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  • 1
    Keywords: Proteomics ; Cytology ; Biochemistry ; Human Genetics ; Cell Physiology ; Proteomics ; Cell Biology ; Animal Biochemistry ; Plant Biochemistry ; Human Genetics ; Cell Physiology ; Springer eBooks
    Description / Table of Contents: The proteome of plant peroxisomes -- Defining the mammalian peroxisomal proteome -- Fungal peroxisomes proteomics -- The craft of peroxisome purification – a technical survey through the decades -- Prediction of peroxisomal matrix proteins in plants -- The obvious and the hidden: Prediction and function of fungal peroxisomal matrix proteins -- Predicting peroxisomal targeting signals to elucidate the peroxisomal proteome of mammals -- Multiple localization by functional translational readthrough -- Evolution of the peroxisomal proteome -- Peroxisome protein prediction in Drosophila melanogaster -- Using Pull Down strategies to analyze the interactome of peroxisomal membrane proteins in human cells -- Identification of peroxisomal protein complexes in mammalian cells -- Unraveling of the structure and function of peroxisomal protein import machineries -- The proteome of fruit peroxisomes: Sweet pepper (Capsicum annuum L.) as a model -- Peroxisomes and their central role in metabolic interaction networks in humans -- Characterisation of peroxisomal regulation networks -- Multi-localized proteins: the peroxisome-mitochondria connection Peroxisome-mitochondria inter-relations in plants -- Peroxisomes and cellular oxidant/antioxidant balance: protein redox -- Cell death or survival against oxidative stress -- A role for RNS in the communication of plant peroxisomes with other
    Abstract: This new edited volume in the Springer Subcellular Biochemistry Series presents a comprehensive, state-of-the-art overview of the proteomics of peroxisomes derived from mammalian, Drosophila, fungal, and plant origin, andcontains contributions from leading experts in the field. The development of sensitive proteomics and mass spectrometry technologies, combined with bioinformatics approaches now allow the identification of low-abundance and transient peroxisomal proteins and permits to identify the complete proteome of peroxisomes, with the consequent increase of our knowledge of the metabolic and regulatory networks of these important cellular organelles. The book lines-up with these developments and is organized in four sections including: (i) mass spectrometry-based organelle proteomics; (ii) prediction of peroxisomal proteomes; (iii) analysis of peroxisome proteome interaction networks; and (iv) peroxisomes in relation to other subcellular compartments. The editor Luis A. del Río is Professor ad honorem of the Spanish National Research Council (CSIC) in the Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry and Cell & Molecular Biology of Plants, at the Estación Experimental del Zaidín, Granada, Spain. Del Río’s research group focuses on the metabolism of reactive oxygen species (ROS), reactive nitrogen species (RNS) and antioxidants in plant peroxisomes, and the ROS- and RNS-dependent role of peroxisomes in plant cell signalling. The editor Michael Schrader is Professor of Cell Biology & Cytopathology in the Department of Biosciences at the University of Exeter, UK. Using mammalian peroxisomes as model organelles, Prof. Schrader and his team aim to unravel the molecular machinery and signalling pathways that mediate and regulate the formation, dynamics and abundance of these medically relevant cellular compartments
    Pages: XIII, 493 p. 55 illus., 49 illus. in color. : online resource.
    ISBN: 9789811322334
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  • 2
    San Diego : Academic Press
    (Lymphokines, 15)  
    Call number: QR180Z:65/15
    Keywords: Interleukin-3
    Pages: xiv, 430 p. : ill.
    ISBN: 9780124320154
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    QR180Z:65/15 available
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  • 3
    Call number: WB15:31
    Keywords: Nervous System Diseases / growth and development ; Poisoning
    Pages: xv, 301 p.
