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  • 1
    Hoboken, New Jersey : John Wiley & Sons Inc.
    Call number: QH587:31
    Keywords: Stem Cells / cytology ; Stem Cells / physiology ; Stem Cells / radionuclide imaging
    Description / Table of Contents: Cell and molecular biology and imaging of stem cells : stem cells from the amniotic fluid and placenta / Amritha Kidiyoor, Sean V. Murphy, and Anthony Atala -- Biomaterials as artificial niches for pluripotent stem cell engineering / Kyung Min Park and Sharon Gerecht -- Low-intensity ultrasound in stem cells and tissue engineering / Byung Hyune Choi, Kil Hwan Kim, Mrigendra Bir Karmacharya, Byoung-Hyun Min, and So Ra Park -- Mammalian neo-oogenesis from ovarian stem cells in vivo and in vitro / Antonin Bukovsky and Michael R. Caudle -- Oct4-EGFP transgenic pigs as a new tool for visualization of pluripotent and reprogrammed cells / Monika Nowak-Imialek and Heiner Niemann -- Regulation of adult intestinal stem cells through thyroid hormone-induced tissue interactions during amphibian metamorphosis / Atsuko Ishizuya-Oka -- Stem cell therapy for veterinary orthopedic lesions / Anna Paula Balesdent Barreira and Ana Liz Garcia Alves -- Sex steroid combinations in regenerative medicine for brain and heart diseases : the vascular stem cell niche and a clinical proposal / Antonin Bukovsky and Michael R. Caudle -- Hair follicle stem cells / Hilda Amalia Pasolli -- The potential of using induced pluripotent stem cells in skin diseases / Shigeki Ohta, Ophelia Veraitch, Hideyuki Okano, Manabu Ohyama, and Yutaka Kawakami -- Mitochondrial differentiation in early embryo cells and pluripotent stem cells / Heide Schatten, Qing-Yuan Sun, and Randall S. Prather -- The role of centrosomes in cancer stem cell functions / Heide Schatten
    Pages: xii, 292 p. : ill.
    ISBN: 9781118284100
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  • 2
    Keywords: Medicine ; Emerging infectious diseases ; Bacteriology ; Medicine & Public Health ; Infectious Diseases ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Luminex℗ʼ Multiplex Bead Suspension Arrays for the Detection and Serotyping of Salmonella spp. -- Quantitative Proteomic Identification of Host Factors Involved in the Salmonella typhimurium Infection Cycle -- Determination of Antimicrobial Resistance in Salmonella spp. -- Red-mediated Recombineering of Salmonella enterica Genomes -- A Method to Introduce an Internal Tag Sequence into a Salmonella Chromosomal Gene -- Generation and use of Site-directed Chromosomal cyaÁ€™ Translational Fusions in Salmonella enteric -- Detection of Antimicrobial (Poly)Peptides with Acid Urea Polyacrylamide Gel Electrophoresis followed by Western Immunoblot -- Detecting non-typhoid Salmonella in Humans by Enzyme-linked Immunosorbent Assays (ELISAs): Practical and Epidemiological Aspects -- Study of the Stn Protein in Salmonella; A Regulator of Membrane Composition and Integrity -- Development of a Bacterial Nanoparticle Vaccine -- Direct Attachment of Nanoparticle Cargo to Salmonella typhimurium℗ Membranes Designed for Combination Bacteriotherapy Against Tumors -- Applications of Microscopy in Salmonella Research -- Live Cell Imaging of Intracellular Salmonella enteric -- In vitro Modeling of Gallbladder-associated Salmonella spp. Colonization -- Salmonella Phages and Prophages ́€“ Genomics, Taxonomy,℗ and Applied Aspects
    Abstract: Salmonella: Methods and Protocols, Second Edition expands upon the previous edition with current, detailed methods on different aspects and landmarks advancing knowledge on salmonella research. With new chapters on molecular assays for detection, identification and serotyping of salmonella, quantitative proteomic identification of host factors involved in salmonella infection, determination of antimicrobial resistance in salmonella, site-directed mutagenesis, chromosomal gene analysis, development of bacterial nanoparticle vaccine, attachment of nanoparticle cargo to biotinylated salmonella for combination bacteriotherapy against tumors, various microscopy methods to analyze salmonella interaction with host cells, in vitro modeling of gallbladder-associated salmonella colonization, and analysis of salmonella phages and prophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Salmonella: Methods and Protocols, Second Edition present methods that are of value to investigators in the salmonella field
    Pages: XI, 301 p. 52 illus., 26 illus. in color. : online resource.
