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  • 1
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Cell growth and organic acid production by Propionibacteria are dependent on the vitamin-nitrogen source in the culture medium. Final cell and propionic acid concentrations produced by Propionibacterium shermanii, using corn-steep liquor, were higher than those obtained utilizing yeast extracts. Since corn-steep liquor is much cheaper than yeast extract, the process becomes more attractive. By calculating the specific growth rates, it was observed that the critical propionic acid concentration, that prevents all growth (μX = 0), is different depending on the vitamin-nitrogen source used and its concentration. For example, for 5.0 and 15.0 g/l Oxoid yeast extract, those critical propionic acid concentrations were 16.0 and 27.0 g/l, respectively. Such propionic acid concentrations inhibit the cell growth, but not the formation of acid. The specific propionic acid production rate also indicates that the critical concentration for metabolic activity, when propionic acid is no longer produced (μP = 0), varies according to the vitamin-nitrogen source and its concentration in the medium. For 5.0 and 15.0 g/l Oxoid yeast extract, those concentrations were 22.1 and 30.1 g/l, respectively.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  Evidenzbasierte Medizin - Anspruch und Wirklichkeit; 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft; 20040923-20040926; Berlin; DOC04dogDO.08.05 /20040922/
    Publication Date: 2004-09-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  GMS Health Technology Assessment; VOL: 1; DOC04 /20051102/
    Publication Date: 2005-11-03
    Description: The issue Diabetes has become the main cause of endstage renal disease. The costs for the treatment of diabetic patients with endstage renal disease have increased in the last years and have become a relevant economic topic of the health service. The first unspecific predictor of a diabetic nephropathy is an albuminuria. The screening for diabetic nephropathy uses microalbuminuria as a proof. Objectives What significance does the determination of albuminuria have on the precaution and course-control of the diabetic nephropathy? a) in type 1 diabetic patients b) in type 2 diabetic patients Which is an appropriate time to determine the albuminuria for the purpose of precaution and course-control of the diabetic nephropathy? a) in type 1 diabetic patients b) in type 2 diabetic patients Which method of testing is most effective concerning economic and medical aspects? Methods Published literature from 1998 up to 2004 was identified by searching in the most important databases. Most of the guidelines were found by hand searching in the internet. Results Of 2,792 citation titles and abstracts examined, 274 articles were retrieved for full-text review. Five metaanalyses and reviews, one review about clearing of guidelines (regarding 18 international guidelines) and four guidelines met the inclusion criteria for screening for microalbuminuria and type 1 diabetes. Seven metaanalyses, one HTA report, one review about clearing of guidelines (regarding 17 international guidelines), and seven guidelines met the inclusion criteria for screening for microalbuminuria and type 2 diabetes. At the moment, the determination of albuminuria still has a great significance because it is recommended in most published literature and guidelines. The time to determine the albuminuria depends on the age of the patients and their type of diabetes. Type 2 diabetic patients should start the determination when the diabetes is diagnosed whereas the determination is recommended five years later when type 1 diabetic patients are concerned. Most guidelines recommend a screening for microalbuminuria every year. Discussion and conclusion All guidelines and most of the literature recommend this screening. However, these recommendations are only based on expert consensus. The specificity of this screening is rather low. False positive tests in type 2 diabetic patients will cause psychological problems. A positive test leads to the recommendation to achieve "normal blood pressure" and "normoglycaemia" - but this applies to each diabetic patient. Based on these facts, the screening for albuminuria in type 1 or type 2 diabetes patients cannot be recommended as long as benefit has not been demonstrated by large, clinical, controlled trials. Without an evidence of the benefit, this screening cannot be economic.
