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  • 1
    ISSN: 1435-1803
    Keywords: Aortic impedance ; afterload ; preload ; stroke volume ; angiotensin II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim was to examine the influence of the independent increase of aortic wall characteristics from vascular resistance on global left ventricular (LV) function in intact hearts. In 11 anesthetized dogs, aortic stiffness was increased by a constriction of the thoracic aorta using a stiff tube, and then, in nine dogs, total systemic resistance (TSR) was increased by an infusion of angiotensin II. During the above procedures, aortic input impedance and LV diemnsion were measured. Aortic input impedance spectra revealed the steady increase in the moduli at high frequencies by aortic constriction, indicating the increase in aortic stiffness. At the stage of increased aortic characteristic impedance (Zc) (134% of control) without a change in TSR, both LV end-diastolic diameter (LVEDD, 99%, p<0.01) and stroke volume (SV, 95%, p<0.01) decreased significantly without a change in LV end-systolic diameter (LVESD). During the increase in TSR produced by angiotensin II (128% of control) without a change in Zc, LVEDD tended to increase and LVESD significantly increased (103%, p<0.01), associated with a decrease in SV (94%, p<0.01). LV systolic mean wall stress was increased by angiotensin II (118%, p<0.01), whereas it was unchanged by aortic constriction. In conclusion, the isolated increase in aortic stiffness without a change in TSR was associated with a reduction in LV preload and SV.
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  • 2
    ISSN: 1420-908X
    Keywords: Thiamylal ; Ketamine ; Phagocytic plaque method ; Phagocytosis ; Polymorphonuclear leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the effects of the intravenous anaesthetic agents, thiamylal and ketamine, on the phagocytic function of polymorphonuclear leukocytes (PMN) in heparinized peripheral blood from healthy individuals using the phagocytic plaque method. Subclinical doses of thiamylal caused enhancement of the phagocytic activity of PMN and super-clinical doses of thiamylal inhibited phagocytic activity of PMN. Ketamine did not adversely affect phagocytic function at relevant therapeutic concentrations. The results presented in this manuscript indicate the phagocytic plaque method can provide a quantitative assessment of the phagocytic function of leukocytes. This method may prove useful in determining whether anaesthetic agents and other drugs adversely affect leukocyte function and hence help prevent the increased susceptibility to infection which can occur in anaesthetized patients. Conversely, the phagocytic plaque method may prove useful in the search for immune-enhancing drugs.
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  • 3
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die Rattenblastocyste synthetisiert, kurz bevor sich die Membrana pellucida auflöst, Nukleinsäuren, wie aus der Aufnahme von Uridin durch die Zellkerne elektronenmikroskopisch und autoradiographisch gezeigt wurde. Bei verzögerter Implantation wird Nukleinsäure in geringerem Ausmass aufgebaut.
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  • 4
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Isolated post mortem human coronary arteries developed rhythmic contractions in physiological saline solution without being exposed to vasoactive agents.
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  • 5
    ISSN: 1432-0711
    Keywords: Ovary ; Malignant lymphoma ; Combination chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 44-year-old woman with stage IV non-Hodgkin's lymphoma (NHL) of the left ovary is described. She had an extended hysterectomy and bilateral salpingooophorectomy and thereafter received six courses of combination chemotherapy (cyclophosphamide, adriamycin, vincristine and predonisolone; CHOP). The patient is well with no evidence of recurrence at 12 months after surgery. The literature on primary ovarian lymphoma is reviewed.
