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  • 1
    ISSN: 1432-1041
    Keywords: Piperine ; Propranolol ; Theophylline ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline. In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Regeneration ; Tectum ; Optic Nerve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In adult goldfish the caudal half of the optic tectum was removed. In some animals the corresponding optic nerve was crushed as well. The animals were later used to map the retinotectal projection. 2. In fishes with the tectal lesion only, the displaced projection from the missing half-tectum was found to be partially restored over the residual rostral half-tectum, in appropriate retinotopic order. Parts of the residual tectum thus received input from two field positions. 3. In fishes with a tectal lesion and crush of the optic nerve, several animals showed compression of the projection of the entire visual field onto the residual half-tectum. In some animals reduplicated field positions were also observed. 4. The results are discussed in relation to the mechanism controlling selective fibre regeneration. It is concluded that a strict place-specificity does not exist along the rostrocaudal axis of the tectum and a mechanism of connection control involving pattern regulation is discussed.
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  • 3
    ISSN: 1432-2242
    Keywords: Wheat ; Single seed descent (SSD) ; Single plant selection (SPS) ; Bulk population (BP) ; Mechanical mass selection (MMS)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Four methods of generation advance (SPS, SSD, BP and MMS) were compared in F3 and F4 generations. In the F3 generation, the SPS and SSD methods of generation advance proved superior to the BP and MMS methods for grain yield per plant and for at least one of the yield component traits. The F3 SSD population did not differ significantly from the F3 SPS for any of the traits. However, the F3 SSD population retained more range and cv for different traits than with other methods of generation advance. F4 progenies derived from F3 SSD population were significantly superior for grain yield than lines derived from the other three F3 populations. The MMS method of generation advance proved useful for increasing the 1,000-grain weight for which initial selection was made.
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  • 4
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have measured menstrual blood loss (MBL) in 56 women with dysfunctional uterine bleeding and in 38 women with normal MBL and also estimated histamine and mast cell counts in the myometrium, myometrial/endometrial border and endometrium following hysterectomies. Our results suggest that excessive menstrual bleeding is associated with mast cell degranulation and histamine release from the uterus.
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  • 5
    ISSN: 1432-0568
    Keywords: Ontogeny ; Immunohistochemistry ; Neu ropeptides ; CNS ; Teleostei
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development of substance P-like immunoreactivity (SPLI) in the goldfish brain was studied by means of the indirect peroxidase-antiperoxidase technique and an antibody to substance P. By 80 h after fertilization, the first SPLI-cell bodies appear in the ventricular zone of the future diencephalon and the first SPLI-fibers appear in the olfactory bulbs. Two days after hatching (which occurs at 100 h after fertilization), SPLI fibers connecting the olfactory bulbs and hypothalamus are seen. In the optic tectum SPLI-fibers appear for the first time 5 days after hatching. In the brain stem, SPLI-cell bodies appear in juvenile animals 40 days after hatching. The highest number and intensity of SPLI-cell bodies and fibers are found in the area postrema. SPLI-cell bodies are also seen in the gustatory nucleus, nucleus ambiguus, reticular formation of the medulla, dorsal motor nucleus of the vagus and commissural nucleus of Cajal. The significant information gained from the present study is: 1. The rostro-caudal sequence in which the SPLI appears in the developing nuclei of the goldfish brain 2. The reduction of SPLI-cell bodies in some nuclei with age Thus, in the brain stem, SPLI-cell bodies that were labeled in juvenile goldfish were not seen in adults. This might be due to changes in the rate of axonal transport, changes of the SP phenotype during development or cell death. The developmental sequence and relative timing in which SPLI-cell bodies appear in the goldfish, rat and mice are similar.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 52 (1991), S. 247-254 
    ISSN: 1432-0630
    Keywords: 78.70.Bj ; 36.10.Dr ; 71.60+z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract We have studied two-dimensional argon and nitrogen physisorbed on grafoil by conducting positron lifetime and Doppler broadening measurements as functions of adsorbate coverage and temperature. Positron lifetime and Doppler broadening parameters show turnarounds near one-half monolayer coverages at 77 K. The s parameter of the Doppler broadening spectra measured for one-half monolayer coverages of argon and nitrogen increases with temperature across the melting phase transition. We discuss the observed coverage and temperature effects following models based on Kosterlitz-Thouless-Nelson-Halperin-Young theory of two dimensional melting and positron localization in surface defects.
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 21 (1989), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 60 patients (45 male and 15 female) with suspected airborne contact dermatitis from Compositae (Asteraceae) plants and 20 age-matched controls (15 male and 5 female) were investigated. Patch tests were performed with ethanolic plant extracts of 4 Compositae plants. Parthenium hysterophorus, Chrysanthemum morifolium, Dahlia pinnata and Tagetes indica, all prevalent in northern India. 55 (92%) patients showed positive patch tests, with 35 (64%) demonstrating positive tests to extracts of only 1 of the 4 plants tested. No positive patch tests were seen in the controls. Parthenium hysterophorus (78%) was the most frequent plant reacting, followed by Chrysanthemum morifolium (42%), Dahlia pinnata (18%) and Tagetes indica (7%).
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 21 (1989), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 32 patients (24 male, 8 female) with contact dermatitis from Chrysanthemum morifolium are reported. 24 (75%) patients gave a history of seasonal variation and 16 (50%) of photoaggravation and/or photosensitivity. Exposure to chrysanthemums was occupational in 18 and recreational in 12. The common clinical presentations were hand and face dermatitis in 13 (41%) and airborne contact dermatitis in 10 (31 %) patients. All 32 patients demonstrated positive patch tests to ethanolic extracts of the flowers, 30 to the leaves, 28 to the whole plant, and only 6 to the stems, in that order of intensity.
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  • 9
    ISSN: 1420-9071
    Keywords: Mast cells ; histamine ; D-galactosamine ; extracellular Ca++
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rat peritoneal mast cells were isolated and purified by differential centrifugation in Ficoll. Cells pooled from three to four rats were suspended at approximately 106 cells/ml in a buffered salt solution and incubated for 1 h at 37°C in 300 μl volumes in the absence or presence (9×10−4 M) of calcium chloride. Addition of D-galactosamine hydrochloride (DGM; 2.8×10−4 M) caused (in addition to basal release) a mean ±SEM percent histamine release of 15.7±5.2 in the presence of Ca++ and 19±4.9 in the absence of Ca++ (p〉0.05). It is suggested that D-galactosamine does not require extracellular Ca++ for the release of histamine from the rat mast cell.
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  • 10
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A TLC technique for the detection and separation of dyestuffs in alcoholic drinks has been described. The migration distance and the colours of the separated coloured spots of 27 internationally recognised dye-stuffs obtained from alcoholic beverages are recorded.
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