    Description: Einleitung In den letzten Jahren hat die diabetische Nephropathie an großer Bedeutung gewonnen, da sie mittlerweile die Hauptursache für die terminale Niereninsuffizienz und damit zu einer großen Kostenbelastung des Gesundheitswesens geworden ist. Die Mikroalbuminurie ist der erste klinische Marker einer diabetischen Nephropathie und damit bei der Diagnostik einer diabetischen Nephropathie von besonderer Bedeutung. Fragestellung Welchen Stellenwert hat die Bestimmung der Albuminausscheidung im Urin bezüglich Vorsorge und Verlaufskontrolle der diabetischen Nephropathie? a) Bei Typ 1-Diabetikern b) Bei Typ 2-Diabetikern Wann sollte zur Vorsorge und Verlaufskontrolle der diabetischen Nephropathie eine Bestimmung der Albuminausscheidung im Urin erfolgen? a) Bei Typ 1-Diabetikern b) Bei Typ 2-Diabetikern Welches Verfahren weist ökonomisch und medizinisch die beste Wirksamkeit auf? Methodik Die bei der breit angelegten systematischen Literaturrecherche in den wichtigsten Datenbanken (1998 bis 2004) ermittelten Publikationen bildeten neben den Ergebnissen einer Internetrecherche die Informationsgrundlage. Ergebnisse Unter den bearbeiteten 2.792 Publikationen befinden sich fünf Metaanalysen und Übersichtsarbeiten, ein Leitlinien-Clearingbericht (bezüglich 18 internationaler Leitlinien) und vier Leitlinien, die den Einschlusskriterien zum Diabetes mellitus Typ 1 entsprechen. Zum Thema Typ 2-Diabetes und Screening auf Mikroalbuminurie wurden ein HTA-Bericht, sieben Metaanalysen, ein Leitlinien-Clearingbericht (bezüglich 17 internationaler Leitlinien) und sieben Leitlinien ermittelt, die die Einschlusskriterien erfüllen. Derzeit hat die Bestimmung der Albuminausscheidung im Urin einen hohen Stellenwert, da sie in den meisten publizierten Arbeiten und Leitlinien empfohlen wird. Der Zeitpunkt der Albuminbestimmung ist abhängig vom Alter und Diabetestyp der Patienten. Während bei Typ 2-Diabetikern direkt nach der Diagnosestellung mit dem Screening begonnen werden sollte, wird das Screening bei Typ 1-Diabetikern erst fünf Jahre später empfohlen. Die meisten Leitlinien raten ein jährliches Screening. Diskussion und Schlussfolgerung Bezüglich der Screeninguntersuchungen besteht in der Literatur weitgehend Übereinstimmung darüber, dass ein Screening notwendig und gerechtfertigt sei. Diese Meinung basiert jedoch nur auf Studien mit einem sehr niedrigen Evidenzgrad, was zu einer kritischen Betrachtung dieser Haltung führen sollte. Insbesondere die Spezifität des Screenings bei Typ 2-Diabetikern ist sehr gering. Das falsch positive Ergebnis des Screenings könnte bei einigen Patienten zu einer psychischen Belastung führen. Zurzeit sind die therapeutischen Konsequenzen des Nachweises einer Mikroalbuminurie nur sehr gering, da die einzigen durch hohe Evidenzgrade belegten Therapiemöglichkeiten (optimale Therapie des Blutdrucks und strenge Einstellung der Blutzuckerwerte) bei allen Diabetikern angestrebt werden sollten. Aus diesem Grund kann die Bestimmung der Albuminausscheidung im Urin bei Diabetikern zur Vorsorge und Kontrolle der diabetischen Nephropathie bis zum Nachweis des Nutzens durch methodisch gute, kontrollierte, klinische Studien nicht empfohlen werden. Bei derzeit fehlendem Nachweis des Nutzens ist die Durchführung dieses Screenings nicht ökonomisch.
