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    Keywords: radiotherapy ; SURVIVAL ; tumor ; Germany ; THERAPY ; imaging ; SUPPORT ; SAMPLE ; TUMORS ; NUCLEAR-MEDICINE ; radiation ; PATIENT ; primary ; BASE ; treatment ; CARBON ; EXPERIENCE ; RADIATION-THERAPY ; COST-EFFECTIVENESS ; RATES ; SKULL BASE ; local control ; side effects ; RECURRENT ; nuclear medicine ; ION RADIOTHERAPY ; radiology ; ONCOLOGY ; THERAPIES ; INCREASE ; LIFE ; chordoma ; radiation therapy ; cost ; CHONDROSARCOMAS ; SKULL-BASE ; methods ; NUCLEAR ; carbon ion radiotherapy ; carbon ion radiation therapy ; PHOTON ; BENEFITS ; carbon ion
    Abstract: Aim: The cost-effectiveness of Carbon ion radiotherapy (RT) for patients with skull base chordoma is analyzed. Materials and Methods: Primary treatment costs and costs for recurrent tumors are estimated. The costs for treatment of recurrent tumors were estimated using a sample of 10 patients presenting with recurrent chordoma at the base of skull at DKFZ. Using various scenarios for the local control rate and reimbursements of Carbon ion therapy the cost-effectiveness of ion therapy for these tumors is analyzed. Results: If local control rate for skull base chordoma achieved with carbon ion therapy exceeds 70.3%, the overall treatment costs for carbon RT are lower than for conventional RTI. The cost-effectiveness ratio for carbon RT is 2539 Euro per 1% increase in survival, or 7692 Euro per additional life year. Conclusion: Current results support the thesis that Carbon ion RT, although more expensive, is at least as cost-effective as advanced photon therapies for these patients. Ion RT, however, offers substantial benefits for the patients such as improved control rates and less severe side effects. 0 2007 Elsevier Ireland Ltd. AR rights reserved
    Type of Publication: Journal article published
    PubMed ID: 17490770
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