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  • 1
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    Berlin : Springer
    Keywords: Oncology ; Medicine ; Oncology   ; Cancer Research ; Molecular Medicine ; Oncology ; Springer Nature Living Reference
    Abstract: The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in℗ 7 Volumes with an A-Z format of℗ approx. 7000℗ entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative℗ Essays are included that cover topics ranging from Pathology, to Clinical Oncology and Targeted Therapies. This new feature should meet the expectance that a wide community has towards a major cancer reference works. The Encyclopedia of Cancer will be accessible both in print and online, and this information source should be of value to both the clinical and basic scientific community as well as to the public
    Pages: LXXXVI, 3984 p. 1071 illus., 710 illus. in color. : online resource.
    ISBN: 9783642278419
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  • 2
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    Berlin : Springer
    Call number: QZ200:475 ; 05-ONK-10:38 ; S020:19
    Keywords: Neoplasms ; DKFZ-publications
    Notes: 2nd ed. with title: Encyclopedia of cancer. 2009.
    Pages: xxiii, 992 p. : ill. + 1 CD-ROM
    ISBN: 3540665277
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    QZ200:475 available
    05-ONK-10:38 departmental collection or stack – please contact the library
    S020:19 departmental collection or stack – please contact the library
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  • 3
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    Berlin : Springer
    Call number: QZ200:475(2)/1 ; QZ200:475(2)/2 ; QZ200:475(2)/3 ; QZ200:475(2)/4
    Keywords: Neoplasms
    Description / Table of Contents: v. 1. A-C -- v. 2. D-K -- v. 3. L-P -- v. 4. Q-Z
    Notes: 1st ed. with title: Encyclopedic reference of cancer. 2001.
    Pages: 4 v., lxxxvii, 3235 p. : ill.
    Edition: 2nd ed.
    ISBN: 9783540368472
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    QZ200:475(2)/1 available
    QZ200:475(2)/2 available
    QZ200:475(2)/3 available
    QZ200:475(2)/4 available
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  • 4
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    OXFORD: PERGAMON PRESS
    Call number: QZ200Z:11/31A,4
    Pages: S. 427-646.
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    QZ200Z:11/31A,4 available
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  • 5
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    Berlin, Heidelberg : Springer
    Keywords: Medicine ; Oncology ; Biomedicine ; Cancer Research ; Molecular Medicine ; Oncology ; Springer eBooks
    Pages: : digital
    Edition: 3. ed.
    ISBN: 9783642164835
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  • 6
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    Keywords: Medicine ; Cancer Research ; Molecular Biology ; Oncology ; Biomedicine ; Cancer Research ; Molecular Medicine ; Oncology ; Springer eBooks
    Pages: 1230 illus., 870 illus. in color. eReference. : online resource.
    ISBN: 9783662468753
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  • 7
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cell lines (COLO 320 DM and COLO 320 HSR), established from a human neuroendocrine tumor, contain an amplified cellular oncogene (c-myc). We have previously shown that the homogeneously staining regions (HSRs) of a marker chromosome in the COLO 320 HSR cells that evolved in culture from COLO 320 DM cells contain amplified c-myc. Molecular hybridization in situ has now been used to demonstrate that the HSRs are on both arms of what was once an X chromosome. We also show that amplified c-myc copies are present in the isolated double minute chromosomes (DMs) of the COLO 320 DM cells that were characteristic of the tumor cells initially established from the patient. The results suggest that the amplified c-myc appeared first as DMs and was subsequently transposed to engender HSRs on an X chromosome. The initial COLO 320 tumor cell may have acquired two “early replicating” (i.e., active) X chromosomes and lost the “late replicating” (i.e., inactive) X.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We used the SEWA cell lines 4031Tc3 (DMs), StamA (HSR) and Rec4Tc2 (CMs) to screen for amplification of oncogenes (for a genealogy of SEWA cells see rf. 2). Preliminary tests, in which we hybridized a ^2P-labelled complementary DNA synthesized from poly( A)+ RNA to nitrocellulose filters containing ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 188 (1982), S. 410-417 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Xiphophorus represents a valuable model for studying genomic contributions to neoplasia. For analyzing these contributions at the molecular level, basic information about the genome organization is a prerequisite. This study presents data on the organization and complexity of the genomes of three species of Xiphophorus, maculatus, variatus and helleri, representative of the problem. Their diploid nuclei, as measured in the erythrocyte, contain 1.19 pg, 1.23 pg, and 1.27 pg DNA, these values representing approximately 50% of that of birds, 20% of that of mammals. The melting curves of native, high molecular weight DNA are homogeneous, the Tm was determined for maculatus as 85.0° C (corresponding to a mean GC-content of 38.3%) for variatus as 86.0° C (GC=40.7%), for helleri as 85.0° C (GC=39.3%). Reassociation of sheared denatured DNA indicated approximately 90% single copy sequences, the remaining 10% are predominantly multiple copy sequences. The complexity of single copy DNA was determined from reassociation kinetics for maculatus as 3.97×108 base pairs, for variatus as 4.31×108 base pairs, and for helleri as 4.49×108 base pairs. The DNA of the three species upon isopycnic density gradient centrifugation in the presence of the fluorescence dye Hoechst 33258 shows in addition to the main band, two heavy (GC-rich) satellites, denoted in the order of increasing density, components I and II. Analytical centrifugation reveals for the main band DNA a buoyant density of 1.6980 gcm-3 (GC=38.7%), for component I 1.7080 gcm-3 (GC=48.9%), for component II 1.7150 gcm-3 (GC=56.1%). Each of the components comprises approximately 0.38% of the total DNA. Complete digestion of components I and II with restriction enzymes EcoRI and BamHI yields a complex banding pattern upon agarose gel-electrophoresis. A 2.4 kb fragment of component I and a 5.3 kb fragment of component II of helleri, cloned and amplified in the pBR322/E. coli RR1 system, hybridize efficiently to purified nuclei of liver. Furthermore, restriction fragments of component II DNA, transferred to nitrocellulose by Southern-blotting, hybridize with 18S and 28S ribosomal DNA.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 318 (1985), S. 188-191 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two mouse teratocarcinoma stem cell lines (embryonal carcinoma (EC) cells), PSA-1 (refs 9, 10) and F9 (rf. 11), were tested for the expression of N-myc. Both cell lines were isolated from embryo-derived teratocarcinomas and form tumours when injected subcutaneously (s.c,) into mice. The two cell ...
    Type of Medium: Electronic Resource
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