    ISBN: 3540544992
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    WB15:31 available
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  • 4
    Keywords: Life sciences ; Proteins ; Life sciences ; Protein Science ; Springer eBooks
    Description / Table of Contents: Origins, Technological Development and Applications of Peptidomics -- Brain Tissue Sample Stabilization and Extraction Strategies for Neuropeptidomics -- Isolation of Endogenous Peptides from Cultured Cell Conditioned Media for Mass Spectrometry -- Mass Spectrometric Identification of Endogenous Peptides -- Bioinformatics for Prohormone and Neuropeptide Discovery -- Substrate Capture Assay using Inactive Oligopeptidases to Identify Novel Peptides -- Non-targeted Identification of d-amino Acid-containing Peptides through Enzymatic Screening, Chiral Amino Acid Analysis and LC-MS -- Quantitative Peptidomics: General Considerations -- Quantitative Peptidomics with Isotopic and Isobaric Tags -- Quantitative Peptidomics using Reductive Methylation of Amines -- Metabolic Labeling to Quantify Drosophila neuropeptides and Peptide Hormones -- Data Preprocessing, Visualization and Statistical Analyses of Non-targeted Peptidomics Data from MALDI-MS -- Affinity Purification of Neuropeptide Precursors from Mice Lacking Carboxypeptidase E Activity -- Mass Spectrometry Based Immunopeptidomics for the Discovery of Cancer Neo-antigens -- Milk Peptidomics to Identify Functional Peptides and for Quality Control of Dairy Products -- Neuropeptidomic Analysis of Zebrafish Brain -- Identification, Quantitation, and Imaging of the Crustacean Peptidome -- Identification of Endogenous Neuropeptides in the Nematode C. elegans using Mass Spectrometry -- EndoProteoFASP as a Tool to Unveil the Peptidome-protease Profile: Application to Salivary Diagnostics -- Methodology for Urine Peptidome Analysis Based on Nano-HPLC coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry -- Identification of Components in Frog Skin Secretions with Therapeutic Potential as Anti-diabetic Agents -- High-Accuracy Mass Spectrometry Based Screening Method for the Discovery of Cysteine Containing Peptides in Animal Venoms and Toxins -- Analysis of the Snake Venom Peptidome -- Identification of Peptides in Spider Venom Using Mass Spectrometry -- Single Cell Peptidomics: Approach for Peptide Identification by N-Terminal Peptide Derivatization -- Peptidomic Identification of Cysteine-Rich Peptides℗ from Plants -- Analysis of Endogenous Peptide Pools of Physcomitrella patens Moss -- The Bright Future of Peptidomics.℗
    Abstract: This volume describes protocols for basic state-of-the-art approaches in the field of peptidomics. Most of these approaches are independent of the instruments used for analysis and can easily be adapted for equipment that is available in a typical proteomics facility. Chapters detail many of the basic techniques used to detect and identify peptides, methods for the relative quantitation of peptides between samples using isotopic labels or label-free approaches, and biological species as well as sample types. Written in the highly successful format of the Methods in Molecular Biology series, each chapter includes an introduction to the topic, a list of the necessary materials and reagents, reproducible step-by-step laboratory protocols, and tips on troubleshooting common problems and avoiding pitfalls. Authoritative and practical, Peptidomics:Methods and Strategies℗ provides useful guidance for studies in the rapidly growing field of peptidomics.℗
    Pages: XVII, 423 p. 79 illus., 17 illus. in color. : online resource.
    ISBN: 9781493975372
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  • 5
    Keywords: Life sciences ; Cell Biology ; Life sciences ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Isolation of Peroxisomes from Rat Liver and Cultured Hepatoma Cells by Density Gradient Centrifugation -- Isolation of Peroxisomes from Mouse Brain Using a Continuous Nycodenz Gradient: A Comparison to the Isolation of Liver and Kidney Peroxisomes -- Determining the Topology of Peroxisomal Proteins Using Protease Protection Assays -- Isolation of Native Soluble and Membrane-Bound Protein Complexes from Yeast Saccharomyces Cerevisiae -- Method for Measurement of Peroxisomal Very Long-Chain Fatty Acid Beta-Oxidation and de novo C26:0 Synthesis Activity in Living Cells Using Stable-Isotope Labelled Docosanoic Acid -- Analysis of Plasmalogen Synthesis in Cultured Cells -- Transfection of Primary Human Skin Fibroblasts for Peroxisomal Studies -- siRNA-Mediated Silencing of Peroxisomal Genes in Mammalian Cells -- Dual Reporter Systems for the Analysis of Translational Readthrough in Mammals -- Cytochemical Detection of Peroxisomes in Light and Electron Microscopy with 3,3’-diaminobenzidine -- Cryo-Immuno Electron Microscopy of Peroxisomal Marker Proteins -- Detection and Immunolabelling of Peroxisomal Proteins -- Labelling of Peroxisomes for Live Cell Imaging in the Filamentous Fungus Ustilago Maydis -- Quantitative Monitoring of Subcellular Redox Dynamics in Living Mammalian Cells