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  • 1
    Keywords: IN-VIVO ; SYSTEM ; magnetic resonance ; virus ; monitoring
    Type of Publication: Journal article published
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie; 20040425-20040428; Köln; DOCMO.11.01 /20040423/
    Publication Date: 2004-04-22
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    facet.materialart.
    German Medical Science; Düsseldorf, Köln
    In:  55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie; 20040425-20040428; Köln; DOCP 09.100 /20040423/
    Publication Date: 2004-04-22
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 9 (1999), S. 1047-1054 
    ISSN: 1432-1084
    Keywords: Key words: Brain tumors ; MR imaging ; Neuronavigation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The radiologic modality that most likely provides the imaging information needed in a patient suspected of having a brain tumor is MR imaging. A brain tumor can be reliably ruled out if the MR examination is performed properly and experts interpret the results as negative. If there is a tumor, however, its exact location and topography must be determined. Important for therapy and prognosis are also tumor properties such as histologic type and grade, as well as effects on adjacent brain structures. Although potentially a noninvasive method of in vivo neuropathology, MR is still far from being sufficiently specific, as dissimilar lesions may look the same despite the use of refined imaging protocols. The evolution of MR imaging continues, however, making further methodologic improvement likely. Presently, advanced methods, such as diffusion- and perfusion-weighted MR imaging, functional MR imaging, neuronavigation based on MR imaging data, and the use of MR imaging during surgery (intraoperative MR imaging), influence the way patients are treated. Likewise, follow-up imaging (monitoring) of tumor patients by MR has become more effective, and experience has shown how to distinguish reactive changes from recurrent tumor. In the future, MR imaging may gain importance in the development of novel therapeutic concepts.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1084
    Keywords: Key words: Cerebral CT ; Nonionic contrast media ; Isotonic dimer ; Double-blind method ; Iodixanol ; Iohexol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Iodixanol is a new nonionic dimer, isotonic with blood at all clinically relevant concentrations. Iodixanol (270 mg I/ml) was compared in a double-blind, randomized, parallel-group, phase-III study to the monomeric nonionic iohexol (300 mg I/ml) for evaluation of safety, tolerability and radiographic efficacy during cerebral CT. One hundred adult patients scheduled to undergo contrast-enhanced cerebral CT were randomly allocated to receive either iodixanol or iohexol. All completed the trial. Safety was evaluated by recording discomfort and other adverse events, tolerance by assessing intensity and incidence of discomfort. Radiographic efficacy was assessed from the diagnostic information and the radiographic density. No serious adverse events occurred. One patient (2 %) in the iodixanol group and one patient (2 %) in the iohexol group experienced a transient reddening at the neck and lower neck-line, respectively. Both contrast agents were well tolerated. One patient (2 %) in the iodixanol group and two patients (4 %) in the iohexol group experienced a sensation of warmth (discomfort) in connection with the injection. No difference between the two contrast media were noted radiographically. This comparison between iodixanol and iohexol showed both contrast media to be safe, well-tolerated and efficacious for use in cerebral CT.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 7 (1997), S. S203 
    ISSN: 1432-1084
    Keywords: Key words: Neuroimaging ; Diffusion-weighted MR ; Perfusion-weighted MR ; Infarction ; Ischaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Cerebral infarct causes over 170, 000 deaths per year in the United States. Recent developments in neuroimaging are providing an insight into focal cerebral ischaemia, including its pathophysiology and the area of brain at risk. Perfusion-weighted magnetic resonance (MR) allows evaluation of the blood supply to the ischaemic area, and diffusion-weighted MR permits assessment of tissue damage. Although both functional imaging techniques require some refinement, it is likely that they will soon become part of the normal clinical routine and allow accurate characterisation of pathology. It is expected that this may eventually lead to the development of new treatments.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Onkologe 6 (2000), S. 930-938 
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0942-0940
