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  • 1
    Rosa, R. G., Falavigna, M., Robinson, C. C., da Silva, D. B., Kochhann, R., de Moura, R. M., Santos, M. M. S., Sganzerla, D., Giordani, N. E., Eugenio, C., Ribeiro, T., Cavalcanti, A. B., Bozza, F., Azevedo, L. C. P., Machado, F. R., Salluh, J. I. F., Pellegrini, J. A. S., Moraes, R. B., Hochegger, T., Amaral, A., Teles, J. M. M., da Luz, L. G., Barbosa, M. G., Birriel, D. C., Ferraz, I. d. L., Nobre, V., Valentim, H. M., Correa e Castro, L., Duarte, P. A. D., Tregnago, R., Barilli, S. L. S., Brandao, N., Giannini, A., Teixeira, C., The ICU Visits Study Group Investigators and the BRICNet, Albuquerque, Vasconcelos, Monteiro, Ticianeli, Leite, Barbosa, Horstmann, Paulo, Barreto, Ferreira, Couto, Oliveira, Freitas, Oliveira, Sampaio, Casaes, Cordeiro, Guimaraes, Silva, Pissinate, Lima, Araujo, Muniz, Klemz, Neves, Ferraz, E silva, Ferreira, Soares, Menezes, Pedroso, Silva, Padua, Castilho, Martins, Oliveira, Oliveira, Carvalho, Pereira, Souza, Ataide, Paranhos, Meireles, Silva, Santos, Assuncao, Monteiro, Silva, Ferreira, Silva, Vasconcelos, E silva, Siva, Mendes, Luz, Albuquerque, Nobre, Germano, Nascimento, Lucena, Costa, Bezerra, Nascimento, Leite, Barros, Vasconcelos, Gallindo, Silva, Manzi, Nogueira, Oliveira, Xavier, Ribeiro, Vlieger junior, Prestes, Vieira, Santos, Lima, Moura, Schmidt, Becker, Ayres, Hoshino, Jorge, Sodre, Oliveira, Entrago, Barcellos, Vilela, Silva, Dantas, Monteiro, Brito, Magalhaes, Silva, Miguel, Karnopp, Bonatto, Rosa, Rutzen, Bastos, Teixeira, Nedel, Dalpra, Lazzari, Specht, Lincho, Pilau, Foscarini, Fraporti, Tallamini, Forni, Santos, Silva, Ferreira, Santos, Carvalho, Schmitz,, Prieb, Filho, Mello, Hohenreuther, Susin, Beck, Martins, Hoff, Silveira, Prestes, Pizzato, Rosa, Cremonese, Santos, Leivas, Pettine, Dobrinsky, Foernges, Carvalho, Souza, Cardoso, Torelly, Hadrich, Marins, Baldisserotto, Santos, Bettega, Barcellos, Silveira, Flores, Giacomazzi, Costa, Souza, Silva, Silva, Xis, Vargas, Filho, Mohr, Souza, Aguiar, Arruda, Lovato, Carvalho, Sprioli, Cerantola, Gomes, Perez, Werneck, Vasconcelos, Neves, Dassi
    BMJ Publishing
    In: BMJ Open
    Publication Date: 2018-04-14
    Description: Introduction Flexible intensive care unit (ICU) visiting hours have been proposed as a means to improve patient-centred and family-centred care. However, randomised trials evaluating the effects of flexible family visitation models (FFVMs) are scarce. This study aims to compare the effectiveness and safety of an FFVM versus a restrictive family visitation model (RFVM) on delirium prevention among ICU patients, as well as to analyse its potential effects on family members and ICU professionals. Methods and analysis A cluster-randomised crossover trial involving adult ICU patients, family members and ICU professionals will be conducted. Forty medical-surgical Brazilian ICUs with RFVMs (〈4.5 hours/day) will be randomly assigned to either an RFVM (visits according to local policies) or an FFVM (visitation during 12 consecutive hours per day) group at a 1:1 ratio. After enrolment and follow-up of 25 patients, each ICU will be switched over to the other visitation model, until 25 more patients per site are enrolled and followed. The primary outcome will be the cumulative incidence of delirium among ICU patients, measured twice a day using the Confusion Assessment Method for the ICU. Secondary outcome measures will include daily hazard of delirium, ventilator-free days, any ICU-acquired infections, ICU length of stay and hospital mortality among the patients; symptoms of anxiety and depression and satisfaction among the family members; and prevalence of burnout symptoms among the ICU professionals. Tertiary outcomes will include need for antipsychotic agents and/or mechanical restraints, coma-free days, unplanned loss of invasive devices and ICU-acquired pneumonia, urinary tract infection or bloodstream infection among the patients; self-perception of involvement in patient care among the family members; and satisfaction among the ICU professionals. Ethics and dissemination The study protocol has been approved by the research ethics committee of all participant institutions. We aim to disseminate the findings through conferences and peer-reviewed journals. Trial registration NCT02932358 .