Using RoGFP2-based Probes -- KillerRed as a Tool to Study the Cellular Responses to Peroxisome-Derived Oxidative Stress -- Determination of Peroxisomal pH in Living Mammalian Cells Using pHRed -- In Cellulo Approaches to Study Peroxisomal Protein Import – Yeast Immunofluorescence Microscopy -- Blue Native Page: Applications to Study Peroxisome Biogenesis -- In Vitro PMP Import Analysis Using Cell-Free Synthesized PMP and Isolated Peroxisomes -- Peroxisomal Membrane and Matrix Protein Import Using a Semi-Intact Mammalian Cell System -- The Use of Glycosylation Tags as Reporters for Protein Entry into the Endoplasmic Reticulum in Yeast and Mammalian Cells -- Detection of Ubiquitinated Peroxisomal Proteins in Yeast -- Assessing Pexophagy in Mammalian Cells -- Experimental Systems to Study Yeast Pexophagy -- Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells -- Study of Peroxisomal Protein Phosphorylation by Functional Proteomics -- Analysis of Peroxisomal β-Oxidation during Storage Oil Mobilization in Arabidopsis Thaliana Seedlings -- Peroxisome Mini-Libraries - Systematic Approaches to Study Peroxisomes Made Easy -- Generation of Peroxisome-Deficient Somatic Animal Cell Mutants -- Clinical and Laboratory Diagnosis of Peroxisomal Disorders
    Abstract: This volume provides easily accessible and comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Chapters detail valuable instructions, guidelines and protocols for molecular cell biologists, biochemists and biomedical researchers with an interest in peroxisome biology. Chapters in Peroxisomes: Methods and Protocols illustrate the isolation of peroxisomes, investigation of properties of membrane proteins, protocols to investigate and manipulate peroxisomes in cellular systems, detection of peroxisomes, including immunofluorescence, cytochemistry, cryo-immuno electron microscopy, and live cell imaging approaches. Authoritative and practical, Peroxisomes: Methods and Protocols aims to be useful for those already working on peroxisomes as well as for those who would like to start working on this fascinating organelle
    Pages: XVII, 347 p. 63 illus., 36 illus. in color. : online resource.
    ISBN: 9781493969371
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  • 6
    Call number: ALLG-BERUF-HF5549:26
    Keywords: Job Application ; Applications for positions
    Pages: 134 p. : ill. + 1 CD-Rom
    ISBN: 9783866689732
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    ALLG-BERUF-HF5549:26 available
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  • 7
    Call number: ALLG-BERUF-HF5549:25
    Keywords: Job Application ; Applications for positions
    Pages: 96 p. : ill.
    ISBN: 9783866687929
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    ALLG-BERUF-HF5549:25 available
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  • 8
    Call number: 01-PR:134
    Keywords: Labor passports ; Germany
    Pages: 161 p.
    ISBN: 3-8218-3805-1
    Signatur Availability
    01-PR:134 departmental collection or stack – please contact the library
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  • 9
    ISSN: 1573-5117
    Keywords: eastern equatorial Pacific ; productivity ; Quaternary ; diatoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Recent marine planktonic diatom assemblages from 47 sediment surface samples retrieved from the eastern equatorial Pacific yielded four significant Q-mode factors that are related to surface water properties. They include a northern subtropical (Factor 1), a southern subtropical (Factor 2), a Peru Current (Factor 3) and an eastern Equatorial Pacific (Factor 4) factor. A transfer function (based on 42 surface sediment samples) with a productivity range of 109 to 210 gC m−2 y−1 was defined using the geographic distribution of the northern and southern subtropical assemblages (Factor 1 and 2) and their relation to ”mapped“ surface water primary productivity. This transfer function has a standard error of estimate of 11.9 gC m−2 y−1 and it is used to estimate late Pleistocene paleo-productivity changes at ODP Leg 111 Site 677 off Ecuador. The Site 677 samples (usually spaced 10 cm apart and with a linear sedimentation rate of 4.3 cm y−3) were the same samples that were used for stable oxygen/carbon isotopic analysis from planktonic Foraminifera. The well constrained oxygen isotope stratigraphy permitted assignment of accurate ages to downcore samples. The interval between oxygen isotope stages 3 and 9 had variable productivity that is generally higher than present values of 175 gC m−2 y−1 A major decline in paleo-productivity below the present value occurred in stage 9, the early part of stage 8 and in the early and late stage 5.
    Type of Medium: Electronic Resource
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  • 10
    German Medical Science GMS Publishing House; Düsseldorf
    In:  29. Jahrestagung der Retinologischen Gesellschaft; 20160617-20160618; Berlin; DOC16rg84 /20160616/
    Publication Date: 2016-06-18
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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