    Keywords: TECHNOLOGY ASSESSMENT, BIOMEDICAL ; ALBUMINURIA ; URINE ; DIABETIC NEPHROPATHIES ; TECHNIKFOLGEN-ABSCHÄTZUNG, BIOMEDIZINISCHE ; ALBUMINURIE ; URIN ; DIABETISCHE NEPHROPATHIEN ; prevention and control ; Vorsorge ; ddc: 610
    Language: English
    Type: article
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  42. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie; 20160602-20160604; Augsburg; DOCFV91 /20160420/
    Publication Date: 2016-04-21
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Jahrestagung der Arbeitsgemeinschaft für medizinisches Bibliothekswesen (AGMB) 2008; 20080923-20080925; Magdeburg; DOC08agmb01 /20080916/
    Publication Date: 2008-09-18
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    Keywords: evaluation ; Germany ; imaging ; QUANTIFICATION ; SYSTEM ; SYSTEMS ; VOLUME ; NEW-YORK ; ACCURACY ; SURGERY ; validation ; FLOW ; magnetic resonance ; MAGNETIC-RESONANCE ; magnetic resonance imaging ; VECTORS ; VECTOR ; SURFACE ; RECONSTRUCTION ; COLOR DOPPLER ; LACKING ; VOLUMES ; AORTIC REGURGITATION ; CARDIOVASCULAR-SYSTEM ; CONTROL-VOLUME METHOD ; INTEGRATION ; MITRAL REGURGITATION ; QUANTITATIVE ASSESSMENT ; resonance imaging ; respiratory system ; STANDARD ; VALVULAR REGURGITATION ; VELOCITY
    Abstract: Background. Three-dimensional assessment of regurgitant jet volume is the prerequisite for stratifying valve insufficiency. However, systematic comparison of three-dimensional methods is lacking. Therefore, we evaluated magnetic resonance imaging and three-dimensional echocardiography experimentally. Methods. An insufficiency chamber (22 x 18.5 x 27 cm; ostia 10, 16, and 20 mm; regurgitant volumes 2.3 to 25 mL) within experimental circulation (BioMedicus pump, tubes, pulsatile flow 0.2 to 1.9 L/min) was used for three-dimensional echocardiography (HP Sonos 2500) and magnetic resonance imaging (Siemens Magnetom Vision). Doppler flowmeter served as a gold standard. Segmentation used thresholding and surface integration of velocity vectors. jet volume was evaluated qualitatively by polynom fitting. Results. jet volume calculated by magnetic resonance (r = 0.99, p 〈 0.0001) and by echocardiography (r = 0.99, p 〈 0.0001) correlated identically to the gold standard. jet volume derived from imaging correlated with each other by r = 0.98 (p 〈 0.0001). Polynom fits indicated a more paraboloid shape of magnetic resonance jet volume. Conclusions. Experimentally, three-dimensional echocardiography and magnetic resonance imaging possess identical accuracy for determining regurgitant jet volume. Magnetic resonance imaging seems to provide qualitatively better image data for three-dimensional reconstruction. (C) 2004 by The Society of Thoracic Surgeons
    Type of Publication: Journal article published
    PubMed ID: 15223411
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  • 7
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 16; DOC07 /20160923/
    Publication Date: 2016-09-23
    Description: To update the ordering process for interlibrary loan we want to reach the following: short and easy ways from research to literature for our users professional tool for order processing with research options and administration of suppliers for the library team The poster illustrates the ordering process, the implementation, the result and the benefits of the new system.
    Description: Mit der Überarbeitung der Bestellprozesse für die Aus- und Fernleihe wollten wir Folgendes erreichen: einen kurzen und direkten Weg von der Recherche bis zur Literatur für unsere Nutzer ein professionelles Tool zur Bestellabwicklung mit erweiterten Recherchemöglichkeiten und Lieferantenverwaltung für das Bibliotheksteam Im Poster werden der Bestellprozess, die Umsetzung, das Ergebnis und die Vorteile des entstandenen Systems dargestellt.