    Keywords: Open access, Intensive care
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 2
    Keywords: Coal gasification. ; Fuel, Combustion. ; Fuel, Combustion, Equipment and supplies.
    Pages: xxv, 439 p.
    ISBN: 0-203-02729-9
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  • 3
    Amsterdam ; New York : Pergamon
    Keywords: Automobile drivers, Psychology. ; Automobile driving. ; Automobilistes, Psychologie. ; Conduite automobile. ; Ergonomie. ; Highway engineering. ; Human engineering. ; Technique routière.
    Pages: xi, 325 p.
    Edition: 1st ed
    ISBN: 0-585-47531-8
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  • 4
    Keywords: Life sciences ; Animal ecology ; Biodiversity ; Evolution (Biology) ; Entomology ; Life sciences ; Entomology ; Animal ecology ; Biodiversity ; Evolutionary Biology ; Springer eBooks
    Description / Table of Contents: Introduction -- 1. Neotropical Insect galls: status of knowledge and perspectives; G. Wilson Fernandes et al -- 2. Developmental Anatomy of Galls in the Neotropics: Arthropods Stimuli vs. Host Plant Constraints; Rosy Mary dos Santos Isaias et al -- 3. Functional Gradients in Insect Gall Tissues: Studies on Neotropical Host Plants; Denis Coelho de Oliveira et al -- 4. Gall Morphotypes in the Neotropics and the Need to Standardize Them; Rosy Mary dos Santos Isaias et al -- 5. Population Ecology of Galling Arthropods in the Neotropics; Tiago Shizen Pacheco Toma, Milton de Souza Mendonça Jr -- 6. Bottom-up Effects on Gall Distribution; Milton Barbosa, Geraldo Wilson Fernandes -- 7. Natural selection on a tropical system: gall-size distribution on Waltheria indica L. (Malvaceae); José M. A. Figueiredo et al -- 8. Density of insect galls in the forest understorey and canopy: Neotropical, Gondwanan or global patterns?; Sérvio Pontes Ribeiro et al -- 9. Galling insects as indicators of habitat quality; Tiago Shizen Pacheco Toma et al -- 10. Host specificity of gall midges (Diptera: Cecidomyiidae) on ten species of Inga (Fabaceae); Amandine Bourg, Paul Hanson -- 11. Galling insect community associated with Copaifera langsdorffii (Fabaceae): the role of inter- and intra-annual host plant phenology; Marcilio Fagundes -- 12. Galling insects on Caryocar brasiliense Camb. (Caryocaraceae); Germano Leão Demolin Leite -- 13. Baccharis: a Neotropical Model System to Study Insect Plant Interactions; G. Wilson Fernandes et al -- 14. Galls and Galling Arthropods of southern Brazil; Milton de Souza Mendonça et al -- 15. Galling insects in the Brazilian Cerrado: Ecological patterns and perspectives; Walter Santos de Araújo et al -- 16. Galls in Brazilian mountains: new reports and perspectives; Marco Antonio A. Carneiro et al -- 17. Galls in the Brazilian Coastal Vegetation; Valéria Cid Maia et al -- 18. Galls from Brazilian Atlantic Forest: status of knowledge and perspectives; Jean Carlos Santos et al -- 19. Galling Insects in the Pantanal Wetland and Amazonian Rainforest; Genimar Rebouças Julião et al -- 20. Galls from Brazilian Tropical Dry Forests: status of knowledge and perspectives; Marcel S. Coelho et al -- 21. Galls of the temperate forest of southern South America: Argentina and Chile; Carolina Quintero et al -- 22. Gall-Inducing Insects and Their Associated Parasitoid Assemblages in the Forests of Panama; Enrique Medianero et al -- 23. Insect galls of Costa Rica and their parasitoids; Paul Hanson et al -- 24. Mexican gall-inducing insects: importance of biotic and abiotic factors on species richness in tropical dry forest; Pablo Cuevas-Reyes et al
    Abstract: This book focuses on one of the most sophisticated guild herbivorous insects, the gall inducing insects.℗ They trespass the defensive lines of their host plants, engineer the host to provide their larvae with shelter against the external harsh environment and natural enemies and in addition provide better food to their larvae.℗ Not surprisingly the gall is often regarded as an extended phenotype of the inducing insect.℗ The reader will find in this book the most updated ecological and evolutionary information on the biogeopgraphy of galling insects in the New World Tropics.℗ Topics range from the very first reactions of the host plant cells to the gall inducing larvae up to the natural enemies that control galling populations, including galling insect relationships with habitats that ultimately result in their spatial distribution and diversity. The book also addresses many important questions in galling studies, such as the role of superhosts, the host plant defenses to galling, and the importance of habitat harshness at the canopy of rain forests, among many other issues.℗ Finally, the book also describes the galling richness in many different Neotropical vegetation types.℗ The reader will find that the information depicted helps to challenge former hypohteses on their geography and diversity, provides new syntheses and open new perspsectives for the study of this℗ spectacular herbivore guild