    Edition: 2nd ed. 2015.
    ISBN: 9781493916252
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  • 3
    Call number: YY Diss Scha/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 184 p. : ill.
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    YY Diss Scha/Mag departmental collection or stack – please contact the library
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  • 4
    Keywords: Life sciences ; Oncology ; Cytology ; Microscopy ; Life sciences ; Cell Biology ; Biological Microscopy ; Cancer Research ; Springer eBooks
    Description / Table of Contents: 1. Histopathology and grading of breast cancer -- 2. Multicentric/multifocal breast cancer: overview, biology and therapy -- 3. The immune system in breast cancer initiation and progression: role of epithelial to mesenchymal transition -- 4. Remodeling of the extracellular matrix: implications for cancer -- 5. Biology and treatment of basal-like breast cancer -- 6. Re-excision after lumpectomy for breast cancer -- 7. Novel anti-angiogenic therapies using naturally-occurring and synthetic drugs to combat progestin-dependent breast cancer -- 8. New insights on estrogen receptor actions in hormone-responsive breast cancer cells by interaction proteomics -- 9. Reprogramming breast cancer cells with embryonic microenvironments: insights from nodal signaling -- 10. Metastatic determinants: breast tumour cells in circulation -- 11. Breast cancer epigenetics: biomarkers and therapeutic potential -- 12. The impact of centrosome abnormalities on breast cancer development and progression with a focus on targeting centrosomes for breast cancer therapy -- 13. A New Perspective on Cyclin D1: beyond cell cycle regulation -- 14. Gene signatures of inflammatory breast cancer: epithelial plasticity and a cancer stem cell phenotype -- 15. An integrated human mammary epithelial cell culture system for studying carcinogenesis and aging -- 16. New breast cancer treatment considerations – a brief review of the use of genetically modified (attenuated) bacteria as therapy for advanced and metastatic breast cancer
    Abstract: Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics, the various impacts of designing new strategies, and identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and to all who are interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer
    Pages: VIII, 383 p. 55 illus., 51 illus. in color. : online resource.
    ISBN: 9781627036344
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  • 5
    Keywords: Life sciences ; Cytology ; Cell Cycle ; Life sciences ; Cell Biology ; Cell Cycle Analysis ; Cell Physiology ; Springer eBooks
    Pages: : digital.
    ISBN: 9781627030359
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  • 6
    Call number: YY Diss Scha/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 183 p.
