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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2018; 26. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20181004-20181006; Wien; DOC18peg22 /20181008/
    Publication Date: 2018-10-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2014; 24. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20141016-20141018; Weimar; DOC14peg42 /20141002/
    Publication Date: 2014-10-03
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien; 20090524-20090527; Münster; DOCP01-03 /20090520/
    Publication Date: 2009-06-30
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Infectious Diseases; VOL: 4; DOC08 /20161128/
    Publication Date: 2016-11-28
    Description: Zincophorin is a polyketide antibiotic that possesses potent activity against Gram-positive bacteria, including human pathogens. While a number of total syntheses of this highly functionalized natural product were reported since its initial discovery, the genetic basis for the biosynthesis of zincophorin has remained unclear. In this study, the co-linearity inherent to polyketide pathways was used to identify the zincophorin biosynthesis gene cluster in the genome of the natural producer Streptomyces griseus HKI 0741. Interestingly, the same locus is fully conserved in the streptomycin-producing actinomycete S. griseus IFO 13350, suggesting that the latter bacterium is also capable of zincophorin biosynthesis. Biological profiling of zincophorin revealed a dose-dependent inhibition of the Gram-positive bacterium Streptococcus pneumoniae . The antibacterial effect, however, is accompanied by cytotoxicity. Antibiotic and cytotoxic activities were completely abolished upon esterification of the carboxylic acid group in zincophorin.
    Keywords: antibiotic ; zincophorin ; griseochelin ; polyketide ; Streptomyces griseus ; Streptococcus pneumoniae ; ddc: 610
    Language: English
    Type: article
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2016; 25. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20161006-20161008; Rostock; DOC16peg25 /20160930/
    Publication Date: 2016-09-30
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2014; 24. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20141016-20141018; Weimar; DOC14peg27 /20141002/
    Publication Date: 2014-10-03
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 7
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2014; 24. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20141016-20141018; Weimar; DOC14peg26 /20141002/
    Publication Date: 2014-10-03
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 8
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Infektiologie Update 2014; 24. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20141016-20141018; Weimar; DOC14peg46 /20141002/
    Publication Date: 2014-10-03
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 9
    Publication Date: 2014-08-26
    Description: Lately, several press releases as well as a parliamentary inquiry questioned the effectiveness of the neuraminidase inhibitors (NAI, oseltamivir and zanamivir) in concerns of therapy of influenza. However, in combination with the unfortunate data communication by the pharma industry after the latest analysis by the Cochrane Collaboration an opinion evolved and was spread supporting the view that the neuraminidase inhibitors are in fact not effective at all.All three scientific expert societies (GfV, DVV and PEG) are considering this point illegitimate and also dangerous simplification. On the one hand, the recent analysis by the Cochrane Collaboration confirms a significant reduction in time to first alleviation of symptoms in children (oseltamivir) and adults (oseltamivir and zanamivir). On the other hand, due to basic methodical specifications, the analyses of the Cochrane Collaboration does not include any results of observational studies revealing that especially with patients at risk, indeed, there was a positive effect of neuraminidase inhibitors. As long as there is no availability of any better antiviral substances against influenza viruses, the possibility of applying the existing neuraminidase inhibitors must be considered carefully for each respective situation and used for the good of the patients as well.
    Description: In der jüngsten Vergangenheit gab es einige Pressemeldungen und auch eine parlamentarische Anfrage zur Frage der Wirksamkeit von Neuraminidasehemmern (NAH, Oseltamivir und Zanamivir) für die Therapie der Influenza. Die unglückliche Informationspolitik der Hersteller hat dazu geführt, dass im Zusammenhang mit der neuesten Analyse der Cochrane Collaboration die Meinung entstanden ist und verbreitet wurde, dass die Neuraminidasehemmer völlig unwirksam seien.Dies ist aus Sicht der drei wissenschaftlichen Fachgesellschaften (GfV, DVV und PEG) eine unzulässige und auch gefährliche Vereinfachung. Zum einen bestätigt auch die neueste Analyse der Cochrane Collaboration eine signifikant verkürzte Krankheitsdauer bei Kindern (Tamiflu) und Erwachsenen (Tamiflu und Relenza. Zum anderen berücksichtigt die Analyse der Cochrane Collaboration aufgrund von grundsätzlichen methodischen Vorgaben die Ergebnisse von Beobachtungsstudien nicht. In diesen konnte gezeigt werden, dass gerade bei Risikopatienten durchaus ein positiver Effekt der Neuraminidasehemmer nachweisbar ist. So lange keine besseren antiviralen Substanzen gegen Influenzaviren zur Verfügung stehen, müssen daher die Möglichkeit der Anwendung der verfügbaren Neuraminidasehemmer in den jeweiligen Situationen geprüft und diese zum Wohl der Patienten auch eingesetzt werden.
    Keywords: ddc: 610
    Language: German
    Type: article
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  • 10
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Spiral-CT ; Mundhöhle/Oropharynx/Hypopharynx ; Karzinome ; Staging ; Key words Spiral CT ; Oral cavity/oropharynx/hypopharynx ; Carcinoma ; Staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Purpose. To compare spiral and conventional CT in the staging of carcinomas of the oral cavity, the oropharynx and hypopharynx. Method. Retrospectively 101 conventional CTs and prospectively 107 spiral CTs were analyzed regarding to correct T and N staging. CT results were compared with histological staging. Results. In conventional CT, there were correctly staged 85% of T stages (T1 62%, T2 74%, T3 81%, T4 94%) and 85% of N stages (N0 79%, N1 71%, N2 89%, N3 94%). Spiral CT showed correct results in 84% of T stages (T1 67%, T2 74%, T3 88%, T4 95%) and in 86% of N stages (N0 82%, N1 78%, N2 90%, N3 93%). No statistically significant differences could be found between both CT methods. Conclusion. In spite of the tendency of improved diagnosis of T1, N0 and N1 stages no clear improvement in the staging of carcinomas of the oral cavity, the oropharynx and hypopharynx could be expected by spiral CT.
    Notes: Zusammenfassung Fragestellung. Ziel der Studie war ein Vergleich konventioneller CT und Spiral-CT im Staging von Karzinomen der Mundhöhle, des Oro- und Hypopharynx. Methode. Retrospektiv wurden 101 konventionelle CTs und prospektiv 107 Spiral-CTs auf Korrektheit des T- und N-Stagings überprüft. Als Golden Standard galt das histologische Staging. Ergebnisse. Mit der konventionellen CT wurden jeweils 85% der Tumore korrekt einem T-Stadium (T1 62%, T2 74%, T3 81%, T4 94%) und einem N-Stadium (N0 79%, N1 71%, N2 89%, N3 94%) zugeordnet. Die Spiral-CT stufte 84% der Fälle richtig im T-Stadium (T1 67%, T2 74%, T3 88%, T4 95%) und 86% im N-Stadium (N0 82%, N1 78%, N2 90%, N3 93%) ein. Die Unterschiede im T- und N-Staging zwischen beiden CT-Methoden waren statistisch nicht signifikant. Schlussfolgerung. Trotz der Tendenz der besseren Beurteilbarkeit von T1-, N0- und N1-Stadien ist von der Spiral-CT keine eindeutige Verbesserung im Staging von Karzinomen der Mundhöhle, des Oro- und Hypopharynx zu erwarten.
    Type of Medium: Electronic Resource
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