    Pages: IX, 550 p. 132 illus., 56 illus. in color. : online resource.
    ISBN: 9789401787833
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  • 5
    Keywords: Pharmaceutical technology ; Astronautics ; Astrophysics ; Pharmaceutical Sciences/Technology ; Aerospace Technology and Astronautics ; Space Sciences (including Extraterrestrial Physics, Space Exploration and Astronautics) ; Springer Nature Living Reference
    Description / Table of Contents: Section I: Principles of Pharmaceuticals -- Section II: Effects of Spaceflight on Human Physiology and its Consequences on Drug Treatment -- Section III: Model Organisms for Pharmaceutical Research in Space -- Section IV: Simulated Microgravity for Pharmaceutical Research -- Section V: Translating Knowledge from Spaceflight Research to Earth Applications -- Section VI: Nutritional and Alternative Approaches to Treatment in Space -- Section VII: Spaceflight Medical Incidents and Potential Pharmaceutical Solutions
    Abstract: This two-volume handbook, directed at medical professionals who are involved in developing the space industry or are academicians (such as at Harvard, Stanford, and MIT) doing research in this area, covers current pharmaceutical knowledge about the difference in medication efficacy in space versus on Earth and includes trial results and best practices for the space research and travel industry. The well-known contributors come from an interdisciplinary background and address all aspects of the subject, from the physiological impact of spaceflight to the effects of radiation. As the commercial space industry expands its operations in industry and tourism, the field of space pharmaceuticals is growing commensurately. Existing pharmacological research from space is thoroughly covered in this book, and Earth applications are also described. Potential pharmacological solutions are posed along with the known challenges and examples from existing studies, which are detailed at length. This major reference work is a comprehensive and important medical resource for all space industry players
    Pages: : online resource.
    ISBN: 9783319509099
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  • 6
    Keywords: Medicine ; Medical parasitology ; Emerging infectious diseases ; Microbial genetics ; Biomedicine ; Parasitology ; Microbial Genetics and Genomics ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: Preface -- Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure -- Selection of Molecular Targets for Drug Development against Trypanosomatids -- A2 and other visceralizing proteins of Leishmania: role in pathogenesis and application for vaccine development -- Arginase in Leishmania -- The heat shock proteins of Trypanosoma cruzi -- The Gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms -- The Gp85 Surface Glycoproteins from Trypanosoma cruzi -- Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications -- Surface Topology Evolution of Trypanosoma Trans-Sialidase -- Ecto-Nucleotidases and Ecto-Phosphatases from Leishmania and Trypanosoma Parasites -- Gp63 Function in the Interaction of Trypanosomatids with the Invertebrate Host – Facts and Prospects -- Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis -- The Expected Outcome of the Trypanosoma cruzi Proteomic Map: a Review of its Potential Biological Applications for Drug Target Discovery -- Proteomics advances in the study of Leishmania parasites and leishmaniasis -- Towards the Phosphoproteome of Trypanosomatids. Index
    Abstract: This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteome of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers
    Pages: X, 381 p. 55 illus., 37 illus. in color. : online resource.
