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  • 1
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    The American Association for Clinical Chemistry (AACC)
    Publication Date: 2018-05-30
    Print ISSN: 0009-9147
    Electronic ISSN: 1530-8561
    Topics: Medicine
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  • 3
    Publication Date: 2018-06-19
    Description: Comparing the abundance of one RNA molecule to another is crucial for understanding cellular functions but most sequencing techniques can target only specific subsets of RNA. In this study, we used a new fragmented ribodepleted TGIRT sequencing method that uses a thermostable group II intron reverse transcriptase (TGIRT) to generate a portrait of the human transcriptome depicting the quantitative relationship of all classes of nonribosomal RNA longer than 60 nt. Comparison between different sequencing methods indicated that FRT is more accurate in ranking both mRNA and noncoding RNA than viral reverse transcriptase-based sequencing methods, even those that specifically target these species. Measurements of RNA abundance in different cell lines using this method correlate with biochemical estimates, confirming tRNA as the most abundant nonribosomal RNA biotype. However, the single most abundant transcript is 7SL RNA, a component of the signal recognition particle. S tructured n on c oding RNAs (sncRNAs) associated with the same biological process are expressed at similar levels, with the exception of RNAs with multiple functions like U1 snRNA. In general, sncRNAs forming RNPs are hundreds to thousands of times more abundant than their mRNA counterparts. Surprisingly, only 50 sncRNA genes produce half of the non-rRNA transcripts detected in two different cell lines. Together the results indicate that the human transcriptome is dominated by a small number of highly expressed sncRNAs specializing in functions related to translation and splicing.
    Print ISSN: 1355-8382
    Electronic ISSN: 1469-9001
    Topics: Biology , Medicine
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  • 4
    Keywords: Medicine ; Pharmacology ; Pharmaceutical technology ; Ophthalmology ; Biomedicine ; Pharmacology/Toxicology ; Pharmaceutical Sciences/Technology ; Ophthalmology ; Springer eBooks
    Description / Table of Contents: General Principles: Principles of Ocular Pharmacology -- Ocular Pharmacokinetics -- Ocular Drug Delivery -- Anterior Segment and Tear Film: Tear Film-dry eye -- Conjunctiva-allergic conjunctivitis, infectious conjunctivitis, conjunctival hyperemia -- Cornea-Keratitis, antibiotics, antifungals, anti-virals, anti-inflammatory agents including corticosteroids and NSAIDS -- Cornea-Keratoconus and other corneal disease, Pharmacologic cross-linking and future therapy -- Lens-management of cataract surgery, cataract prevention, floppy iris syndrome -- Trabecular Meshwork and Uvea: Glaucoma-Intraocular Pressure Reduction -- Glaucoma-Neuroprotection -- Uveitis -- Posterior Segment and Optic Nerve: Retina Anti-angiogenesis, AMD, Myopia, DME -- Retina Anti-inflammatory therapy, corticosteroids, anti-complement, AMD, DME -- Atrophic AMD -- Hereditary Retinal Disease -- Optic Nerve
    Abstract: There have been major advancements in the pharmacologic treatment of eye diseases over the past decade. With newly discovered disease targets and novel approaches to deliver therapeutic compounds to the eye, patients are seeing improved outcomes. Not only are there better treatments for diseases where treatments existed, we now have effective therapy for previously untreatable and blinding eye disorders. This volume will cover the pharmacologic treatment of eye diseases from the front of the eye including eyelids, conjunctiva and cornea all the way back to the retina and optic nerve. The first section of the volume reviews general principles of ocular pharmacology, pharmacokinetics, pharmaceutical sciences, and drug delivery. In addition, the volume provides an up to date guide to the pharmacologic approach to the key eye diseases that threaten sight or ocular function
    Pages: VIII, 394 p. : online resource.
