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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.; 20060524-20060528; Mannheim; DOC06hnod213 /20060424/
    Publication Date: 2006-04-25
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    ISSN: 1432-1076
    Keywords: Key words Malignant infantile osteopetrosis ; Rickets ; Neonate ; Vitamin D deficiency ; Abbreviations25OHD 25-Hydroxyvitamin D ; 1,25(OH)2D 1,25-Dihydroxyvitamin D ; PTH Parathyroid hormone ; ALP Alkaline phosphatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A neonate presented with clinical, biochemical, endocrine and radiographic features consistent with vitamin D deficiency rickets of maternal origin. Persistent hypocalcemia and subsequent development of pancytopenia, hemolysis and hepatosplenomegaly prompted further studies that led to the diagnosis of infantile osteopetrosis. Conclusion Osteopetrosis is an important differential diagnosis of neonatal rickets and is not excluded by low vitamin D levels.
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  • 3
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Gastroenteropankreatische neuroendokrine Tumoren (NET) sind bezüglich ihres Differenzierungsgrads, der Lokalisation, Hormonproduktion und Prognose heterogen. Sie treten überwiegend sporadisch, aber auch familiär z. B. bei der multiplen endokrinen Neoplasie Typ 1 und dem von-Hippel-Lindau-Syndrom auf. Die komplexen Manifestationsformen spiegeln sich in den differenten bisher verwendeten Definitionen, Terminologien und Gradierungen von NET wider. Die allgemeinen Bezeichnungen “Karzinoid” bzw. “endokriner Pankreastumor” oder die funktions- bzw. funktionalitätsbezogenen Termini “Insulinom, Gastrinom, Somatostatinom” vermitteln nicht, ob die Neoplasien als benigne, potenziell maligne oder eindeutig maligne einzustufen sind. Neue molekular- und zellbiologische Entwicklungen auf dem Gebiet der Neurobiologie leisteten einen entscheidenden Beitrag zur Identifizierung und Charakterisierung von NET und bilden heute auch die Grundlage der aktuellen pathologisch-diagnostischen Beurteilung, auf deren Aspekte der folgende Beitrag eingeht.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2307
    Keywords: Cytoskeleton ; Wound healing ; Fibrosis ; Extracellular matrix ; Cytokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilament bundles and the expression of α-SM actin, the actin isoform present in SM cells and myoepithelial cells and particularly abundant in vascular SM cells. Myofibroblasts have been suggested to play a role in wound contraction and in retractile phenomena observed during fibrotic diseases. When contraction stops and the wound is fully epithelialized, myofibroblasts containing α-SM actin disappear, probably as a result of apoptosis, and the scar classically becomes less cellular and composed of typical fibroblasts with well-developed rough endoplasmic reticulum but with no more microfilaments. In contrast, α-SM actin expressing myofibroblasts persist in hypertrophic scars and in fibrotic lesions of many organs, including stroma reaction to epithelial tumours, where they are allegedly involved in retractile phenomena as well as in extracellular matrix accumulation. The mechanisms leading to the development of myofibroblastic features remain to be investigated. In vivo and in vitro investigations have shown that γ-interferon exerts an antifibrotic activity at least in part by decreasing α-SM actin expression whereas heparin increases the proportion of α-SM actin positive cells. Recently, we have observed that the subcutaneous administration of transforming growth factor-β1 to rats results in the formation of a granulation tissue in which α-SM actin expressing myofibroblasts are particularly abundant. Other cytokines and growth factors, such as platelet-derived growth factor, basic fibroblast growth factor and tumour necrosis factor-α, despite their profibrotic activity, do not induce α-SM actin in myofibroblasts. In conclusion, fibroblastic cells are relatively undifferentiated and can assume a particular phenotype according to the physiological needs and/or the microenvironmental stimuli. Further studies on fibroblast adaptation phenomena appear to be useful for the understanding of the mechanisms of development and regression of pathological processes such as wound healing and fibrocontractive diseases.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 46 (1983), S. 227-229 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 6
    ISSN: 1432-0584
    Keywords: Key words Hairy cell leukemia ; Interferon alpha ; Tumorous manifestation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Tumorous-manifestation of hairy cell leukemia in a patient treated with IFNα for 7 years is described. After this time, while the patient still was in hematological remission, a tumorous involvement of the lung by hairy cells developed and was successfully treated by surgery. No differences in the phenotype of hairy cells in the lung tumor, in the bone marrow, or in the blood could be detected.
