteine-Selective cPILOT -- Proteomic Analysis of Extracellular Vesicles in Neurological Diseases -- Quantitative In-Depth Profiling of the Postsynaptic Density Proteome to Understand the Molecular Mechanisms Governing Synaptic Physiology and Pathology -- Nuclear Proteomics for Exploring MK-801 Treated Oligodendrocytes to Better Understand Schizophrenia -- Localized Proteomics of Individual Neurons Isolated from Formalin-Fixed, Paraffin Embedded Tissue Sections using Laser Capture Microdissection -- Creation of Reusable Bioinformatics Workflows for Reproducible Analysis of LC-MS Proteomics Data -- Integration of Transcriptomic and Proteomic Data for Disease Insights
    Abstract: This volume focuses on protein analysis covering a wide spectrum of the utility of mass spectrometry within neurobiological disciplines. The chapters in this book discuss label (iTRAQ, TMT, protein arrays) and label-free workflows (SWATH, MALDI Imaging, and label-free quantitation). Other chapters look at experimental strategies targeted to the identification and quantitation of specific lipids and post-translational modifications, as well as proteomic workflows that focus on characterization of subcellular proteomes. The last few chapters in the book describe various bioinformatics pipelines used to analyze the molecular data derived from high-throughput transcriptomic and proteomic experiments on brain tissue. The Neuromethods series offers chapters with key advice and procedure specifics to empower the readers to successfully achieve their own scientific and experimental goals. Thorough and comprehensive, Current Proteomic Approaches Applied to Brain Function is a valuable resource for graduate students and postdoctoral fellows interested in neuroproteomics, as well as researchers looking for further insight into the growing field of mass spectrometry in neuroscience
    Pages: XVI, 360 p. 91 illus., 61 illus. in color. : online resource.
    ISBN: 9781493971190
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  • 4
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-6903
    Keywords: Quinolinic acid ; nitric oxide ; neurotoxicity ; lipid peroxidation ; oxidative stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nitric oxide (NO) is a potential contributor to neurotoxicity following overactivation of N-methyl-D-aspartate (NMDA) receptors. In this work we investigated the effect of Nω-nitro-L-arginine (L-NARG 25, 50, or 100 μM), a selective inhibitor of nitric oxide synthase (NOS) -the synthetic enzyme of NO- on quinolinic acid (QUIN 100 μM)-induced neurotoxicity (measured as lactate dehydrogenase (LDH) leakage) in rat striatal slices. Oxidative stress was also measured both as lipid peroxidation and as the levels of reduced (GSH) and oxidized (GSSG) glutathione, in an effort to elucidate a possible participation of NO in the toxic mechanisms involved in NMDA receptor-mediated neuronal injury. The action of L-arginine (L-ARG 100 or 200 μM), a well-known NO precursor, was also tested on QUIN-induced neurotoxicity and oxidative stress. Results showed that QUIN produced significant changes in both cell damage (177%) and oxidative injury (203% in lipid peroxidation, 68% in GSH, and 123% in GSSG) as compared to control values. All these effects were antagonized by adding L-NARG to the incubation media, whereas L-ARG alone, or in combination with QUIN, significantly enhanced both lipid peroxidation and LDH leakage. Moreover, the protective effects of L-NARG on QUIN-induced lipid peroxidation were reversed by addition of an excess of L-ARG to the media. These findings indicate that NO is probably mediating the mechanism of neurotoxicity produced by QUIN, which may be of potential value to explain the molecular basis of neurodegenerative processes linked to QUIN-mediated NMDA receptor overactivation.
    Type of Medium: Electronic Resource
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  7th EFSMA - European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation; 20111026-20111029; Salzburg; DOC11esm167 /20111024/
    Publication Date: 2011-10-24
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 7
    Abstract: Patients with advanced Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant lung adenocarcinoma are currently treated with standard chemotherapy because of a lack of efficacious targeted therapies. We reasoned that the identification of mediators of Kras signaling in early mouse lung hyperplasias might bypass the difficulties that are imposed by intratumor heterogeneity in advanced tumors, and that it might unveil relevant therapeutic targets. Transcriptional profiling of Kras(G12V)-driven mouse hyperplasias revealed intertumor diversity with a subset that exhibited an aggressive transcriptional profile analogous to that of advanced human adenocarcinomas. The top-scoring gene in this profile encodes the tyrosine kinase receptor DDR1. The genetic and pharmacological inhibition of DDR1 blocked tumor initiation and tumor progression, respectively. The concomitant inhibition of both DDR1 and Notch signaling induced the regression of KRAS;TP53-mutant patient-derived lung xenografts (PDX) with a therapeutic efficacy that was at least comparable to that of standard chemotherapy. Our data indicate that the combined inhibition of DDR1 and Notch signaling could be an effective targeted therapy for patients with KRAS-mutant lung adenocarcinoma.
    Type of Publication: Journal article published
    PubMed ID: 26855149
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  • 8
  • 9
    Keywords: CELLS ; Germany ; human ; THERAPY ; DISEASE ; DISEASES ; ENZYMES ; GENE ; GENES ; MICE ; treatment ; knockout ; IDENTIFICATION ; ESCHERICHIA-COLI ; MUTATION ; BIOSYNTHESIS ; DISPLAY ; MUTATIONS ; COMPLEMENTATION ; Jun ; PHENOTYPE ; isolation ; DEFICIENCY ; THERAPIES ; RESCUE ; SULFUR ; MOLYBDOPTERIN SYNTHASE GENE ; NITRATE REDUCTASE ; OXIDOREDUCTASE ; SULFITE OXIDASE ; XANTHINE DEHYDROGENASE
    Abstract: Substitution therapies for orphan genetic diseases, including enzyme replacement methods, are frequently hampered by the limited availability of the required therapeutic substance. We describe the isolation of a pterin intermediate from bacteria that was successfully used for the therapy of a hitherto incurable and lethal disease. Molybdenum cofactor (Moco) deficiency is a pleiotropic genetic disorder characterized by the loss of the molybdenum-dependent enzymes sulphite oxidase, xanthine oxidoreductase and aldehyde oxidase due to mutations in Moco biosynthesis genes. An intermediate of this pathway-'precursor Z'-is more stable than the cofactor itself and has an identical structure in all phyla. Thus, it was overproduced in the bacterium Escherichia coli, purified and used to inject precursor Z-deficient knockout mice that display a phenotype which resembles that of the human deficiency state. Precursor Z-substituted mice reach adulthood and fertility. Biochemical analyses further suggest that the described treatment can lead to the alleviation of most symptoms associated with human Moco deficiency
    Type of Publication: Journal article published
    PubMed ID: 15115759
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  • 10
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  7th EFSMA - European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation; 20111026-20111029; Salzburg; DOC11esm199 /20111024/
    Publication Date: 2011-10-24
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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