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  • 1
    Keywords: Life sciences ; Plant Ecology ; Wood ; Plant anatomy ; Life sciences ; Plant Anatomy/Development ; Plant Systematics/Taxonomy/Biogeography ; Wood Science & Technology ; Plant Ecology ; Springer eBooks
    Pages: : digital.
    ISBN: 9783642204357
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  • 2
    Keywords: Medicine ; Gene Therapy ; Human Physiology ; Molecular Biology ; Blood Transfusion ; Hematology ; Cell Biology ; Biomedicine ; Human Physiology ; Hematology ; Cell Biology ; Gene Therapy ; Molecular Medicine ; Blood Transfusion Medicine ; Springer eBooks
    Description / Table of Contents: I. Thrombopoiesis 1. A short history of the platelet (N.N.) -- 2. Megakaryopoiesis and Platelet biogenesis (Italiano) -- 3. Transcription factors in MKs and platelets (Cantor / Tijssen & Ghavaert) -- 4. Platelet biogenesis in vivo and the Vascular Niche (Schulze). II. Platelet biology -- 5. Platelet contents (Hartwig) -- 6. Platelet signal transduction (Yonis / S. Watson) -- 7. Thrombosis (Bergmeier) -- 8. Platelets and coagulation (N.N.) -- 9. The platelet life span (Kile). III. Animal models 10. Platelets in mice and men (N.N) -- 11. Animal models for platelet function (Nieswandt) -- 12. Other animal models /zebrafish (N.N.). IV. Platelets in Health and Disease -- 13. Platelet parameters and function testing in the clinic (Schulze / Dame) -- 14. Atherothrombosis and Coronary Artery Disease (Nieswandt) -- 15. Thrombocytopenias and Thrombocytopathies (Ballmaier) -- 16. Platelets in myeloproliferative disorders and leukemia (N.N.) -- 17. Platelet Apheresis and Transfusions (N.N) -- 18. Platelet Biogenesis following Stem Cell Transplantation (N.N)
    Abstract: This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine
    Pages: X, 460 p. 56 illus., 41 illus. in color. : online resource.
    ISBN: 9783319395623
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  • 3
    Keywords: Life sciences ; Plant Ecology ; Wood ; Plant anatomy ; Life sciences ; Plant Anatomy/Development ; Plant Systematics/Taxonomy/Biogeography ; Wood Science & Technology ; Plant Ecology ; Springer eBooks
    Pages: : digital
    ISBN: 9783642116384
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  • 4
    Keywords: Plant Ecology ; Plant physiology ; Plant Biochemistry ; Plant genetics ; Climate Change ; Plant Ecology ; Plant physiology ; Plant Biochemistry ; Plant Genetics and Genomics ; Climate Change ; Springer eBooks
    Description / Table of Contents: Introduction -- General Themes of Molecular Stress Physiology -- Light -- Temperature -- Oxygen Deficiency -- Water Deficiency (Drought) -- Adverse Soil Mineral Availability -- Biotic Stress -- Thermal Balance of Plants and Plant Communities -- Water Relations -- Nutrient Relations -- Carbon Relations -- Ecosystem Characteristics -- Approaches to Study Terrestrial Ecosystems -- Approaches to Model Processes at the Ecosystem Level -- Biogeochemical Fluxes in Terrestrial Ecosystems -- Development of Plant Communities in Time -- Spatial Distribution of Plants and Plant Communities -- Interactions between Plants, Plant Communities and the Abiotic and Biotic Environment -- Biodiversity -- Global Biogeochemical Cycles -- Dynamic Global Vegetation Models -- Global Change and Terrestrial Ecosystems
    Abstract: This completely updated and revised second edition provides a unique and up-to-date treatment of all aspects of plant ecology, making it an ideal textbook and reference work for students, researchers and practitioners. More than 500 high-quality images and drawings, mostly in colour, aid readers’ understanding of various key topics, while the clear structure and straightforward style make it user friendly and particularly useful for students. Written by leading experts, it offers authoritative information, including relevant references. While Plant Ecology primarily addresses graduate students in biology and ecology, it is also a valuable resource for post-graduate students and researchers in botany, environmental sciences and landscape ecology, as well as all those whose study or work touches on agriculture, forestry, land use, and landscape management. Key Topics: - Molecular ecophysiology (molecular stress physiology: light, temperature, oxygen deficiency, water deficit (drought), unfavorable soil mineral conditions, biotic stress) - Physiological and biophysical plant ecology (ecophysiology of plants: thermal balance, water, nutrient, carbon relations) - Ecosystem ecology (characteristics of ecosystems, approaches how to study and how to model terrestrial ecosystems, biogeochemical fluxes in terrestrial ecosystems) - Community ecology and biological diversity (development of plant communities in time and space, interactions between plants and plant communities with the abiotic and the biotic environment, biodiversity and ecosystem functioning) - Global ecology (global biogeochemical cycles, Dynamic Global Vegetation Models, global change and terrestrial ecosystems)
    Pages: XXI, 926 p. 580 illus., 527 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9783662562338
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  • 5
    Call number: W26.5:112
    Keywords: Clinical Trials ; Clinical Trials / methods
    Pages: 113 p. : ill.
