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  • 1
    Call number: M120:309
    Pages: xiii, 205 p.
    ISBN: 9783662533079
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  • 2
    Call number: M230:31
    Pages: 185 p.
    ISBN: 3406555373
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  • 3
    Call number: YY Diss Schl/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 89 p.
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  • 4
    Unknown
    Stuttgart : Thieme
    Call number: QR46:18(7)
    Keywords: Microbiology
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php)
    Pages: xx, 718 p.
    Edition: 7., vollst. überarb. u. erw. Aufl.
    ISBN: 9783132423558
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  • 5
    Call number: Z060:23
    Keywords: Hazardous substances / Law and legislation / Germany ; Chemicals / Law and legislation / Germany
    Notes: Not kept up to date.
    Pages: loose-leaf + 1 CD-ROM
    Edition: Grundwerk Januar 2005
    ISBN: 3935064241
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  • 6
    Unknown
    Cham : Springer International Publishing
    Keywords: Life sciences ; Human Physiology ; Pharmaceutical technology ; Cardiology ; Cell Biology ; Life sciences ; Cell Biology ; Cardiology ; Human Physiology ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: Cardiomyocytes: Function and Regeneration -- 1.Ways to study the biology of cardiomyocytes -- 2.Cardiomyocytes: Function and Regeneration -- 3.Excitation-contraction coupling of cardiomyocytes -- 4.Cardiac metabolism and energetic control -- 5.Endogenous mechanisms for regulating myocardial contractility -- Cardiomyocytes in ageing, disease, and protection -- 6.Growth regulation of cardiomyocytes: Control of cell size and its role in cardiac hypertrophy -- 7.Protein Degradation in Cardiomyocytes – Target Proteins and clinical consequences -- 8.Ischemia and Reperfusion -- 9.Mechanisms of cardiac cell death -- 10.Oxidative stress and nitrosative stress
    Abstract: This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology
    Pages: XV, 278 p. 40 illus., 13 illus. in color. : online resource.
    ISBN: 9783319312514
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  • 7
    ISSN: 1432-0533
    Keywords: Key words HSA ; GL7 ; Toxoplasma gondii ; Encephalitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The co-expression of various cell surface molecules by cells of the nervous system and the immune system is a remarkable feature. To identify novel molecules that are shared between cells of the neural and hematopoietic lineage, the expression and regulation of heat-stable antigen (HSA, CD24, nectadrin) and GL7, two hematolymphoid differentiation antigens that are involved in antigen presentation, cell adhesion, signal transduction and activation, was studied in the adult normal and Toxoplasma gondii-infected murine brain by immunohistochemistry and flow cytometry of isolated cerebral leukocytes. In the normal brain ependymal cells, plexus macrophages and a fraction of blood vessel endothelial cells were HSA positive (+), whereas the choroid plexus epithelium was GL7+. This basal expression of HSA and GL7 was not further modified on these cell populations in Toxoplasma encephalitis (TE). In acute and chronic TE, HSA and GL7 were strongly induced on resident brain cells, and activated astrocytes were the predominant HSA+ and GL7+ cell type. FACS analysis additionally identified a minor fraction of HSA+ microglia in the normal brain with a small, but significant increase in TE. The differential expression pattern of HSA and GL7 on distinct resident cell populations in various anatomic compartments of the normal adult brain and their up-regulation in TE may indicate that their intracerebral role is diverse and may include both immunological as well as non-immunological functions.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-1285
    Keywords: Key words Accessory pathway — radiofrequent current — catheter ablation — comparative study ; Schlüsselwörter Akzessorische Leitungsbahn — Hochfrequenzstrom — Katheterablation — vergleichende Untersuchung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 1076 consecutive patients referred for radiofrequency current catheter ablation, the anatomical distribution and conduction properties of accessory pathways (APs) as well as the mode of recurrence after ablation were retrospectively analyzed and compared in patients with multiple and single APs. Except for 17 patients with Ebstein's anomaly, the prevalence of patients of multiple APs in this cohort was 5.4%. Patients with multiple APs, as opposed to patients with a single AP, had significantly more often APs located on the right free wall (23% versus 10%) and — since the prevalence of septal APs was identical in both groups — less frequently APs located on the left free wall (44% versus 56%). Also, concealed APs were significantly more often encountered in patients with multiple APs (45% versus 24%). Recurrence of conduction across an AP which had presumably been ablated was observed in both groups with statistically equal incidence of 〈 5%. In 11 patients with multiple APs, the additional AP was only found at the repeat session. These "new" APs were mostly concealed (9 out of 11) and necessitated an intervention predominantly late after the initial ablation session. Intermittent concealed conduction appears to be a likely explanation for this phenomenon. Patients with multiple APs exhibit a higher incidence of right free-wall and concealed APs, yet they stand the same, approximately 95%, chance of cure as do patients with a single AP. Nearly 25% of repeat sessions in patients initially thought to have a single AP are caused by the late manifestation of an additional AP.