    ISBN: 9789400773059
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  • 7
    Keywords: Life sciences ; Life sciences ; Life Sciences, general ; Springer eBooks
    Pages: : digital.
    ISBN: 9789086867554
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  • 8
    Keywords: Bioinformatics ; Bioinformatics ; Springer eBooks
    Description / Table of Contents: Rule-based Models and Applications in Biology -- Optimized Protein-protein Interaction Network usage with Context Filtering -- SignaLink: Multi-layered Regulatory Networks -- Interplay between Long Non-coding RNAs and microRNAs in Cancer -- Methods and Tools in Genome-wide Association Studies -- Identifying Differentially Expressed Genes using Fluorescence-Activated Cell Sorting (FACS) and RNA Sequencing from Low Input Samples -- Computational and Experimental Approaches to Predict Host-parasite Protein-protein Interactions -- An Integrative Approach to Virus-host Protein-protein Interactions -- The SQUAD Method for the Qualitative Modeling of Regulatory Networks -- miRNet - functional Analysis and Visual Exploration of miRNA-target Interactions in a Network Context -- Systems Biology Analysis to Understand Regulatory miRNA Networks in Lung Cancer -- Spatial Analysis of Functional Enrichment (SAFE) in Large Biological Networks -- Toward Large Scale Computational Prediction of Protein Complexes -- Computational Models of Cell Cycle Transitions -- Simultaneous Profiling of DNA Accessibility and Gene Expression Dynamics with ATAC -- Computational Network Analysis for Drug Toxicity Prediction -- Modeling the Epigenetic Landscape in Plant Development -- Developing Network Models of Multi-scale Host Responses Involved in Infections and Diseases -- Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling
    Abstract: This volume details computational techniques for analyses of a wide range of biological contexts, providing an overview of the most up-to-date techniques used in the field. Chapters guide the reader through available data resources and analysis methods and easy-to-follow protocols that allow the researcher to apply various computational tools to an array of different data types. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Cell Biology: Method and Protocols aims to ensure successful results in the further study of this vital field
    Pages: XI, 436 p. 77 illus., 69 illus. in color. : online resource.
    ISBN: 9781493986187
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  • 9
    Keywords: Chemistry ; Biotechnology ; Microscopy ; Nanotechnology ; Chemistry ; Biotechnology ; Nanotechnology ; Biological Microscopy ; Springer eBooks
    Description / Table of Contents: Quantum Dots as Biophotonics Tools -- Photoligation Combined with Zwitterion-Modified Lipoic Acid Ligands Provides Compact and Biocompatible Quantum Dots -- Analysis of Quantum Dots and Their Conjugates by Capillary Electrophoresis with Detection of Laser-Induced Luminescence -- Advanced Procedure for Oriented Conjugation of Full-Size Antibodies with Quantum Dots -- Quantum Dots-Antibody Conjugates via Carbodiimide-Mediated Coupling for Cellular Imaging -- Measuring the Hydrodynamic Radius of Quantum Dots by Fluorescence Correlation Spectroscopy -- Quantum Dots Fluorescence Quantum Yield Measured by Thermal Lens Spectroscopy -- Semiquantitative Fluorescence Method for Bioconjugation Analysis -- Assembly, Characterization and Delivery of Quantum Dot Labeled Biotinylated Lipid Particles -- Oriented Conjugation of Single-Domain Antibodies and Quantum Dots -- Functional Integration of Quantum Dot Labeled Mesenchymal Stem Cells in a Cardiac Microenvironment -- In Vitro Approaches to Assessing the Toxicity of Quantum Dots -- Basics for the Preparation of Quantum Dots and their Interactions with Living Cells -- In Vivo Approaches to Assessing the Toxicity of Quantum Dots -- Quantum Dots for Imaging Neural Cells In Vitro and In VivoA Short-Term Inhalation Study Protocol – Designed for Testing of Toxicity and Fate of Nanomaterials -- Quantitative Measurement of Proteolytic Rates with Quantum Dot-Peptide Substrate Conjugates and Förster Resonance Energy Transfer -- Solid-Phase Supports for the in situ Assembly of Quantum Dot-FRET Hybridization Assays in Microfluidics
