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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  17. Deutscher Kongress für Versorgungsforschung (DKVF); 20181010-20181012; Berlin; DOC18dkvf210 /20181012/
    Publication Date: 2018-10-13
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  17. Deutscher Kongress für Versorgungsforschung (DKVF); 20181010-20181012; Berlin; DOC18dkvf049 /20181012/
    Publication Date: 2018-10-13
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    Keywords: GROWTH ; TUMOR-CELLS ; ACTIVATION ; MIGRATION ; TRANSFORMATION ; INTEGRIN ; DIFFERENTIAL EXPRESSION ; ACTIN ; HUMAN T-LYMPHOCYTES ; PROTEIN L-PLASTIN
    Abstract: BACKGROUND: Tumor cell migration and metastasis require dynamic rearrangements of the actin cytoskeleton. Interestingly, the F-actin cross-linking and stabilizing protein L-plastin, originally described as a leukocyte specific protein, is aberrantly expressed in several non-hematopoietic malignant tumors. Therefore, it has been discussed as a tumor marker. However, systematic in vivo analyses of the functional relevance of L-plastin for tumor cell metastasis were so far lacking. METHODS: We investigated the relevance of L-plastin expression and phosphorylation by ectopical expression of L-plastin in human melanoma cells (MV3) and knock-down of endogenous L-plastin in prostate cancer (PC3M). The growth and metastatic potential of tumor cells expressing no L-plastin, phosphorylatable or non-phosphorylatable L-plastin was analyzed in a preclinical mouse model after subcutaneous and intracardial injection of the tumor cells. RESULTS: Knock-down of endogenous L-plastin in human prostate carcinoma cells led to reduced tumor cell growth and metastasis. Vice versa, and in line with these findings, ectopic expression of L-plastin in L-plastin negative melanoma cells significantly increased the number of metastases. Strikingly, the metastasis promoting effect of L-plastin was not observed if a non-phosphorylatable L-plastin mutant was expressed. CONCLUSIONS: Our data provide the first in vivo evidence that expression of L-plastin promotes tumor metastasis and, importantly, that this effect depends on an additionally required phosphorylation of L-plastin. In conclusion, these findings imply that for determining the importance of tumor-associated proteins like L-plastin a characterization of posttranslational modifications is indispensable.
    Type of Publication: Journal article published
    PubMed ID: 24438191
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  18. Deutscher Kongress für Versorgungsforschung (DKVF); 20191009-20191011; Berlin; DOC19dkvf062 /20191002/
    Publication Date: 2019-10-03
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Paraffin sections of seven cases of nephroblastoma and one case of clear cell sarcoma were stained with a battery of eleven lectins conjugated to horseradish peroxidase. Lectin staining revealed similarities between blastema and stroma with respect to their content of glycoconjugates whereas blastema and epithelial cells exhibited major differences. In general, blastema and stroma contained glycoconjugates with terminal or penultimate β-galactose, glycoconjugates having either biantennary or triantennary N-linked sugar chains or both, sialoglycoconjugates, and occasionally glycogen. Epithelial cells also showed these complex carbohydrates but stained additionally for terminal disaccharide galactose-(β1→3)-N-acetylgalactosamine, terminal α-galactose and terminal α-N-acetylgalactosamine. Furthermore, staining with three fucose-binding lectins revealed that the linkage between terminal α-fucose residues to the constituent oligosaccharide chains varied between epithelial cells, blastema and stroma. In general, the distribution and content of glycoconjugates in tumour cells comprising clear cell sarcoma resembled that in blastema and stroma of nephroblastoma. Other findings included differences in content of glycosubstance between cuboidal and columnar cells within the same tumour. Also observed were variations between a primary tumour and its metastasis with respect to the occurrence of certain complex carbohydrates.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-4927
    Keywords: evolution ; polyploidy ; RNA content ; protein content ; enzyme activities ; Cyprinidae ; Isospondyli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The ratio of cellular RNA and protein content is about 1:1 between phylogenetically diploid and tetraploid species of the teleost family Cyprinidae, but is roughly in proportion to ploidy in species of the teleost order Isospondyli. Enzyme activities do not unequivocally comply with this scheme. These findings are discussed in view of the hypothesis that a regulatory mechanism which reduces genic activity has evolved in the tetraploid cyprinids but not in the tetraploid species of the order Isospondyli.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Wilson's disease in a young woman presenting with an acute course is described. The clinical manifestations were fulminant hepatic failure associated with marked intravascular hemolysis. Immediated-penicillamine and high-dose steroid therapy did not infuence the course of the disease. Necropsy revealed an increased hepatic copper content and cirrhosis with extensive necrosis of the liver.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-1544
    Keywords: Key words Single-chamber cardioverter/defibrillator – dual-chamber cardioverter/defibrillator – arrhythmia detection – sensitivity – specificity ; Schlüsselwörter Einkammer-Kardioverter/Defibrillator – Zweikammer-Kardioverter/Defibrillator – Arrhythmiedetektion – Sensitivität – Spezifität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung: Eine falsch-positive Erkennung atrialer Tachyarrhythmien als ventrikuläre Rhythmusstörungen mit der Konsequenz elektrischer Therapien stellt auch heute noch ein bedeutsames klinisches Problem in der Therapie mit implantierbaren Kardiovertern/Defibrillatoren dar. Die methodischen Limitationen einer einkanaligen frequenzgebunden Arrhythmiedetektion wurden durch die Einführung ergänzender Arrhythmiedetektionskriterien zu überwinden versucht. Neben den seit Jahren eingeführten, ergänzenden Detektionskriterien wie “Arrhythmiestabilität” und “Arrhythmieonset” wurden zusätzlich Detektionskriterien basierend auf der Morphologieanalyse der endokardialen Elektrogramme in die klinische Therapie mit implantierbaren Defibrillatoren eingeführt. Die Einführung von Zweikammer-Defibrillator-Systemen brachte neben der wichtigen Therapieoption einer physiologischen antibradykarden Stimulation die methodischen Voraussetzungen einer verbesserten Arrhythmiedetektion durch eine simultane Zwei-Kanal-Analyse atrialer und ventrikulärer Signale. In der vorliegenden Übersicht sollen die unterschiedlichen technischen Bedingungen der Arrhythmiedetektion in Einkammer- und Zweikammer-Defibrillatoren unter Einbeziehung der Mehrzahl der klinisch eingeführten ergänzenden Detektionskriterien und Algorithmen kurz zusammenfassend beschrieben werden. Weiter wird versucht eine Übersicht über publizierte Studien und Behandlungsergebnisse zur Sensitivität und Spezifität der Arrhythmiedetektion durch Einkammer und Zweikammer Defibrillatoren darzustellen.