    ISBN: 9783170215542
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    W26.5:112 available
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  • 6
    Keywords: Life sciences ; Proteomics ; Botany ; Life sciences ; Plant Sciences ; Proteomics ; Springer eBooks
    Description / Table of Contents: The Plant Kinome -- Phosphatases in Plants -- Phosphoproteomics in Cereals -- Screening of Kinase Substrates Using Kinase-Knockout Mutants -- Phosphopeptide Profiling of Receptor Kinase Mutants -- Combining Metabolic 15N Labelling with Improved TandemMOAC for Enhanced Probing of the Phosphoproteome -- Kinase Activity and Specificity Assay Using Synthetic Peptides -- Absolute Quantitation of Protein Post-Translational Modification Isoform -- Phosphorylation Stoichiometry Determination in Plant Photosynthetic Membranes -- Phosphopeptide Immuno-Affinity Enrichment to Enhance Detection of Tyrosine Phosphorylation in Plants -- The Peptide Microarray ChloroPhos1.0: A Screening Tool for the Identification of Arabidopsis thaliana Chloroplast Protein Kinase Substrates -- Plant Protein Kinase Substrates Identification Using Protein Microarrays -- Targeted Analysis of Protein Phosphorylation by 2D Electrophoresis -- Computational Phosphorylation Network Reconstruction: Methods and Resources -- Computational Identification of Protein Kinases and Kinase-Specific Substrates in Plants -- Databases for Plant Phosphoproteomics -- Phosphorylation Site Prediction in Plants
    Abstract: This detailed volume addresses recent developments in phosphoproteomic techniques with a particular focus on the plant system. Over the recent decades, proteomic methods were refined to study the significance and dynamics of protein phosphorylation in various biological contexts. However, working with plant tissue imposes particular challenges to the biologist which are attributed to the rigid cell wall making protein extraction more difficult, the skewed protein abundance with Rubisco as a highly abundant protein, and a large central vacuole leading to low protein yield and increased degradative enzyme activity. The methodologies in this book seek to move beyond these issues.℗ Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Plant Phosphoproteomics: Methods and Protocols serves as an ideal reference for researchers investigating this vital area of plant science
    Pages: X, 231 p. 24 illus., 16 illus. in color. : online resource.
    ISBN: 9781493926480
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  • 7
    Call number: Z070:224 ; Z070:225
    Pages: 259 p. : ill.
    Edition: 3., komplett überarb. Aufl.
    ISBN: 9783800731343
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    Z070:224 departmental collection or stack – please contact the library
    Z070:225 departmental collection or stack – please contact the library
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  • 8
    Call number: QV137:61/3 ; ZZ2003:2/3/Mag
    Keywords: Tobacco Industry ; Tobacco / chemistry ; Hydrogen-Ion Concentration ; Substance-Related Disorders ; DKFZ-publications
    Notes: Verantwortlich für den Inhalt: Deutsches Krebsforschungszentrum Stabsstelle Krebsprävention und WHO-Kollaborationszentrum für Tabakkontrolle.
    Pages: 77 p.
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    QV137:61/3 available
    ZZ2003:2/3/Mag departmental collection or stack – please contact the library
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  • 9
    Call number: ZZ2006:5a ; ZZ2006:5/Mag
    Keywords: Smoking / statistical and numerical data ; Taxes / legislation & jurisprudence ; DKFZ-publications
    Pages: 12 p.
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    ZZ2006:5a available
    ZZ2006:5/Mag departmental collection or stack – please contact the library
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  • 10
    Keywords: RECEPTOR ; APOPTOSIS ; EXPRESSION ; Germany ; PATHWAY ; SYSTEM ; SYSTEMS ; DEATH ; SITE ; GENE ; PROTEIN ; PROTEINS ; DIFFERENTIATION ; MONOCLONAL-ANTIBODY ; MECHANISM ; FAMILY ; INDUCTION ; mechanisms ; BINDING ; ALPHA ; CELL-DEATH ; PROMOTER ; p53 ; DNA-DAMAGE ; BAX ; MITOCHONDRIA ; RECEPTORS ; TRAIL ; Bcl-2 ; CD95 ; chemoresistance ; WILD-TYPE P53 ; signaling ; chemosensitivity ; CLINICAL-RELEVANCE ; CHEMOTHERAPEUTIC DRUGS ; INDUCE ; P63 ; death receptor ; BCL-2 FAMILY MEMBERS ; BINDING-SITE ; KINASE C-ABL ; P53-DEPENDENT APOPTOSIS ; REGULATES P73 ; TAp63 ; TUMOR-SUPPRESSOR P53
    Abstract: TP63, an important epithelial developmental gene, has significant homology to p53. Unlike p53, the expression of p63 is regulated by two different promoters resulting in proteins with opposite functions: the full-length transcriptionally active TAp63 and the dominant-negative DNp63. We investigated the downstream mechanisms by which TAp63 alpha elicits apoptosis. TAp63 alpha directly transactivates the CD95 gene via the p53 binding site in the first intron resulting in upregulation of a functional CD95 death receptor. Stimulation and blocking experiments of the CD95, TNF-R and TRAIL-R death receptor systems revealed that TAp63a can trigger expression of each of these death receptors. Furthermore, our findings demonstrate a link between TAp63a and the mitochondrial apoptosis pathway. TAp63a upregulates expression of proapoptotic Bcl-2 family members like Bax and BCL2L11 and the expression of RAD9, DAP3 and APAF1. Of clinical relevance is the fact that TAp63a is induced by many chemotherapeutic drugs and that inhibiting TAp63 function leads to chemoresistance. Thus, beyond its importance in development and differentiation, we describe an important role for TAp63a in the induction of apoptosis and chemosensitivity
    Type of Publication: Journal article published
    PubMed ID: 15944736
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