    Abstract: In Quantum Dots: Applications in Biology, Second Edition, expert researchers in the field detail consolidated approaches as well as new trends in the field. Organized into five parts, the first part comprises an introduction on Quantum Dots(QDs) as fluorescent probes in Life Sciences. While the second section covers important features about QDs℗þ preparative processes and characterizations for their successful application as fluorophores. The third part presents main aspects related to QDs methods applied to live cells and tissues. The fourth section focuses on QDs experiments in small animals, and the fifth part demonstrates the versatility of QDs in a set of FRET applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. ℗ ℗ Thorough and intuitive, In Quantum Dots: Applications in Biology, Second Edition aids scientists in continuing to study QDs by providing information about methods and protocols helping to expand their research
    Pages: XI, 258 p. 76 illus., 65 illus. in color. : online resource.
    Edition: 2nd ed. 2014.
    ISBN: 9781493912803
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  • 10
    Keywords: Biomedical Engineering ; Microbiology ; Biomedical Engineering/Biotechnology ; Microbiology ; Springer eBooks
    Description / Table of Contents: Pathway and Gene Discovery from Natural Hosts and Organisms -- Metabolic In silico Network Expansions to Predict and Exploit Enzyme Promiscuity -- Antisense RNA Elements for Downregulating Expression -- Chemically Inducible Chromosomal Evolution (CIChE) for Multi-copy Metabolic Pathway Engineering -- Bacterial Expression of Membrane Associated Cytochrome P450s and their Activity Assay in Nanodiscs -- Delta Integration CRISPR-Cas (Di-CRISPR) in Saccharomyces cerevisiae -- Assembly of Complex Pathways using Type IIs Restriction Enzymes -- Combinatorial Assembly of Multigene Pathways by Combining Single Strand Assembly with Golden Gate Assembly -- Checks and Balances with Use of the Keio Collection for Phenotype Testing -- Genetic Engineering of Cyanobacteria: Design, Implementation, and Characterization of Recombinant Synechocystis sp. PCC 6803 -- Genetic Tools for Streamlined and Accelerated Pathway Engineering in Yarrowia lipolytica -- Gas Chromatography-mass Spectrometry Microbial Metabolomics for Applications in Strain Optimization -- Targeted Mass Spectrometry-based Proteomics Tools for Strain Optimization -- A Protocol for the Construction and Curation of Genome-scale Integrated Metabolic and Regulatory Network Models -- 13C-Fingerprinting and Metabolic Flux Analysis of Microbial Metabolisms -- A Genetic Screen for the Isolation of Mutants with Increased Flux in the Isoprenoid Pathway of Yeast
    Abstract: This volume covers a wide array of topics that will aid researchers in the task of engineering complex biological systems. This book is divided into three parts: Part One discusses the discovery and identification of relevant biosynthetic pathways for engineering; Part Two looks at the development of genetic tools for manipulating enzymes, biosynthetic pathways, and whole genomes; and Part Three covers the characterization of engineered microbes using targeted and global systems biology tools, as well as in silico models. Chapters explore topics such as leveraging enzyme promiscuity to construct novel biosynthetic pathways; assembling combinatorial multigene pathways for rapid strain optimization; applying 'omics technologies for identifying bottlenecks; and engineering nontraditional host organisms like cyanobacterium and Yarrowia lipolytica. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, Microbial Metabolic Engineering: Methods and Protocols is a valuable resource for researchers and scientists interested in engineering and optimizing microbes for a variety of biotechnological applications
    Pages: X, 252 p. 46 illus., 39 illus. in color. : online resource.
    ISBN: 9781493991426
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