    Notes: Summary False-positive detection of atrial tachyarrhythmias as ventricular arrhythmias, resulting in electrical therapy, is still a major clinical problem in implantable defibrillator therapy. The introduction of enhanced arrhythmia detection parameters tried to overcome the methodical limitations of a single-channel arrhythmia classification. In addition to the enhanced detection parameters, such as “arrhythmia-stability” and “arrhythmia-onset”, introduced several years ago, new additional detection parameters, based on the analysis of intracardiac electrogram morphology, were recently introduced in clinical defibrillator therapy. The introduction of dual-chamber defibrillators provide the important option of physiological antibradycardia pacing and the technical preconditions for an improved arrhythmia classification, based on the simultaneous dual-channel analysis of atrial and ventricular signals. This manuscript will give and an overview of the technical conditions of arrhythmia detection in single and dual-chamber implantable defibrillators with respect to the majority of the clinically used enhanced arrhythmia detection parameters and detection algorithms. Additionally a summary of published studies and clinical results regarding the sensitivity and specificity of arrhythmia detection in single and dual-chamber implantable defibrillator therapy is presented.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-1285
    Keywords: Key words Dual AV nodal conduction – double ventricular responses – slow pathway radiofrequency ablation ; Schlüsselwörter Duale AV-Knoten Leitungsphysiologie – doppelte Ventrikelerregung – Hochfrequenz-Katheterablation der langsamen Leitungsbahn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unterschiedliche elektrokardiographische Manifestationen einer dualen AV-Knoten-Leitungsphysiologie sind beschrieben. Ein besonders selten auftretender Subtyp stellt hier die doppelte ventrikuläre Erregung dar. Wir berichten über eine 53-jährige Patientin mit über sieben Jahren bestehenden typischen paroxysmalen regelmäßigen Tachykardien. In den vergangenen sechs Monaten kam es zu einer Änderung der vorbestehenden Symptomatologie der Herzrhythmusstörungen mit einem Wechsel zu länger anhaltenden und irregulär empfundenen Rhythmusstörungen. Medikamentöse Behandlungsversuche mit Antiarrhythmika der Klasse I waren nicht erfolgreich. Ein Therapieversuch mit Beta-Blockern verstärkte die subjektiven Beschwerden. Nach erneuter Befundung des EKG der Patientin wurde vom zuweisenden Krankenhaus die Diagnose einer dualen AV-nodalen Leitungsphysiologie mit doppelter Ventrikelerregung gestellt und die Patientin unserer Klinik zur invasiven elektrophysiologischen Untersuchung und zur Katheterablation des langsamen Leitungsweges des dualen AV-Knotens zugewiesen. Die invasive elektrophysiologische Untersuchung bestätigte die Diagnose eines dualen AV-Knotens mit doppelter Ventrikelerregung. Die Hochfrequenz-Katheterablation der langsamen Leitungsbahn erreichte die vollständige Unterbrechung der doppelten Ventrikelerregung. Das erfolgreiche Ablationsergebnis konnte durch Langzeit-EKG-Registrierung und Belastungsergometrie weiterführend bestätigt werden. Während einer dreimonatigen Nachbeobachtung blieb die Patientin vollständig asymptomatisch und es kam zu keiner Wiedererholung der dualen AV-Knoten Leitungsphysiologie im Oberflächen-EKG.
    Notes: Summary A variety of electrocardiographic manifestations of dual AV nodal physiology have been reported. The specific subtype dual ventricular response is considered as a very rare phenomenon. We present the case of a 53 year old lady who suffered from paroxysmal regular tachycardias for more than seven years. In the last 6 months the symptomatology of the cardiac arrhythmia changed to more persistent und irregular rhythm disturbances. Treatment with class Ia antiarrhythmic drugs and beta-blocking agents failed. The latter even seemed to worsen her very disturbing palpitations. After examination of the ECG recordings, the diagnosis of dual AV nodal physiology with double ventricular response was made – the lady was referred to our institution for electrophysiological testing and radiofrequency catheter ablation of the slow pathway. An invasive electrophysiological study reconfirmed the diagnosis of a dual AV nodal conduction pattern with irregular double ventricular response. The radiofrequency catheter ablation of the the slow pathway achieved a complete cessation of the double ventricular response. This satisfactory outcome was confirmed by analysis of a postinterventional 24hour holter recording and an exercise stress test. During a follow-up period of three months, the patient remained free of symptoms and there was no recurrence of dual AV nodal conduction physiology in the surface ECG.
    Type of Medium: Electronic Resource
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