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  • 7
    Keywords: Cell Cycle ; Medicine ; Oncology ; Urology ; Radiology, Medical ; Cell Cycle Analysis ; Molecular Medicine ; Cancer Research ; Urology ; Diagnostic Radiology ; Springer eBooks
    Description / Table of Contents: 1. The role of imaging in clinical prostate cancer – Overview of Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Dynamic Contrast-Enhanced MRI (DCE-MRI), MR spectroscopic Imaging (MRSI), Photoacoustic Imaging (PAI) -- 2. Automated quantitative cell and tissue imaging technologies -- 3. Diagnostic and early prostate cancer imaging; imaging of advanced prostate cancer -- 4. Emerging radiation techniques -- 5. Radiation therapy and partial prostate irradiation -- 6. Prostate cancer screening: radiology perspectives -- 7. Preclinical imaging of metastasis and dormancy: clinical implications -- 8. Utility of CT in the management of prostate cancer -- 9. Nanotechnology, cancer diagnosis and treatments -- 10. Imaging approaches to distinguish lethal from non-lethal disease -- 11. Photoacoustic imaging -- 12. Molecular and anatomical imaging in drug development -- 13. Molecular imaging modalities including CT, PET, SPECT, MRI, MRS, Hyperpolarized MRI, Ultrasound, X-ray computed tomography, Fusion Imaging (Molecular/Anatomic) -- 14. Functional imaging (PET vs. SPECT) -- 15. Optical bioluminescence molecular imaging -- 16. Therapeutic radiopharmaceutical translational research imaging -- 17. Accuracy of magnetic resonance imaging for local staging of prostate cancer: diagnostic meta-analysis -- 18. Adjuvant radiotherapy for pathologically advanced prostate cancer: randomized clinical trial -- 19. High-intensity focused ultrasound (HIFU) with histopathological analysis -- 20. Image-directed, tissue-preserving focal therapy of prostate cancer with a novel deformable magnetic resonance-ultrasound (MR-US) registration system -- 21. Focal therapy for localized unifocal and multifocal prostate cancer -- 22. Focal cryotherapy for clinically unilateral, low to intermediate risk prostate cancer -- 23. Impact of obesity on clinico-pathologic outcomes after robot-assisted laparoscopic prostatectomy -- 24. Body mass index, prostate weight and transrectal ultrasound prostate volume accuracy
    Abstract: The second of two companion books which address the biology and clinical aspects of prostate cancer. This volume, Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, discusses both classic and the most recent imaging approaches for detection, early diagnosis and treatment of prostate cancer. The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature
    Pages: XI, 194 p. 23 illus., 19 illus. in color. : online resource.
    ISBN: 9783319992860
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  • 8
    New York, NY : Springer International Publishing
    Keywords: Life sciences ; Cell Cycle ; Cytology ; Life sciences ; Cell Physiology ; Cell Cycle Analysis ; Springer eBooks
    Description / Table of Contents: Part 1. Overview of the Cytoskeleton -- Brief Overview of the Cytoskeleton -- Part 2. Focus on Cytoskeletal Interactions -- Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats -- Regulation of Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease -- The Role of the Cytoskeleton in Cell Migration, Its Influence on Stem Cells and the Special Role of GFAP in Glial Functions -- Centrosome-Microtubule Interactions in Health, Disease, and Disorders -- Cytoskeletal Elements and Reproductive Success in Animals -- Part 3. Focus on Microtubules -- Cytoskeleton and Regulation of Mitochondrial Translocation in Mammalian Eggs -- Tubulin Detyrosination in Epithelial Cells -- Mutations in Adenomatous Polyposis Coli, Their Role in Cytoskeletal Dynamics and Cancer Onset -- Small GTPases Act as Cellular Switches in the Context of Cilia -- Part 4. Focus on Intermediate Filaments -- Desmin Plays Dual Structural and Regulatory Functions Through Its Interaction with Partners in Muscle -- Desmin Filaments and Desmin-Related Myopathy -- Possible Functions of Intermediate Filaments in Mammalian Ovarian Follicles and Oocytes -- Part 5. Focus on Microfilaments -- Actin Organizing Proteins in Regulation of Osteoclast Function -- The Role of Drebrin-Binding Stable Actin Filaments in Dendritic Spine Morphogenesis -- The Role of the Actin Cytoskeleton in Cancer and Its Potential Use as a Therapeutic Target