    Keywords: Middle cerebral artery occlusion ; cerebral blood flow ; ischaemia ; reperfusion ; laser Doppler flowmetry ; hydrogen clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monitoring cerebral blood flow during focal ischaemia and reperfusion with established techniques such as hydrogen clearance and autoradiography is difficult. Laser Doppler flowmetry is a new technique, it allows one to continuously measure blood flow in small tissue samples. The objective of this study was to compare laser Doppler flowmetry with hydrogen clearance using a new single fiber probe to obtain measurements in deep brain structures and then to show the temporal profile of cerebral blood flow during focal ischaemia and after reperfusion. First, the single fiber laser Doppler method was compared with the hydrogen clearance method in ten Wistar rats. Second, focal cerebral ischaemia was induced in fifteen Wistar rats using a model of middle cerebral artery occlusion based on the intravascular insertion of a nylon suture; reperfusion occurred after withdrawal of the suture. The laser Doppler probe was placed in the lateral caudatoputamen, and local cerebral blood flow was measured continuously before and during occlusion as well as after reperfusion. The relative blood flow values obtained by the laser Doppler method and the hydrogen clearance method showed a good correlation (r=0.76) and a linear relationship. A rapid decrease in laser Doppler flowmetry to 42±16% of former baseline values was seen with occlusion of the middle cerebral artery; during occlusion cerebral blood flow remained at this level. Reperfusion resulted in a heterogeneous pattern of cerebral blood flow as laser Doppler flowmetry values ranged from 25% to 134% of baseline values. The effects of middle cerebral artery occlusion and reperfusion on cerebral blood flow can be monitored on-line with laser Doppler flowmetry. Our findings suggest that this method, with the high spatial and temporal resolution characteristics of its new single fiber probe, allows one to continuously measure microcirculatory blood flow in deep brain structures.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Systematic review of the cerebral angiograms of 446 head trauma patients (1971–1978) revealed the presence of an arteriovenous (AV) fistula of the middle meningeal artery (MMA) in 8 cases (1.8%), the total number of angiographically demonstrable injuries of the MMA being 18 (4%). AV fistulae of the MMA may prevent formation of epidural haematoma, but they are frequently associated with so severe damage to skull and brain that prognosis is nevertheless grave. A close relationship between the tighter adherence of the dura to bone in older age and development of an AV fistula of the MMA following trauma to the skull may be presumed.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2102
    Keywords: Schlüsselwörter CTA ; Basilarisverschluß ; Basilaristhrombose ; Key words Basilar artery ; Occlusion ; Thrombosis ; Diagnosis ; Spiral CT angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background and purpose: Without recanalisation, acute basilar artery (BA) occlusion has a mortality of 90 %, which is reduced to 50 % if recanalisation is achieved. Fast diagnosis of BA occlusion is necessary in order to start thrombolytic therapy without delay. We wanted to assess the role of CT angiography (CTA) in the diagnostic evaluation of suspected acute BA occlusion. Materials and methods: Ten patients with clinically suspected BA occlusion were examined with conventional CT and spiral CT angiography. Spiral scanning extended from the foramen magnum to the tip of the basilar artery. For CTA, 130 ml of nonionic contrast media were injected into an antecubital vein. In four patients, transfemoral digital subtraction angiography (DSA) was additionally performed. All but one patient had a follow-up CT examination the next day. Results: CTA demonstrated BA occlusion in six patients and a partially thrombosed megadolichobasilar artery in one patient. In four of the six patients with CT angiographically diagnosed BA occlusion, an additional DSA was performed, which confirmed the CTA findings. In three patients the BA showed normal intravasal contrast, and follow-up CT did not show infarctions in the vertebrobasilar territory. Conclusion: Although the number of cases is still small, CTA seems to be a promising method for the rapid diagnosis of BA occlusion. It may become a valuable tool for therapy decisions in acute BA occlusions.
    Notes: Zusammenfassung Die Letalität nicht rekanalisierter akuter Basilarisverschlüsse liegt bei 90 %. Erfolgt eine Rekanalisation, sinkt die Mortalität auf etwa 50 %. Eine schnelle Diagnostik eines Basilarisverschlusses ist erforderlich, um gegebenenfalls eine thrombolytische Therapie zu beginnen. Wir berichten über erste Erfahrungen mit der CT-Angiographie (CTA) in der Diagnose akuter Basilarisverschlüsse. Bei 10 Patienten mit klinisch begründetem Verdacht auf einen Basilarisverschluß wurde eine CTA des hinteren Hirnkreislaufs durchgeführt, die bei 6 Patienten einen Verschluß der A. basilaris und bei einem Patienten eine teilthrombosierte Megadolicho-Basilaris zeigte. Bei 4 der 6 Patienten mit CT-angiographisch nachgewiesenem Basilarisverschluß wurde eine DSA durchgeführt, die die Diagnose bestätigte. Bei 3 Patienten, bei denen sich die gesamte A. basilaris in der CTA regelrecht kontrastierte, zeigte das Kontroll-CT keine Infarkte. Wenngleich unsere Fallzahlen noch gering sind, scheint die CTA ein vielversprechendes, schnelles Verfahren zur Diagnostik akuter Basilarisverschlüsse zu sein und könnte ein wichtiges Hilfsmittel bei Therapieentscheidungen werden.
    Type of Medium: Electronic Resource
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