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  • 1
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    New York, NY : Springer Science+Business Media, LLC
    Keywords: Medicine ; Radiology, Medical ; Medicine & Public Health ; Imaging / Radiology ; Diagnostic Radiology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441917287
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  • 2
    Keywords: Life sciences ; Ecology ; Biodiversity ; Plant Ecology ; Conservation biology ; Botany ; Life sciences ; Plant Sciences ; Ecology ; Plant Ecology ; Biodiversity ; Conservation Biology/Ecology ; Springer eBooks
    Description / Table of Contents: Introduction -- 1. Mycorrhizas: An Overview -- 2. Mycorrhizas: Global Patterns and Trends -- 3. Mycorrhizas and Global Climate Change -- 4. Mycorrhizas in Relation to Plant Rarity and Invasiveness -- 5. Mycorrhizas and Ecological Restoration -- 6. Mycorrhizas in Extreme Environments -- 7. Mycorrhizas in Aquatic Plants -- 8. Approaches to Mycorrhizal Studies -- Glossary -- Index -- Bibliography. ℗ ℗
    Abstract: The book provides basic knowledge in mycorrhizal ecology, knitted with novel conceptual frameworks and contemporary perspectives, especially in the context of global change. In a fast changing world wherein anthropogenic climate change, biological invasions, deforestation, desertiƠ̐cation, and frequent droughts have become routine hard realities, the contents of this book urge readers to rethink basic notions of setting and accomplishing objectives in mycorrhizal research to make sense vis-© -vis contemporary challenges. In this book, a global perspective of mycorrhizal diversity and distribution is provided, followed by some insights into the impact of various global change elements such as climate change, plant invasion, and extreme environmental conditions on mycorrhizas and the role of these mutualists in turn to help their host plants to withstand such novel selection pressures. Special attention here is given to the interesting, but largely neglected, topics such as the role of mycorrhizas in ecological restoration of degraded environments and mycorrhizal status of aquatic plants. The basic idea is to unify various topical areas in mycorrhizal science in an integrated framework. This book can be used by the undergraduate and graduate level students studying mycorrhizal symbioses in the context of current ecological applications. The materials in this book will beneƠ̐t biological scientists actively involved in research on mycorrhizal ecology and global environmental change. Besides, the contents of the book could be of special interest to restoration ecologists and biodiversity managers
    Pages: XI, 87 p. 26 illus., 9 illus. in color. : online resource.
    ISBN: 9788132218654
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  • 3
    Keywords: Medicine ; Human Genetics ; Medical laboratories ; Biomedicine ; Human Genetics ; Laboratory Medicine ; Springer eBooks
    Description / Table of Contents: Array Comparative Genomic Hybridization: An Overview of Protocols, Applications and Technology Trends -- Ultra Dense Array CGH and Discovery of Micro-Copy Number Alterations and Gene Fusions in the Cancer Genome -- Epigenomics: Sequencing the Methylome -- Application of Array Comparative Genomic Hybridization in Chronic Myeloid Leukemia -- The Use of Cytogenetic Microarrays in Myelodysplastic Syndrome Characterization -- CGH Protocols - Chronic Lymphocytic Leukemia -- Analysis of Acquire Genomic Copy Number Aberrations and Regions of Loss of Heterozygosity in Acute Myelogenous Leukemia Fenomes using Affymetrix SNP 6.0 Arrays and Supporting Software Tools -- Clinical Applications of BAC Array-CGH to the Study of Diffuse Large B-Cell Lymphomas -- Genomic Profiling of Mantle Cell Lymphoma -- Copy Number Analysis in EBV-Positive Nodal Peripheral T-Cell Lymphoma, Unspecified -- Mycosis Fungoides and Sézary Syndrome -- Array CGH Reveals Clonal Evolution of Adult T Cell Leukemia/Lymphoma -- Array-CGH Analysis of Cutaneous Anaplastic Large Cell Lymphoma -- Genome Wide DNA-Profiling of HIV-Related B-Cell Lymphomas -- Array Comparative Genomic Hybridization in Osteosarcoma -- Comparative Genomic Hybridization of Wilms' Tumor -- Array-CGH in Childhood MDS -- Non-Familial Breast Cancer Subtypes -- Applications of Array-CGH for Lung Cancer -- Array CGH in Brain Tumours -- Finding Common Regions of Alteration in Copy Number Data -- Distinguishing Somatic and Germline Copy Number Events in Cancer Patient DNA Hybridized to Whole Genome SNP Genotyping Arrays
    Abstract: The earliest descriptions of human chromosomes initiated the genomics revolution that is now upon us. Array Comparative Genomic Hybridization: Protocols and Applications explores the scope of what is now possible as far as documenting abnormalities associated with several human cancers. While the technology for interrogating the human genome continues to evolve, refinement of comparative genomic hybridization (CGH) using array CGH and related technologies have provided enormous insight into human cancers at an affordable scale. Written in the successful Methods in Molecular Biologý„Ø series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. ℗ Authoritative and easily accessible, Array Comparative Genomic Hybridization: Protocols and Applications provides researchers with well-honed methodologies to learn these techniques for their own use in research or clinical diagnostic laboratories
    Pages: XII, 382 p. 33 illus., 16 illus. in color. : digital.