    Notes: Zusammenfassung In dieser Studie wurden die Befunde von 1076 konsekutiven Patienten, bei denen eine Hochfrequenzstrom-Katheterablation von akzessorischen Leitungsbahnen durchgeführt worden war, retrospektiv unter der Fragestellung analysiert, ob es hinsichtlich der anatomischen Verteilung und den Leitungseigenschaften der akzessorischen Bündel sowie dem Rezidivverhalten nach Ablation Unterschiede zwischen Patienten mit multiplen Leitungsbahnen und Patienten mit singulärer Leitungsbahn gibt. Unter Ausschluß von 17 Patienten mit Ebsteinscher Anomalie betrug der Anteil von Patienten mit multiplen Leitungsbahnen im untersuchten Kollektiv 5,4%. Bei diesen Patienten fanden sich im Unterschied zu Patienten mit singulärer Leitungsbahn statistisch signifikant häufiger akzessorische Bahnen an der rechten freien Wand (23% gegenüber 10%) und — da der Anteil septaler Leitungsbahnen in beiden Patientengruppen gleich groß war — entsprechend weniger häufig akzessorische Leitungsbahnen an der linken freien Wand (44% gegenüber 56%). Ebenso war der Anteil von verborgenen akzessorischen Leitungsbahnen bei Patienten mit multiplen Leitungsbahnen signifikant erhöht (45% gegenüber 24%). Rezidivierende Leitung über eine akzessorische Faser, die vermeintlich erfolgreich unterbrochen wurde, fand sich in beiden Patientengruppen mit einer statistisch gleichen Häufigkeit von unter 5%. Bei 11 Patienten mit multiplen Leitungsbahnen wurde die zusätzliche Leitungsbahn erst im Rahmen einer Zweitprozedur gefunden. Diese "neuen" Leitungsbündel leiteten zumeist nur retrograd (9 von 11) und manifestierten sich erst Tage bis Monate nach der initialen Ablationssitzung. Intermittierende retrograde akzessorische Leitung bietet sich als wahrscheinliche Erklärung für dieses Phänomen an. Trotz der größeren Häufigkeit von akzessorischen Bündeln an der rechten freien Herzwand und von ausschließlich retrograden Leitungseigenschaften der akzessorischen Fasern besteht bei Patienten mit multiplen Leitungsbahnen dieselbe, etwa 95%ige Heilungswahrscheinlichkeit wie bei Patienten mit singulärer Leitungsbahn. Knapp 25% der Zweitprozeduren bei Patienten, die sich zur Ablation einer singulären akzessorischen Leitungsbahn vorstellten und bei denen es zu einem Arrhythmierezidiv kam, sind durch eine initial nicht nachweisbare zusätzliche Leitungsbahn bedingt.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dormant Accessory Pathways. Introduction: Recurrence of clinical symptoms after radiofrequency catheter ablation of an accessory atrioventricular pathway (AP) may be due to the late manifestation of an additional AP that was not detected during the initial ablation session. It was the purpose of this study to elucidate the phenomenon of these “dormant” APs. Methods and Results: Of 1280 consecutive patients who underwent radiofrequency catheter ablation of an AP, 54 patients (4.2 %) developed clinical symptoms postablation, necessitating a repeat ablation session. Recurrence of conduction over the AP targeted al the initial ablation session was found in 45 patients, whereas in the other 9 patients (0.7%) the manifestation of a previously unnoticed AP had caused symptom recurrence. Retrospective analysis of the data from these patients’ ablation sessions revealed that the late manifesting AP was ablated at a site clearly different from that of the initially targeted AP, and that the manifestation of conduction over a previously “dormant” AP occurred significantly later than the recovery of a presumably ablated AP. Seven (78%) of the 9 “dormant” APs were concealed, and none exhibited decremental conduction properties. Conclusion: The incidence of clinical recurrences mediated by the late manifestation of conduction over a previously “dormant” AP is low. The lack of an anatomic vicinity of these predominantly concealed APs with the initially targeted AP and the lack of evidence for their presence during the initial ablation session suggest intermittent conduction as the most likely explanation for their late manifestation.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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