    Keywords: interlibrary loan ; ordering of literature ; ordering process ; medical library ; optimized workflow ; annual meeting of AGMB 2015 ; Aus- und Fernleihe ; Literaturbestellung ; Bestellprozess ; optimierte Arbeitsabläufe ; Medizinbibliothek ; AGMB-Jahrestagung 2015 ; ddc: 610
    Language: German
    Type: article
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  • 8
    Keywords: RISK ; DEFECTS ; BIRTHS ; CLOACAL EXSTROPHY ; POSSIBLE ASSOCIATION
    Abstract: Objective To identify genetic and nongenetic risk factors that contribute to the severity of the bladder exstrophy-epispadias complex (BEEC). Study design Patients with BEEC from North America (n = 167) and Europe (n = 274) were included. The following data were collected: associated anomalies, parental age at conception, mode of conception, periconceptional folic acid supplementation, maternal risk factors during pregnancy, and environmental risk factors. The patients were divided into 3 subgroups according to phenotype severity: (i) mild, epispadias (n = 43); (ii) intermediate, classic bladder exstrophy (n = 366); and (iii) severe, cloacal exstrophy (n = 31). These subgroups then were compared with identify factors that contribute to phenotype severity. Results Males were overrepresented in all subgroups. A relatively high prevalence of cleft lip, with or without cleft palate, was observed. Maternal smoking and medical radiation during the first trimester were associated with the severe cloacal exstrophy phenotype. Compliance with periconceptional folic acid supplementation was associated with the mildest phenotype (epispadias). Conclusions Periconceptional folic acid supplementation appears to prevent the development of the severe phenotype of BEEC.
    Type of Publication: Journal article published
    PubMed ID: 21679965
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  • 9
    Abstract: Melanoma originates in the epidermis and becomes metastatic after invasion into the dermis. Prior interactions between melanoma cells and dermis are poorly studied. Here, we show that melanoma cells directly affect the formation of the dermal tumour niche by microRNA trafficking before invasion. Melanocytes, cells of melanoma origin, are specialized in releasing pigment vesicles, termed melanosomes. In melanoma in situ, we found melanosome markers in distal fibroblasts before melanoma invasion. The melanosomes carry microRNAs into primary fibroblasts triggering changes, including increased proliferation, migration and pro-inflammatory gene expression, all known features of cancer-associated fibroblasts (CAFs). Specifically, melanosomal microRNA-211 directly targets IGF2R and leads to MAPK signalling activation, which reciprocally encourages melanoma growth. Melanosome release inhibitor prevented CAF formation. Since the first interaction of melanoma cells with blood vessels occurs in the dermis, our data suggest an opportunity to block melanoma invasion by preventing the formation of the dermal tumour niche.
    Type of Publication: Journal article published
    PubMed ID: 27548915
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  • 10
    Abstract: Despite intensive efforts in recent years, a curative therapy for cutaneous T-cell lymphoma (CTCL) has not yet been developed. Therefore, the establishment of new therapeutic approaches with higher efficacy rates and milder side effects is strongly desired. A characteristic feature of the malignant T-cell population in CTCL is resistance toward cell death resulting from constitutive NF-kappaB activation. Therefore, NF-kappaB-dependent cell death resistance represents an interesting therapeutic target in CTCL because an NF-kappaB-directed therapy would leave bystander T cells widely unaffected. We investigated the effects of dimethyl fumarate (DMF) on CTCL cells in vitro and in vivo. DMF induced cell death in primary patient-derived CD4(+) cells and CTCL cell lines, but hardly in T cells from healthy donors. DMF-induced cell death was linked specifically to NF-kappaB inhibition. To study the impact of DMF in vivo, we developed 2 CTCL xenograft mouse models with different cutaneous localizations of the T-cell infiltrate. DMF treatment delayed the growth of CTCL tumors and prevented formation of distant metastases. In addition, DMF induced increased cell death in primary CTCL tumors and in liver metastases. In summary, DMF treatment represents a remarkable therapeutic option in CTCL because it restores CTCL apoptosis in vitro and in preclinical models in vivo and prevents spreading of the disease to distant sites. DMF treatment is of particular promise in CTCL because DMF is already in successful clinical use in the treatment of psoriasis and multiple sclerosis allowing fast translation into clinical studies in CTCL.
    Type of Publication: Journal article published
    PubMed ID: 27268084
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