    ISBN: 9781627032810
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  • 4
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Basic Principles of Sterile Product Formulation Development -- Molecule and Manufacturability Assessment Leading to Robust Commercial Formulation for Therapeutic Proteins -- Polymer and Lipid Based Systems for Parenteral Drug Delivery -- Formulation Approaches and Strategies for PEGylated Biotherapeutics -- Nasal Delivery -- Formulation Approaches and Strategies for Vaccines and Adjuvants -- Challenges in Freeze-Thaw Processing of Bulk Protein Solutions -- Best Practices for Technology Transfer of Sterile Products: Case Studies -- Transfer Across Barrier Systems: A New Source of Simplification in Aseptic Fill and Finish Operations -- Challenges and Innovation in Aseptic Filling: Case Study with the Closed Vial Technology -- Contemporary Approaches to Development and Manufacturing of Lyophilized Parenterals -- Advances in Container Closure Integrity Testing -- Pen and Autoinjector Drug Delivery Devices -- Particulate Matter in Sterile Parenteral Products -- Appearance Evaluation of Parenteral Pharmaceutical Products -- Sterile Filtration Principles, Best Practices and New Developments -- Intravenous Admixture Compatibility for Sterile Products: Challenges and Regulatory Guidance -- Basics of Sterilization Methods -- Avoiding Common Errors during Viable Microbial Contamination Investigations -- Validation of Rapid Microbiology Methods (RMMs) -- Validation of Moist and Dry Heat Sterilization
    Abstract: This comprehensive book encompasses various facets of sterile product development. Key concepts relevant to the successful development of sterile products are illustrated through case studies and are covered under three sections in this book: • Formulation approaches that discuss a variety of dosage forms including protein therapeutics, lipid-based controlled delivery systems, PEGylated biotherapeutics, nasal dosage form, and vaccines • Process, container closure and delivery considerations including freeze-thaw process challenges, best practices for technology transfer to enable commercial product development, innovations and advancement in aseptic fill-finish operations, approaches to manufacturing lyophilized parenteral products, pen / auto-injector delivery devices, and associated container closure integrity testing hurdles for sterile product closures • Regulatory and quality aspects in the areas of particulate matter and appearance evaluation, sterile filtration, admixture compatibility considerations, sterilization process considerations, microbial contamination investigations and validation of rapid microbiological methods, and dry and moist heat sterilizers This book is a useful resource to scientists and researchers in both industry and academia, and it gives process and product development engineers insight into current industry practices and evolving regulatory expectations for sterile product development
    Pages: XVI, 585 p. 89 illus., 67 illus. in color. : online resource.