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  • 7
    ISSN: 1432-0584
    Keywords: Hairy cell leukemia ; Interferon alpha Tumorous manifestation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tumorous-manifestation of hairy cell leukemia in a patient treated with IFNα for 7 years is described. After this time, while the patient still was in hematological remission, a tumorous involvement of the lung by hairy cells developed and was successfully treated by surgery. No differences in the phenotype of hairy cells in the lung tumor, in the bone marrow, or in the blood could be detected.
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  • 8
    ISSN: 1434-4726
    Keywords: Vocal fold polyps ; Endothelial cell ; Immunohistochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gelatinous and telangiectatic types can be differentiated among the human vocal fold polyps. Telangiectatic polyps are characterized by eosinophilic deposits consisting of fibrin and cellular blood constituents. Labyrinthine vascular channels are characteristic of these polyps, and are partially or completely lined by a single layer of flat cells. Using electron microscopy and immunohistochemical stainings (antibodies against factor VIII-related antigen, Ulex europaeus I lectin, and antibodies against lysozyme), we found that the lining cells are true vascular endothelial cells and are not organizing histiocytic cells that are arranged in an endothelial-like pattern.
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  • 9
    ISSN: 1434-4726
    Keywords: Extramedullary plasmacytomas ; Intracytoplasmic monoclonal immunoglobulins ; Choice of treatment ; Prognosis ; Extramedulläre Plasmocytome ; Intracytoplasmische monoclonale Immunglobuline ; Behandlungsmethode ; Prognose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwei Beobachtungen eines solitären extramedullären Plasmocytoms des Epipharynx bzw. der Zunge werden vorgestellt, bei denen trotz fehlender Paraproteinsekretion intracytoplasmatisch ein monoklonales Immunglobulin vom Typ Ig G, Kappa, immunhistochemisch nachgewiesen werden konnte. Nach chirurgischer Exstirpation im Gesunden sind beide Patienten nach einem Beobachtungszeitraum von 12 bzw. 14 Monaten rezidivfrei. Bei regelmäßiger Kontrolle scheint die Prognose des solitären extramedullären Plasmocytoms nach chirurgischer oder kombinierter chirurgisch-radiologischer Therapie günstig zu sein.
    Notes: Summary Two cases of solitary extramedullary plasmacytoma, one of the nasopharynx and one of the tongue are reported. Although there was no paraprotein secretion present, we were able to demonstrate an intracytoplasmic monoclonal immunoglobulin (type IgG-kappa) by immunohistochemical methods. Twelve months following surgical treatment both patients locally and by serum controls are free of residual disease. We confirm former studies in the literature that the prognosis of solitary extramedullary plasmacytomas seems to be good after surgical or radiation therapy. Continuous individual follow-up including serum and X-ray controls are obligatory.
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  • 10
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: AimsBone marrow histopathology reveals a striking heterogeneity at diagnosis of Philadelphia chromosome positive (Ph1+) chronic myelogenous leukaemia (CML). Based on semiquantitative evaluations of the number of megakaryocytes and the content of fibres, various histological subtypes have been postulated. However, little information exists on whether these groups represent stable categories of the different classification systems and whether therapeutic regimes exert any influence on the putative shift of histological patterns.Methods and resultsA retrospective clinicopathological study was performed on 396 bone marrow biopsies derived from 173 patients. There were at least two representative trephines taken at diagnosis and at median intervals of 16 months. Processing of the specimens involved immunostaining with CD61 (megakaryopoiesis) and Ret40f (erythropoiesis) and Gomori's silver impregnation technique. Based on morphometric analysis and in accordance with the general appearance of bone marrow histology three different histological subtypes were distinguished. These consisted of a granulocytic (51 patients), a predominantly megakaryocytic (73 patients) and a myelofibrotic pattern (49 patients). Follow-up biopsies revealed that a significant transition of histological groups occurred and that, independently of treatment modalities, the myelofibrotic category was associated with an unfavourable prognosis. Of the 124 patients without myelofibrosis at onset, 42% later transformed into the myelofibrotic subtype. However, these patients showed no prevalence of either a pre-existing granulocytic or megakaryocytic growth. Myelofibrotic changes were significantly associated with interferon (IFN) and busulfan (BU) therapy. On the other hand, a transition of a myelofibrotic into a nonfibrotic subtype was detectable in 17 of the 49 patients under study and related to hydroxyurea (HU) treatment.ConclusionsHistological classification systems of bone marrow features in CML do not represent stable patterns, but may be significantly altered by therapy, in particular IFN and HU.
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