    ISBN: 9783319582900
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  • 5
    New York, NY : Springer Science+Business Media, LLC
    Keywords: Medicine ; Family medicine ; Cardiology ; Heart / Surgery ; Medicine & Public Health ; Cardiology ; Cardiac Surgery ; Health Promotion and Disease Prevention ; General Practice / Family Medicine ; Medicine/Public Health, general ; Springer eBooks
    Pages: : digital
    ISBN: 9781441958396
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  • 6
    Keywords: Medicine ; Dermatology ; Family medicine ; Internal Medicine ; Pediatrics ; Medicine & Public Health ; Dermatology ; Internal Medicine ; General Practice / Family Medicine ; Pediatrics ; Springer eBooks
    Edition: 2nd ed
    ISBN: 9783642280061
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  • 7
    Boca Raton : Chapman & Hall/CRC
    Call number: W26.5:109 ; C060:217 ; G040:64
    Keywords: Clinical Trials as Topic ; Bayes Theorem
    Description / Table of Contents: (Publisher-supplied data) Statistical approaches for clinical trials -- Basics of Bayesian inference -- Phase I studies -- Phase II studies -- Phase III studies -- Special topics
    Abstract: "As has been well-discussed, the explosion of interest in Bayesian methods over the last 10 to 20 years has been the result of the convergence of modern computing power and ełcient Markov chain Monte Carlo (MCMC) algo- rithms for sampling from and summarizing posterior distributions. Prac- titioners trained in traditional, frequentist statistical methods appear to have been drawn to Bayesian approaches for three reasons. One is that Bayesian approaches implemented with the majority of their informative content coming from the current data, and not any external prior informa- tion, typically have good frequentist properties (e.g., low mean squared er- ror in repeated use). Second, these methods as now readily implemented in WinBUGS and other MCMC-driven software packages now oʼer the simplest approach to hierarchical (random eʼects) modeling, as routinely needed in longitudinal, frailty, spatial, time series, and a wide variety of other settings featuring interdependent data. Third, practitioners are attracted by the greater ʻexibility and adaptivity of the Bayesian approach, which permits stopping for ełcacy, toxicity, and futility, as well as facilitates a straightforward solution to a great many other specialized problems such as dose-nding, adaptive randomization, equivalence testing, and others we shall describe. This book presents the Bayesian adaptive approach to the design and analysis of clinical trials"--Provided by publisher
    Pages: xvii, 305 p. : ill.
    ISBN: 9781439825488
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    W26.5:109 available
    C060:217 departmental collection or stack – please contact the library
    G040:64 departmental collection or stack – please contact the library
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  • 8
    Keywords: Medicine ; Human Genetics ; Biomedicine ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Long Term Selection Experiments: Epistasis and The Response To Selection -- Finding the Epistasis Needles in the Genome-Wide Haystack -- Biological Knowledge-Driven Analysis of Epistasis in Human GWAS with Application to Lipid Traits -- Epistasis for Quantitative Traits in Drosophila -- Epistasis In The Risk Of Human Neuropsychiatric Disease -- On the Partitioning of Genetic Variance with Epistasis -- Measuring Gene Interactions -- Two Rules for the Detection and Quantification of Epistasis and other Interaction Effects -- Direct Approach to Modeling Epistasis -- Capacitating Epistasis℗ - Detection and Role in the Genetic Architecture of Complex Traits -- Compositional Epistasis: An Epidemiologic Perspective -- Identification Of Genom途Wide SNṔ€”SNP and SNṔ€”Clinical Boolean Interactions In Age Related Macular Degeneration -- Epistasis Analysis Using Information Theory -- Genome-Wide Epistasis and Pleiotropy Characterized by the Bipartite Human -- Network Theory for Data-Driven Epistasis Networks -- ℗ Epistasis Analysis Using Multifactor Dimensionality Reduction -- ℗ Epistasis Analysis Using ReliefF -- Epistasis Analysis Using Artificial Intelligence
    Abstract: This volume presents a valuable and readily reproducible collection of established and emerging techniques on modern genetic analyses. Chapters focus on statistical or data mining analyses, genetic architecture, the burden of multiple testing, genetic variance, measuring epistasis, multifactor dimensionality reduction, and ReliefF. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. ℗ Authoritative and practical, Epistasis: Methods and Protocols aids scientists in continuing to study elucidate epistasis in the context of modern data availability
    Pages: X, 350 p. 61 illus., 17 illus. in color. : online resource.
    ISBN: 9781493921553
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  • 9
    Abstract: The diagnosis of hematologic malignancies relies on multidisciplinary workflows involving morphology, flow cytometry, cytogenetic, and molecular genetic analyses. Advances in cancer genomics have identified numerous recurrent mutations with clear prognostic and/or therapeutic significance to different cancers. In myeloid malignancies, there is a clinical imperative to test for such mutations in mainstream diagnosis; however, progress toward this has been slow and piecemeal. Here we describe Karyogene, an integrated targeted resequencing/analytical platform that detects nucleotide substitutions, insertions/deletions, chromosomal translocations, copy number abnormalities, and zygosity changes in a single assay. We validate the approach against 62 acute myeloid leukemia, 50 myelodysplastic syndrome, and 40 blood DNA samples from individuals without evidence of clonal blood disorders. We demonstrate robust detection of sequence changes in 49 genes, including difficult-to-detect mutations such as FLT3 internal-tandem and mixed-lineage leukemia (MLL) partial-tandem duplications, and clinically significant chromosomal rearrangements including MLL translocations to known and unknown partners, identifying the novel fusion gene MLL-DIAPH2 in the process. Additionally, we identify most significant chromosomal gains and losses, and several copy neutral loss-of-heterozygosity mutations at a genome-wide level, including previously unreported changes such as homozygosity for DNMT3A R882 mutations. Karyogene represents a dependable genomic diagnosis platform for translational research and for the clinical management of myeloid malignancies, which can be readily adapted for use in other cancers.
    Type of Publication: Journal article published
    PubMed ID: 27121471
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  • 10
    ISSN: 0303-7207
    Keywords: dexamethasone resistance ; human lymphoid cells ; mutagenesis ; tetraploid cells
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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