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  • 1
    ISSN: 1432-1106
    Keywords: Noradrenergic hyperactivity ; NE ; ACh ; Fornix section ; DSP4 ; Spatial memory ; Alzheimer's disease ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats with unilateral or bilateral partial section of the fornix were impaired on an eight arm radial maze task. Neurochemical analysis of hippocampal tissue four weeks after the lesions revealed a 50% reduction of choline acetyltransferase (ChAT) activity. The cholinergic marker was correlated negatively with the number of errors in the maze; the lower the ChAT activity, the higher the error score. The fornix lesion also induced a 50% reduction in norepinephrine (NE), but no change in the noradrenergic metabolite methylhydroxyphenylglycol (MHPG), suggesting a net increase in turnover of NE in these animals. Additional lesion of the noradrenergic system with the neurotoxin DSP4 reduced both MHPG and NE levels by more than 90%, compared to nonlesioned controls, and reversed the behavioral deficit. This treatment had no further effect on cholinergic markers. There was a significant negative correlation between ChAT activity and the index of NE turnover, suggesting that hyperactivity in the noradrenergic system after fornix section inhibits the spared cholinergic function and thus exacerbates the cognitive deficit. The pattern of neurochemical results bear a striking resemblance to those seen in some Alzheimer's patients and suggest that an equilibrium among neurotransmitters is important to cognitive function.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Hypoxia ; Memory Consolidation ; One Trial ; Learning ; Piracetam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were given Piracetam or saline 30 min orally before one trial passive avoidance training; after training they were submitted to nitrogen induced hypoxia (“Sudden” and “Progressive” procedure) or were confined to the hypoxia cage with a normal atmosphere. Results showed that 1. hypoxia prevented the avoidance response on day 2 for the saline injected animals and 2. Piracetam protected the animals from this hypoxia induced amnesia. The results are discussed in terms of electrophysiological and biochemical modifications which have been found to be associated with both hypoxia and Piracetam.
    Type of Medium: Electronic Resource
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