    ISBN: 9781461479789
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  • 5
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    Cham : Springer International Publishing
    Keywords: Medicine ; Neurosciences ; Data mining ; Semantics ; Cognitive Psychology ; Biomedicine ; Neurosciences ; Data Mining and Knowledge Discovery ; Semantics ; Cognitive Psychology ; Springer eBooks
    Abstract: This book presents a study of semantics and sentics understanding derived from user-generated multimodal content (UGC). It enables researchers to learn about the ways multimodal analysis of UGC can augment semantics and sentics understanding and it helps in addressing several multimedia analytics problems from social media such as event detection and summarization, tag recommendation and ranking, soundtrack recommendation, lecture video segmentation, and news video uploading. Readers will discover how the derived knowledge structures from multimodal information are beneficial for efficient multimedia search, retrieval, and recommendation. However, real-world UGC is complex, and extracting the semantics and sentics from only multimedia content is very difficult because suitable concepts may be exhibited in different representations. Moreover, due to the increasing popularity of social media websites and advancements in technology, it is now possible to collect a significant amount of important contextual information (e.g., spatial, temporal, and preferential information). Thus, there is a need to analyze the information of UGC from multiple modalities to address these problems. A discussion of multimodal analysis is presented followed by studies on how multimodal information is exploited to address problems that have a significant impact on different areas of society (e.g., entertainment, education, and journalism). Specifically, the methods presented exploit the multimedia content (e.g., visual content) and associated contextual information (e.g., geo-, temporal, and other sensory data). The reader is introduced to several knowledge bases and fusion techniques to address these problems. This work includes future directions for several interesting multimedia analytics problems that have the potential to significantly impact society. The work is aimed at researchers in the multimedia field who would like to pursue research in the area of multimodal analysis of UGC
    Pages: XXII, 263 p. 63 illus., 42 illus. in color. : online resource.
    ISBN: 9783319618074
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  • 6
    Call number: WN200:66/4
    Keywords: Pain / radiography ; Pain / etiology ; Radiography / methods
    Description / Table of Contents: General principles -- Diagnostic techniques -- Skull base -- Cervical spine -- Thoracic spine -- Lumbar spine -- Vertebral body -- Intervertebral disc -- Pelvis -- Other
    Pages: xvii, 191, vi p. : ill.
    ISBN: 9781931884198
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    WN200:66/4 available
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  • 7
    Keywords: Life sciences ; Biodiversity ; Plant Ecology ; Botany ; Plant anatomy ; Plant physiology ; Life sciences ; Plant Sciences ; Plant physiology ; Biodiversity ; Plant Systematics/Taxonomy/Biogeography ; Plant Anatomy/Development ; Plant Ecology ; Springer eBooks
    Description / Table of Contents: Pakistan and Pakistani Himalayas -- Ethnobotany and Ethnomedicine -- Phytochemicals and Nutraceuticals -- Ethnobotanical Aspects of Wild Edible Vegetables -- Nutritional Contents of Wild Edible Vegetables -- Metal Levels in Wile Edible Vegetables -- Phytochemical Contents of Wild Edible Vegetables -- Antioxidant Properties of Wild Edible Vegetables.℗ ℗ ℗ ℗ ℗
    Abstract: Our intention with this book was to present the reader with the most accurate, significant, and up-to-date background and knowledge in the areas of ethnomedicinal and nutraceutical vegetation for the Lesser Himalayas in a comprehensive text. Wild Edible Vegetables of Lesser Himalayas provides a complete review of over 50 important plants of this region and details each species including photographs, botanical name, local name, family, flowering and fruiting period, status and habitat, parts used, distribution, ethnobotanical uses, cultural aspects, medicinal uses, and nutraceutical aspects. Medicinal uses include mode of preparation, method of application and diseases studied; cultural aspects and index; nutraceutical data provides analysis of fats, proteins, fibers, carbohydrates, ash, moisture content, dry matter, and energy value; elemental analysis includes various essential and toxic metals; phytochemical screening includes total phenolics, flavonoids, flavonols and ascorbic acid, and antioxidant potential in terms of DPPH scavenging activity, hydroxyl radical scavenging activity, H2O2 scavenging activity, Fe2+ chelating activity, ferric reducing antioxidant power, and phosphomolybdenum assay for each species. Wild Edible Vegetables of Lesser Himalayas is a concise and handy guide for scientists, scholars, and students interested in the study of agriculture, food science, nutraceutical science, bioscience, biodiversity, applied ethnobotany, ethnoecology, and ecology.℗ ℗
    Pages: XVII, 360 p. 251 illus. in color. : online resource.