    Abstract: This volume℗ explores the cytoskeleton, examining its structural and functional roles and its dysfunctions which often lead to disease.℗ Microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems are thoroughly discussed. The text is organized into four sections, each of which covers℗ specific subtopics. These consist of℗ an introductory chapter℗ followed by topics of current interest and expert-provided contributions which℗ include each topic's℗ key cell and molecular details. Comprehensive℗ yet concise,℗ ℗ The Cytoskeleton in Health and Disease℗ presents cutting- edge new℗ knowledge℗ balanced with background information, both of which are readily understandable for the newcomer and for the experienced researcher alike. The book℗ highlights the new aspects of the℗ research and its impact on℗ the design of℗ new strategies or the identification of new targets for therapeutic intervention. This book will be essential reading for scientists, students, teachers who are interested in expanding their knowledge related to the cytoskeleton for diagnostic, therapeutic or℗ research-based purposes
    Pages: XII, 395 p. 55 illus., 42 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9781493929047
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  • 9
    Keywords: Cell Cycle ; Medicine ; Oncology ; Oncology   ; Urology ; Cell Cycle Analysis ; Molecular Medicine ; Cancer Research ; Oncology ; Urology ; Springer eBooks
    Description / Table of Contents: Chapter 1: Brief overview of prostate cancer statistics, grading, diagnosis and treatment strategies -- Chapter 2:Novel biomarkers for prostate cancer detection and prognosis -- Chapter 3:Inflammation and prostate cancer -- Chapter 4:The impact of centrosome pathologies on prostate cancer development and progression -- Chapter 5:MicroRNAs as regulators of Prostate Cancer Metastasis -- Chapter 6:Epithelial-mesenchymal Transition (EMT) and Prostate Cancer -- Chapter 7:The role of multi-parametric MRI and fusion biopsy for the diagnosis of prostate cancer -- Chapter 8:Prostate Cancer Treatment Considerations: A Geneticist’s Brief Review of New Treatment Possibilities
    Abstract: This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature
    Pages: X, 129 p. 11 illus. in color. : online resource.
    ISBN: 9783319956930
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  • 10
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The events of mammalian fertilization overlap with the completion of meiosis and first mitosis; the pronuclei never fuse, instead the parental genomes first intermix at the mitotic spindle equator at metaphase. Since kinetochores are essential for the attachment of chromosomes to spindle microtubules, this study explores their appearance and behavior in mouse oocytes, zygotes and embryos undergoing the completion of meiosis, fertilization and mitoses. Kinetochores are traced with immunofluorescence microscopy using autoimmune sera from patients with CREST (CREST = calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) scleroderma. These sera cross-react with the 17 kDa centromere protein (CENP-A) and the 80 kDa centromere protein (CENP-B) found at the kinetochores in human cell cultures. The unfertilized oocyte is ovulated arrested at second meiotic metaphase and kinetochores are detectable as paired structures aligned at the spindle equator. At meiotic anaphase, the kinetochores separate and remain aligned at the distal sides of the chromosomes until telophase, when their alignment perpendicular to the spindle axis is lost. The female pronucleus and the second polar body nucleus each receive a detectable complement of kinetochores. Mature sperm have neither detectable centrosomes nor detectable kinetochores, and shortly after sperm incorporation kinetochores become detectable in the decondensing male pronucleus. In pronuclei, the kinetochores are initially distributed randomly and later found in apposition with nucleoli. At mitosis, the kinetochores behave in a pattern similar to that observed at meiosis or mitosis in somatic cells: irregular distribution at prophase, alignment at metaphase, separation at anaphase and redistribution at telophase. They are also detectable in later stage embryos. Colcemid treatment disrupts the meiotic spindle and results in the dispersion of the meiotic chromosomes along the oocyte cortex; the chromosomes remain condensed with detectable kinetochores. Fertilization of Colcemid-treated oocytes results in the incorporation of a sperm which is unable to decondense into a male pronucleus. Remarkably kinetochores become detectable at 5 h post-insemination, suggesting that the emergence of the paternal kinetochores is not strictly dependent on male pronuclear decondensation.
    Type of Medium: Electronic Resource
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