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  • 1
    Keywords: Medicine ; Oncology ; Biochemistry ; Cytology ; Stem Cells ; Biomedicine ; Cancer Research ; Medical Biochemistry ; Cell Biology ; Stem Cells ; Springer eBooks
    Description / Table of Contents: Introduction -- Alcohol and breast cancer: Reconciling epidemiological and molecular data -- Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking -- Alcohol and Cancer: an Overview With special Emphasis on the Role of Acetaldehyde and Cytochrome P-4502E1 -- Implications of acetaldehyde-derived DNA adducts for understanding alcohol related carcinogenesis -- The role of iron in alcohol-mediated hepatocarcinogenesis -- Alcoholic Cirrhosis and Hepatocellular Carcinoma -- TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis -- Synergistic Toxic Interactions Between CYP2E1, LPS/TNFÎł and JNK/p38 MAP Kinase and their Implications in Alcohol-induced Liver Injury -- Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma -- Alcohol consumption, Wnt/b-catenin signaling and hepatocarcinogensis -- Alcohol and HCV: Implications for Liver Cancer -- Application of Mass Spectrometry-based Metabolomics in Identification of Early Noninvasive Biomarkers of Alcohol-Induced Liver Disease Using Mouse Model -- Alcohol Metabolism by Oral Streptococci and Interaction with Human Papillomavirus Leads to Malignant Transformation of Oral Keratinocytes -- Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers -- Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic cancers -- Alcohol, Carcinoembryonic Antigen Processing and Colorectal Liver Metastases -- Alcohol Consumption and Antitumor Immunity:℗ Dynamic Changes from Activation to Accelerated Deterioration of the Immune System -- A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma -- The effects of alcohol and aldehyde dehydrogenases on disorders of hematopoiesis -- The effect of alcohol on sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC) -- Transgenic Mouse Models for Alcohol Metabolism, Toxicity and Cancer -- Fetal alcohol exposure increases susceptibility to carcinogenesis and promotes tumor progression in prostate gland -- Fetal Alcohol Exposure and Mammary Tumorigenesis in Offspring:℗ Role of the Estrogen and Insulin-like Growth Factor Systems
    Abstract: This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer, cell signaling and cancer, stem cells, biomarkers and metabolomics, aerodigestive cancers, cancer and the immune system, and more. In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated and this volume gives a comprehensive overview of these advancements
    Pages: XVI, 436 p. 97 illus., 57 illus. in color. : online resource.
    ISBN: 9783319096148
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  • 2
    Keywords: Oncology ; Stem Cells ; Cancer Research ; Stem Cells ; Springer eBooks
    Description / Table of Contents: Alcohol Consumption and Risk of Thyroid Cancer: A Population Based Case-Control Study in Connecticut -- Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens -- Glutathione and Transsulfuration in Alcohol-associated Tissue Injury and Carcinogenesis -- Fatty liver disease and hepatocellular carcinoma: The pathologist’s view -- Alcoholic liver disease accelerates early hepatocellular cancer in a mouse model -- Chronic ethanol consumption and generation of etheno-DNA adducts in cancer-prone tissues -- Role of TGF-β in Alcohol-Induced Liver Disease -- NANOG-dependent metabolic reprogramming and symmetric division in tumor-initiating stem-like cells -- Diet supplementation with soy protein isolate, but not the isoflavone genistein, protects against alcohol-induced tumor progression in DEN-treated male mice -- ALDH1L1 and ALDH1L2 folate regulatory enzymes in cancer -- Developmental Morphogens & Recovery from Alcoholic Liver Disease -- Suppressed fat mobilization due to PNPLA3 rs738409 -associated liver damage in heavy drinkers: The liver damage feedback hypothesis -- Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease -- Engineered animal models designed for investigating ethanol metabolism, toxicity and cancer -- Index
    Abstract: Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells. More specifically, it delves into the effects of alcohol consumption and thyroid cancer, CD133+ progenitor cells, carcinogenic iron accumulation, developmental morphogens, and cancer-inducing epigenetic changes. Alcohol and Cancer: Proceedings of the Third International Conference is a timely update to Biological Basis of Alcohol-Induced Cancer, which followed the Second Alcohol and Cancer Conference, compiling cutting-edge research from graduate students, young scientists, and researchers. It is ideal for graduate students and researchers in oncology, hepatology, epigenetics, and alcohol consumption
    Pages: XII, 271 p. 36 illus., 23 illus. in color. : online resource.
    ISBN: 9783319987880
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