    ISBN: 9783319095431
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  • 8
    Keywords: Medicine ; Toxicology ; Animal Physiology ; Biomedicine ; Pharmacology/Toxicology ; Animal Physiology ; Biophysics and Biological Physics ; Springer eBooks
    Description / Table of Contents: 1 Percutaneous Absorption -- 2 Animal Models for Percutaneous Absorption -- 3 Mitigating Dermal Exposure to Agrochemicals -- 4 Importance of In Vitro Drug Release -- 5 Diffusion Cell Design -- 6 In Vitro Product Quality Tests and Product Performance Tests for Topical and Transdermal Drug Products -- 7 Safety and efficacy testing of topical products; Practical considerations -- 8 Challenges in Evaluating Bioequivalence of Topical Dermatological Drug Products -- 9 Methods for the Assessment of Bioequivalence of Topical Dosage Forms: Correlations, Optimization Strategies and Innovative Approaches -- 10 Application of Microdialysis in Assessing Cutaneous Bioavailability -- 11 Follicular Drug Penetration -- 12 Development of Pilosebaceous Unit-Targeted Drug Products -- 13 Deep Percutaneous Penetration into Muscles and Joints: Update -- 14 Efficacy & Toxicity of Microneedle based devices -- 15 Mathematical Models for Topical and Transdermal Drug Products -- 16 Transdermal Patches: An Industrial Perspective on the Relevance of in vitro Skin Permeation Studies and Approaches on Design of Manufacturing Processes -- 17 Transdermal Drug Delivery Systems. Regulatory Considerations:℗ NDA and ANDA Requirements -- 18 Transdermal Estradiol and Testosterone Transfer in Man: Existence, Models, and Strategies for Prevention -- 19 Effects of occlusion on dermal drug delivery: implications for bioequivalence measurement -- 20 Challenges with Clinical Endpoints ́€“ Bioequivalence -- 21 Clinical Considerations of Bioequivalence For Topical Dermatologic Drugs -- 22 OECD Test Guideline 428 ́€“ A method for in vitro percutaneous absorption measurement? -- 23 Bioequivalence, Quality, and Novel Assessment Technologies for Topical Products: Current Challenges and Future Prospects
    Abstract: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modeling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation. ℗ Vinod P. Shah is a pharmaceutical consultant. He was Scientific Secretary of the International Pharmaceutical Federation (FIP) and is now Chair of the FIP Regulatory Sciences Special Interest Group. Dr. Shah has served at the U.S. Food and Drug Administration and has developed several regulatory guidances for the pharmaceutical industry in biopharmaceutics and topical drug products. Howard I. Maibach is professor of dermatology at the University of California, San Francisco. He received his M.D. at Tulane University Medical School in New Orleans, Louisiana, and completed his residency and research fellowships at the University of Pennsylvania in Philadelphia, Pennsylvania. Professor Maibach is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted research and written extensively. John Jenner is a principal scientist at The Defence Science and Technology Laboratory in the UK. He has a degree in pharmacology from the University of Manchester in Manchester, UK, and a Ph.D. from the University of Surrey, Guildford, UK. John has spent his career studying defense against and treatment of highly toxic chemicals. He has an enduring research interest in percutaneously active chemicals, whether toxic materials or drugs, and experience in the design and testing of transdermal formulations
    Pages: XIII, 402 p. 64 illus., 16 illus. in color. : online resource.
    Edition: 2nd ed. 2014.
    ISBN: 9781493912896
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  • 9
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    Eagleville, PA : DNA Press
    Call number: A0500:63
    Keywords: DNA microarrays ; Oligonucleotide Array Sequence Analysis
    Pages: vi, 206 p.
    ISBN: 0-9664027-5-8
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    A0500:63 departmental collection or stack – please contact the library
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  • 10
    Keywords: Medicine ; Pathology ; Urology ; Medicine & Public Health ; Pathology ; Urology/Andrology ; Springer eBooks
    Pages: : digital
    ISBN: 9783642213694
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