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 22 (1993), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Osteoid osteoma is a benign bone tumour characterized by pain which is relieved by non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin. To clarify the mechanism of the pain, five osteoid osteomas were studied immunohistochemically using polyclonal antibodies against prostaglandin E2 (PGE2), S-100 protein and protein gene product 9.5 (PGP 9.5). In all five cases, the pain had been relieved by NSAIDs. Nerve fibres positive for S-100 protein and PGP 9.5 were observed in the fibrous zone, especially close to the blood vessels, around the nidus in all the lesions and also within the nidus in three lesions. PGE2 immunoreactivity was variably positive in the nidus of three lesions. In one case a large number of actively proliferating osteoblasts reacted with this antibody. The other cases showed unevenly distributed PGE2 positivity which tended to be prominent in the plump osteoblasts. As control material we examined fibrous dysplasia (3 cases), osteosarcomas (3) and giant-cell tumours of bone (3). The plump osteoblastic tumour cells of three osteosarcomas and the bone-forming cells in two cases of fibrous dysplasia gave a positive reaction for PGE2. No S-100 or PGP 9.5 immunoreactive nerve fibres were seen in these lesions. It is concluded that the presence of nerve fibres alone might play a more important role in mediation of pain in osteoid osteomas than some effects of osteoblast-produced PGE2 on the nerves and proliferated blood vessels.
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  • 7
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Ultraviolet photoelectron spectroscopy (UPS) has been applied to the investigation of the electronic structure of oligothiophenes with 4–8 thiophene rings. In a series of α-linked oligomers (αn with n being the number of rings), a systematic evolution of the π band is observed. Several peaks which correspond to the π band are observed in the region of 0.7–3 eV below the Fermi level (EF), and the bandwidth becomes broader with increasing n. The nonbonding π band is observed at 3.5 eV below EF and its energy is almost independent of the number of thiophene units. UPS spectra of α7 and α8 are fairly similar to the spectra of polythiophene, showing that these oligomers are good model compounds of the polymer. The ionization threshold energy of α7 and polythiophene was observed to be 5.3 eV. The effect of irregularity on the π-electron system was also studied by using oligomers which contain a β linkage or a vinylene group at the middle of the molecule. The UPS spectra showed that the β linkages significantly affect the electronic structure of polythiophene, while the vinylene group does not. In order to analyze the UPS spectra and to investigate the electronic structures of oligomers, the orbital energies and the geometries of these oligomers are calculated by the semiempirical MNDO-SCF-MO (modified neglect of diatomic overlap self-consistent-field molecular orbital) method. Theoretically simulated spectra of these oligothiophenes derived from the obtained orbital energies by Gaussian broadening are compared with the observed ones. The agreement between the observed and calculated spectra is very good, particularly in the π region. It is shown from the optimized geometry that (1) αn 's have planar structure and π electrons are delocalized, (2) the oligomer with β linkages has nonplanar structure leading to limited delocalization of π electrons, and (3) the oligomers with a vinylene group are almost planar and the disturbance by the vinylene group on the delocalization is small.
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  • 8
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 117 (2002), S. 1377-1384 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report a Brownian dynamics (BD) simulation study of the Förster energy transfer in a dye-labeled Rouse polymer chain. The simulation method is based on the normal mode BD propagation and numerical path integration of the survival probability. It is shown that a properly constructed truncated normal-mode approximation (TNMA) can speed up the simulations considerably, without essential loss of accuracy. In particular, an effective-sink TNMA scheme is found to be quite efficient. The idea is based on a standard time scale separation ansatz, where all the normal modes are separated into slow and fast, in terms of the corresponding relaxation times. The fast normal modes are assumed to be equilibrated in the course of reaction and thus can be integrated out. Their effect is to modify the reaction sink for the slow modes. The first-order approximation can be handled most easily, without a simulation. Even this simple approximation can be preferable to the well-known Wilemski–Fixman approximation, if the reaction sink is wide, i.e., when the Förster radius exceeds the polymer mean bond length, the condition often chosen in experiments on polymer folding. © 2002 American Institute of Physics.
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  • 10
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Electronic structures of 5, 10, 15, 20-zinctetraphenylporphyrin (ZnTPP)/metal (Au, Ag, Al, Mg) interfaces prepared in ultrahigh vacuum were investigated by ultraviolet photoelectron spectroscopy (UPS). We found that the electronic energy levels of ZnTPP align to the vacuum level of substrate metal, with a constant energy shift of vacuum levels across the interface. These findings cannot be explained by the simple models assuming vacuum level alignment at the interface. We also found that sample exposure to oxygen induces energy level shift in close relation with change of substrate work function at oxygen exposure. © 1995 American Institute of Physics.
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